1E2NA

Hpt + hmtt
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 114
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 5-117 113 1-4 306-329 118-305 4 24 slipknot
Chain Sequence
MPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGS----PPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQCGGSWREDWGQLSGPRPH---------------IGDTLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRSMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPTICDLARTFAREMGE
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 8-116 109 1-7 150-310 117-149 7 161 slipknot
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3.1 7-151 145 1-6 164-310 152-163 6 147 slipknot
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3.1 7-163 157 1-6 178-310 164-177 6 133 slipknot
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2.1 8-170 163 1-7 285-310 171-284 7 26 slipknot
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2.1 9-164 156 1-7, 282-310 8-8, 165-281 7 29 slipknot
sequence length 329
structure length 310
publication title The Effect of Substrate Binding on the Conformation and Structural Stability of Herpes Simplex Virus Type 1 Thymidine Kinase
pubmed doi rcsb
molecule tags Transferase
molecule keywords THYMIDINE KINASE
source organism Herpes simplex virus (type 1 / strain 17)
missing residues 105-108, 220-234
total genus Genus: 114
ec nomenclature ec 2.7.1.21: Thymidine kinase.
pdb deposition date 2000-05-23
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00693 Herpes_TK Thymidine kinase from herpesvirus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolases 1e2nA00
1P7CA 1KI2A 1P6XA 1E2PA 1VTKA 4IVQA 1P75A 4JBXA 3F0TA 4IVPA 3RDPA 1E2NA 1E2KA 1E2IA 1KI4A 1KI7A 1F48A 4JBYA 1KI6A 1OF1A 4IVRA 1E2JA 1E2LA 1P72A 1II9A 1KIMA 1OSNA 1E2HA 1KI8A 1GKUB 1E2MA 1P73A 2KI5A 1KI6B 1QHIA 1KI3A 2VTKA 3VTKA
chains in the KnotProt database with same CATH superfamily
1DBIA 1P7CA 1KI2A 1P6XA 3KZKA 1YRLA 1E2PA 1VTKA 3KZCA 1JS1X 3M5DA 4IVQA 1P75A 3KZOA 4JBXA 3F0TA 4IVPA 3RDPA 1E2NA 1E2KA 1E2IA 1KI4A 1KI7A 1F48A 3L05A 1KI6A 3M4JA 4JBYA 1OF1A 2XTJA 3M5CA 4IVRA 1LNSA 1E2JA 1E2LA 3L04A 1P72A 3KZMA 1II9A 3L06A 3FR7A 1KIMA 1YVEI 1QMGA 1E2HA 1OSNA 2G7MC 3FSGA 1KI8A 3M4NA 1R4NB 3KZNA 1GKUB 1E2MA 1P73A 3FR8A 2KI5A 1KI6B 1QHIA 2FG6C 3L02A 1YH1A 1KI3A 1R4MB 2VTKA 3VTKA
chains in the KnotProt database with same CATH topology
1P7CA 1KI2A 1P6XA 1E2PA 1VTKA 4IVQA 1P75A 4JBXA 3F0TA 4IVPA 3RDPA 1E2NA 1E2KA 1E2IA 1KI4A 1KI7A 1F48A 4JBYA 1KI6A 1OF1A 4IVRA 1E2JA 1E2LA 1P72A 1II9A 1KIMA 1OSNA 1E2HA 1KI8A 1GKUB 1E2MA 1P73A 2KI5A 1KI6B 1QHIA 1KI3A 2VTKA 3VTKA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1P7C A;  1KI2 A;  1P6X A;  1E2P A;  1VTK A;  4IVQ A;  1P75 A;  4JBX A;  3F0T A;  4IVP A;  3RDP A;  1E2N A;  1E2K A;  1E2I A;  1KI4 A;  1KI7 A;  1F48 A;  4JBY A;  1KI6 A;  1OF1 A;  4IVR A;  1E2J A;  1E2L A;  1P72 A;  1II9 A;  1KIM A;  1OSN A;  1E2H A;  1KI8 A;  1GKU B;  1E2M A;  1P73 A;  2KI5 A;  1KI6 B;  1QHI A;  1KI3 A;  2VTK A;  3VTK A; 
#chains in the KnotProt database with same CATH topology
 1DBI A;  1P7C A;  1KI2 A;  1P6X A;  3KZK A;  1YRL A;  1E2P A;  1VTK A;  3KZC A;  1JS1 X;  3M5D A;  4IVQ A;  1P75 A;  3KZO A;  4JBX A;  3F0T A;  4IVP A;  3RDP A;  1E2N A;  1E2K A;  1E2I A;  1KI4 A;  1KI7 A;  1F48 A;  3L05 A;  1KI6 A;  3M4J A;  4JBY A;  1OF1 A;  2XTJ A;  3M5C A;  4IVR A;  1LNS A;  1E2J A;  1E2L A;  3L04 A;  1P72 A;  3KZM A;  1II9 A;  3L06 A;  3FR7 A;  1KIM A;  1YVE I;  1QMG A;  1E2H A;  1OSN A;  2G7M C;  3FSG A;  1KI8 A;  3M4N A;  1R4N B;  3KZN A;  1GKU B;  1E2M A;  1P73 A;  3FR8 A;  2KI5 A;  1KI6 B;  1QHI A;  2FG6 C;  3L02 A;  1YH1 A;  1KI3 A;  1R4M B;  2VTK A;  3VTK A; 
#chains in the KnotProt database with same CATH homology
 1P7C A;  1KI2 A;  1P6X A;  1E2P A;  1VTK A;  4IVQ A;  1P75 A;  4JBX A;  3F0T A;  4IVP A;  3RDP A;  1E2N A;  1E2K A;  1E2I A;  1KI4 A;  1KI7 A;  1F48 A;  4JBY A;  1KI6 A;  1OF1 A;  4IVR A;  1E2J A;  1E2L A;  1P72 A;  1II9 A;  1KIM A;  1OSN A;  1E2H A;  1KI8 A;  1GKU B;  1E2M A;  1P73 A;  2KI5 A;  1KI6 B;  1QHI A;  1KI3 A;  2VTK A;  3VTK A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling