2WD3A

Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 23-253 231 1-22, 254-257 22 4 knot
Chain Sequence
HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 3x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 24-252 229 1-23, 253-257 23 5 knot
Fingerprint Knot forming loop Loop type
K +31 His4 ... His94 <->
Bridging ionZn1263
<-> His96 ...
Chain closureLys260 <-> His4
probabilistic
K +31 His4 ... His96 <->
Bridging ionZn1263
<-> His119 ...
Chain closureLys260 <-> His4
probabilistic
K +31 His4 ... His94 <->
Bridging ionZn1263
<-> His119 ...
Chain closureLys260 <-> His4
probabilistic
Chain Sequence
HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 24-256 233 1-23, 257-257 23 1 knot
view details
2.1 24-251 228 1-23 257-257 252-256 23 1 slipknot
view details
3.1 25-255 231 256-257 1-23 24-24 23 1 slipknot
sequence length 257
structure length 257
publication title Highly Potent First Examples of Dual Aromatase-Steroid Sulfatase Inhibitors Based on a Biphenyl Template.
pubmed doi rcsb
molecule tags Lyase
molecule keywords CARBONIC ANHYDRASE 2
source organism Homo sapiens
total genus Genus: 74
ec nomenclature ec 4.2.1.1: Carbonate dehydratase.
pdb deposition date 2009-03-19
KnotProt deposition date 2018-10-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00194 Carb_anhydrase Eukaryotic-type carbonic anhydrase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.200.10 Alpha Beta Roll Carbonic Anhydrase II Carbonic Anhydrase II 2wd3A00
3.10.200.10 Alpha Beta Roll Carbonic Anhydrase II Carbonic Anhydrase II 2wd3A00
3KONA 3M1JA 2ZNCA 2NMXA 2FOSA 3BETA 1FR4A 1CA2A 1BNUA 1RAYA 3CZVA 1YO0A 1G52A 1I9NA 2POVA 3M2NA 1IF5A 1ZSCA 2CABA 1BN4A 1RZEA 2VVAX 1CAMA 3D8WA 3DVDA 2FOQA 1CVHA 1ZNCA 3F4XA 2AX2A 3P4VA 1CNJA 2FOUA 8CA2A 3MNHA 3R17B 1CVCA 3C7PA 1H9NA 3MDZA 9CA2A 2FNMA 3JXGA 3M96A 3MWOA 1BZMA 1BN1A 3HKNA 1XEGA 3IBNA 2H15A 3GZ0A 3KIGA 3K2FA 1LGDA 1HUGA 1CNYA 1AM6A 1HVAA 3DAZA 3M67A 1I9LA 1CAOA 1BCDA 1CA3A 3MNIA 3DCWA 4CA2A 1CILA 1I9QA 3F8EA 1OQ5A 1CAKA 3IBLA 1RZAA 2WEGA 1IF9A 3D9ZA 3FFPX 3MHOA 3R16A 3MNJA 1YO1A 3BL1A 1KOQA 2HNCA 2FNKA 1BNQA 2Q38A 1ZSBA 1UGBA 2HFWA 2HOCA 2CBAA 3OIMA 3MHLA 1A42A 1YDCA 1CAIA 1KWQA 3M98A 1DMYA 1G53A 2NWZA 1I90A 2NWYA 3HS4A 1XPZA 3L14A 1RZDA 1HECA 3IQKA 1H4NA 1FQLA 1IF8A 3HKQA 1CANA 1KOPA 1BV3A 3KWAA 1CCTA 3CAJA 1AZMA 1XEVA 1TH9A 1CINA 1CAHA 3DCCA 2NWPA 3NI5A 1CAYA 3N4BA 1HUHA 3MMFA 3OIKA 1URTA 1CNGA 1YDBA 1KEQA 2GEHA 3OILA 1FSQA 3D0NA 3PYKA 7CA2A 3OKVA 3DC3A 3JXFA 2Q1QA 2Q1BA 1UGFA 3M2ZA 1TEUX 3DD0A 2CBDA 2F14A 1OKNA 3N3JA 1CVAA 3B4FA 1EOUA 1CALA 2WEJA 3MHIA 2EZ7A 1DCBA 3KKXA 2WEHA 2EU2A 2NXSA 3DC9A 2ILIA 1FSNA 3DVBA 2AW1A 3ML5A 3M5TA 2IT4A 3DV7A 1MUAA 1CNIA 1BNTA 2NXRA 3IBUA 1BNVA 1CVEA 2POUA 2FW4A 1V9EA 1LZVA 2HD6A 3N2PA 3HKTA 1CVBA 2NXTA 3IGPA 1RAZA 3M5SA 3MNKA 1IF4A 1F2WA 1CNHA 3ZNCA 1FQMA 1DCAA 3N0NA 3DVCA 3ML2A 3KOKA 2WD3A 2VVBX 1LG6A 1J9WA 1UGDA 1CNCA 5CA2A 1BNNA 1I9MA 2HFXA 1THKA 2HKKA 3F7BA 1V9IC 1HEBA 2WD2A 1G1DA 1G48A 3MNUA 3M1QA 1HCAA 1UGAA 1HEDA 1CNWA 3KS3A 3IBIA 2NN1A 1CAJA 2FNNA 1BNMA 1FQNA 2X7SA 2FMGA 2O4ZA 2OSFA 1G6VA 3EFIA 3MHCA 2OSMA 2NNVA 3M2YA 5CACA 1I9OA 2CBCA 6CA2A 1RZCA 3DD8A 3HKUA 2NWOA 4CACA 3IAIA 1RZBA 1CRMA 3M5EA 3DBUA 2NNSA 3DA2A 3JXHC 2POWA 1IF7A 1CVFA 3M1WA 1CIMA 3MNAA 3M3XA 1G4OA 1G45A 3D92A 1CRAA 3CA2A 3MHMA 1JV0A 3OKUA 1I9PA 3HLJA 1FR7A 2ABEA 1YO2A 1I91A 2WEOA 3MZCA 1Z97A 1LUGA 3EFTA 1CVDA 2X7UA 1CAZA 3FW3A 2W2JA 2CBEA 4PYYA 1H9QA 3D93A 1RJ5A 2CBBA 2NNOA 3LXEA 1JD0A 1ZSAA 2X7TA 1G0EA 3HFPA 1T9NA 2HFYA 1CNXA 1XQ0A 2EU3A 1I8ZA 3NJ9A 1G4JA 3MYQA 3M40A 3PO6A 1TE3X 12CAA 1YDDA 2CA2A 1G46A 1OKMA 1G0FA 1Z93A 1CZMA 1UGEA 1CCUA 1TBTX 1HEAA 1TG3A 3FE4A 1FLJA 1CCSA 1BICA 3BL0A 1BNWA 3K7KA 1AVNA 1KWRA 3K34A 1Y7WA 1LG5A 3B1BA 1IF6A 1RJ6A 1TTMA 1HCBA 1TG9A 2GD8A 3DCSA 2HL4A 1ZE8A 2NN7A 1YDAA 2NNGA 1FQRA 3IEOA 1FSRA 1BN3A 1G3ZA 3F7UA 2FMZA
chains in the KnotProt database with same CATH superfamily
3KONA 3M1JA 2ZNCA 2NMXA 2FOSA 3BETA 1FR4A 1CA2A 1BNUA 1RAYA 3CZVA 1YO0A 1G52A 1I9NA 2POVA 3M2NA 1IF5A 1ZSCA 2CABA 1BN4A 1RZEA 2VVAX 1CAMA 3D8WA 3DVDA 2FOQA 1CVHA 1ZNCA 3F4XA 2AX2A 3P4VA 1CNJA 2FOUA 8CA2A 3MNHA 3R17B 1CVCA 3C7PA 1H9NA 3MDZA 9CA2A 2FNMA 3JXGA 3M96A 3MWOA 1BZMA 1BN1A 3HKNA 1XEGA 3IBNA 2H15A 3GZ0A 3KIGA 3K2FA 1LGDA 1HUGA 1CNYA 1AM6A 1HVAA 3DAZA 3M67A 1I9LA 1CAOA 1BCDA 1CA3A 3MNIA 3DCWA 4CA2A 1CILA 1I9QA 3F8EA 1OQ5A 1CAKA 3IBLA 1RZAA 2WEGA 1IF9A 3D9ZA 3FFPX 3MHOA 3R16A 3MNJA 1YO1A 3BL1A 1KOQA 2HNCA 2FNKA 1BNQA 2Q38A 1ZSBA 1UGBA 2HFWA 2HOCA 2CBAA 3OIMA 3MHLA 1A42A 1YDCA 1CAIA 1KWQA 3M98A 1DMYA 1G53A 2NWZA 1I90A 2NWYA 3HS4A 1XPZA 3L14A 1RZDA 1HECA 3IQKA 1H4NA 1FQLA 1IF8A 3HKQA 1CANA 1KOPA 1BV3A 3KWAA 1CCTA 3CAJA 1AZMA 1XEVA 1TH9A 1CINA 1CAHA 3DCCA 2NWPA 3NI5A 1CAYA 3N4BA 1HUHA 3MMFA 3OIKA 1URTA 1CNGA 1YDBA 1KEQA 2GEHA 3OILA 1FSQA 3D0NA 3PYKA 7CA2A 3OKVA 3DC3A 3JXFA 2Q1QA 2Q1BA 1UGFA 3M2ZA 1TEUX 3DD0A 2CBDA 2F14A 1OKNA 3N3JA 1CVAA 3B4FA 1EOUA 1CALA 2WEJA 3MHIA 2EZ7A 1DCBA 3KKXA 2WEHA 2EU2A 2NXSA 3DC9A 2ILIA 1FSNA 3DVBA 2AW1A 3ML5A 3M5TA 2IT4A 3DV7A 1MUAA 1CNIA 1BNTA 2NXRA 3IBUA 1BNVA 1CVEA 2POUA 2FW4A 1V9EA 1LZVA 2HD6A 3N2PA 3HKTA 1CVBA 2NXTA 3IGPA 1RAZA 3M5SA 3MNKA 1IF4A 1F2WA 1CNHA 3ZNCA 1FQMA 1DCAA 3N0NA 3DVCA 3ML2A 3KOKA 2WD3A 2VVBX 1LG6A 1J9WA 1UGDA 1CNCA 5CA2A 1BNNA 1I9MA 2HFXA 1THKA 2HKKA 3F7BA 1V9IC 1HEBA 2WD2A 1G1DA 1G48A 3MNUA 3M1QA 1HCAA 1UGAA 1HEDA 1CNWA 3KS3A 3IBIA 2NN1A 1CAJA 2FNNA 1BNMA 1FQNA 2X7SA 2FMGA 2O4ZA 2OSFA 1G6VA 3EFIA 3MHCA 2OSMA 2NNVA 3M2YA 5CACA 1I9OA 2CBCA 6CA2A 1RZCA 3DD8A 3HKUA 2NWOA 4CACA 3IAIA 1RZBA 1CRMA 3M5EA 3DBUA 2NNSA 3DA2A 3JXHC 2POWA 1IF7A 1CVFA 3M1WA 1CIMA 3MNAA 3M3XA 1G4OA 1G45A 3D92A 1CRAA 3CA2A 3MHMA 1JV0A 3OKUA 1I9PA 3HLJA 1FR7A 2ABEA 1YO2A 1I91A 2WEOA 3MZCA 1Z97A 1LUGA 3EFTA 1CVDA 2X7UA 1CAZA 3FW3A 2W2JA 2CBEA 4PYYA 1H9QA 3D93A 1RJ5A 2CBBA 2NNOA 3LXEA 1JD0A 1ZSAA 2X7TA 1G0EA 3HFPA 1T9NA 2HFYA 1CNXA 1XQ0A 2EU3A 1I8ZA 3NJ9A 1G4JA 3MYQA 3M40A 3PO6A 1TE3X 12CAA 1YDDA 2CA2A 1G46A 1OKMA 1G0FA 1Z93A 1CZMA 1UGEA 1CCUA 1TBTX 1HEAA 1TG3A 3FE4A 1FLJA 1CCSA 1BICA 3BL0A 1BNWA 3K7KA 1AVNA 1KWRA 3K34A 1Y7WA 1LG5A 3B1BA 1IF6A 1RJ6A 1TTMA 1HCBA 1TG9A 2GD8A 3DCSA 2HL4A 1ZE8A 2NN7A 1YDAA 2NNGA 1FQRA 3IEOA 1FSRA 1BN3A 1G3ZA 3F7UA 2FMZA
chains in the KnotProt database with same CATH topology
3KONA 3M1JA 2ZNCA 2NMXA 2FOSA 3BETA 1FR4A 1CA2A 1BNUA 1RAYA 3CZVA 1YO0A 1G52A 1I9NA 2POVA 3M2NA 1IF5A 1ZSCA 2CABA 1BN4A 1RZEA 2VVAX 1CAMA 3D8WA 3DVDA 2FOQA 1CVHA 1ZNCA 3F4XA 2AX2A 3P4VA 1CNJA 2FOUA 8CA2A 3MNHA 3R17B 1CVCA 3C7PA 1H9NA 3MDZA 9CA2A 2FNMA 3JXGA 3M96A 3MWOA 1BZMA 1BN1A 3HKNA 1XEGA 3IBNA 2H15A 3GZ0A 3KIGA 3K2FA 1LGDA 1HUGA 1CNYA 1AM6A 1HVAA 3DAZA 3M67A 1I9LA 1CAOA 1BCDA 1CA3A 3MNIA 3DCWA 4CA2A 1CILA 1I9QA 3F8EA 1OQ5A 1CAKA 3IBLA 1RZAA 2WEGA 1IF9A 3D9ZA 3FFPX 3MHOA 3R16A 3MNJA 1YO1A 3BL1A 1KOQA 2HNCA 2FNKA 1BNQA 2Q38A 1ZSBA 1UGBA 2HFWA 2HOCA 2CBAA 3OIMA 3MHLA 1A42A 1YDCA 1CAIA 1KWQA 3M98A 1DMYA 1G53A 2NWZA 1I90A 2NWYA 3HS4A 1XPZA 3L14A 1RZDA 1HECA 3IQKA 1H4NA 1FQLA 1IF8A 3HKQA 1CANA 1KOPA 1BV3A 3KWAA 1CCTA 3CAJA 1AZMA 1XEVA 1TH9A 1CINA 1CAHA 3DCCA 2NWPA 3NI5A 1CAYA 3N4BA 1HUHA 3MMFA 3OIKA 1URTA 1CNGA 1YDBA 1KEQA 2GEHA 3OILA 1FSQA 3D0NA 3PYKA 7CA2A 3OKVA 3DC3A 3JXFA 2Q1QA 2Q1BA 1UGFA 3M2ZA 1TEUX 3DD0A 2CBDA 2F14A 1OKNA 3N3JA 1CVAA 3B4FA 1EOUA 1CALA 2WEJA 3MHIA 2EZ7A 1DCBA 3KKXA 2WEHA 2EU2A 2NXSA 3DC9A 2ILIA 1FSNA 3DVBA 2AW1A 3ML5A 3M5TA 2IT4A 3DV7A 1MUAA 1CNIA 1BNTA 2NXRA 3IBUA 1BNVA 1CVEA 2POUA 2FW4A 1V9EA 1LZVA 2HD6A 3N2PA 3HKTA 1CVBA 2NXTA 3IGPA 1RAZA 3M5SA 3MNKA 1IF4A 1F2WA 1CNHA 3ZNCA 1FQMA 1DCAA 3N0NA 3DVCA 3ML2A 3KOKA 2WD3A 2VVBX 1LG6A 1J9WA 1UGDA 1CNCA 5CA2A 1BNNA 1I9MA 2HFXA 1THKA 2HKKA 3F7BA 1V9IC 1HEBA 2WD2A 1G1DA 1G48A 3MNUA 3M1QA 1HCAA 1UGAA 1HEDA 1CNWA 3KS3A 3IBIA 2NN1A 1CAJA 2FNNA 1BNMA 1FQNA 2X7SA 2FMGA 2O4ZA 2OSFA 1G6VA 3EFIA 3MHCA 2OSMA 2NNVA 3M2YA 5CACA 1I9OA 2CBCA 6CA2A 1RZCA 3DD8A 3HKUA 2NWOA 4CACA 3IAIA 1RZBA 1CRMA 3M5EA 3DBUA 2NNSA 3DA2A 3JXHC 2POWA 1IF7A 1CVFA 3M1WA 1CIMA 3MNAA 3M3XA 1G4OA 1G45A 3D92A 1CRAA 3CA2A 3MHMA 1JV0A 3OKUA 1I9PA 3HLJA 1FR7A 2ABEA 1YO2A 1I91A 2WEOA 3MZCA 1Z97A 1LUGA 3EFTA 1CVDA 2X7UA 1CAZA 3FW3A 2W2JA 2CBEA 1H9QA 3D93A 1RJ5A 2CBBA 2NNOA 3LXEA 1JD0A 1ZSAA 2X7TA 1G0EA 3HFPA 1T9NA 2HFYA 1CNXA 1XQ0A 2EU3A 1I8ZA 3NJ9A 1G4JA 3MYQA 3M40A 3PO6A 1TE3X 12CAA 1YDDA 2CA2A 1G46A 1OKMA 1G0FA 1Z93A 1CZMA 1UGEA 1CCUA 1TBTX 1HEAA 1TG3A 3FE4A 1FLJA 1CCSA 1BICA 3BL0A 1BNWA 3K7KA 1AVNA 1KWRA 3K34A 1Y7WA 1LG5A 3B1BA 1IF6A 1RJ6A 1TTMA 1HCBA 1TG9A 2GD8A 3DCSA 2HL4A 1ZE8A 2NN7A 1YDAA 2NNGA 1FQRA 3IEOA 1FSRA 1BN3A 1G3ZA 3F7UA 2FMZA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 3KON A;  3M1J A;  2ZNC A;  2NMX A;  2FOS A;  3BET A;  1FR4 A;  1CA2 A;  1BNU A;  1RAY A;  3CZV A;  1YO0 A;  1G52 A;  1I9N A;  2POV A;  3M2N A;  1IF5 A;  1ZSC A;  2CAB A;  1BN4 A;  1RZE A;  2VVA X;  1CAM A;  3D8W A;  3DVD A;  2FOQ A;  1CVH A;  1ZNC A;  3F4X A;  2AX2 A;  3P4V A;  1CNJ A;  2FOU A;  8CA2 A;  3MNH A;  3R17 B;  1CVC A;  3C7P A;  1H9N A;  3MDZ A;  9CA2 A;  2FNM A;  3JXG A;  3M96 A;  3MWO A;  1BZM A;  1BN1 A;  3HKN A;  1XEG A;  3IBN A;  2H15 A;  3GZ0 A;  3KIG A;  3K2F A;  1LGD A;  1HUG A;  1CNY A;  1AM6 A;  1HVA A;  3DAZ A;  3M67 A;  1I9L A;  1CAO A;  1BCD A;  1CA3 A;  3MNI A;  3DCW A;  4CA2 A;  1CIL A;  1I9Q A;  3F8E A;  1OQ5 A;  1CAK A;  3IBL A;  1RZA A;  2WEG A;  1IF9 A;  3D9Z A;  3FFP X;  3MHO A;  3R16 A;  3MNJ A;  1YO1 A;  3BL1 A;  1KOQ A;  2HNC A;  2FNK A;  1BNQ A;  2Q38 A;  1ZSB A;  1UGB A;  2HFW A;  2HOC A;  2CBA A;  3OIM A;  3MHL A;  1A42 A;  1YDC A;  1CAI A;  1KWQ A;  3M98 A;  1DMY A;  1G53 A;  2NWZ A;  1I90 A;  2NWY A;  3HS4 A;  1XPZ A;  3L14 A;  1RZD A;  1HEC A;  3IQK A;  1H4N A;  1FQL A;  1IF8 A;  3HKQ A;  1CAN A;  1KOP A;  1BV3 A;  3KWA A;  1CCT A;  3CAJ A;  1AZM A;  1XEV A;  1TH9 A;  1CIN A;  1CAH A;  3DCC A;  2NWP A;  3NI5 A;  1CAY A;  3N4B A;  1HUH A;  3MMF A;  3OIK A;  1URT A;  1CNG A;  1YDB A;  1KEQ A;  2GEH A;  3OIL A;  1FSQ A;  3D0N A;  3PYK A;  7CA2 A;  3OKV A;  3DC3 A;  3JXF A;  2Q1Q A;  2Q1B A;  1UGF A;  3M2Z A;  1TEU X;  3DD0 A;  2CBD A;  2F14 A;  1OKN A;  3N3J A;  1CVA A;  3B4F A;  1EOU A;  1CAL A;  2WEJ A;  3MHI A;  2EZ7 A;  1DCB A;  3KKX A;  2WEH A;  2EU2 A;  2NXS A;  3DC9 A;  2ILI A;  1FSN A;  3DVB A;  2AW1 A;  3ML5 A;  3M5T A;  2IT4 A;  3DV7 A;  1MUA A;  1CNI A;  1BNT A;  2NXR A;  3IBU A;  1BNV A;  1CVE A;  2POU A;  2FW4 A;  1V9E A;  1LZV A;  2HD6 A;  3N2P A;  3HKT A;  1CVB A;  2NXT A;  3IGP A;  1RAZ A;  3M5S A;  3MNK A;  1IF4 A;  1F2W A;  1CNH A;  3ZNC A;  1FQM A;  1DCA A;  3N0N A;  3DVC A;  3ML2 A;  3KOK A;  2WD3 A;  2VVB X;  1LG6 A;  1J9W A;  1UGD A;  1CNC A;  5CA2 A;  1BNN A;  1I9M A;  2HFX A;  1THK A;  2HKK A;  3F7B A;  1V9I C;  1HEB A;  2WD2 A;  1G1D A;  1G48 A;  3MNU A;  3M1Q A;  1HCA A;  1UGA A;  1HED A;  1CNW A;  3KS3 A;  3IBI A;  2NN1 A;  1CAJ A;  2FNN A;  1BNM A;  1FQN A;  2X7S A;  2FMG A;  2O4Z A;  2OSF A;  1G6V A;  3EFI A;  3MHC A;  2OSM A;  2NNV A;  3M2Y A;  5CAC A;  1I9O A;  2CBC A;  6CA2 A;  1RZC A;  3DD8 A;  3HKU A;  2NWO A;  4CAC A;  3IAI A;  1RZB A;  1CRM A;  3M5E A;  3DBU A;  2NNS A;  3DA2 A;  3JXH C;  2POW A;  1IF7 A;  1CVF A;  3M1W A;  1CIM A;  3MNA A;  3M3X A;  1G4O A;  1G45 A;  3D92 A;  1CRA A;  3CA2 A;  3MHM A;  1JV0 A;  3OKU A;  1I9P A;  3HLJ A;  1FR7 A;  2ABE A;  1YO2 A;  1I91 A;  2WEO A;  3MZC A;  1Z97 A;  1LUG A;  3EFT A;  1CVD A;  2X7U A;  1CAZ A;  3FW3 A;  2W2J A;  2CBE A;  4PYY A;  1H9Q A;  3D93 A;  1RJ5 A;  2CBB A;  2NNO A;  3LXE A;  1JD0 A;  1ZSA A;  2X7T A;  1G0E A;  3HFP A;  1T9N A;  2HFY A;  1CNX A;  1XQ0 A;  2EU3 A;  1I8Z A;  3NJ9 A;  1G4J A;  3MYQ A;  3M40 A;  3PO6 A;  1TE3 X;  12CA A;  1YDD A;  2CA2 A;  1G46 A;  1OKM A;  1G0F A;  1Z93 A;  1CZM A;  1UGE A;  1CCU A;  1TBT X;  1HEA A;  1TG3 A;  3FE4 A;  1FLJ A;  1CCS A;  1BIC A;  3BL0 A;  1BNW A;  3K7K A;  1AVN A;  1KWR A;  3K34 A;  1Y7W A;  1LG5 A;  3B1B A;  1IF6 A;  1RJ6 A;  1TTM A;  1HCB A;  1TG9 A;  2GD8 A;  3DCS A;  2HL4 A;  1ZE8 A;  2NN7 A;  1YDA A;  2NNG A;  1FQR A;  3IEO A;  1FSR A;  1BN3 A;  1G3Z A;  3F7U A;  2FMZ A; 
#chains in the KnotProt database with same CATH topology
 3KON A;  3M1J A;  2ZNC A;  2NMX A;  2FOS A;  3BET A;  1FR4 A;  1CA2 A;  1BNU A;  1RAY A;  3CZV A;  1YO0 A;  1G52 A;  1I9N A;  2POV A;  3M2N A;  1IF5 A;  1ZSC A;  2CAB A;  1BN4 A;  1RZE A;  2VVA X;  1CAM A;  3D8W A;  3DVD A;  2FOQ A;  1CVH A;  1ZNC A;  3F4X A;  2AX2 A;  3P4V A;  1CNJ A;  2FOU A;  8CA2 A;  3MNH A;  3R17 B;  1CVC A;  3C7P A;  1H9N A;  3MDZ A;  9CA2 A;  2FNM A;  3JXG A;  3M96 A;  3MWO A;  1BZM A;  1BN1 A;  3HKN A;  1XEG A;  3IBN A;  2H15 A;  3GZ0 A;  3KIG A;  3K2F A;  1LGD A;  1HUG A;  1CNY A;  1AM6 A;  1HVA A;  3DAZ A;  3M67 A;  1I9L A;  1CAO A;  1BCD A;  1CA3 A;  3MNI A;  3DCW A;  4CA2 A;  1CIL A;  1I9Q A;  3F8E A;  1OQ5 A;  1CAK A;  3IBL A;  1RZA A;  2WEG A;  1IF9 A;  3D9Z A;  3FFP X;  3MHO A;  3R16 A;  3MNJ A;  1YO1 A;  3BL1 A;  1KOQ A;  2HNC A;  2FNK A;  1BNQ A;  2Q38 A;  1ZSB A;  1UGB A;  2HFW A;  2HOC A;  2CBA A;  3OIM A;  3MHL A;  1A42 A;  1YDC A;  1CAI A;  1KWQ A;  3M98 A;  1DMY A;  1G53 A;  2NWZ A;  1I90 A;  2NWY A;  3HS4 A;  1XPZ A;  3L14 A;  1RZD A;  1HEC A;  3IQK A;  1H4N A;  1FQL A;  1IF8 A;  3HKQ A;  1CAN A;  1KOP A;  1BV3 A;  3KWA A;  1CCT A;  3CAJ A;  1AZM A;  1XEV A;  1TH9 A;  1CIN A;  1CAH A;  3DCC A;  2NWP A;  3NI5 A;  1CAY A;  3N4B A;  1HUH A;  3MMF A;  3OIK A;  1URT A;  1CNG A;  1YDB A;  1KEQ A;  2GEH A;  3OIL A;  1FSQ A;  3D0N A;  3PYK A;  7CA2 A;  3OKV A;  3DC3 A;  3JXF A;  2Q1Q A;  2Q1B A;  1UGF A;  3M2Z A;  1TEU X;  3DD0 A;  2CBD A;  2F14 A;  1OKN A;  3N3J A;  1CVA A;  3B4F A;  1EOU A;  1CAL A;  2WEJ A;  3MHI A;  2EZ7 A;  1DCB A;  3KKX A;  2WEH A;  2EU2 A;  2NXS A;  3DC9 A;  2ILI A;  1FSN A;  3DVB A;  2AW1 A;  3ML5 A;  3M5T A;  2IT4 A;  3DV7 A;  1MUA A;  1CNI A;  1BNT A;  2NXR A;  3IBU A;  1BNV A;  1CVE A;  2POU A;  2FW4 A;  1V9E A;  1LZV A;  2HD6 A;  3N2P A;  3HKT A;  1CVB A;  2NXT A;  3IGP A;  1RAZ A;  3M5S A;  3MNK A;  1IF4 A;  1F2W A;  1CNH A;  3ZNC A;  1FQM A;  1DCA A;  3N0N A;  3DVC A;  3ML2 A;  3KOK A;  2WD3 A;  2VVB X;  1LG6 A;  1J9W A;  1UGD A;  1CNC A;  5CA2 A;  1BNN A;  1I9M A;  2HFX A;  1THK A;  2HKK A;  3F7B A;  1V9I C;  1HEB A;  2WD2 A;  1G1D A;  1G48 A;  3MNU A;  3M1Q A;  1HCA A;  1UGA A;  1HED A;  1CNW A;  3KS3 A;  3IBI A;  2NN1 A;  1CAJ A;  2FNN A;  1BNM A;  1FQN A;  2X7S A;  2FMG A;  2O4Z A;  2OSF A;  1G6V A;  3EFI A;  3MHC A;  2OSM A;  2NNV A;  3M2Y A;  5CAC A;  1I9O A;  2CBC A;  6CA2 A;  1RZC A;  3DD8 A;  3HKU A;  2NWO A;  4CAC A;  3IAI A;  1RZB A;  1CRM A;  3M5E A;  3DBU A;  2NNS A;  3DA2 A;  3JXH C;  2POW A;  1IF7 A;  1CVF A;  3M1W A;  1CIM A;  3MNA A;  3M3X A;  1G4O A;  1G45 A;  3D92 A;  1CRA A;  3CA2 A;  3MHM A;  1JV0 A;  3OKU A;  1I9P A;  3HLJ A;  1FR7 A;  2ABE A;  1YO2 A;  1I91 A;  2WEO A;  3MZC A;  1Z97 A;  1LUG A;  3EFT A;  1CVD A;  2X7U A;  1CAZ A;  3FW3 A;  2W2J A;  2CBE A;  4PYY A;  1H9Q A;  3D93 A;  1RJ5 A;  2CBB A;  2NNO A;  3LXE A;  1JD0 A;  1ZSA A;  2X7T A;  1G0E A;  3HFP A;  1T9N A;  2HFY A;  1CNX A;  1XQ0 A;  2EU3 A;  1I8Z A;  3NJ9 A;  1G4J A;  3MYQ A;  3M40 A;  3PO6 A;  1TE3 X;  12CA A;  1YDD A;  2CA2 A;  1G46 A;  1OKM A;  1G0F A;  1Z93 A;  1CZM A;  1UGE A;  1CCU A;  1TBT X;  1HEA A;  1TG3 A;  3FE4 A;  1FLJ A;  1CCS A;  1BIC A;  3BL0 A;  1BNW A;  3K7K A;  1AVN A;  1KWR A;  3K34 A;  1Y7W A;  1LG5 A;  3B1B A;  1IF6 A;  1RJ6 A;  1TTM A;  1HCB A;  1TG9 A;  2GD8 A;  3DCS A;  2HL4 A;  1ZE8 A;  2NN7 A;  1YDA A;  2NNG A;  1FQR A;  3IEO A;  1FSR A;  1BN3 A;  1G3Z A;  3F7U A;  2FMZ A; 
#chains in the KnotProt database with same CATH homology
 3KON A;  3M1J A;  2ZNC A;  2NMX A;  2FOS A;  3BET A;  1FR4 A;  1CA2 A;  1BNU A;  1RAY A;  3CZV A;  1YO0 A;  1G52 A;  1I9N A;  2POV A;  3M2N A;  1IF5 A;  1ZSC A;  2CAB A;  1BN4 A;  1RZE A;  2VVA X;  1CAM A;  3D8W A;  3DVD A;  2FOQ A;  1CVH A;  1ZNC A;  3F4X A;  2AX2 A;  3P4V A;  1CNJ A;  2FOU A;  8CA2 A;  3MNH A;  3R17 B;  1CVC A;  3C7P A;  1H9N A;  3MDZ A;  9CA2 A;  2FNM A;  3JXG A;  3M96 A;  3MWO A;  1BZM A;  1BN1 A;  3HKN A;  1XEG A;  3IBN A;  2H15 A;  3GZ0 A;  3KIG A;  3K2F A;  1LGD A;  1HUG A;  1CNY A;  1AM6 A;  1HVA A;  3DAZ A;  3M67 A;  1I9L A;  1CAO A;  1BCD A;  1CA3 A;  3MNI A;  3DCW A;  4CA2 A;  1CIL A;  1I9Q A;  3F8E A;  1OQ5 A;  1CAK A;  3IBL A;  1RZA A;  2WEG A;  1IF9 A;  3D9Z A;  3FFP X;  3MHO A;  3R16 A;  3MNJ A;  1YO1 A;  3BL1 A;  1KOQ A;  2HNC A;  2FNK A;  1BNQ A;  2Q38 A;  1ZSB A;  1UGB A;  2HFW A;  2HOC A;  2CBA A;  3OIM A;  3MHL A;  1A42 A;  1YDC A;  1CAI A;  1KWQ A;  3M98 A;  1DMY A;  1G53 A;  2NWZ A;  1I90 A;  2NWY A;  3HS4 A;  1XPZ A;  3L14 A;  1RZD A;  1HEC A;  3IQK A;  1H4N A;  1FQL A;  1IF8 A;  3HKQ A;  1CAN A;  1KOP A;  1BV3 A;  3KWA A;  1CCT A;  3CAJ A;  1AZM A;  1XEV A;  1TH9 A;  1CIN A;  1CAH A;  3DCC A;  2NWP A;  3NI5 A;  1CAY A;  3N4B A;  1HUH A;  3MMF A;  3OIK A;  1URT A;  1CNG A;  1YDB A;  1KEQ A;  2GEH A;  3OIL A;  1FSQ A;  3D0N A;  3PYK A;  7CA2 A;  3OKV A;  3DC3 A;  3JXF A;  2Q1Q A;  2Q1B A;  1UGF A;  3M2Z A;  1TEU X;  3DD0 A;  2CBD A;  2F14 A;  1OKN A;  3N3J A;  1CVA A;  3B4F A;  1EOU A;  1CAL A;  2WEJ A;  3MHI A;  2EZ7 A;  1DCB A;  3KKX A;  2WEH A;  2EU2 A;  2NXS A;  3DC9 A;  2ILI A;  1FSN A;  3DVB A;  2AW1 A;  3ML5 A;  3M5T A;  2IT4 A;  3DV7 A;  1MUA A;  1CNI A;  1BNT A;  2NXR A;  3IBU A;  1BNV A;  1CVE A;  2POU A;  2FW4 A;  1V9E A;  1LZV A;  2HD6 A;  3N2P A;  3HKT A;  1CVB A;  2NXT A;  3IGP A;  1RAZ A;  3M5S A;  3MNK A;  1IF4 A;  1F2W A;  1CNH A;  3ZNC A;  1FQM A;  1DCA A;  3N0N A;  3DVC A;  3ML2 A;  3KOK A;  2WD3 A;  2VVB X;  1LG6 A;  1J9W A;  1UGD A;  1CNC A;  5CA2 A;  1BNN A;  1I9M A;  2HFX A;  1THK A;  2HKK A;  3F7B A;  1V9I C;  1HEB A;  2WD2 A;  1G1D A;  1G48 A;  3MNU A;  3M1Q A;  1HCA A;  1UGA A;  1HED A;  1CNW A;  3KS3 A;  3IBI A;  2NN1 A;  1CAJ A;  2FNN A;  1BNM A;  1FQN A;  2X7S A;  2FMG A;  2O4Z A;  2OSF A;  1G6V A;  3EFI A;  3MHC A;  2OSM A;  2NNV A;  3M2Y A;  5CAC A;  1I9O A;  2CBC A;  6CA2 A;  1RZC A;  3DD8 A;  3HKU A;  2NWO A;  4CAC A;  3IAI A;  1RZB A;  1CRM A;  3M5E A;  3DBU A;  2NNS A;  3DA2 A;  3JXH C;  2POW A;  1IF7 A;  1CVF A;  3M1W A;  1CIM A;  3MNA A;  3M3X A;  1G4O A;  1G45 A;  3D92 A;  1CRA A;  3CA2 A;  3MHM A;  1JV0 A;  3OKU A;  1I9P A;  3HLJ A;  1FR7 A;  2ABE A;  1YO2 A;  1I91 A;  2WEO A;  3MZC A;  1Z97 A;  1LUG A;  3EFT A;  1CVD A;  2X7U A;  1CAZ A;  3FW3 A;  2W2J A;  2CBE A;  1H9Q A;  3D93 A;  1RJ5 A;  2CBB A;  2NNO A;  3LXE A;  1JD0 A;  1ZSA A;  2X7T A;  1G0E A;  3HFP A;  1T9N A;  2HFY A;  1CNX A;  1XQ0 A;  2EU3 A;  1I8Z A;  3NJ9 A;  1G4J A;  3MYQ A;  3M40 A;  3PO6 A;  1TE3 X;  12CA A;  1YDD A;  2CA2 A;  1G46 A;  1OKM A;  1G0F A;  1Z93 A;  1CZM A;  1UGE A;  1CCU A;  1TBT X;  1HEA A;  1TG3 A;  3FE4 A;  1FLJ A;  1CCS A;  1BIC A;  3BL0 A;  1BNW A;  3K7K A;  1AVN A;  1KWR A;  3K34 A;  1Y7W A;  1LG5 A;  3B1B A;  1IF6 A;  1RJ6 A;  1TTM A;  1HCB A;  1TG9 A;  2GD8 A;  3DCS A;  2HL4 A;  1ZE8 A;  2NN7 A;  1YDA A;  2NNG A;  1FQR A;  3IEO A;  1FSR A;  1BN3 A;  1G3Z A;  3F7U A;  2FMZ A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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