2WEGA

Thermodynamic optimisation of carbonic anhydrase fragment inhibitors
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 22-256 235 257-259 1-1 2-21 1 2 slipknot
Chain Sequence
HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 3x +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 22-256 235 1-21, 257-259 21 3 knot
Fingerprint Knot forming loop Loop type
K +31
Chain closureHis3 <-> Lys261
... His96 <->
Bridging ionZn1262
<-> His94 ... His3
probabilistic
K +31 His3 ... His96 <->
Bridging ionZn1262
<-> His119 ...
Chain closureLys261 <-> His3
probabilistic
K +31 His3 ... His94 <->
Bridging ionZn1262
<-> His119 ...
Chain closureLys261 <-> His3
probabilistic
Chain Sequence
HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 27-257 231 1-26, 258-258 26 1 knot
view details
2.1 25-252 228 1-24 258-258 253-257 24 1 slipknot
sequence length 258
structure length 258
publication title Thermodynamic Optimisation in Drug Discovery: A Case Study Using Carbonic Anhydrase Inhibitors.
pubmed doi rcsb
molecule tags Lyase
molecule keywords CARBONIC ANHYDRASE 2
source organism Homo sapiens
total genus Genus: 75
ec nomenclature ec 4.2.1.1: Carbonate dehydratase.
pdb deposition date 2009-03-31
KnotProt deposition date 2018-10-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00194 Carb_anhydrase Eukaryotic-type carbonic anhydrase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.200.10 Alpha Beta Roll Carbonic Anhydrase II Carbonic Anhydrase II 2wegA00
3.10.200.10 Alpha Beta Roll Carbonic Anhydrase II Carbonic Anhydrase II 2wegA00
1TG9A 2Q1BA 6CA2A 1OQ5A 1CAHA 3HKUA 3HKQA 1IF4A 3ZNCA 2HNCA 1AM6A 1CVBA 1YO2A 1BZMA 2NNOA 3K2FA 3JXFA 1TE3X 2EU2A 2O4ZA 1G6VA 2FMZA 1FLJA 1J9WA 12CAA 3DD0A 1TH9A 3MNHA 8CA2A 3MZCA 3DVCA 1G0EA 3JXHC 1IF5A 4CACA 1YDAA 3DC3A 1ZSAA 1RZEA 3NJ9A 3MNIA 3M1JA 2VVAX 3GZ0A 1CRAA 1CNYA 2HL4A 2W2JA 3M2NA 2FNMA 3MHCA 1CAJA 3OIKA 9CA2A 3DBUA 1URTA 2HFXA 3M67A 1LUGA 1I8ZA 3M3XA 3M2YA 3M1QA 3N4BA 2Q1QA 3KKXA 1V9EA 2IT4A 1BN1A 3IBUA 3FE4A 1KOQA 2HFWA 3M98A 3C7PA 1BV3A 3KONA 1KWQA 1CCUA 3B4FA 7CA2A 1FSNA 3M1WA 3MYQA 3PYKA 1ZSBA 1YDCA 2X7TA 3M96A 3BL0A 1RAYA 1BN4A 2NWPA 1JV0A 2EU3A 1YDBA 3KWAA 1AZMA 3HKTA 1RZDA 3P4VA 2WD2A 3ML5A 2WEGA 1TG3A 1CVDA 3F7UA 3N2PA 3MNKA 3IQKA 1I9PA 3JXGA 3KOKA 3DCCA 4CA2A 1CNCA 1G45A 2POVA 1UGBA 3DCSA 1IF7A 1XEVA 1H4NA 4PYYA 1HEDA 2WEJA 3D0NA 2FMGA 1CNXA 3EFTA 3K7KA 1KOPA 1XEGA 3CA2A 3B1BA 3OIMA 1I9QA 3DD8A 3NI5A 1ZSCA 2NN7A 1BN3A 1MUAA 1CAOA 2ABEA 1G4OA 1OKNA 3MHMA 3MDZA 1G46A 2HOCA 3KIGA 1YDDA 1FR7A 2ILIA 1HVAA 3KS3A 2FOQA 1BNQA 2POWA 2OSFA 1DCAA 3ML2A 2NMXA 3M5SA 1JD0A 2X7SA 1CCSA 1LG5A 1CVEA 2VVBX 2NNGA 3M5EA 1TTMA 3R17B 1LGDA 1CNIA 1HUHA 1BNUA 3MMFA 2AW1A 3M2ZA 3DAZA 2NWOA 2FNNA 1I9NA 1THKA 1DMYA 2CABA 1HCAA 2AX2A 3K34A 3MHIA 3N3JA 1UGAA 2HKKA 1I91A 5CA2A 1G52A 3MNJA 1CVAA 2X7UA 1I9OA 1G3ZA 1FR4A 1EOUA 1CILA 2FOSA 1HEAA 1CA3A 1UGDA 1Z93A 2ZNCA 2GD8A 3OKUA 1CVHA 1TEUX 1I9LA 1ZE8A 2POUA 3FFPX 3D9ZA 1CCTA 1CVCA 1XQ0A 2WEOA 1A42A 3DA2A 1BNVA 1BNTA 1G53A 2H15A 1YO0A 2NN1A 2HD6A 3OKVA 3D8WA 2HFYA 1FSRA 2NNVA 3HFPA 3PO6A 2CBEA 1HEBA 3HKNA 3R16A 2NXSA 1CAYA 2CBBA 3MHOA 1Z97A 2CBAA 2CBCA 3DVBA 1BICA 1FQRA 1BNWA 1CAIA 1UGEA 2NWYA 3HLJA 1HUGA 1UGFA 3FW3A 3M40A 2EZ7A 2F14A 1LG6A 1OKMA 1BCDA 3BL1A 3DCWA 2FW4A 1G4JA 1RZCA 1CALA 1CAMA 3F8EA 1V9IC 1G0FA 1H9QA 1RAZA 1ZNCA 2FOUA 3BETA 1CNWA 1FQMA 1CINA 1CAKA 1FQNA 1I90A 1CA2A 2OSMA 1RJ6A 2NWZA 3D92A 1DCBA 1BNMA 3LXEA 3F4XA 3N0NA 1CAZA 3IEOA 3DVDA 3IGPA 2Q38A 1FSQA 1H9NA 3IBNA 1XPZA 1BNNA 2NNSA 3CAJA 3MNAA 1KWRA 1CVFA 5CACA 2WD3A 2FNKA 1I9MA 1IF8A 1KEQA 1YO1A 3DC9A 1RZAA 2GEHA 1IF6A 1Y7WA 1CZMA 3IBLA 3MNUA 1CRMA 2CBDA 1TBTX 2CA2A 1RJ5A 1HECA 3EFIA 2NXTA 1FQLA 1T9NA 3D93A 1HCBA 1CNHA 1G48A 1CNJA 1RZBA 3MWOA 3MHLA 3IAIA 1IF9A 1G1DA 1CANA 1F2WA 3M5TA 1LZVA 2WEHA 2NXRA 3F7BA 3DV7A 3OILA 3IBIA 1CNGA 3L14A 3CZVA 3HS4A 1AVNA 1CIMA
chains in the KnotProt database with same CATH superfamily
1TG9A 2Q1BA 6CA2A 1OQ5A 1CAHA 3HKUA 3HKQA 1IF4A 3ZNCA 2HNCA 1AM6A 1CVBA 1YO2A 1BZMA 2NNOA 3K2FA 3JXFA 1TE3X 2EU2A 2O4ZA 1G6VA 2FMZA 1FLJA 1J9WA 12CAA 3DD0A 1TH9A 3MNHA 8CA2A 3MZCA 3DVCA 1G0EA 3JXHC 1IF5A 4CACA 1YDAA 3DC3A 1ZSAA 1RZEA 3NJ9A 3MNIA 3M1JA 2VVAX 3GZ0A 1CRAA 1CNYA 2HL4A 2W2JA 3M2NA 2FNMA 3MHCA 1CAJA 3OIKA 9CA2A 3DBUA 1URTA 2HFXA 3M67A 1LUGA 1I8ZA 3M3XA 3M2YA 3M1QA 3N4BA 2Q1QA 3KKXA 1V9EA 2IT4A 1BN1A 3IBUA 3FE4A 1KOQA 2HFWA 3M98A 3C7PA 1BV3A 3KONA 1KWQA 1CCUA 3B4FA 7CA2A 1FSNA 3M1WA 3MYQA 3PYKA 1ZSBA 1YDCA 2X7TA 3M96A 3BL0A 1RAYA 1BN4A 2NWPA 1JV0A 2EU3A 1YDBA 3KWAA 1AZMA 3HKTA 1RZDA 3P4VA 2WD2A 3ML5A 2WEGA 1TG3A 1CVDA 3F7UA 3N2PA 3MNKA 3IQKA 1I9PA 3JXGA 3KOKA 3DCCA 4CA2A 1CNCA 1G45A 2POVA 1UGBA 3DCSA 1IF7A 1XEVA 1H4NA 4PYYA 1HEDA 2WEJA 3D0NA 2FMGA 1CNXA 3EFTA 3K7KA 1KOPA 1XEGA 3CA2A 3B1BA 3OIMA 1I9QA 3DD8A 3NI5A 1ZSCA 2NN7A 1BN3A 1MUAA 1CAOA 2ABEA 1G4OA 1OKNA 3MHMA 3MDZA 1G46A 2HOCA 3KIGA 1YDDA 1FR7A 2ILIA 1HVAA 3KS3A 2FOQA 1BNQA 2POWA 2OSFA 1DCAA 3ML2A 2NMXA 3M5SA 1JD0A 2X7SA 1CCSA 1LG5A 1CVEA 2VVBX 2NNGA 3M5EA 1TTMA 3R17B 1LGDA 1CNIA 1HUHA 1BNUA 3MMFA 2AW1A 3M2ZA 3DAZA 2NWOA 2FNNA 1I9NA 1THKA 1DMYA 2CABA 1HCAA 2AX2A 3K34A 3MHIA 3N3JA 1UGAA 2HKKA 1I91A 5CA2A 1G52A 3MNJA 1CVAA 2X7UA 1I9OA 1G3ZA 1FR4A 1EOUA 1CILA 2FOSA 1HEAA 1CA3A 1UGDA 1Z93A 2ZNCA 2GD8A 3OKUA 1CVHA 1TEUX 1I9LA 1ZE8A 2POUA 3FFPX 3D9ZA 1CCTA 1CVCA 1XQ0A 2WEOA 1A42A 3DA2A 1BNVA 1BNTA 1G53A 2H15A 1YO0A 2NN1A 2HD6A 3OKVA 3D8WA 2HFYA 1FSRA 2NNVA 3HFPA 3PO6A 2CBEA 1HEBA 3HKNA 3R16A 2NXSA 1CAYA 2CBBA 3MHOA 1Z97A 2CBAA 2CBCA 3DVBA 1BICA 1FQRA 1BNWA 1CAIA 1UGEA 2NWYA 3HLJA 1HUGA 1UGFA 3FW3A 3M40A 2EZ7A 2F14A 1LG6A 1OKMA 1BCDA 3BL1A 3DCWA 2FW4A 1G4JA 1RZCA 1CALA 1CAMA 3F8EA 1V9IC 1G0FA 1H9QA 1RAZA 1ZNCA 2FOUA 3BETA 1CNWA 1FQMA 1CINA 1CAKA 1FQNA 1I90A 1CA2A 2OSMA 1RJ6A 2NWZA 3D92A 1DCBA 1BNMA 3LXEA 3F4XA 3N0NA 1CAZA 3IEOA 3DVDA 3IGPA 2Q38A 1FSQA 1H9NA 3IBNA 1XPZA 1BNNA 2NNSA 3CAJA 3MNAA 1KWRA 1CVFA 5CACA 2WD3A 2FNKA 1I9MA 1IF8A 1KEQA 1YO1A 3DC9A 1RZAA 2GEHA 1IF6A 1Y7WA 1CZMA 3IBLA 3MNUA 1CRMA 2CBDA 1TBTX 2CA2A 1RJ5A 1HECA 3EFIA 2NXTA 1FQLA 1T9NA 3D93A 1HCBA 1CNHA 1G48A 1CNJA 1RZBA 3MWOA 3MHLA 3IAIA 1IF9A 1G1DA 1CANA 1F2WA 3M5TA 1LZVA 2WEHA 2NXRA 3F7BA 3DV7A 3OILA 3IBIA 1CNGA 3L14A 3CZVA 3HS4A 1AVNA 1CIMA
chains in the KnotProt database with same CATH topology
1TG9A 2Q1BA 6CA2A 1OQ5A 1CAHA 3HKUA 3HKQA 1IF4A 3ZNCA 2HNCA 1AM6A 1CVBA 1YO2A 1BZMA 2NNOA 3K2FA 3JXFA 1TE3X 2EU2A 2O4ZA 1G6VA 2FMZA 1FLJA 1J9WA 12CAA 3DD0A 1TH9A 3MNHA 8CA2A 3MZCA 3DVCA 1G0EA 3JXHC 1IF5A 4CACA 1YDAA 3DC3A 1ZSAA 1RZEA 3NJ9A 3MNIA 3M1JA 2VVAX 3GZ0A 1CRAA 1CNYA 2HL4A 2W2JA 3M2NA 2FNMA 3MHCA 1CAJA 3OIKA 9CA2A 3DBUA 1URTA 2HFXA 3M67A 1LUGA 1I8ZA 3M3XA 3M2YA 3M1QA 3N4BA 2Q1QA 3KKXA 1V9EA 2IT4A 1BN1A 3IBUA 3FE4A 1KOQA 2HFWA 3M98A 3C7PA 1BV3A 3KONA 1KWQA 1CCUA 3B4FA 7CA2A 1FSNA 3M1WA 3MYQA 3PYKA 1ZSBA 1YDCA 2X7TA 3M96A 3BL0A 1RAYA 1BN4A 2NWPA 1JV0A 2EU3A 1YDBA 3KWAA 1AZMA 3HKTA 1RZDA 3P4VA 2WD2A 3ML5A 2WEGA 1TG3A 1CVDA 3F7UA 3N2PA 3MNKA 3IQKA 1I9PA 3JXGA 3KOKA 3DCCA 4CA2A 1CNCA 1G45A 2POVA 1UGBA 3DCSA 1IF7A 1XEVA 1H4NA 1HEDA 2WEJA 3D0NA 2FMGA 1CNXA 3EFTA 3K7KA 1KOPA 1XEGA 3CA2A 3B1BA 3OIMA 1I9QA 3DD8A 3NI5A 1ZSCA 2NN7A 1BN3A 