3RDP | KnotProt

Genus: 110

Slipknot S +3₁

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Help Knotting data interpretation Full screen

					Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details				+3₁	5-117	113	1-4	305-329	118-304	4	25	slipknot

Chain Sequence

MPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQCGGSWREDWGQLSG---------------PRPHIGDTLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRSMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPTICDLARTFAREMGE

Whole chain analysis

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Subchain analysis

Knotoid cutoff: 0.5

Knotoid matrix content: 1

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Help Knotoid subchains data interpretation Full screen

		Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details	3.1	4-154	151	1-3	177-314	155-176	3	138	slipknot
view details	2.1	8-156	149	1-7	289-314	157-288	7	26	slipknot
view details	2.1	8-120	113		1-2, 155-314	3-7, 121-154	2	160	slipknot
view details	2.1	9-172	164		1-7, 283-314	8-8, 173-282	7	32	slipknot

sequence length	329
structure length	314
publication title	Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo. pubmed doi rcsb
molecule tags	Transferase
molecule keywords	Thymidine kinase
source organism	Human herpesvirus 1
missing residues	220-234
total genus	Genus: 110
ec nomenclature	ec 2.7.1.21: Thymidine kinase.
pdb deposition date	2011-04-01
KnotProt deposition date	2014-08-18

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00693	Herpes_TK	Thymidine kinase from herpesvirus

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	3rdpA00

1OF1A 1E2KA 4IVQA 1E2MA 1P6XA 1KI2A 1F48A 1E2LA 2KI5A 1KI7A 1KI4A 1GKUB 1KI3A 3F0TA 4JBXA 4IVRA 1P72A 1E2JA 1VTKA 1E2NA 1KI8A 3RDPA 1P73A 1II9A 1E2HA 1E2IA 1P75A 3VTKA 2VTKA 1QHIA 4JBYA 1OSNA 1E2PA 4IVPA 1KI6B 1KI6A 1P7CA 1KIMA
chains in the KnotProt database with same CATH superfamily

1OF1A 1E2KA 4IVQA 1E2MA 3M5DA 1P6XA 3L06A 1R4MB 1KI2A 3L04A 1YVEI 1F48A 1E2LA 3L02A 3FR7A 2KI5A 3FSGA 1KI7A 1KI4A 1R4NB 1KI3A 3F0TA 1GKUB 4JBXA 4IVRA 1P72A 3KZMA 1E2JA 1VTKA 1E2NA 3KZNA 1YH1A 3FR8A 2FG6C 1KI8A 3RDPA 1P73A 1II9A 1E2HA 3M4NA 1DBIA 1E2IA 1P75A 2G7MC 3KZKA 3VTKA 1JS1X 3KZCA 3L05A 2VTKA 2XTJA 1QHIA 4JBYA 1QMGA 3KZOA 3M5CA 1OSNA 3M4JA 1E2PA 4IVPA 1KI6B 1KI6A 1P7CA 1LNSA 1YRLA 1KIMA
chains in the KnotProt database with same CATH topology

#chains in the KnotProt database with same CATH superfamily
 1OF1 A;  1E2K A;  4IVQ A;  1E2M A;  1P6X A;  1KI2 A;  1F48 A;  1E2L A;  2KI5 A;  1KI7 A;  1KI4 A;  1GKU B;  1KI3 A;  3F0T A;  4JBX A;  4IVR A;  1P72 A;  1E2J A;  1VTK A;  1E2N A;  1KI8 A;  3RDP A;  1P73 A;  1II9 A;  1E2H A;  1E2I A;  1P75 A;  3VTK A;  2VTK A;  1QHI A;  4JBY A;  1OSN A;  1E2P A;  4IVP A;  1KI6 B;  1KI6 A;  1P7C A;  1KIM A; 
#chains in the KnotProt database with same CATH topology
 1OF1 A;  1E2K A;  4IVQ A;  1E2M A;  3M5D A;  1P6X A;  3L06 A;  1R4M B;  1KI2 A;  3L04 A;  1YVE I;  1F48 A;  1E2L A;  3L02 A;  3FR7 A;  2KI5 A;  3FSG A;  1KI7 A;  1KI4 A;  1R4N B;  1KI3 A;  3F0T A;  1GKU B;  4JBX A;  4IVR A;  1P72 A;  3KZM A;  1E2J A;  1VTK A;  1E2N A;  3KZN A;  1YH1 A;  3FR8 A;  2FG6 C;  1KI8 A;  3RDP A;  1P73 A;  1II9 A;  1E2H A;  3M4N A;  1DBI A;  1E2I A;  1P75 A;  2G7M C;  3KZK A;  3VTK A;  1JS1 X;  3KZC A;  3L05 A;  2VTK A;  2XTJ A;  1QHI A;  4JBY A;  1QMG A;  3KZO A;  3M5C A;  1OSN A;  3M4J A;  1E2P A;  4IVP A;  1KI6 B;  1KI6 A;  1P7C A;  1LNS A;  1YRL A;  1KIM A; 
#chains in the KnotProt database with same CATH homology
 1OF1 A;  1E2K A;  4IVQ A;  1E2M A;  1P6X A;  1KI2 A;  1F48 A;  1E2L A;  2KI5 A;  1KI7 A;  1KI4 A;  1GKU B;  1KI3 A;  3F0T A;  4JBX A;  4IVR A;  1P72 A;  1E2J A;  1VTK A;  1E2N A;  1KI8 A;  3RDP A;  1P73 A;  1II9 A;  1E2H A;  1E2I A;  1P75 A;  3VTK A;  2VTK A;  1QHI A;  4JBY A;  1OSN A;  1E2P A;  4IVP A;  1KI6 B;  1KI6 A;  1P7C A;  1KIM A;

1E2IA 1E2KA 1E2MA 1E2NA 1E2PA 1KI2A 1KI3A 1KI4A 1KI6B
similar chains in the KnotProt database (40% sequence similarity)

None
similar chains in the pdb database (40% sequence similarity)

#similar chains in the KnotProt database (40% sequence similarity)
1E2I A; 1E2K A; 1E2M A; 1E2N A; 1E2P A; 1KI2 A; 1KI3 A; 1KI4 A; 1KI6 B; 
#similar chains, but unknotted

#similar chains in the pdb database (40% sequence similarity)

3RDPA

Slipknot S +31

Chain Sequence

pfam database annotations

Slipknot S +3₁