1R4M | KnotProt

Cysteine knot

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				Loop	Piercing
view details				202-c-343-b-346-c-346	199-b-343

Chain Sequence

DWEGRWNHVKKFLERSGPFTHPDFEPSTESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDIGRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLISLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMATIASMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYRLTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAERKENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATN----RTLYLQSVTSIEERTRKELGL-------VDGQEAVADVTTPQTVL-FKLHFT

sequence length	430
structure length	418
publication title	The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. pubmed doi rcsb
molecule tags	Cell cycle
molecule keywords	amyloid beta precursor protein-binding protein 1
source organism	Homo sapiens
missing residues	374-377, 395-401, 412
ec nomenclature
pdb deposition date	2003-10-07

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
1.10.10.520	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Ubiquitin activating enzymes (Uba3). Chain: B, domain 2	1r4mB02
3.10.20.260	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Ubiquitin activating enzymes (Uba3). Chain: B, domain 3	1r4mB03
3.40.50.720	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	NAD(P)-binding Rossmann-like Domain	1r4mB01

1R4NB 1YVEI 1R4MB 3FR8A 3FR7A 1QMGA 1YRLA
chains in the KnotProt database with same CATH superfamily

1E2HA 1E2LA 1R4NB 3VTKA 4IVQA 3L04A 3M5DA 1P73A 3M4NA 1KIMA 1KI3A 4IVRA 3KZKA 3RDPA 3L02A 1YH1A 2FG7X 1E2KA 1E2PA 1DBIA 2G7MC 1KI2A 1KI6A 1OSNA 3FR8A 1QHIA 2KI5A 3KZMA 2FG7C 1KI6B 1II9A 3FR7A 2XTJA 1QMGA 1E2IA 3KZOA 1JS1X 3M4JA 2FG6C 1P75A 4JBYA 1R4MB 3KZNA 1LNSA 4IVPA 1YRLA 2VTKA 1OF1A 1P72A 1KI4A 1KI8A 1KI7A 1E2MA 3KZCA 3M5CA 1P6XA 1E2NA 4JBXA 1F48A 3L05A 1YVEI 1E2JA 3F0TA 3FSGA 1VTKA 1P7CA 3L06A 1GKUB
chains in the KnotProt database with same CATH topology

1R4NB 1YVEI 1R4MB 3FR8A 3FR7A 1QMGA 1YRLA
chains in the KnotProt database with same CATH homology

#chains in the KnotProt database with same CATH superfamily
 1R4N B;  1YVE I;  1R4M B;  3FR8 A;  3FR7 A;  1QMG A;  1YRL A; 
#chains in the KnotProt database with same CATH topology
 1E2H A;  1E2L A;  1R4N B;  3VTK A;  4IVQ A;  3L04 A;  3M5D A;  1P73 A;  3M4N A;  1KIM A;  1KI3 A;  4IVR A;  3KZK A;  3RDP A;  3L02 A;  1YH1 A;  2FG7 X;  1E2K A;  1E2P A;  1DBI A;  2G7M C;  1KI2 A;  1KI6 A;  1OSN A;  3FR8 A;  1QHI A;  2KI5 A;  3KZM A;  2FG7 C;  1KI6 B;  1II9 A;  3FR7 A;  2XTJ A;  1QMG A;  1E2I A;  3KZO A;  1JS1 X;  3M4J A;  2FG6 C;  1P75 A;  4JBY A;  1R4M B;  3KZN A;  1LNS A;  4IVP A;  1YRL A;  2VTK A;  1OF1 A;  1P72 A;  1KI4 A;  1KI8 A;  1KI7 A;  1E2M A;  3KZC A;  3M5C A;  1P6X A;  1E2N A;  4JBX A;  1F48 A;  3L05 A;  1YVE I;  1E2J A;  3F0T A;  3FSG A;  1VTK A;  1P7C A;  3L06 A;  1GKU B; 
#chains in the KnotProt database with same CATH homology
 1R4N B;  1YVE I;  1R4M B;  3FR8 A;  3FR7 A;  1QMG A;  1YRL A;

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similar chains in the KnotProt database (?% sequence similarity)

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similar chains in the pdb database (?% sequence similarity)

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