1MUAA 1CAOA 2ABEA 1G4OA 1OKNA 3MHMA 3MDZA 1G46A 2HOCA 3KIGA 1YDDA 1FR7A 2ILIA 1HVAA 3KS3A 2FOQA 1BNQA 2POWA 2OSFA 1DCAA 3ML2A 2NMXA 3M5SA 1JD0A 2X7SA 1CCSA 1LG5A 1CVEA 2VVBX 2NNGA 3M5EA 1TTMA 3R17B 1LGDA 1CNIA 1HUHA 1BNUA 3MMFA 2AW1A 3M2ZA 3DAZA 2NWOA 2FNNA 1I9NA 1THKA 1DMYA 2CABA 1HCAA 2AX2A 3K34A 3MHIA 3N3JA 1UGAA 2HKKA 1I91A 5CA2A 1G52A 3MNJA 1CVAA 2X7UA 1I9OA 1G3ZA 1FR4A 1EOUA 1CILA 2FOSA 1HEAA 1CA3A 1UGDA 1Z93A 2ZNCA 2GD8A 3OKUA 1CVHA 1TEUX 1I9LA 1ZE8A 2POUA 3FFPX 3D9ZA 1CCTA 1CVCA 1XQ0A 2WEOA 1A42A 3DA2A 1BNVA 1BNTA 1G53A 2H15A 1YO0A 2NN1A 2HD6A 3OKVA 3D8WA 2HFYA 1FSRA 2NNVA 3HFPA 3PO6A 2CBEA 1HEBA 3HKNA 3R16A 2NXSA 1CAYA 2CBBA 3MHOA 1Z97A 2CBAA 2CBCA 3DVBA 1BICA 1FQRA 1BNWA 1CAIA 1UGEA 2NWYA 3HLJA 1HUGA 1UGFA 3FW3A 3M40A 2EZ7A 2F14A 1LG6A 1OKMA 1BCDA 3BL1A 3DCWA 2FW4A 1G4JA 1RZCA 1CALA 1CAMA 3F8EA 1V9IC 1G0FA 1H9QA 1RAZA 1ZNCA 2FOUA 3BETA 1CNWA 1FQMA 1CINA 1CAKA 1FQNA 1I90A 1CA2A 2OSMA 1RJ6A 2NWZA 3D92A 1DCBA 1BNMA 3LXEA 3F4XA 3N0NA 1CAZA 3IEOA 3DVDA 3IGPA 2Q38A 1FSQA 1H9NA 3IBNA 1XPZA 1BNNA 2NNSA 3CAJA 3MNAA 1KWRA 1CVFA 5CACA 2WD3A 2FNKA 1I9MA 1IF8A 1KEQA 1YO1A 3DC9A 1RZAA 2GEHA 1IF6A 1Y7WA 1CZMA 3IBLA 3MNUA 1CRMA 2CBDA 1TBTX 2CA2A 1RJ5A 1HECA 3EFIA 2NXTA 1FQLA 1T9NA 3D93A 1HCBA 1CNHA 1G48A 1CNJA 1RZBA 3MWOA 3MHLA 3IAIA 1IF9A 1G1DA 1CANA 1F2WA 3M5TA 1LZVA 2WEHA 2NXRA 3F7BA 3DV7A 3OILA 3IBIA 1CNGA 3L14A 3CZVA 3HS4A 1AVNA 1CIMA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1TG9 A;  2Q1B A;  6CA2 A;  1OQ5 A;  1CAH A;  3HKU A;  3HKQ A;  1IF4 A;  3ZNC A;  2HNC A;  1AM6 A;  1CVB A;  1YO2 A;  1BZM A;  2NNO A;  3K2F A;  3JXF A;  1TE3 X;  2EU2 A;  2O4Z A;  1G6V A;  2FMZ A;  1FLJ A;  1J9W A;  12CA A;  3DD0 A;  1TH9 A;  3MNH A;  8CA2 A;  3MZC A;  3DVC A;  1G0E A;  3JXH C;  1IF5 A;  4CAC A;  1YDA A;  3DC3 A;  1ZSA A;  1RZE A;  3NJ9 A;  3MNI A;  3M1J A;  2VVA X;  3GZ0 A;  1CRA A;  1CNY A;  2HL4 A;  2W2J A;  3M2N A;  2FNM A;  3MHC A;  1CAJ A;  3OIK A;  9CA2 A;  3DBU A;  1URT A;  2HFX A;  3M67 A;  1LUG A;  1I8Z A;  3M3X A;  3M2Y A;  3M1Q A;  3N4B A;  2Q1Q A;  3KKX A;  1V9E A;  2IT4 A;  1BN1 A;  3IBU A;  3FE4 A;  1KOQ A;  2HFW A;  3M98 A;  3C7P A;  1BV3 A;  3KON A;  1KWQ A;  1CCU A;  3B4F A;  7CA2 A;  1FSN A;  3M1W A;  3MYQ A;  3PYK A;  1ZSB A;  1YDC A;  2X7T A;  3M96 A;  3BL0 A;  1RAY A;  1BN4 A;  2NWP A;  1JV0 A;  2EU3 A;  1YDB A;  3KWA A;  1AZM A;  3HKT A;  1RZD A;  3P4V A;  2WD2 A;  3ML5 A;  2WEG A;  1TG3 A;  1CVD A;  3F7U A;  3N2P A;  3MNK A;  3IQK A;  1I9P A;  3JXG A;  3KOK A;  3DCC A;  4CA2 A;  1CNC A;  1G45 A;  2POV A;  1UGB A;  3DCS A;  1IF7 A;  1XEV A;  1H4N A;  4PYY A;  1HED A;  2WEJ A;  3D0N A;  2FMG A;  1CNX A;  3EFT A;  3K7K A;  1KOP A;  1XEG A;  3CA2 A;  3B1B A;  3OIM A;  1I9Q A;  3DD8 A;  3NI5 A;  1ZSC A;  2NN7 A;  1BN3 A;  1MUA A;  1CAO A;  2ABE A;  1G4O A;  1OKN A;  3MHM A;  3MDZ A;  1G46 A;  2HOC A;  3KIG A;  1YDD A;  1FR7 A;  2ILI A;  1HVA A;  3KS3 A;  2FOQ A;  1BNQ A;  2POW A;  2OSF A;  1DCA A;  3ML2 A;  2NMX A;  3M5S A;  1JD0 A;  2X7S A;  1CCS A;  1LG5 A;  1CVE A;  2VVB X;  2NNG A;  3M5E A;  1TTM A;  3R17 B;  1LGD A;  1CNI A;  1HUH A;  1BNU A;  3MMF A;  2AW1 A;  3M2Z A;  3DAZ A;  2NWO A;  2FNN A;  1I9N A;  1THK A;  1DMY A;  2CAB A;  1HCA A;  2AX2 A;  3K34 A;  3MHI A;  3N3J A;  1UGA A;  2HKK A;  1I91 A;  5CA2 A;  1G52 A;  3MNJ A;  1CVA A;  2X7U A;  1I9O A;  1G3Z A;  1FR4 A;  1EOU A;  1CIL A;  2FOS A;  1HEA A;  1CA3 A;  1UGD A;  1Z93 A;  2ZNC A;  2GD8 A;  3OKU A;  1CVH A;  1TEU X;  1I9L A;  1ZE8 A;  2POU A;  3FFP X;  3D9Z A;  1CCT A;  1CVC A;  1XQ0 A;  2WEO A;  1A42 A;  3DA2 A;  1BNV A;  1BNT A;  1G53 A;  2H15 A;  1YO0 A;  2NN1 A;  2HD6 A;  3OKV A;  3D8W A;  2HFY A;  1FSR A;  2NNV A;  3HFP A;  3PO6 A;  2CBE A;  1HEB A;  3HKN A;  3R16 A;  2NXS A;  1CAY A;  2CBB A;  3MHO A;  1Z97 A;  2CBA A;  2CBC A;  3DVB A;  1BIC A;  1FQR A;  1BNW A;  1CAI A;  1UGE A;  2NWY A;  3HLJ A;  1HUG A;  1UGF A;  3FW3 A;  3M40 A;  2EZ7 A;  2F14 A;  1LG6 A;  1OKM A;  1BCD A;  3BL1 A;  3DCW A;  2FW4 A;  1G4J A;  1RZC A;  1CAL A;  1CAM A;  3F8E A;  1V9I C;  1G0F A;  1H9Q A;  1RAZ A;  1ZNC A;  2FOU A;  3BET A;  1CNW A;  1FQM A;  1CIN A;  1CAK A;  1FQN A;  1I90 A;  1CA2 A;  2OSM A;  1RJ6 A;  2NWZ A;  3D92 A;  1DCB A;  1BNM A;  3LXE A;  3F4X A;  3N0N A;  1CAZ A;  3IEO A;  3DVD A;  3IGP A;  2Q38 A;  1FSQ A;  1H9N A;  3IBN A;  1XPZ A;  1BNN A;  2NNS A;  3CAJ A;  3MNA A;  1KWR A;  1CVF A;  5CAC A;  2WD3 A;  2FNK A;  1I9M A;  1IF8 A;  1KEQ A;  1YO1 A;  3DC9 A;  1RZA A;  2GEH A;  1IF6 A;  1Y7W A;  1CZM A;  3IBL A;  3MNU A;  1CRM A;  2CBD A;  1TBT X;  2CA2 A;  1RJ5 A;  1HEC A;  3EFI A;  2NXT A;  1FQL A;  1T9N A;  3D93 A;  1HCB A;  1CNH A;  1G48 A;  1CNJ A;  1RZB A;  3MWO A;  3MHL A;  3IAI A;  1IF9 A;  1G1D A;  1CAN A;  1F2W A;  3M5T A;  1LZV A;  2WEH A;  2NXR A;  3F7B A;  3DV7 A;  3OIL A;  3IBI A;  1CNG A;  3L14 A;  3CZV A;  3HS4 A;  1AVN A;  1CIM A; 
#chains in the KnotProt database with same CATH topology
 1TG9 A;  2Q1B A;  6CA2 A;  1OQ5 A;  1CAH A;  3HKU A;  3HKQ A;  1IF4 A;  3ZNC A;  2HNC A;  1AM6 A;  1CVB A;  1YO2 A;  1BZM A;  2NNO A;  3K2F A;  3JXF A;  1TE3 X;  2EU2 A;  2O4Z A;  1G6V A;  2FMZ A;  1FLJ A;  1J9W A;  12CA A;  3DD0 A;  1TH9 A;  3MNH A;  8CA2 A;  3MZC A;  3DVC A;  1G0E A;  3JXH C;  1IF5 A;  4CAC A;  1YDA A;  3DC3 A;  1ZSA A;  1RZE A;  3NJ9 A;  3MNI A;  3M1J A;  2VVA X;  3GZ0 A;  1CRA A;  1CNY A;  2HL4 A;  2W2J A;  3M2N A;  2FNM A;  3MHC A;  1CAJ A;  3OIK A;  9CA2 A;  3DBU A;  1URT A;  2HFX A;  3M67 A;  1LUG A;  1I8Z A;  3M3X A;  3M2Y A;  3M1Q A;  3N4B A;  2Q1Q A;  3KKX A;  1V9E A;  2IT4 A;  1BN1 A;  3IBU A;  3FE4 A;  1KOQ A;  2HFW A;  3M98 A;  3C7P A;  1BV3 A;  3KON A;  1KWQ A;  1CCU A;  3B4F A;  7CA2 A;  1FSN A;  3M1W A;  3MYQ A;  3PYK A;  1ZSB A;  1YDC A;  2X7T A;  3M96 A;  3BL0 A;  1RAY A;  1BN4 A;  2NWP A;  1JV0 A;  2EU3 A;  1YDB A;  3KWA A;  1AZM A;  3HKT A;  1RZD A;  3P4V A;  2WD2 A;  3ML5 A;  2WEG A;  1TG3 A;  1CVD A;  3F7U A;  3N2P A;  3MNK A;  3IQK A;  1I9P A;  3JXG A;  3KOK A;  3DCC A;  4CA2 A;  1CNC A;  1G45 A;  2POV A;  1UGB A;  3DCS A;  1IF7 A;  1XEV A;  1H4N A;  4PYY A;  1HED A;  2WEJ A;  3D0N A;  2FMG A;  1CNX A;  3EFT A;  3K7K A;  1KOP A;  1XEG A;  3CA2 A;  3B1B A;  3OIM A;  1I9Q A;  3DD8 A;  3NI5 A;  1ZSC A;  2NN7 A;  1BN3 A;  1MUA A;  1CAO A;  2ABE A;  1G4O A;  1OKN A;  3MHM A;  3MDZ A;  1G46 A;  2HOC A;  3KIG A;  1YDD A;  1FR7 A;  2ILI A;  1HVA A;  3KS3 A;  2FOQ A;  1BNQ A;  2POW A;  2OSF A;  1DCA A;  3ML2 A;  2NMX A;  3M5S A;  1JD0 A;  2X7S A;  1CCS A;  1LG5 A;  1CVE A;  2VVB X;  2NNG A;  3M5E A;  1TTM A;  3R17 B;  1LGD A;  1CNI A;  1HUH A;  1BNU A;  3MMF A;  2AW1 A;  3M2Z A;  3DAZ A;  2NWO A;  2FNN A;  1I9N A;  1THK A;  1DMY A;  2CAB A;  1HCA A;  2AX2 A;  3K34 A;  3MHI A;  3N3J A;  1UGA A;  2HKK A;  1I91 A;  5CA2 A;  1G52 A;  3MNJ A;  1CVA A;  2X7U A;  1I9O A;  1G3Z A;  1FR4 A;  1EOU A;  1CIL A;  2FOS A;  1HEA A;  1CA3 A;  1UGD A;  1Z93 A;  2ZNC A;  2GD8 A;  3OKU A;  1CVH A;  1TEU X;  1I9L A;  1ZE8 A;  2POU A;  3FFP X;  3D9Z A;  1CCT A;  1CVC A;  1XQ0 A;  2WEO A;  1A42 A;  3DA2 A;  1BNV A;  1BNT A;  1G53 A;  2H15 A;  1YO0 A;  2NN1 A;  2HD6 A;  3OKV A;  3D8W A;  2HFY A;  1FSR A;  2NNV A;  3HFP A;  3PO6 A;  2CBE A;  1HEB A;  3HKN A;  3R16 A;  2NXS A;  1CAY A;  2CBB A;  3MHO A;  1Z97 A;  2CBA A;  2CBC A;  3DVB A;  1BIC A;  1FQR A;  1BNW A;  1CAI A;  1UGE A;  2NWY A;  3HLJ A;  1HUG A;  1UGF A;  3FW3 A;  3M40 A;  2EZ7 A;  2F14 A;  1LG6 A;  1OKM A;  1BCD A;  3BL1 A;  3DCW A;  2FW4 A;  1G4J A;  1RZC A;  1CAL A;  1CAM A;  3F8E A;  1V9I C;  1G0F A;  1H9Q A;  1RAZ A;  1ZNC A;  2FOU A;  3BET A;  1CNW A;  1FQM A;  1CIN A;  1CAK A;  1FQN A;  1I90 A;  1CA2 A;  2OSM A;  1RJ6 A;  2NWZ A;  3D92 A;  1DCB A;  1BNM A;  3LXE A;  3F4X A;  3N0N A;  1CAZ A;  3IEO A;  3DVD A;  3IGP A;  2Q38 A;  1FSQ A;  1H9N A;  3IBN A;  1XPZ A;  1BNN A;  2NNS A;  3CAJ A;  3MNA A;  1KWR A;  1CVF A;  5CAC A;  2WD3 A;  2FNK A;  1I9M A;  1IF8 A;  1KEQ A;  1YO1 A;  3DC9 A;  1RZA A;  2GEH A;  1IF6 A;  1Y7W A;  1CZM A;  3IBL A;  3MNU A;  1CRM A;  2CBD A;  1TBT X;  2CA2 A;  1RJ5 A;  1HEC A;  3EFI A;  2NXT A;  1FQL A;  1T9N A;  3D93 A;  1HCB A;  1CNH A;  1G48 A;  1CNJ A;  1RZB A;  3MWO A;  3MHL A;  3IAI A;  1IF9 A;  1G1D A;  1CAN A;  1F2W A;  3M5T A;  1LZV A;  2WEH A;  2NXR A;  3F7B A;  3DV7 A;  3OIL A;  3IBI A;  1CNG A;  3L14 A;  3CZV A;  3HS4 A;  1AVN A;  1CIM A; 
#chains in the KnotProt database with same CATH homology
 1TG9 A;  2Q1B A;  6CA2 A;  1OQ5 A;  1CAH A;  3HKU A;  3HKQ A;  1IF4 A;  3ZNC A;  2HNC A;  1AM6 A;  1CVB A;  1YO2 A;  1BZM A;  2NNO A;  3K2F A;  3JXF A;  1TE3 X;  2EU2 A;  2O4Z A;  1G6V A;  2FMZ A;  1FLJ A;  1J9W A;  12CA A;  3DD0 A;  1TH9 A;  3MNH A;  8CA2 A;  3MZC A;  3DVC A;  1G0E A;  3JXH C;  1IF5 A;  4CAC A;  1YDA A;  3DC3 A;  1ZSA A;  1RZE A;  3NJ9 A;  3MNI A;  3M1J A;  2VVA X;  3GZ0 A;  1CRA A;  1CNY A;  2HL4 A;  2W2J A;  3M2N A;  2FNM A;  3MHC A;  1CAJ A;  3OIK A;  9CA2 A;  3DBU A;  1URT A;  2HFX A;  3M67 A;  1LUG A;  1I8Z A;  3M3X A;  3M2Y A;  3M1Q A;  3N4B A;  2Q1Q A;  3KKX A;  1V9E A;  2IT4 A;  1BN1 A;  3IBU A;  3FE4 A;  1KOQ A;  2HFW A;  3M98 A;  3C7P A;  1BV3 A;  3KON A;  1KWQ A;  1CCU A;  3B4F A;  7CA2 A;  1FSN A;  3M1W A;  3MYQ A;  3PYK A;  1ZSB A;  1YDC A;  2X7T A;  3M96 A;  3BL0 A;  1RAY A;  1BN4 A;  2NWP A;  1JV0 A;  2EU3 A;  1YDB A;  3KWA A;  1AZM A;  3HKT A;  1RZD A;  3P4V A;  2WD2 A;  3ML5 A;  2WEG A;  1TG3 A;  1CVD A;  3F7U A;  3N2P A;  3MNK A;  3IQK A;  1I9P A;  3JXG A;  3KOK A;  3DCC A;  4CA2 A;  1CNC A;  1G45 A;  2POV A;  1UGB A;  3DCS A;  1IF7 A;  1XEV A;  1H4N A;  1HED A;  2WEJ A;  3D0N A;  2FMG A;  1CNX A;  3EFT A;  3K7K A;  1KOP A;  1XEG A;  3CA2 A;  3B1B A;  3OIM A;  1I9Q A;  3DD8 A;  3NI5 A;  1ZSC A;  2NN7 A;  1BN3 A;  1MUA A;  1CAO A;  2ABE A;  1G4O A;  1OKN A;  3MHM A;  3MDZ A;  1G46 A;  2HOC A;  3KIG A;  1YDD A;  1FR7 A;  2ILI A;  1HVA A;  3KS3 A;  2FOQ A;  1BNQ A;  2POW A;  2OSF A;  1DCA A;  3ML2 A;  2NMX A;  3M5S A;  1JD0 A;  2X7S A;  1CCS A;  1LG5 A;  1CVE A;  2VVB X;  2NNG A;  3M5E A;  1TTM A;  3R17 B;  1LGD A;  1CNI A;  1HUH A;  1BNU A;  3MMF A;  2AW1 A;  3M2Z A;  3DAZ A;  2NWO A;  2FNN A;  1I9N A;  1THK A;  1DMY A;  2CAB A;  1HCA A;  2AX2 A;  3K34 A;  3MHI A;  3N3J A;  1UGA A;  2HKK A;  1I91 A;  5CA2 A;  1G52 A;  3MNJ A;  1CVA A;  2X7U A;  1I9O A;  1G3Z A;  1FR4 A;  1EOU A;  1CIL A;  2FOS A;  1HEA A;  1CA3 A;  1UGD A;  1Z93 A;  2ZNC A;  2GD8 A;  3OKU A;  1CVH A;  1TEU X;  1I9L A;  1ZE8 A;  2POU A;  3FFP X;  3D9Z A;  1CCT A;  1CVC A;  1XQ0 A;  2WEO A;  1A42 A;  3DA2 A;  1BNV A;  1BNT A;  1G53 A;  2H15 A;  1YO0 A;  2NN1 A;  2HD6 A;  3OKV A;  3D8W A;  2HFY A;  1FSR A;  2NNV A;  3HFP A;  3PO6 A;  2CBE A;  1HEB A;  3HKN A;  3R16 A;  2NXS A;  1CAY A;  2CBB A;  3MHO A;  1Z97 A;  2CBA A;  2CBC A;  3DVB A;  1BIC A;  1FQR A;  1BNW A;  1CAI A;  1UGE A;  2NWY A;  3HLJ A;  1HUG A;  1UGF A;  3FW3 A;  3M40 A;  2EZ7 A;  2F14 A;  1LG6 A;  1OKM A;  1BCD A;  3BL1 A;  3DCW A;  2FW4 A;  1G4J A;  1RZC A;  1CAL A;  1CAM A;  3F8E A;  1V9I C;  1G0F A;  1H9Q A;  1RAZ A;  1ZNC A;  2FOU A;  3BET A;  1CNW A;  1FQM A;  1CIN A;  1CAK A;  1FQN A;  1I90 A;  1CA2 A;  2OSM A;  1RJ6 A;  2NWZ A;  3D92 A;  1DCB A;  1BNM A;  3LXE A;  3F4X A;  3N0N A;  1CAZ A;  3IEO A;  3DVD A;  3IGP A;  2Q38 A;  1FSQ A;  1H9N A;  3IBN A;  1XPZ A;  1BNN A;  2NNS A;  3CAJ A;  3MNA A;  1KWR A;  1CVF A;  5CAC A;  2WD3 A;  2FNK A;  1I9M A;  1IF8 A;  1KEQ A;  1YO1 A;  3DC9 A;  1RZA A;  2GEH A;  1IF6 A;  1Y7W A;  1CZM A;  3IBL A;  3MNU A;  1CRM A;  2CBD A;  1TBT X;  2CA2 A;  1RJ5 A;  1HEC A;  3EFI A;  2NXT A;  1FQL A;  1T9N A;  3D93 A;  1HCB A;  1CNH A;  1G48 A;  1CNJ A;  1RZB A;  3MWO A;  3MHL A;  3IAI A;  1IF9 A;  1G1D A;  1CAN A;  1F2W A;  3M5T A;  1LZV A;  2WEH A;  2NXR A;  3F7B A;  3DV7 A;  3OIL A;  3IBI A;  1CNG A;  3L14 A;  3CZV A;  3HS4 A;  1AVN A;  1CIM A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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