1P6XA

Crystal structure of ehv4-tk complexed with thy and so4
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 7-118 112 1-6 310-333 119-309 6 24 slipknot
Chain Sequence
SHMVTIVRIYLDGVYGIGKSTTGRVMASAASGGSPTLYFPEPMAYWRTLFETDVISGIYDTQNRKQQGNLAVDDAALITAHYQSRFTTPYLILHDHTCTLFGGNSLQRGTQPDLTLVFDRHPVASTVCFPAARYLLGDMSMCALMAMVATLPREPQGGNIVVTTLNVEEHIRRLRTRARIGEQIDITLIATLRNVYFMLVNTCHFLRSGRVWRDGWGELPTSCGAYKHRATQMDAFQERVSPELGDTLFALFKTQELLDDRGVILEVHAWALDALMLKLRNLNVFSADLSGTPRQCAAVVESLLPLMSSTLSDFDSASALERAARTFNAEMGV
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 7-133 127 1-6 281-333 134-280 6 53 slipknot
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3.1 6-282 277 1-5 309-333 283-308 5 25 slipknot
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3.1 9-187 179 1-2, 286-333 3-8, 188-285 2 48 slipknot
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3.1 10-119 110 1-3, 175-333 4-9, 120-174 3 159 slipknot
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3.1 9-174 166 1-6, 188-333 7-8, 175-187 6 146 slipknot
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2.1 10-190 181 1-8, 286-333 9-9, 191-285 8 48 slipknot
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2.1 10-174 165 1-8, 179-333 9-9, 175-178 8 155 slipknot
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2.1 10-285 276 1-5, 301-333 6-9, 286-300 5 33 slipknot
view details
2.1 10-300 291 1-5, 308-333 6-9, 301-307 5 26 slipknot
sequence length 333
structure length 333
publication title Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases.
pubmed doi rcsb
molecule tags Transferase
molecule keywords Thymidine kinase
source organism Equid herpesvirus 4
total genus Genus: 127
ec nomenclature ec 2.7.1.21: Thymidine kinase.
pdb deposition date 2003-04-30
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00693 Herpes_TK Thymidine kinase from herpesvirus
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.50.300 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold P-loop containing nucleotide triphosphate hydrolases 1p6xA00
1E2KA 3F0TA 3RDPA 1P75A 1KI6B 2KI5A 4JBYA 1II9A 4IVRA 2VTKA 1E2NA 1OSNA 1KI2A 1E2JA 1KI4A 1KI8A 1P6XA 1QHIA 1KIMA 1KI6A 1OF1A 1VTKA 1P73A 1GKUB 1E2LA 4IVPA 1P7CA 1E2IA 1E2PA 1KI7A 1E2HA 1P72A 1E2MA 4IVQA 1KI3A 3VTKA 1F48A 4JBXA
chains in the KnotProt database with same CATH superfamily
1E2KA 3F0TA 3L05A 3RDPA 1P75A 3M4NA 1YVEI 1R4NB 1KI6B 2KI5A 4JBYA 3L02A 1II9A 3M4JA 4IVRA 3FR7A 1YH1A 1QMGA 2VTKA 1E2NA 1OSNA 3KZNA 3KZKA 3KZOA 3FR8A 1KI2A 1E2JA 1KI4A 1JS1X 1KI8A 1P6XA 1QHIA 3M5DA 1KIMA 1R4MB 1KI6A 1OF1A 1LNSA 1VTKA 1P73A 1GKUB 1E2LA 4IVPA 1P7CA 1YRLA 1E2IA 1E2PA 1KI7A 1E2HA 1P72A 3L06A 1DBIA 1E2MA 2G7MC 2FG6C 4IVQA 3M5CA 3KZCA 1KI3A 3L04A 3VTKA 3KZMA 3FSGA 1F48A 4JBXA 2XTJA
chains in the KnotProt database with same CATH topology
1E2KA 3F0TA 3RDPA 1P75A 1KI6B 2KI5A 4JBYA 1II9A 4IVRA 2VTKA 1E2NA 1OSNA 1KI2A 1E2JA 1KI4A 1KI8A 1P6XA 1QHIA 1KIMA 1KI6A 1OF1A 1VTKA 1P73A 1GKUB 1E2LA 4IVPA 1P7CA 1E2IA 1E2PA 1KI7A 1E2HA 1P72A 1E2MA 4IVQA 1KI3A 3VTKA 1F48A 4JBXA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1E2K A;  3F0T A;  3RDP A;  1P75 A;  1KI6 B;  2KI5 A;  4JBY A;  1II9 A;  4IVR A;  2VTK A;  1E2N A;  1OSN A;  1KI2 A;  1E2J A;  1KI4 A;  1KI8 A;  1P6X A;  1QHI A;  1KIM A;  1KI6 A;  1OF1 A;  1VTK A;  1P73 A;  1GKU B;  1E2L A;  4IVP A;  1P7C A;  1E2I A;  1E2P A;  1KI7 A;  1E2H A;  1P72 A;  1E2M A;  4IVQ A;  1KI3 A;  3VTK A;  1F48 A;  4JBX A; 
#chains in the KnotProt database with same CATH topology
 1E2K A;  3F0T A;  3L05 A;  3RDP A;  1P75 A;  3M4N A;  1YVE I;  1R4N B;  1KI6 B;  2KI5 A;  4JBY A;  3L02 A;  1II9 A;  3M4J A;  4IVR A;  3FR7 A;  1YH1 A;  1QMG A;  2VTK A;  1E2N A;  1OSN A;  3KZN A;  3KZK A;  3KZO A;  3FR8 A;  1KI2 A;  1E2J A;  1KI4 A;  1JS1 X;  1KI8 A;  1P6X A;  1QHI A;  3M5D A;  1KIM A;  1R4M B;  1KI6 A;  1OF1 A;  1LNS A;  1VTK A;  1P73 A;  1GKU B;  1E2L A;  4IVP A;  1P7C A;  1YRL A;  1E2I A;  1E2P A;  1KI7 A;  1E2H A;  1P72 A;  3L06 A;  1DBI A;  1E2M A;  2G7M C;  2FG6 C;  4IVQ A;  3M5C A;  3KZC A;  1KI3 A;  3L04 A;  3VTK A;  3KZM A;  3FSG A;  1F48 A;  4JBX A;  2XTJ A; 
#chains in the KnotProt database with same CATH homology
 1E2K A;  3F0T A;  3RDP A;  1P75 A;  1KI6 B;  2KI5 A;  4JBY A;  1II9 A;  4IVR A;  2VTK A;  1E2N A;  1OSN A;  1KI2 A;  1E2J A;  1KI4 A;  1KI8 A;  1P6X A;  1QHI A;  1KIM A;  1KI6 A;  1OF1 A;  1VTK A;  1P73 A;  1GKU B;  1E2L A;  4IVP A;  1P7C A;  1E2I A;  1E2P A;  1KI7 A;  1E2H A;  1P72 A;  1E2M A;  4IVQ A;  1KI3 A;  3VTK A;  1F48 A;  4JBX A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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