1P72A

Crystal structure of ehv4-tk complexed with thy and adp
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 122
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 7-119 113 1-6 310-333 120-309 6 24 slipknot
Chain Sequence
SHMVTIVRIYLDGVYGIGKSTTGRVMASAASGGSPTLYFPEPMAYWRTLFETDVISGIYDTQN----------DAALITAHYQSRFTTPYLILHDHTCTLFGGNSLQRGTQPDLTLVFDRHPVASTVCFPAARYLLGDMSMCALMAMVATLPREPQGGNIVVTTLNVEEHIRRLRTRARIGEQIDITLIATLRNVYFMLVNTCHFLRSGRVWRDGWGELPTSCGAYKHRATQMDAFQERVSPELGDTLFALFKTQELLDDRGVILEVHAWALDALMLKLRNLNVFSADLSGTPRQCAAVVESLLPLMSSTLSDFDSASALERAARTFNAEMGV
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 7-150 144 1-6 299-323 151-298 6 25 slipknot
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2.1 10-114 105 1-3, 149-323 4-9, 115-148 3 175 slipknot
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3.1 10-215 206 1-6, 281-323 7-9, 216-280 6 43 slipknot
sequence length 333
structure length 323
publication title Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
pubmed doi rcsb
molecule tags Transferase
molecule keywords Thymidine kinase
source organism Equid herpesvirus 4
missing residues 64-73
total genus Genus: 122
ec nomenclature ec 2.7.1.21: Thymidine kinase.
pdb deposition date 2003-04-30
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00693 Herpes_TK Thymidine kinase from herpesvirus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolases 1p72A00
4IVRA 2KI5A 1E2PA 1E2JA 1E2KA 1E2MA 1OF1A 4IVPA 2VTKA 1KI8A 1P73A 1E2HA 3RDPA 1P75A 1P6XA 1KI6B 1E2IA 1QHIA 1E2LA 3F0TA 1KI4A 1KI3A 4JBYA 1II9A 1E2NA 1KIMA 1F48A 4JBXA 1KI7A 4IVQA 1P7CA 1GKUB 1KI2A 1OSNA 3VTKA 1VTKA 1P72A 1KI6A
chains in the KnotProt database with same CATH superfamily
1YH1A 2KI5A 1E2PA 3KZKA 3L04A 1E2JA 1E2KA 3L05A 4IVRA 1DBIA 1E2MA 1OF1A 4IVPA 2VTKA 1KI8A 1P73A 3KZCA 1E2HA 3RDPA 3M4NA 3KZMA 1P75A 1P6XA 3M5CA 1KI6B 1E2IA 1QHIA 1E2LA 3F0TA 3FR8A 3FR7A 1YVEI 1KI4A 1KI3A 1JS1X 1YRLA 4JBYA 1II9A 3FSGA 1E2NA 1KIMA 3KZOA 3M4JA 1F48A 1LNSA 3L02A 4JBXA 1KI7A 2G7MC 1P7CA 2XTJA 3L06A 4IVQA 1GKUB 2FG6C 1KI2A 3M5DA 1OSNA 3VTKA 1VTKA 3KZNA 1R4MB 1QMGA 1R4NB 1P72A 1KI6A
chains in the KnotProt database with same CATH topology
4IVRA 2KI5A 1E2PA 1E2JA 1E2KA 1E2MA 1OF1A 4IVPA 2VTKA 1KI8A 1P73A 1E2HA 3RDPA 1P75A 1P6XA 1KI6B 1E2IA 1QHIA 1E2LA 3F0TA 1KI4A 1KI3A 4JBYA 1II9A 1E2NA 1KIMA 1F48A 4JBXA 1KI7A 4IVQA 1P7CA 1GKUB 1KI2A 1OSNA 3VTKA 1VTKA 1P72A 1KI6A
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 4IVR A;  2KI5 A;  1E2P A;  1E2J A;  1E2K A;  1E2M A;  1OF1 A;  4IVP A;  2VTK A;  1KI8 A;  1P73 A;  1E2H A;  3RDP A;  1P75 A;  1P6X A;  1KI6 B;  1E2I A;  1QHI A;  1E2L A;  3F0T A;  1KI4 A;  1KI3 A;  4JBY A;  1II9 A;  1E2N A;  1KIM A;  1F48 A;  4JBX A;  1KI7 A;  4IVQ A;  1P7C A;  1GKU B;  1KI2 A;  1OSN A;  3VTK A;  1VTK A;  1P72 A;  1KI6 A; 
#chains in the KnotProt database with same CATH topology
 1YH1 A;  2KI5 A;  1E2P A;  3KZK A;  3L04 A;  1E2J A;  1E2K A;  3L05 A;  4IVR A;  1DBI A;  1E2M A;  1OF1 A;  4IVP A;  2VTK A;  1KI8 A;  1P73 A;  3KZC A;  1E2H A;  3RDP A;  3M4N A;  3KZM A;  1P75 A;  1P6X A;  3M5C A;  1KI6 B;  1E2I A;  1QHI A;  1E2L A;  3F0T A;  3FR8 A;  3FR7 A;  1YVE I;  1KI4 A;  1KI3 A;  1JS1 X;  1YRL A;  4JBY A;  1II9 A;  3FSG A;  1E2N A;  1KIM A;  3KZO A;  3M4J A;  1F48 A;  1LNS A;  3L02 A;  4JBX A;  1KI7 A;  2G7M C;  1P7C A;  2XTJ A;  3L06 A;  4IVQ A;  1GKU B;  2FG6 C;  1KI2 A;  3M5D A;  1OSN A;  3VTK A;  1VTK A;  3KZN A;  1R4M B;  1QMG A;  1R4N B;  1P72 A;  1KI6 A; 
#chains in the KnotProt database with same CATH homology
 4IVR A;  2KI5 A;  1E2P A;  1E2J A;  1E2K A;  1E2M A;  1OF1 A;  4IVP A;  2VTK A;  1KI8 A;  1P73 A;  1E2H A;  3RDP A;  1P75 A;  1P6X A;  1KI6 B;  1E2I A;  1QHI A;  1E2L A;  3F0T A;  1KI4 A;  1KI3 A;  4JBY A;  1II9 A;  1E2N A;  1KIM A;  1F48 A;  4JBX A;  1KI7 A;  4IVQ A;  1P7C A;  1GKU B;  1KI2 A;  1OSN A;  3VTK A;  1VTK A;  1P72 A;  1KI6 A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling