2XTJA

The crystal structure of pcsk9 in complex with 1d05 fab
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 83
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 29-99 71 1-28 102-268 100-101 28 167 slipknot
Chain Sequence
PWN--------------------SLVEVYLLDTSIQSDHREIEGRVMVTDFENVPEEDQASKCDSHGTHLAGVVSGRD------AGVAKGASMRSLRVLNCQGKGTVSGTLIGLEFIRKSQLVQPVGPLVVLLPLAGGYSRVLNAACQRLARAGVVLVTAAGNFRDDACLYSPASAPEVITVGATNAQDQPVTLGTLGTNFGRCVDLFAPGEDIIGASSDCSTCFVSQSGTSQAAAHVAGIAAMMLSAEPELTLAELRQRLILFSAKD
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 10-69 60 1-9 78-242 70-77 9 165 slipknot
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1.1 15-70 56 1-9, 78-242 10-14, 71-77 9 165 slipknot
sequence length 268
structure length 242
publication title A Pcsk9-Binding Antibody that Structurally Mimics the Egf(A) Domain of Ldl-Receptor Reduces Ldl Cholesterol in Vivo.
pubmed doi rcsb
molecule tags Hydrolase/antibody
molecule keywords PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9
source organism Homo sapiens
missing residues 4-23, 59-64
total genus Genus: 83
ec nomenclature ec 3.4.21.-:
pdb deposition date 2010-10-10
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00082 Peptidase_S8 Subtilase family
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.50.200 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold Rossmann fold 2xtjA00
2XTJA 1DBIA
chains in the KnotProt database with same CATH superfamily
1P73A 2G7MC 1R4NB 3KZOA 1E2NA 1F48A 1OF1A 3M5CA 3RDPA 1DBIA 1E2IA 1KI6A 3M4NA 1GKUB 1KI8A 1P72A 1KI6B 1JS1X 1E2PA 1E2JA 3F0TA 1YRLA 2XTJA 2FG6C 3KZNA 1KI2A 1YVEI 3VTKA 1E2MA 2KI5A 3KZCA 4JBYA 1KIMA 4IVPA 3FSGA 2VTKA 3M5DA 3KZMA 1KI7A 1VTKA 1R4MB 1OSNA 1E2KA 1KI4A 1P6XA 3L06A 3KZKA 3FR8A 1II9A 1LNSA 1E2HA 1YH1A 3M4JA 3L04A 1E2LA 3L02A 3L05A 4IVRA 1P75A 1KI3A 3FR7A 1QMGA 4IVQA 4JBXA 1QHIA 1P7CA
chains in the KnotProt database with same CATH topology
3KZOA 3M5CA 1DBIA 3M4NA 1GKUB 1JS1X 2XTJA 2FG6C 3KZNA 3KZCA 3FSGA 3M5DA 3KZMA 3L06A 3KZKA 1LNSA 1YH1A 3M4JA 3L04A 3L02A 3L05A 2G7MC
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 2XTJ A;  1DBI A; 
#chains in the KnotProt database with same CATH topology
 1P73 A;  2G7M C;  1R4N B;  3KZO A;  1E2N A;  1F48 A;  1OF1 A;  3M5C A;  3RDP A;  1DBI A;  1E2I A;  1KI6 A;  3M4N A;  1GKU B;  1KI8 A;  1P72 A;  1KI6 B;  1JS1 X;  1E2P A;  1E2J A;  3F0T A;  1YRL A;  2XTJ A;  2FG6 C;  3KZN A;  1KI2 A;  1YVE I;  3VTK A;  1E2M A;  2KI5 A;  3KZC A;  4JBY A;  1KIM A;  4IVP A;  3FSG A;  2VTK A;  3M5D A;  3KZM A;  1KI7 A;  1VTK A;  1R4M B;  1OSN A;  1E2K A;  1KI4 A;  1P6X A;  3L06 A;  3KZK A;  3FR8 A;  1II9 A;  1LNS A;  1E2H A;  1YH1 A;  3M4J A;  3L04 A;  1E2L A;  3L02 A;  3L05 A;  4IVR A;  1P75 A;  1KI3 A;  3FR7 A;  1QMG A;  4IVQ A;  4JBX A;  1QHI A;  1P7C A; 
#chains in the KnotProt database with same CATH homology
 3KZO A;  3M5C A;  1DBI A;  3M4N A;  1GKU B;  1JS1 X;  2XTJ A;  2FG6 C;  3KZN A;  3KZC A;  3FSG A;  3M5D A;  3KZM A;  3L06 A;  3KZK A;  1LNS A;  1YH1 A;  3M4J A;  3L04 A;  3L02 A;  3L05 A;  2G7M C;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling