3FR7A

Ketol-acid reductoisomerase (kari) in complex with mg2+
Genus: 211
Alphaknot: Q65XK0
Knot K 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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41 234-440 207 1-233, 441-495 233 55 knot
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+31 267-382 116 1-243, 437-495 244-266, 383-436 243 59 slipknot
Chain Sequence
LDFDTSVFNKEKVSLAGHEEYIVRGGRNLFPLLPEAFKGIKQIGVIGWGSQGPAQAQNLRDSLAEAKSDIVVKIGLRKGSKSFDEARAAGFTEESGTLGDIWETVSGSDLVLLLISDAAQADNYEKIFSHMKPNSILGLSHGFLLGHLQSAGLDFPKNISVIAVCPKGMGPSVRRLYVQGKEINGAGINSSFAVHQDVDGRATDVALGWSVALGSPFTFATTLEQEYKSDIFGERGILLGAVHGIVEALFRRYTEQGMDEEMAYKNTVEGITGIISKTISKKGMLEVYNSLTEEGKKEFNKAYSASFYPCMDILYECYEDVASGSEIRSVVLAGRRFYEKEGLPAFPMGNIDQTRMWKVGEKVRSTRPENDLGPLHPFTAGVYVALMMAQIEVLRKKGHSYSEIINESVIESVDSLNPFMHARGVAFMVDNCSTTARLGSRKWAPRFDYILTQQAFVTVDKDAPINQDLISNFMSDPVHGAIEVCAELRPTVDIS
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 1x 41 +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
41 233-439 207 1-232, 440-493 232 54 knot
+ 31 265-381 117 1-241, 436-493 242-264, 382-435 241 58 slipknot
Fingerprint Knot forming loop Loop type
K 41 +31 Leu86 ... Asp315 <->
Bridging ionMg1576
<-> Glu319 ...
Chain closureSer580 <-> Leu86
 probabilistic
Chain Sequence
LDFDTSVFNKEKVSLAGHEEYIVRGGRNLFPLLPEAFKGIKQIGVIGWGSQGPAQAQNLRDSLAEAKSDIVVKIGLRKGSKSFDEARAAGFTEESGTLGDIWETVSGSDLVLLLISDAAQADNYEKIFSHMKPNSILGLSHGFLLGHLQSAGLDFPKNISVIAVCPKGMGPSVRRLYVQGKEINGAGINSSFAVHQDVDGRATDVALGWSVALGSPFTFATTLEQEYKSDIFGERGILLGAVHGIVEALFRRYTEQGMDEEMAYKNTVEGITGIISKTISKKGMLEVYNSLTEEGKKEFNKAYSASFYPCMDILYECYEDVASGSEIRSVVLAGRRFYEKEGLPAFPMGNIDQTRMWKVGEKVRSTRPENDLGPLHPFTAGVYVALMMAQIEVLRKKGHSYSEIINESVIESVDSLNPFMHARGVAFMVDNCSTTARLGSRKWAPRFDYILTQQAFVTVDKDAPINQDLISNFMSDPVHGAIEVCAELRPTVDIS
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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4.1 232-448 217 1-231, 449-495 231 47 knot
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3.2 231-433 203 1-230 452-495 434-451 230 44 slipknot
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3.2 242-456 215 1-231, 483-495 232-241, 457-482 231 13 slipknot
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3.2 242-482 241 1-231, 484-495 232-241, 483-483 231 12 slipknot
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2.3 243-430 188 1-230, 447-495 231-242, 431-446 230 49 slipknot
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2.3 244-430 187 1-242, 440-495 243-243, 431-439 242 56 slipknot
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2.1 253-382 130 1-233, 412-495 234-252, 383-411 233 84 slipknot
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2.1 253-411 159 1-233, 435-495 234-252, 412-434 233 61 slipknot
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2.1 254-387 134 1-252, 435-495 253-253, 388-434 252 61 slipknot
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3.1 272-387 116 1-253, 435-495 254-271, 388-434 253 61 slipknot
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3.1 271-434 164 1-243, 438-495 244-270, 435-437 243 58 slipknot
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2.1 266-437 172 1-249, 440-495 250-265, 438-439 249 56 slipknot
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3.1 267-439 173 1-244, 444-495 245-266, 440-443 244 52 slipknot
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2.1 263-443 181 1-243, 446-495 244-262, 444-445 243 50 slipknot
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3.1 263-386 124 1-252, 388-495 253-262, 387-387 252 108 slipknot
sequence length 495
structure length 495
publication title Conformational changes in a plant ketol-acid reductoisomerase upon Mg(2+) and NADPH binding as revealed by two crystal structures
pubmed doi rcsb
molecule tags Oxidoreductase
molecule keywords Putative ketol-acid reductoisomerase (Os05g0573700 protein)
source organism Oryza sativa japonica group
total genus Genus: 211
ec nomenclature ec 1.1.1.86: Ketol-acid reductoisomerase.
pdb deposition date 2009-01-08
KnotProt deposition date 2018-10-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01450 IlvC Acetohydroxy acid isomeroreductase, catalytic domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.1040.10 Mainly Alpha Orthogonal Bundle N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 3fr7A02
3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like Domain 3fr7A01
1.10.1040.10 Mainly Alpha Orthogonal Bundle N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 3fr7A02
3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like Domain 3fr7A01
1YVEI 3FR8A 1R4NB 3FR7A 1QMGA 1R4MB 1YRLA 3ULKA
chains in the KnotProt database with same CATH superfamily
1P73A 2G7MC 1R4NB 3KZOA 1E2NA 1F48A 1OF1A 3M5CA 3RDPA 3ULKA 1DBIA 1E2IA 1KI6A 3M4NA 1GKUB 1KI8A 1P72A 1KI6B 1JS1X 1E2PA 1E2JA 3F0TA 1YRLA 2XTJA 2FG6C 3KZNA 1YVEI 1KI2A 3VTKA 1E2MA 2KI5A 3KZCA 4JBYA 1KIMA 4IVPA 3FSGA 2VTKA 3M5DA 3KZMA 1KI7A 1VTKA 1R4MB 3FR8A 1KI4A 1E2KA 1OSNA 1P6XA 3KZKA 3L06A 1II9A 1LNSA 1E2HA 1YH1A 3M4JA 3L04A 1E2LA 3L02A 3L05A 4IVRA 3FR7A 1QMGA 1KI3A 1P75A 4IVQA 4JBXA 1QHIA 1P7CA
chains in the KnotProt database with same CATH topology
1YVEI 3FR8A 1R4NB 3FR7A 1QMGA 1R4MB 1YRLA 3ULKA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1YVE I;  3FR8 A;  1R4N B;  3FR7 A;  1QMG A;  1R4M B;  1YRL A;  3ULK A; 
#chains in the KnotProt database with same CATH topology
 1P73 A;  2G7M C;  1R4N B;  3KZO A;  1E2N A;  1F48 A;  1OF1 A;  3M5C A;  3RDP A;  3ULK A;  1DBI A;  1E2I A;  1KI6 A;  3M4N A;  1GKU B;  1KI8 A;  1P72 A;  1KI6 B;  1JS1 X;  1E2P A;  1E2J A;  3F0T A;  1YRL A;  2XTJ A;  2FG6 C;  3KZN A;  1YVE I;  1KI2 A;  3VTK A;  1E2M A;  2KI5 A;  3KZC A;  4JBY A;  1KIM A;  4IVP A;  3FSG A;  2VTK A;  3M5D A;  3KZM A;  1KI7 A;  1VTK A;  1R4M B;  3FR8 A;  1KI4 A;  1E2K A;  1OSN A;  1P6X A;  3KZK A;  3L06 A;  1II9 A;  1LNS A;  1E2H A;  1YH1 A;  3M4J A;  3L04 A;  1E2L A;  3L02 A;  3L05 A;  4IVR A;  3FR7 A;  1QMG A;  1KI3 A;  1P75 A;  4IVQ A;  4JBX A;  1QHI A;  1P7C A; 
#chains in the KnotProt database with same CATH homology
 1YVE I;  3FR8 A;  1R4N B;  3FR7 A;  1QMG A;  1R4M B;  1YRL A;  3ULK A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling