1P72A

Crystal structure of ehv4-tk complexed with thy and adp
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 122
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 7-119 113 1-6 310-333 120-309 6 24 slipknot
Chain Sequence
SHMVTIVRIYLDGVYGIGKSTTGRVMASAASGGSPTLYFPEPMAYWRTLFETDVISGIYDTQN----------DAALITAHYQSRFTTPYLILHDHTCTLFGGNSLQRGTQPDLTLVFDRHPVASTVCFPAARYLLGDMSMCALMAMVATLPREPQGGNIVVTTLNVEEHIRRLRTRARIGEQIDITLIATLRNVYFMLVNTCHFLRSGRVWRDGWGELPTSCGAYKHRATQMDAFQERVSPELGDTLFALFKTQELLDDRGVILEVHAWALDALMLKLRNLNVFSADLSGTPRQCAAVVESLLPLMSSTLSDFDSASALERAARTFNAEMGV
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 7-150 144 1-6 299-323 151-298 6 25 slipknot
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2.1 10-114 105 1-3, 149-323 4-9, 115-148 3 175 slipknot
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3.1 10-215 206 1-6, 281-323 7-9, 216-280 6 43 slipknot
sequence length 333
structure length 323
publication title Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
pubmed doi rcsb
molecule tags Transferase
molecule keywords Thymidine kinase
source organism Equid herpesvirus 4
missing residues 64-73
total genus Genus: 122
ec nomenclature ec 2.7.1.21: Thymidine kinase.
pdb deposition date 2003-04-30
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00693 Herpes_TK Thymidine kinase from herpesvirus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolases 1p72A00
1P72A 1P75A 2VTKA 1E2HA 1E2LA 1QHIA 1P73A 1P7CA 4IVQA 1F48A 1OSNA 1KI6A 1E2IA 1KIMA 1P6XA 1KI6B 3F0TA 3RDPA 1OF1A 1KI3A 1GKUB 1KI7A 1II9A 4IVPA 1E2MA 1VTKA 3VTKA 4JBXA 1KI2A 4IVRA 1E2NA 1E2JA 1E2PA 1E2KA 2KI5A 4JBYA 1KI4A 1KI8A
chains in the KnotProt database with same CATH superfamily
3L06A 1QMGA 3FR8A 1P72A 1DBIA 1P75A 1LNSA 2VTKA 2FG6C 1E2HA 1E2LA 1QHIA 3KZOA 3M5DA 1P73A 1P7CA 4IVQA 1F48A 1OSNA 3L05A 1R4MB 3M4JA 1YRLA 1KI6A 1E2IA 1KIMA 1P6XA 1KI6B 3F0TA 3RDPA 1OF1A 1YH1A 1KI3A 1GKUB 1KI7A 3KZNA 1II9A 2XTJA 4IVPA 1E2MA 1R4NB 1VTKA 3VTKA 4JBXA 1JS1X 3L02A 1KI2A 4IVRA 1E2NA 1E2JA 3FSGA 1E2PA 3KZKA 1E2KA 2G7MC 3L04A 2KI5A 3M4NA 1YVEI 3M5CA 3KZCA 4JBYA 1KI4A 3KZMA 1KI8A 3FR7A
chains in the KnotProt database with same CATH topology
1P72A 1P75A 2VTKA 1E2HA 1E2LA 1QHIA 1P73A 1P7CA 4IVQA 1F48A 1OSNA 1KI6A 1E2IA 1KIMA 1P6XA 1KI6B 3F0TA 3RDPA 1OF1A 1KI3A 1GKUB 1KI7A 1II9A 4IVPA 1E2MA 1VTKA 3VTKA 4JBXA 1KI2A 4IVRA 1E2NA 1E2JA 1E2PA 1E2KA 2KI5A 4JBYA 1KI4A 1KI8A
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1P72 A;  1P75 A;  2VTK A;  1E2H A;  1E2L A;  1QHI A;  1P73 A;  1P7C A;  4IVQ A;  1F48 A;  1OSN A;  1KI6 A;  1E2I A;  1KIM A;  1P6X A;  1KI6 B;  3F0T A;  3RDP A;  1OF1 A;  1KI3 A;  1GKU B;  1KI7 A;  1II9 A;  4IVP A;  1E2M A;  1VTK A;  3VTK A;  4JBX A;  1KI2 A;  4IVR A;  1E2N A;  1E2J A;  1E2P A;  1E2K A;  2KI5 A;  4JBY A;  1KI4 A;  1KI8 A; 
#chains in the KnotProt database with same CATH topology
 3L06 A;  1QMG A;  3FR8 A;  1P72 A;  1DBI A;  1P75 A;  1LNS A;  2VTK A;  2FG6 C;  1E2H A;  1E2L A;  1QHI A;  3KZO A;  3M5D A;  1P73 A;  1P7C A;  4IVQ A;  1F48 A;  1OSN A;  3L05 A;  1R4M B;  3M4J A;  1YRL A;  1KI6 A;  1E2I A;  1KIM A;  1P6X A;  1KI6 B;  3F0T A;  3RDP A;  1OF1 A;  1YH1 A;  1KI3 A;  1GKU B;  1KI7 A;  3KZN A;  1II9 A;  2XTJ A;  4IVP A;  1E2M A;  1R4N B;  1VTK A;  3VTK A;  4JBX A;  1JS1 X;  3L02 A;  1KI2 A;  4IVR A;  1E2N A;  1E2J A;  3FSG A;  1E2P A;  3KZK A;  1E2K A;  2G7M C;  3L04 A;  2KI5 A;  3M4N A;  1YVE I;  3M5C A;  3KZC A;  4JBY A;  1KI4 A;  3KZM A;  1KI8 A;  3FR7 A; 
#chains in the KnotProt database with same CATH homology
 1P72 A;  1P75 A;  2VTK A;  1E2H A;  1E2L A;  1QHI A;  1P73 A;  1P7C A;  4IVQ A;  1F48 A;  1OSN A;  1KI6 A;  1E2I A;  1KIM A;  1P6X A;  1KI6 B;  3F0T A;  3RDP A;  1OF1 A;  1KI3 A;  1GKU B;  1KI7 A;  1II9 A;  4IVP A;  1E2M A;  1VTK A;  3VTK A;  4JBX A;  1KI2 A;  4IVR A;  1E2N A;  1E2J A;  1E2P A;  1E2K A;  2KI5 A;  4JBY A;  1KI4 A;  1KI8 A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling