1YVEI

Acetohydroxy acid isomeroreductase complexed with nadph, magnesium and inhibitor ipoha (n-hydroxy-n-isopropyloxamate)
Genus: 210
Knot K 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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41 236-440 205 1-235, 441-513 235 73 knot
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+31 268-385 118 1-242, 443-513 243-267, 386-442 242 71 slipknot
Chain Sequence
ATTFDFDSSVFKKEKVTLSGHDEYIVRGGRNLFPLLPDAFKGIKQIGVIGWGSQAPAQAQNLKDSLTEAKSDVVVKIGLRKGSNSFAEARAAGFSEENGTLGDMWETISGSDLVLLLISDSAQADNYEKVFSHMKPNSILGLSHGFLLGHLQSLGQDFPKNISVIAVCPKGMGPSVRRLYVQGKEVNGAGINSSFAVHQDVDGRATDVALGWSIALGSPFTFATTLEQEYKSDIFGERGILLGAVHGIVECLFRRYTESGMSEDLAYKNTVECITGVISKTISTKGMLALYNSLSEEGKKDFQAAYSASYYPSMDILYECYEDVASGSEIRSVVLAGRRFYEKEGLPAFPMGKIDQTRMWKVGEKVRSVRPAGDLGPLYPFTAGVYVALMMAQIEILRKKGHSYSEIINESVIEAVDSLNPFMHARGVSFMVDNCSTTARLGSRKWAPRFDYILSQQALVAVDNGAPINQDLISNFLSDPVHEAIGVCAQLRPSVDISVTADADFVRPELRQA
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 1x 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
41 236-441 206 1-235, 442-511 235 70 knot
+ 31 268-384 117 1-244, 443-511 245-267, 385-442 244 69 slipknot
Fingerprint Knot forming loop Loop type
K 41 +31
Chain closureAla83 <-> Ala595
... Glu319 <->
Bridging ionMg601
<-> Asp315 ... Ala83		 probabilistic
Chain Sequence
ATTFDFDSSVFKKEKVTLSGHDEYIVRGGRNLFPLLPDAFKGIKQIGVIGWGSQAPAQAQNLKDSLTEAKSDVVVKIGLRKGSNSFAEARAAGFSEENGTLGDMWETISGSDLVLLLISDSAQADNYEKVFSHMKPNSILGLSHGFLLGHLQSLGQDFPKNISVIAVCPKGMGPSVRRLYVQGKEVNGAGINSSFAVHQDVDGRATDVALGWSIALGSPFTFATTLEQEYKSDIFGERGILLGAVHGIVECLFRRYTESGMSEDLAYKNTVECITGVISKTISTKGMLALYNSLSEEGKKDFQAAYSASYYPSMDILYECYEDVASGSEIRSVVLAGRRFYEKEGLPAFPMGKIDQTRMWKVGEKVRSVRPAGDLGPLYPFTAGVYVALMMAQIEILRKKGHSYSEIINESVIEAVDSLNPFMHARGVSFMVDNCSTTARLGSRKWAPRFDYILSQQALVAVDNGAPINQDLISNFLSDPVHEAIGVCAQLRPSVDISVTADADFVRPELRQA
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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4.1 235-450 216 1-234, 451-513 234 63 knot
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3.2 234-436 203 1-233 455-513 437-454 233 59 slipknot
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3.2 244-459 216 1-234, 488-513 235-243, 460-487 234 26 slipknot
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4.1 244-487 244 1-234, 493-513 235-243, 488-492 234 21 slipknot
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2.3 245-436 192 1-233, 450-513 234-244, 437-449 233 64 slipknot
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2.1 254-416 163 1-241, 438-513 242-253, 417-437 241 76 slipknot
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3.1 274-389 116 1-243, 441-513 244-273, 390-440 243 73 slipknot
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2.1 270-440 171 1-244, 448-513 245-269, 441-447 244 66 slipknot
sequence length 513
structure length 513
publication title The crystal structure of plant acetohydroxy acid isomeroreductase complexed with NADPH, two magnesium ions and a herbicidal transition state analog determined at 1.65 A resolution.
pubmed doi rcsb
molecule tags Oxidoreductase
molecule keywords ACETOHYDROXY ACID ISOMEROREDUCTASE
source organism Spinacia oleracea
total genus Genus: 210
ec nomenclature ec 1.1.1.86: Ketol-acid reductoisomerase.
pdb deposition date 1996-10-11
KnotProt deposition date 2018-10-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF01450 IlvC Acetohydroxy acid isomeroreductase, catalytic domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1040.10 Mainly Alpha Orthogonal Bundle N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 1yveI02
3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like Domain 1yveI01
1.10.1040.10 Mainly Alpha Orthogonal Bundle N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 1yveI02
3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like Domain 1yveI01
1R4MB 1R4NB 1YRLA 3FR7A 3FR8A 1QMGA 3ULKA 1YVEI
chains in the KnotProt database with same CATH superfamily
1JS1X 1P72A 2FG6C 3KZCA 1KI2A 1LNSA 3L06A 4IVPA 4JBXA 1P6XA 1KIMA 3L04A 1QHIA 4IVQA 1II9A 3M4NA 3VTKA 3ULKA 1KI4A 3KZMA 1R4NB 1OF1A 1E2MA 1P7CA 1P75A 3KZKA 3L02A 1E2KA 1E2IA 3FSGA 3M4JA 3FR8A 1F48A 1QMGA 1KI7A 1KI8A 2XTJA 1KI6B 4IVRA 1E2LA 1E2PA 1DBIA 3M5CA 1KI6A 1KI3A 1E2NA 1GKUB 3KZNA 3RDPA 3L05A 1YRLA 2KI5A 1R4MB 1OSNA 3F0TA 1E2HA 1E2JA 1VTKA 2G7MC 3KZOA 1YH1A 3M5DA 3FR7A 1P73A 2VTKA 4JBYA 1YVEI
chains in the KnotProt database with same CATH topology
1R4MB 1R4NB 1YRLA 3FR7A 3FR8A 1QMGA 3ULKA 1YVEI
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1R4M B;  1R4N B;  1YRL A;  3FR7 A;  3FR8 A;  1QMG A;  3ULK A;  1YVE I; 
#chains in the KnotProt database with same CATH topology
 1JS1 X;  1P72 A;  2FG6 C;  3KZC A;  1KI2 A;  1LNS A;  3L06 A;  4IVP A;  4JBX A;  1P6X A;  1KIM A;  3L04 A;  1QHI A;  4IVQ A;  1II9 A;  3M4N A;  3VTK A;  3ULK A;  1KI4 A;  3KZM A;  1R4N B;  1OF1 A;  1E2M A;  1P7C A;  1P75 A;  3KZK A;  3L02 A;  1E2K A;  1E2I A;  3FSG A;  3M4J A;  3FR8 A;  1F48 A;  1QMG A;  1KI7 A;  1KI8 A;  2XTJ A;  1KI6 B;  4IVR A;  1E2L A;  1E2P A;  1DBI A;  3M5C A;  1KI6 A;  1KI3 A;  1E2N A;  1GKU B;  3KZN A;  3RDP A;  3L05 A;  1YRL A;  2KI5 A;  1R4M B;  1OSN A;  3F0T A;  1E2H A;  1E2J A;  1VTK A;  2G7M C;  3KZO A;  1YH1 A;  3M5D A;  3FR7 A;  1P73 A;  2VTK A;  4JBY A;  1YVE I; 
#chains in the KnotProt database with same CATH homology
 1R4M B;  1R4N B;  1YRL A;  3FR7 A;  3FR8 A;  1QMG A;  3ULK A;  1YVE I;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling