2VTKA

Thymidine kinase from herpes simplex virus type 1 in complex with adp and deoxythymidine
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 114
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 5-117 113 1-4 304-331 118-303 4 28 slipknot
Chain Sequence
MPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGS---PPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQCGGSWREDWGQLSGPRP---------------HIGDTLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRSMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPTICDLARTFAREMGEAN
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 8-115 108 1-7 155-313 116-154 7 159 slipknot
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2.1 8-156 149 1-7 185-313 157-184 7 129 slipknot
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2.1 8-185 178 1-7 254-313 186-253 7 60 slipknot
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3.1 7-254 248 1-6 285-313 255-284 6 29 slipknot
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2.1 9-196 188 1-7, 254-313 8-8, 197-253 7 60 slipknot
sequence length 331
structure length 313
publication title The structures of thymidine kinase from herpes simplex virus type 1 in complex with substrates and a substrate analogue.
pubmed rcsb
molecule tags Transferase
molecule keywords THYMIDINE KINASE
source organism Herpes simplex virus (type 1 / strain f)
missing residues 105-107, 220-234
total genus Genus: 114
ec nomenclature ec 2.7.1.21: Thymidine kinase.
pdb deposition date 1997-04-01
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00693 Herpes_TK Thymidine kinase from herpesvirus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolases 2vtkA00
1E2HA 1GKUB 1E2IA 1OF1A 3F0TA 1KI3A 1E2NA 4IVPA 4JBXA 1P72A 3RDPA 1KIMA 1VTKA 4JBYA 1P73A 1KI6A 1P7CA 1P75A 1OSNA 1KI6B 4IVRA 1F48A 1KI7A 1KI4A 1E2MA 2VTKA 1P6XA 1QHIA 2KI5A 1E2JA 4IVQA 1KI2A 1E2KA 1E2LA 1KI8A 1E2PA 1II9A 3VTKA
chains in the KnotProt database with same CATH superfamily
3M4JA 2FG6C 1E2HA 1GKUB 1E2IA 1OF1A 3F0TA 1KI3A 1E2NA 3KZCA 3L04A 4IVPA 3KZNA 3L02A 1DBIA 1QMGA 1LNSA 4JBXA 1P72A 3RDPA 1KIMA 1R4MB 1VTKA 4JBYA 1P73A 1YRLA 1YH1A 2XTJA 1KI6A 3FSGA 1P7CA 3KZOA 1P75A 1R4NB 1OSNA 1KI6B 4IVRA 3FR7A 1F48A 3L06A 1KI7A 1KI4A 1E2MA 2VTKA 3FR8A 1P6XA 3M4NA 1YVEI 3KZKA 3KZMA 1II9A 1QHIA 2KI5A 3L05A 1E2JA 4IVQA 1KI2A 3M5CA 1JS1X 1E2KA 3M5DA 1E2LA 1KI8A 1E2PA 2G7MC 3VTKA
chains in the KnotProt database with same CATH topology
1E2HA 1GKUB 1E2IA 1OF1A 3F0TA 1KI3A 1E2NA 4IVPA 4JBXA 1P72A 3RDPA 1KIMA 1VTKA 4JBYA 1P73A 1KI6A 1P7CA 1P75A 1OSNA 1KI6B 4IVRA 1F48A 1KI7A 1KI4A 1E2MA 2VTKA 1P6XA 1QHIA 2KI5A 1E2JA 4IVQA 1KI2A 1E2KA 1E2LA 1KI8A 1E2PA 1II9A 3VTKA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1E2H A;  1GKU B;  1E2I A;  1OF1 A;  3F0T A;  1KI3 A;  1E2N A;  4IVP A;  4JBX A;  1P72 A;  3RDP A;  1KIM A;  1VTK A;  4JBY A;  1P73 A;  1KI6 A;  1P7C A;  1P75 A;  1OSN A;  1KI6 B;  4IVR A;  1F48 A;  1KI7 A;  1KI4 A;  1E2M A;  2VTK A;  1P6X A;  1QHI A;  2KI5 A;  1E2J A;  4IVQ A;  1KI2 A;  1E2K A;  1E2L A;  1KI8 A;  1E2P A;  1II9 A;  3VTK A; 
#chains in the KnotProt database with same CATH topology
 3M4J A;  2FG6 C;  1E2H A;  1GKU B;  1E2I A;  1OF1 A;  3F0T A;  1KI3 A;  1E2N A;  3KZC A;  3L04 A;  4IVP A;  3KZN A;  3L02 A;  1DBI A;  1QMG A;  1LNS A;  4JBX A;  1P72 A;  3RDP A;  1KIM A;  1R4M B;  1VTK A;  4JBY A;  1P73 A;  1YRL A;  1YH1 A;  2XTJ A;  1KI6 A;  3FSG A;  1P7C A;  3KZO A;  1P75 A;  1R4N B;  1OSN A;  1KI6 B;  4IVR A;  3FR7 A;  1F48 A;  3L06 A;  1KI7 A;  1KI4 A;  1E2M A;  2VTK A;  3FR8 A;  1P6X A;  3M4N A;  1YVE I;  3KZK A;  3KZM A;  1II9 A;  1QHI A;  2KI5 A;  3L05 A;  1E2J A;  4IVQ A;  1KI2 A;  3M5C A;  1JS1 X;  1E2K A;  3M5D A;  1E2L A;  1KI8 A;  1E2P A;  2G7M C;  3VTK A; 
#chains in the KnotProt database with same CATH homology
 1E2H A;  1GKU B;  1E2I A;  1OF1 A;  3F0T A;  1KI3 A;  1E2N A;  4IVP A;  4JBX A;  1P72 A;  3RDP A;  1KIM A;  1VTK A;  4JBY A;  1P73 A;  1KI6 A;  1P7C A;  1P75 A;  1OSN A;  1KI6 B;  4IVR A;  1F48 A;  1KI7 A;  1KI4 A;  1E2M A;  2VTK A;  1P6X A;  1QHI A;  2KI5 A;  1E2J A;  4IVQ A;  1KI2 A;  1E2K A;  1E2L A;  1KI8 A;  1E2P A;  1II9 A;  3VTK A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling