1QMGA

Acetohydroxyacid isomeroreductase complexed with its reaction product dihydroxy-methylvalerate, manganese and adp-ribose.
Genus: 210
Slipknot S 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 271-388 118 1-246, 449-514 247-270, 389-448 246 66 slipknot
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41 237-444 208 1-236, 445-514 236 69 slipknot
Chain Sequence
SATTFDFDSSVFKKEKVTLSGHDEYIVRGGRNLFPLLPDAFKGIKQIGVIGWGSQAPAQAQNLKDSLTEAKSDVVVKIGLRKGSNSFAEARAAGFSEENGTLGDMWETISGSDLVLLLISDSAQADNYEKVFSHMKPNSILGLSHGFLLGHLQSLGQDFPKNISVIAVCPKGMGPSVRRLYVQGKEVNGAGINSSFAVHQDVDGRATDVALGWSIALGSPFTFATTLEQEYKSDIFGERGILLGAVHGIVECLFRRYTESGMSEDLAYKNTVECITGVISKTISTKGMLALYNSLSEEGKKDFQAAYSASYYPSMDILYECYEDVASGSEIRSVVLAGRRFYEKEGLPAFPMGKIDQTRMWKVGEKVRSVRPAGDLGPLYPFTAGVYVALMMAQIEILRKKGHSYSEIINESVIEAVDSLNPFMHARGVSFMVDNCSTTARLGSRKWAPRFDYILSQQALVAVDNGAPINQDLISNFLSDPVHEAIGVCAQLRPSVDISVTADADFVRPELRQA
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 1x 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
41 236-443 208 1-235, 444-512 235 69 knot
+ 31 270-385 116 1-244, 444-512 245-269, 386-443 244 69 slipknot
Fingerprint Knot forming loop Loop type
K 41 +31
Chain closureSer82 <-> Ala595
... Glu319 <->
Bridging ionMn601
<-> Asp315 ... Ser82		 probabilistic
Chain Sequence
SATTFDFDSSVFKKEKVTLSGHDEYIVRGGRNLFPLLPDAFKGIKQIGVIGWGSQAPAQAQNLKDSLTEAKSDVVVKIGLRKGSNSFAEARAAGFSEENGTLGDMWETISGSDLVLLLISDSAQADNYEKVFSHMKPNSILGLSHGFLLGHLQSLGQDFPKNISVIAVCPKGMGPSVRRLYVQGKEVNGAGINSSFAVHQDVDGRATDVALGWSIALGSPFTFATTLEQEYKSDIFGERGILLGAVHGIVECLFRRYTESGMSEDLAYKNTVECITGVISKTISTKGMLALYNSLSEEGKKDFQAAYSASYYPSMDILYECYEDVASGSEIRSVVLAGRRFYEKEGLPAFPMGKIDQTRMWKVGEKVRSVRPAGDLGPLYPFTAGVYVALMMAQIEILRKKGHSYSEIINESVIEAVDSLNPFMHARGVSFMVDNCSTTARLGSRKWAPRFDYILSQQALVAVDNGAPINQDLISNFLSDPVHEAIGVCAQLRPSVDISVTADADFVRPELRQA
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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4.1 235-456 222 1-234, 457-514 234 58 knot
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3.2 235-438 204 1-234 457-514 439-456 234 58 slipknot
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3.2 244-460 217 1-234, 490-514 235-243, 461-489 234 25 slipknot
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2.3 247-435 189 1-234, 451-514 235-246, 436-450 234 64 slipknot
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2.3 247-450 204 1-234, 452-514 235-246, 451-451 234 63 slipknot
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2.1 276-413 138 1-243, 436-514 244-275, 414-435 243 79 slipknot
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3.1 276-435 160 1-246, 439-514 247-275, 436-438 246 76 slipknot
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2.1 272-438 167 1-246, 440-514 247-271, 439-439 246 75 slipknot
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2.1 271-439 169 1-247, 441-514 248-270, 440-440 247 74 slipknot
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2.1 271-440 170 1-248, 449-514 249-270, 441-448 248 66 slipknot
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3.1 270-388 119 1-250, 414-514 251-269, 389-413 250 101 slipknot
sequence length 514
structure length 514
publication title Structure of Spinach Acetohydroxyacid Isomeroreductase Complexed with its Product of Reaction Dihydroxy-Methylvalerate, Manganese and Adp-Ribose
pubmed doi rcsb
molecule tags Oxidoreductase
molecule keywords ACETOHYDROXY-ACID ISOMEROREDUCTASE
source organism Spinacia oleracea
total genus Genus: 210
ec nomenclature ec 1.1.1.86: Ketol-acid reductoisomerase.
pdb deposition date 1999-09-28
KnotProt deposition date 2018-10-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01450 IlvC Acetohydroxy acid isomeroreductase, catalytic domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1040.10 Mainly Alpha Orthogonal Bundle N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 1qmgA02
3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like Domain 1qmgA01
1.10.1040.10 Mainly Alpha Orthogonal Bundle N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 1qmgA02
3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like Domain 1qmgA01
3ULKA 1YVEI 3FR8A 1QMGA 1R4MB 1R4NB 3FR7A 1YRLA
chains in the KnotProt database with same CATH superfamily
1QHIA 1P72A 1E2PA 1P7CA 1GKUB 1VTKA 1P75A 3VTKA 1DBIA 3FSGA 3M4JA 1R4NB 3L02A 1KI6B 1P6XA 1E2MA 2G7MC 1YH1A 1F48A 1OF1A 3M5CA 3KZKA 1E2KA 3FR8A 3M5DA 1KI8A 3L04A 4IVPA 1OSNA 1JS1X 1KIMA 3L05A 1KI4A 1YVEI 2FG6C 1E2LA 1LNSA 3F0TA 3KZCA 3KZOA 1R4MB 3FR7A 1E2NA 3RDPA 1P73A 3KZNA 2VTKA 4IVRA 3KZMA 3ULKA 3M4NA 1KI3A 1QMGA 3L06A 1KI6A 1E2HA 1KI2A 1II9A 4IVQA 4JBYA 2KI5A 4JBXA 1E2JA 2XTJA 1KI7A 1E2IA 1YRLA
chains in the KnotProt database with same CATH topology
3ULKA 1YVEI 3FR8A 1QMGA 1R4MB 1R4NB 3FR7A 1YRLA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 3ULK A;  1YVE I;  3FR8 A;  1QMG A;  1R4M B;  1R4N B;  3FR7 A;  1YRL A; 
#chains in the KnotProt database with same CATH topology
 1QHI A;  1P72 A;  1E2P A;  1P7C A;  1GKU B;  1VTK A;  1P75 A;  3VTK A;  1DBI A;  3FSG A;  3M4J A;  1R4N B;  3L02 A;  1KI6 B;  1P6X A;  1E2M A;  2G7M C;  1YH1 A;  1F48 A;  1OF1 A;  3M5C A;  3KZK A;  1E2K A;  3FR8 A;  3M5D A;  1KI8 A;  3L04 A;  4IVP A;  1OSN A;  1JS1 X;  1KIM A;  3L05 A;  1KI4 A;  1YVE I;  2FG6 C;  1E2L A;  1LNS A;  3F0T A;  3KZC A;  3KZO A;  1R4M B;  3FR7 A;  1E2N A;  3RDP A;  1P73 A;  3KZN A;  2VTK A;  4IVR A;  3KZM A;  3ULK A;  3M4N A;  1KI3 A;  1QMG A;  3L06 A;  1KI6 A;  1E2H A;  1KI2 A;  1II9 A;  4IVQ A;  4JBY A;  2KI5 A;  4JBX A;  1E2J A;  2XTJ A;  1KI7 A;  1E2I A;  1YRL A; 
#chains in the KnotProt database with same CATH homology
 3ULK A;  1YVE I;  3FR8 A;  1QMG A;  1R4M B;  1R4N B;  3FR7 A;  1YRL A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling