1YRLA

Escherichia coli ketol-acid reductoisomerase
Knot K 41 +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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41 222-420 199 1-221, 421-487 221 67 knot
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+31 251-363 113 1-231, 418-487 232-250, 364-417 231 70 slipknot
Chain Sequence
NYFNTLNLRQQLAQLGKCRFMGRDEFADGASYLQGKKVVIVGCGAQGLNQGLNMRDSGLDISYALRKEAIAEKRASWRKATENGFKVGTYEELIPQADLVINLTPDKQHSDVVRTVQPLMKDGAALGYSHGFNIVEVGEQIRKDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPENDPKGEGMAIAKAWAAATGGHRAGVLESSFVAEVKSDLMGEQTILCGMLQAGSLLCFDKLVEEGTDPAYAEKLIQFGWETITEALKQGGITLMMDRLSNPAKLRAYALSEQLKEIMAPLFQKHMDDIISGEFSSGMMADWANDDKKLLTWREETGKTAFETAPQYEGKIGEQEYFDKGVLMIAMVKAGVELAFETMVDSGIIEESAYYESLHELPLIANTIARKRLYEMNVVISDTAEYGNYLFSYACVPLLKPFMAELQPGDLGKAIPEGAVDNGQLRDVNEAIRSHAIEQVGKKLRGYMTDMKRIAV
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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4.1 216-426 211 1-215, 427-487 215 61 knot
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3.2 211-414 204 1-210 430-487 415-429 210 58 slipknot
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4.1 163-429 267 1-162 440-487 430-439 162 48 slipknot
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4.1 217-426 210 427-487 1-215 216-216 215 60 slipknot
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3.2 227-444 218 1-216, 472-487 217-226, 445-471 216 16 slipknot
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3.2 227-471 245 1-216, 474-487 217-226, 472-473 216 14 slipknot
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2.1 237-367 131 1-220, 390-487 221-236, 368-389 220 98 slipknot
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2.3 238-413 176 1-225, 427-487 226-237, 414-426 225 61 slipknot
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1.1 253-397 145 1-233, 413-487 234-252, 398-412 233 75 slipknot
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3.1 247-370 124 1-235, 396-487 236-246, 371-395 235 92 slipknot
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2.1 248-413 166 1-237, 427-487 238-247, 414-426 237 61 slipknot
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2.1 257-366 110 1-246, 387-487 247-256, 367-386 246 101 slipknot
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1.1 257-414 158 1-247, 429-487 248-256, 415-428 247 59 slipknot
sequence length 487
structure length 487
publication title The crystal structure of a bacterial class II ketol-acid reductoisomerase: domain conservation and evolution
pubmed doi rcsb
molecule tags Oxidoreductase
molecule keywords Ketol-acid reductoisomerase
source organism Escherichia coli
total genus Genus: 195
ec nomenclature ec 1.1.1.86: Ketol-acid reductoisomerase.
pdb deposition date 2005-02-04
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01450 IlvC Acetohydroxy acid isomeroreductase, catalytic domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1040.10 Mainly Alpha Orthogonal Bundle N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 1yrlA02
3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like Domain 1yrlA01
1YRLA 1YVEI 3FR7A 3FR8A 1QMGA 1R4NB 1R4MB 3ULKA
chains in the KnotProt database with same CATH superfamily
4JBYA 1KI7A 1P72A 3FSGA 1P75A 1KIMA 1LNSA 1KI8A 3L04A 3L06A 1KI6B 1P73A 1KI2A 3KZOA 4IVPA 3M5CA 3KZMA 1E2MA 1OSNA 1QMGA 1R4NB 1P6XA 1KI6A 2XTJA 2FG6C 1E2JA 1JS1X 2VTKA 1OF1A 1E2KA 3RDPA 1KI3A 1P7CA 1VTKA 1KI4A 3KZNA 1QHIA 3FR7A 3FR8A 3KZCA 2G7MC 3M5DA 2KI5A 3ULKA 1GKUB 1E2LA 1YRLA 1E2PA 3M4JA 1YVEI 1E2HA 3L02A 3VTKA 3M4NA 1II9A 3KZKA 3F0TA 1DBIA 4JBXA 1R4MB 1YH1A 4IVQA 1F48A 3L05A 1E2IA 1E2NA 4IVRA
chains in the KnotProt database with same CATH topology
1YRLA 1YVEI 3FR7A 3FR8A 1QMGA 1R4NB 1R4MB 3ULKA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1YRL A;  1YVE I;  3FR7 A;  3FR8 A;  1QMG A;  1R4N B;  1R4M B;  3ULK A; 
#chains in the KnotProt database with same CATH topology
 4JBY A;  1KI7 A;  1P72 A;  3FSG A;  1P75 A;  1KIM A;  1LNS A;  1KI8 A;  3L04 A;  3L06 A;  1KI6 B;  1P73 A;  1KI2 A;  3KZO A;  4IVP A;  3M5C A;  3KZM A;  1E2M A;  1OSN A;  1QMG A;  1R4N B;  1P6X A;  1KI6 A;  2XTJ A;  2FG6 C;  1E2J A;  1JS1 X;  2VTK A;  1OF1 A;  1E2K A;  3RDP A;  1KI3 A;  1P7C A;  1VTK A;  1KI4 A;  3KZN A;  1QHI A;  3FR7 A;  3FR8 A;  3KZC A;  2G7M C;  3M5D A;  2KI5 A;  3ULK A;  1GKU B;  1E2L A;  1YRL A;  1E2P A;  3M4J A;  1YVE I;  1E2H A;  3L02 A;  3VTK A;  3M4N A;  1II9 A;  3KZK A;  3F0T A;  1DBI A;  4JBX A;  1R4M B;  1YH1 A;  4IVQ A;  1F48 A;  3L05 A;  1E2I A;  1E2N A;  4IVR A; 
#chains in the KnotProt database with same CATH homology
 1YRL A;  1YVE I;  3FR7 A;  3FR8 A;  1QMG A;  1R4N B;  1R4M B;  3ULK A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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