1P73A

Crystal structure of ehv4-tk complexed with tp4a
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 108
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 5-116 112 1-4 307-331 117-306 4 25 slipknot
Chain Sequence
MVTIVRIYLDGVYGIGKSTTGRVMAS-----SPTLYFPEPMAYWRTLFETDVISGIYDTQNRKVDDAA------LITAHYQSRFTTPYLILHDHTCTLFGGNSLQRGTQPDLTLVFDRHPVASTVCFPAARYLLGDMSMCALMAMVATLPREPQGGNIVVTTLNVEEHIRRLRTRARIGEQIDITLIATLRNVYFMLVNTCHFLRSGRVWRDGWGELPTSCGAYKHRATQMDAFQERVSPELGDTLFALFKTQELLDDRGVILEVHAWALDALMLKLRNLNVFSADLSGTPRQCAAVVESLLPLMSSTLSDFDSASALERAARTFNAEMGV
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 8-108 101 1-7 144-320 109-143 7 177 slipknot
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3.1 7-184 178 1-6 295-320 185-294 6 26 slipknot
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2.1 7-144 138 1-2, 161-320 3-6, 145-160 2 160 slipknot
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2.1 7-181 175 1-2, 185-320 3-6, 182-184 2 136 slipknot
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2.1 8-187 180 1-6, 284-320 7-7, 188-283 6 37 slipknot
sequence length 331
structure length 320
publication title Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
pubmed doi rcsb
molecule tags Transferase
molecule keywords Thymidine kinase
source organism Equid herpesvirus 4
missing residues 27-31, 64-69
total genus Genus: 108
ec nomenclature ec 2.7.1.21: Thymidine kinase.
pdb deposition date 2003-04-30
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00693 Herpes_TK Thymidine kinase from herpesvirus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolases 1p73A00
4JBYA 2KI5A 1E2LA 1P72A 1OF1A 1E2JA 1F48A 1VTKA 1KI6B 3VTKA 1P7CA 1KI7A 3RDPA 4IVRA 2VTKA 1E2MA 1II9A 1KI4A 1OSNA 4IVQA 4JBXA 1E2NA 1KI6A 1KI8A 1P75A 3F0TA 1KIMA 1GKUB 1E2PA 1QHIA 1P6XA 1E2HA 1E2KA 1KI3A 4IVPA 1KI2A 1P73A 1E2IA
chains in the KnotProt database with same CATH superfamily
3L02A 4JBYA 2KI5A 1E2LA 1P72A 3L05A 1OF1A 1E2JA 1F48A 3FR7A 1YVEI 3M4NA 1VTKA 1KI6B 3FR8A 3M5CA 3VTKA 1P7CA 3L04A 3KZOA 1KI7A 3FSGA 3M4JA 3RDPA 4IVRA 2VTKA 2G7MC 1E2MA 3M5DA 1LNSA 1II9A 1KI4A 2XTJA 1OSNA 4IVQA 1DBIA 4JBXA 1E2NA 1KI6A 1KI8A 1P75A 3F0TA 3KZNA 3L06A 1KIMA 3KZKA 3KZMA 1E2PA 1YH1A 1QHIA 1P6XA 1E2HA 1GKUB 1JS1X 1E2KA 1YRLA 1KI3A 4IVPA 1R4NB 1KI2A 1P73A 1QMGA 2FG6C 3KZCA 1R4MB 1E2IA
chains in the KnotProt database with same CATH topology
4JBYA 2KI5A 1E2LA 1P72A 1OF1A 1E2JA 1F48A 1VTKA 1KI6B 3VTKA 1P7CA 1KI7A 3RDPA 4IVRA 2VTKA 1E2MA 1II9A 1KI4A 1OSNA 4IVQA 4JBXA 1E2NA 1KI6A 1KI8A 1P75A 3F0TA 1KIMA 1GKUB 1E2PA 1QHIA 1P6XA 1E2HA 1E2KA 1KI3A 4IVPA 1KI2A 1P73A 1E2IA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 4JBY A;  2KI5 A;  1E2L A;  1P72 A;  1OF1 A;  1E2J A;  1F48 A;  1VTK A;  1KI6 B;  3VTK A;  1P7C A;  1KI7 A;  3RDP A;  4IVR A;  2VTK A;  1E2M A;  1II9 A;  1KI4 A;  1OSN A;  4IVQ A;  4JBX A;  1E2N A;  1KI6 A;  1KI8 A;  1P75 A;  3F0T A;  1KIM A;  1GKU B;  1E2P A;  1QHI A;  1P6X A;  1E2H A;  1E2K A;  1KI3 A;  4IVP A;  1KI2 A;  1P73 A;  1E2I A; 
#chains in the KnotProt database with same CATH topology
 3L02 A;  4JBY A;  2KI5 A;  1E2L A;  1P72 A;  3L05 A;  1OF1 A;  1E2J A;  1F48 A;  3FR7 A;  1YVE I;  3M4N A;  1VTK A;  1KI6 B;  3FR8 A;  3M5C A;  3VTK A;  1P7C A;  3L04 A;  3KZO A;  1KI7 A;  3FSG A;  3M4J A;  3RDP A;  4IVR A;  2VTK A;  2G7M C;  1E2M A;  3M5D A;  1LNS A;  1II9 A;  1KI4 A;  2XTJ A;  1OSN A;  4IVQ A;  1DBI A;  4JBX A;  1E2N A;  1KI6 A;  1KI8 A;  1P75 A;  3F0T A;  3KZN A;  3L06 A;  1KIM A;  3KZK A;  3KZM A;  1E2P A;  1YH1 A;  1QHI A;  1P6X A;  1E2H A;  1GKU B;  1JS1 X;  1E2K A;  1YRL A;  1KI3 A;  4IVP A;  1R4N B;  1KI2 A;  1P73 A;  1QMG A;  2FG6 C;  3KZC A;  1R4M B;  1E2I A; 
#chains in the KnotProt database with same CATH homology
 4JBY A;  2KI5 A;  1E2L A;  1P72 A;  1OF1 A;  1E2J A;  1F48 A;  1VTK A;  1KI6 B;  3VTK A;  1P7C A;  1KI7 A;  3RDP A;  4IVR A;  2VTK A;  1E2M A;  1II9 A;  1KI4 A;  1OSN A;  4IVQ A;  4JBX A;  1E2N A;  1KI6 A;  1KI8 A;  1P75 A;  3F0T A;  1KIM A;  1GKU B;  1E2P A;  1QHI A;  1P6X A;  1E2H A;  1E2K A;  1KI3 A;  4IVP A;  1KI2 A;  1P73 A;  1E2I A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling