1E2PA

Thymidine kinase, dhbt
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 112
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 5-117 113 1-4 306-329 118-305 4 24 slipknot
Chain Sequence
MPTLLRVYIDGPHGMGKTTTTQLL-----RDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSPPALT----LIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQCGGSWREDWGQLSGPRPHIGDTL---------------FTLFRAPELLAPNGDLYNVFAWALDVLAKRLRSMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPTICDLARTFAREMGE
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 8-110 103 1-7 146-305 111-145 7 160 slipknot
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2.1 7-158 152 1-6 195-305 159-194 6 111 slipknot
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2.1 8-173 166 1-7 256-305 174-255 7 50 slipknot
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3.1 7-256 250 1-6 279-305 257-278 6 27 slipknot
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2.1 4-278 275 1-3 280-305 279-279 3 26 slipknot
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2.1 8-150 143 1-2, 172-305 3-7, 151-171 2 134 slipknot
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2.1 9-258 250 1-6, 278-305 7-8, 259-277 6 28 slipknot
sequence length 329
structure length 305
publication title The Effect of Substrate Binding on the Conformation and Structural Stability of Herpes Simplex Virus Type 1 Thymidine Kinase
pubmed doi rcsb
molecule tags Transferase
molecule keywords THYMIDINE KINASE
source organism Herpes simplex virus type 1
missing residues 25-29, 105-108, 220-234
total genus Genus: 112
ec nomenclature ec 2.7.1.21: Thymidine kinase.
pdb deposition date 2000-05-23
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00693 Herpes_TK Thymidine kinase from herpesvirus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolases 1e2pA00
1P73A 1E2NA 1F48A 1OF1A 3RDPA 1E2IA 1KI6A 1GKUB 1KI8A 1P72A 1KI6B 1E2PA 1E2JA 3F0TA 1KI2A 3VTKA 1E2MA 2KI5A 4JBYA 1KIMA 4IVPA 2VTKA 1KI7A 1VTKA 1OSNA 1P6XA 1E2KA 1KI4A 1II9A 1E2HA 1E2LA 4IVRA 1P75A 1KI3A 4IVQA 4JBXA 1QHIA 1P7CA
chains in the KnotProt database with same CATH superfamily
1P73A 2G7MC 1R4NB 3KZOA 1E2NA 1F48A 1OF1A 3M5CA 3RDPA 1DBIA 1E2IA 1KI6A 3M4NA 1GKUB 1KI8A 1P72A 1KI6B 1JS1X 1E2PA 1E2JA 3F0TA 1YRLA 2XTJA 2FG6C 3KZNA 1KI2A 1YVEI 3VTKA 1E2MA 2KI5A 3KZCA 4JBYA 1KIMA 4IVPA 3FSGA 2VTKA 3M5DA 3KZMA 1KI7A 1VTKA 1R4MB 1OSNA 1E2KA 1KI4A 1P6XA 3L06A 3KZKA 3FR8A 1II9A 1LNSA 1E2HA 1YH1A 3M4JA 3L04A 1E2LA 3L02A 3L05A 4IVRA 1P75A 1KI3A 3FR7A 1QMGA 4IVQA 4JBXA 1QHIA 1P7CA
chains in the KnotProt database with same CATH topology
1P73A 1E2NA 1F48A 1OF1A 3RDPA 1E2IA 1KI6A 1GKUB 1KI8A 1P72A 1KI6B 1E2PA 1E2JA 3F0TA 1KI2A 3VTKA 1E2MA 2KI5A 4JBYA 1KIMA 4IVPA 2VTKA 1KI7A 1VTKA 1OSNA 1P6XA 1E2KA 1KI4A 1II9A 1E2HA 1E2LA 4IVRA 1P75A 1KI3A 4IVQA 4JBXA 1QHIA 1P7CA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1P73 A;  1E2N A;  1F48 A;  1OF1 A;  3RDP A;  1E2I A;  1KI6 A;  1GKU B;  1KI8 A;  1P72 A;  1KI6 B;  1E2P A;  1E2J A;  3F0T A;  1KI2 A;  3VTK A;  1E2M A;  2KI5 A;  4JBY A;  1KIM A;  4IVP A;  2VTK A;  1KI7 A;  1VTK A;  1OSN A;  1P6X A;  1E2K A;  1KI4 A;  1II9 A;  1E2H A;  1E2L A;  4IVR A;  1P75 A;  1KI3 A;  4IVQ A;  4JBX A;  1QHI A;  1P7C A; 
#chains in the KnotProt database with same CATH topology
 1P73 A;  2G7M C;  1R4N B;  3KZO A;  1E2N A;  1F48 A;  1OF1 A;  3M5C A;  3RDP A;  1DBI A;  1E2I A;  1KI6 A;  3M4N A;  1GKU B;  1KI8 A;  1P72 A;  1KI6 B;  1JS1 X;  1E2P A;  1E2J A;  3F0T A;  1YRL A;  2XTJ A;  2FG6 C;  3KZN A;  1KI2 A;  1YVE I;  3VTK A;  1E2M A;  2KI5 A;  3KZC A;  4JBY A;  1KIM A;  4IVP A;  3FSG A;  2VTK A;  3M5D A;  3KZM A;  1KI7 A;  1VTK A;  1R4M B;  1OSN A;  1E2K A;  1KI4 A;  1P6X A;  3L06 A;  3KZK A;  3FR8 A;  1II9 A;  1LNS A;  1E2H A;  1YH1 A;  3M4J A;  3L04 A;  1E2L A;  3L02 A;  3L05 A;  4IVR A;  1P75 A;  1KI3 A;  3FR7 A;  1QMG A;  4IVQ A;  4JBX A;  1QHI A;  1P7C A; 
#chains in the KnotProt database with same CATH homology
 1P73 A;  1E2N A;  1F48 A;  1OF1 A;  3RDP A;  1E2I A;  1KI6 A;  1GKU B;  1KI8 A;  1P72 A;  1KI6 B;  1E2P A;  1E2J A;  3F0T A;  1KI2 A;  3VTK A;  1E2M A;  2KI5 A;  4JBY A;  1KIM A;  4IVP A;  2VTK A;  1KI7 A;  1VTK A;  1OSN A;  1P6X A;  1E2K A;  1KI4 A;  1II9 A;  1E2H A;  1E2L A;  4IVR A;  1P75 A;  1KI3 A;  4IVQ A;  4JBX A;  1QHI A;  1P7C A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling