2EZ7A

Carbonic anhydrase activators. activation of isozymes i, ii, iv, va, vii and xiv with l- and d-histidine and crystallographic analysis of their adducts with isoform ii: engineering proton transfer processes within the active site of an enzyme
Genus: 78
Alphaknot: P00918
Knot K +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 20-255 236 1-19, 256-259 19 4 knot
Chain Sequence
HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 7x +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 24-256 233 1-23, 257-259 23 3 knot
Fingerprint Knot forming loop Loop type
K +31 His3 ... His94 <->
Bridging ionZn262
<-> His96 ...
Chain closureLys261 <-> His3
 probabilistic
K +31
Chain closureHis3 <-> Lys261
... Glu205 <->
Bridging ionHg483
<-> Gln137 ... His3		 probabilistic
K +31 His3 ... His96 <->
Bridging ionZn262
<-> His119 ...
Chain closureLys261 <-> His3
 probabilistic
K +31 His3 ... His94 <->
Bridging ionZn262
<-> His119 ...
Chain closureLys261 <-> His3
 probabilistic
K +31
Chain closureHis3 <-> Lys261
... Glu205 <->
Bridging ionHg483
<-> Gln137 ... His96 <->
Bridging ionZn262
<-> His94 ... His3		 probabilistic
K +31
Chain closureHis3 <-> Lys261
... Glu205 <->
Bridging ionHg483
<-> Gln137 ... His119 <->
Bridging ionZn262
<-> His96 ... His3		 probabilistic
K +31
Chain closureHis3 <-> Lys261
... Glu205 <->
Bridging ionHg483
<-> Gln137 ... His119 <->
Bridging ionZn262
<-> His94 ... His3		 probabilistic
Chain Sequence
HHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 26-256 231 1-25, 257-258 25 2 knot
view details
2.1 25-252 228 1-24 258-258 253-257 24 1 slipknot
sequence length 258
structure length 258
publication title Carbonic Anhydrase Activators. Activation of Isozymes I, II, IV, VA, VII, and XIV with L- and D-Histidine and Crystallographic Analysis of Their Adducts with Isoform II: Engineering Proton-Transfer Processes within the Active Site of an Enzyme.
pubmed doi rcsb
molecule tags Lyase
molecule keywords Carbonic anhydrase 2
source organism Homo sapiens
total genus Genus: 78
ec nomenclature ec 4.2.1.1: Carbonate dehydratase.
pdb deposition date 2005-11-10
KnotProt deposition date 2018-10-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00194 Carb_anhydrase Eukaryotic-type carbonic anhydrase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.200.10 Alpha Beta Roll Carbonic Anhydrase II Carbonic Anhydrase II 2ez7A00
3.10.200.10 Alpha Beta Roll Carbonic Anhydrase II Carbonic Anhydrase II 2ez7A00
2NXSA 1LG6A 3LXEA 1CA2A 3DA2A 3IBNA 1UGFA 1FQMA 3KOKA 2WEHA 9CA2A 3M67A 1IF4A 1TBTX 1CNYA 3DVBA 3DBUA 1KWQA 1BNMA 1V9IC 3HLJA 2ZNCA 1KEQA 1FSQA 3BETA 3D92A 2POUA 2NXTA 1FQLA 2HNCA 1G4OA 1I91A 2CA2A 1BN3A 2WEGA 1ZSAA 2AX2A 1YO2A 1TG9A 1BNQA 1G46A 2IT4A 1YO0A 1ZNCA 1KWRA 1UGAA 1I90A 3F7UA 3M5EA 1A42A 3DCCA 3MDZA 3FW3A 2NWYA 2Q1BA 3MHIA 1YDBA 1HUHA 1G48A 3HKNA 2O4ZA 1BN1A 3BL1A 1I9QA 1AM6A 1CALA 2NWOA 3MNAA 3IBUA 1ZE8A 1I9OA 1HECA 1OKNA 3HFPA 1G0EA 1HEAA 3DC9A 2NNOA 3M2ZA 5CACA 1HEBA 1URTA 1BNUA 5CA2A 2FMGA 1FQRA 1TTMA 1TG3A 2Q1QA 2X7SA 3CZVA 1XEGA 3OIKA 1G4JA 3F4XA 2CABA 2CBAA 2EU3A 1CZMA 2NNSA 3NJ9A 3MNUA 1UGEA 2CBBA 1HEDA 3B1BA 3MYQA 2FOUA 1CNWA 1I8ZA 1OQ5A 1CILA 1I9PA 1CAMA 2CBDA 2CBCA 1F2WA 1I9LA 3P4VA 2NN7A 3K2FA 1FLJA 1H4NA 3OILA 2ABEA 3MHCA 1BCDA 3DVCA 1DCBA 3PO6A 1CVCA 1YO1A 1CVHA 1CANA 1CAZA 2NXRA 3B4FA 3F8EA 2X7TA 1Y7WA 1XEVA 1TH9A 6CA2A 3MNIA 3MNJA 2CBEA 2HOCA 3N2PA 3D93A 2HKKA 1FSRA 2FNNA 1CNHA 1CNXA 1TEUX 3EFIA 1BZMA 3C7PA 2GEHA 1Z97A 3NI5A 1HCBA 3JXFA 1BN4A 2Q38A 1ZSBA 2ILIA 1YDAA 1RZEA 2HFXA 1YDDA 1FR7A 4CA2A 3N3JA 3HKTA 1XPZA 3EFTA 2WEOA 1CVEA 3MNHA 3BL0A 3M98A 1EOUA 3CA2A 1BNWA 1HVAA 3DC3A 2OSMA 2POWA 1CCSA 1IF5A 3CAJA 3DCWA 1CCUA 3OIMA 1HCAA 1YDCA 4PYYA 2W2JA 1CRMA 2F14A 1OKMA 1TE3X 1G53A 3M1WA 2WD3A 3GZ0A 3DD8A 1RZBA 2HFWA 2NMXA 1CNIA 1CAJA 2FW4A 3FE4A 3OKUA 2NWZA 1CVAA 3MHMA 1CRAA 1IF6A 3DVDA 1UGDA 1CAYA 1CAIA 3DV7A 3N0NA 1CNGA 4CACA 1CVDA 3M3XA 2H15A 3R16A 1CVBA 1DCAA 3KIGA 3M1JA 1LUGA 2NN1A 1FSNA 2FNKA 3HKQA 3N4BA 2NWPA 3MHLA 3ML2A 3M2NA 1JD0A 3ZNCA 1LGDA 3DAZA 3D8WA 1J9WA 3HS4A 7CA2A 3MNKA 1CIMA 3K34A 3D0NA 1IF7A 1V9EA 3JXGA 2POVA 1CNJA 1H9NA 2HL4A 1KOPA 3IBIA 1CNCA 3IEOA 3HKUA 3IQKA 1LG5A 1XQ0A 3DD0A 1CA3A 3OKVA 3FFPX 1RZAA 1G52A 1I9NA 3IBLA 1RJ6A 1G3ZA 1IF9A 1CAKA 2AW1A 3M96A 3PYKA 1BICA 3M5TA 3DCSA 3K7KA 3ML5A 1JV0A 2FOQA 3MMFA 3KS3A 1H9QA 1T9NA 2FOSA 2HFYA 3KKXA 1RZCA 3MZCA 1AVNA 1CVFA 1G6VA 1RJ5A 12CAA 1HUGA 1MUAA 3IGPA 1Z93A 3M5SA 3D9ZA 3F7BA 2NNVA 3IAIA 3L14A 1G0FA 1I9MA 1G45A 1BNVA 1CAOA 2OSFA 2NNGA 1AZMA 1CAHA 1BNNA 2VVAX 2HD6A 2FNMA 1G1DA 1CCTA 1ZSCA 2WD2A 2EU2A 3M2YA 8CA2A 1KOQA 3M40A 3JXHC 1RAYA 2GD8A 1FQNA 3R17B 1BNTA 1THKA 2FMZA 1DMYA 3MHOA 2VVBX 1RZDA 1UGBA 1IF8A 1BV3A 1CINA 3KONA 3M1QA 2EZ7A 3MWOA 1LZVA 1FR4A 2WEJA 3KWAA 1RAZA 2X7UA
chains in the KnotProt database with same CATH superfamily
2NXSA 1LG6A 3LXEA 1CA2A 3DA2A 3IBNA 1UGFA 1FQMA 3KOKA 2WEHA 9CA2A 3M67A 1IF4A 1TBTX 1CNYA 3DVBA 3DBUA 1KWQA 1BNMA 1V9IC 3HLJA 2ZNCA 1KEQA 1FSQA 3BETA 3D92A 2POUA 2NXTA 1FQLA 2HNCA 1G4OA 1I91A 2CA2A 1BN3A 2WEGA 1ZSAA 2AX2A 1YO2A 1TG9A 1BNQA 1G46A 2IT4A 1YO0A 1ZNCA 1KWRA 1UGAA 1I90A 3F7UA 3M5EA 1A42A 3DCCA 3MDZA 3FW3A 2NWYA 2Q1BA 3MHIA 1YDBA 1HUHA 1G48A 3HKNA 2O4ZA 1BN1A 3BL1A 1I9QA 1AM6A 1CALA 2NWOA 3MNAA 3IBUA 1ZE8A 1I9OA 1HECA 1OKNA 3HFPA 1G0EA 1HEAA 3DC9A 2NNOA 3M2ZA 5CACA 1HEBA 1URTA 1BNUA 5CA2A 2FMGA 1FQRA 1TTMA 1TG3A 2Q1QA 2X7SA 3CZVA 1XEGA 3OIKA 1G4JA 3F4XA 2CABA 2CBAA 2EU3A 1CZMA 2NNSA 3NJ9A 3MNUA 1UGEA 2CBBA 1HEDA 3B1BA 3MYQA 2FOUA 1CNWA 1I8ZA 1OQ5A 1CILA 1I9PA 1CAMA 2CBDA 2CBCA 1F2WA 1I9LA 3P4VA 2NN7A 3K2FA 1FLJA 1H4NA 3OILA 2ABEA 3MHCA 1BCDA 3DVCA 1DCBA 3PO6A 1CVCA 1YO1A 1CVHA 1CANA 1CAZA 2NXRA 3B4FA 3F8EA 2X7TA 1Y7WA 1XEVA 1TH9A 6CA2A 3MNIA 3MNJA 2CBEA 2HOCA 3N2PA 3D93A 2HKKA 1FSRA 2FNNA 1CNHA 1CNXA 1TEUX 3EFIA 1BZMA 3C7PA 2GEHA 1Z97A 3NI5A 1HCBA 3JXFA 1BN4A 2Q38A 1ZSBA 2ILIA 1YDAA 1RZEA 2HFXA 1YDDA 1FR7A 4CA2A 3N3JA 3HKTA 1XPZA 3EFTA 2WEOA 1CVEA 3MNHA 3BL0A 3M98A 1EOUA 3CA2A 1BNWA 1HVAA 3DC3A 2OSMA 2POWA 1CCSA 1IF5A 3CAJA 3DCWA 1CCUA 3OIMA 1HCAA 1YDCA 4PYYA 2W2JA 1CRMA 2F14A 1OKMA 1TE3X 1G53A 3M1WA 2WD3A 3GZ0A 3DD8A 1RZBA 2HFWA 2NMXA 1CNIA 1CAJA 2FW4A 3FE4A 3OKUA 2NWZA 1CVAA 3MHMA 1CRAA 1IF6A 3DVDA 1UGDA 1CAYA 1CAIA 3DV7A 3N0NA 1CNGA 4CACA 1CVDA 3M3XA 2H15A 3R16A 1CVBA 1DCAA 3KIGA 3M1JA 1LUGA 2NN1A 1FSNA 2FNKA 3HKQA 3N4BA 2NWPA 3MHLA 3ML2A 3M2NA 1JD0A 3ZNCA 1LGDA 3DAZA 3D8WA 1J9WA 3HS4A 7CA2A 3MNKA 1CIMA 3K34A 3D0NA 1IF7A 1V9EA 3JXGA 2POVA 1CNJA 1H9NA 2HL4A 1KOPA 3IBIA 1CNCA 3IEOA 3HKUA 3IQKA 1LG5A 1XQ0A 3DD0A 1CA3A 3OKVA 3FFPX 1RZAA 1G52A 1I9NA 3IBLA 1RJ6A 1G3ZA 1IF9A 1CAKA 2AW1A 3M96A 3PYKA 1BICA 3M5TA 3DCSA 3K7KA 3ML5A 1JV0A 2FOQA 3MMFA 3KS3A 1H9QA 1T9NA 2FOSA 2HFYA 3KKXA 1RZCA 3MZCA 1AVNA 1CVFA 1G6VA 1RJ5A 12CAA 1HUGA 1MUAA 3IGPA 1Z93A 3M5SA 3D9ZA 3F7BA 2NNVA 3IAIA 3L14A 1G0FA 1I9MA 1G45A 1BNVA 1CAOA 2OSFA 2NNGA 1AZMA 1CAHA 1BNNA 2VVAX 2HD6A 2FNMA 1G1DA 1CCTA 1ZSCA 2WD2A 2EU2A 3M2YA 8CA2A 1KOQA 3M40A 3JXHC 1RAYA 2GD8A 1FQNA 3R17B 1BNTA 1THKA 2FMZA 1DMYA 3MHOA 2VVBX 1RZDA 1UGBA 1IF8A 1BV3A 1CINA 3KONA 3M1QA 2EZ7A 3MWOA 1LZVA 1FR4A 2WEJA 3KWAA 1RAZA 2X7UA
chains in the KnotProt database with same CATH topology
2NXSA 1LG6A 3LXEA 1CA2A 3DA2A 3IBNA 1UGFA 1FQMA 3KOKA 2WEHA 9CA2A 3M67A 1IF4A 1TBTX 1CNYA 3DVBA 3DBUA 1KWQA 1BNMA 1V9IC 3HLJA 2ZNCA 1KEQA 1FSQA 3BETA 3D92A 2POUA 2NXTA 1FQLA 2HNCA 1G4OA 1I91A 2CA2A 1BN3A 2WEGA 1ZSAA 2AX2A 1YO2A 1TG9A 1BNQA 1G46A 2IT4A 1YO0A 1ZNCA 1KWRA 1UGAA 1I90A 3F7UA 3M5EA 1A42A 3DCCA 3MDZA 3FW3A 2NWYA 2Q1BA 3MHIA 1YDBA 1HUHA 1G48A 3HKNA 2O4ZA 1BN1A 3BL1A 1I9QA 1AM6A 1CALA 2NWOA 3MNAA 3IBUA 1ZE8A 1I9OA 1HECA 1OKNA 3HFPA 1G0EA 1HEAA 3DC9A 2NNOA 3M2ZA 5CACA 1HEBA 1URTA 1BNUA 5CA2A 2FMGA 1FQRA 1TTMA 1TG3A 2Q1QA 2X7SA 3CZVA 1XEGA 3OIKA 1G4JA 3F4XA 2CABA 2CBAA 2EU3A 1CZMA 2NNSA 3NJ9A 3MNUA 1UGEA 2CBBA 1HEDA 3B1BA 3MYQA 2FOUA 1CNWA 1I8ZA 1OQ5A 1CILA 1I9PA 1CAMA 2CBDA 2CBCA 1F2WA 1I9LA 3P4VA 2NN7A 3K2FA 1FLJA 1H4NA 3OILA 2ABEA 3MHCA 1BCDA 3DVCA 1DCBA 3PO6A 1CVCA 1YO1A 1CVHA 1CANA 1CAZA 2NXRA 3B4FA 3F8EA 2X7TA 1Y7WA 1XEVA 1TH9A 6CA2A 3MNIA 3MNJA 2CBEA 2HOCA 3N2PA 3D93A 2HKKA 1FSRA 2FNNA 1CNHA 1CNXA 1TEUX 3EFIA 1BZMA 3C7PA 2GEHA 1Z97A 3NI5A 1HCBA 3JXFA 1BN4A 2Q38A 1ZSBA 2ILIA 1YDAA 1RZEA 2HFXA 1YDDA 1FR7A 4CA2A 3N3JA 3HKTA 1XPZA 3EFTA 2WEOA 1CVEA 3MNHA 3BL0A 3M98A 1EOUA 3CA2A 1BNWA 1HVAA 3DC3A 2OSMA 2POWA 1CCSA 1IF5A 3CAJA 3DCWA 1CCUA 3OIMA 1HCAA 1YDCA 2W2JA 1CRMA 2F14A 1OKMA 1TE3X 1G53A 3M1WA 2WD3A 3GZ0A 3DD8A 1RZBA 2HFWA 2NMXA 1CNIA 1CAJA 2FW4A 3FE4A 3OKUA 2NWZA 1CVAA 3MHMA 1CRAA 1IF6A 3DVDA 1UGDA 1CAYA 1CAIA 3DV7A 3N0NA 1CNGA 4CACA 1CVDA 3M3XA 2H15A 3R16A 1CVBA 1DCAA 3KIGA 3M1JA 1LUGA 2NN1A 1FSNA 2FNKA 3HKQA 3N4BA 2NWPA 3MHLA 3ML2A 3M2NA 1JD0A 3ZNCA 1LGDA 3DAZA 3D8WA 1J9WA 3HS4A 7CA2A 3MNKA 1CIMA 3K34A 3D0NA 1IF7A 1V9EA 3JXGA 2POVA 1CNJA 1H9NA 2HL4A 1KOPA 3IBIA 1CNCA 3IEOA 3HKUA 3IQKA 1LG5A 1XQ0A 3DD0A 1CA3A 3OKVA 3FFPX 1RZAA 1G52A 1I9NA 3IBLA 1RJ6A 1G3ZA 1IF9A 1CAKA 2AW1A 3M96A 3PYKA 1BICA 3M5TA 3DCSA 3K7KA 3ML5A 1JV0A 2FOQA 3MMFA 3KS3A 1H9QA 1T9NA 2FOSA 2HFYA 3KKXA 1RZCA 3MZCA 1AVNA 1CVFA 1G6VA 1RJ5A 12CAA 1HUGA 1MUAA 3IGPA 1Z93A 3M5SA 3D9ZA 3F7BA 2NNVA 3IAIA 3L14A 1G0FA 1I9MA 1G45A 1BNVA 1CAOA 2OSFA 2NNGA 1AZMA 1CAHA 1BNNA 2VVAX 2HD6A 2FNMA 1G1DA 1CCTA 1ZSCA 2WD2A 2EU2A 3M2YA 8CA2A 1KOQA 3M40A 3JXHC 1RAYA 2GD8A 1FQNA 3R17B 1BNTA 1THKA 2FMZA 1DMYA 3MHOA 2VVBX 1RZDA 1UGBA 1IF8A 1BV3A 1CINA 3KONA 3M1QA 2EZ7A 3MWOA 1LZVA 1FR4A 2WEJA 3KWAA 1RAZA 2X7UA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 2NXS A;  1LG6 A;  3LXE A;  1CA2 A;  3DA2 A;  3IBN A;  1UGF A;  1FQM A;  3KOK A;  2WEH A;  9CA2 A;  3M67 A;  1IF4 A;  1TBT X;  1CNY A;  3DVB A;  3DBU A;  1KWQ A;  1BNM A;  1V9I C;  3HLJ A;  2ZNC A;  1KEQ A;  1FSQ A;  3BET A;  3D92 A;  2POU A;  2NXT A;  1FQL A;  2HNC A;  1G4O A;  1I91 A;  2CA2 A;  1BN3 A;  2WEG A;  1ZSA A;  2AX2 A;  1YO2 A;  1TG9 A;  1BNQ A;  1G46 A;  2IT4 A;  1YO0 A;  1ZNC A;  1KWR A;  1UGA A;  1I90 A;  3F7U A;  3M5E A;  1A42 A;  3DCC A;  3MDZ A;  3FW3 A;  2NWY A;  2Q1B A;  3MHI A;  1YDB A;  1HUH A;  1G48 A;  3HKN A;  2O4Z A;  1BN1 A;  3BL1 A;  1I9Q A;  1AM6 A;  1CAL A;  2NWO A;  3MNA A;  3IBU A;  1ZE8 A;  1I9O A;  1HEC A;  1OKN A;  3HFP A;  1G0E A;  1HEA A;  3DC9 A;  2NNO A;  3M2Z A;  5CAC A;  1HEB A;  1URT A;  1BNU A;  5CA2 A;  2FMG A;  1FQR A;  1TTM A;  1TG3 A;  2Q1Q A;  2X7S A;  3CZV A;  1XEG A;  3OIK A;  1G4J A;  3F4X A;  2CAB A;  2CBA A;  2EU3 A;  1CZM A;  2NNS A;  3NJ9 A;  3MNU A;  1UGE A;  2CBB A;  1HED A;  3B1B A;  3MYQ A;  2FOU A;  1CNW A;  1I8Z A;  1OQ5 A;  1CIL A;  1I9P A;  1CAM A;  2CBD A;  2CBC A;  1F2W A;  1I9L A;  3P4V A;  2NN7 A;  3K2F A;  1FLJ A;  1H4N A;  3OIL A;  2ABE A;  3MHC A;  1BCD A;  3DVC A;  1DCB A;  3PO6 A;  1CVC A;  1YO1 A;  1CVH A;  1CAN A;  1CAZ A;  2NXR A;  3B4F A;  3F8E A;  2X7T A;  1Y7W A;  1XEV A;  1TH9 A;  6CA2 A;  3MNI A;  3MNJ A;  2CBE A;  2HOC A;  3N2P A;  3D93 A;  2HKK A;  1FSR A;  2FNN A;  1CNH A;  1CNX A;  1TEU X;  3EFI A;  1BZM A;  3C7P A;  2GEH A;  1Z97 A;  3NI5 A;  1HCB A;  3JXF A;  1BN4 A;  2Q38 A;  1ZSB A;  2ILI A;  1YDA A;  1RZE A;  2HFX A;  1YDD A;  1FR7 A;  4CA2 A;  3N3J A;  3HKT A;  1XPZ A;  3EFT A;  2WEO A;  1CVE A;  3MNH A;  3BL0 A;  3M98 A;  1EOU A;  3CA2 A;  1BNW A;  1HVA A;  3DC3 A;  2OSM A;  2POW A;  1CCS A;  1IF5 A;  3CAJ A;  3DCW A;  1CCU A;  3OIM A;  1HCA A;  1YDC A;  4PYY A;  2W2J A;  1CRM A;  2F14 A;  1OKM A;  1TE3 X;  1G53 A;  3M1W A;  2WD3 A;  3GZ0 A;  3DD8 A;  1RZB A;  2HFW A;  2NMX A;  1CNI A;  1CAJ A;  2FW4 A;  3FE4 A;  3OKU A;  2NWZ A;  1CVA A;  3MHM A;  1CRA A;  1IF6 A;  3DVD A;  1UGD A;  1CAY A;  1CAI A;  3DV7 A;  3N0N A;  1CNG A;  4CAC A;  1CVD A;  3M3X A;  2H15 A;  3R16 A;  1CVB A;  1DCA A;  3KIG A;  3M1J A;  1LUG A;  2NN1 A;  1FSN A;  2FNK A;  3HKQ A;  3N4B A;  2NWP A;  3MHL A;  3ML2 A;  3M2N A;  1JD0 A;  3ZNC A;  1LGD A;  3DAZ A;  3D8W A;  1J9W A;  3HS4 A;  7CA2 A;  3MNK A;  1CIM A;  3K34 A;  3D0N A;  1IF7 A;  1V9E A;  3JXG A;  2POV A;  1CNJ A;  1H9N A;  2HL4 A;  1KOP A;  3IBI A;  1CNC A;  3IEO A;  3HKU A;  3IQK A;  1LG5 A;  1XQ0 A;  3DD0 A;  1CA3 A;  3OKV A;  3FFP X;  1RZA A;  1G52 A;  1I9N A;  3IBL A;  1RJ6 A;  1G3Z A;  1IF9 A;  1CAK A;  2AW1 A;  3M96 A;  3PYK A;  1BIC A;  3M5T A;  3DCS A;  3K7K A;  3ML5 A;  1JV0 A;  2FOQ A;  3MMF A;  3KS3 A;  1H9Q A;  1T9N A;  2FOS A;  2HFY A;  3KKX A;  1RZC A;  3MZC A;  1AVN A;  1CVF A;  1G6V A;  1RJ5 A;  12CA A;  1HUG A;  1MUA A;  3IGP A;  1Z93 A;  3M5S A;  3D9Z A;  3F7B A;  2NNV A;  3IAI A;  3L14 A;  1G0F A;  1I9M A;  1G45 A;  1BNV A;  1CAO A;  2OSF A;  2NNG A;  1AZM A;  1CAH A;  1BNN A;  2VVA X;  2HD6 A;  2FNM A;  1G1D A;  1CCT A;  1ZSC A;  2WD2 A;  2EU2 A;  3M2Y A;  8CA2 A;  1KOQ A;  3M40 A;  3JXH C;  1RAY A;  2GD8 A;  1FQN A;  3R17 B;  1BNT A;  1THK A;  2FMZ A;  1DMY A;  3MHO A;  2VVB X;  1RZD A;  1UGB A;  1IF8 A;  1BV3 A;  1CIN A;  3KON A;  3M1Q A;  2EZ7 A;  3MWO A;  1LZV A;  1FR4 A;  2WEJ A;  3KWA A;  1RAZ A;  2X7U A; 
#chains in the KnotProt database with same CATH topology
 2NXS A;  1LG6 A;  3LXE A;  1CA2 A;  3DA2 A;  3IBN A;  1UGF A;  1FQM A;  3KOK A;  2WEH A;  9CA2 A;  3M67 A;  1IF4 A;  1TBT X;  1CNY A;  3DVB A;  3DBU A;  1KWQ A;  1BNM A;  1V9I C;  3HLJ A;  2ZNC A;  1KEQ A;  1FSQ A;  3BET A;  3D92 A;  2POU A;  2NXT A;  1FQL A;  2HNC A;  1G4O A;  1I91 A;  2CA2 A;  1BN3 A;  2WEG A;  1ZSA A;  2AX2 A;  1YO2 A;  1TG9 A;  1BNQ A;  1G46 A;  2IT4 A;  1YO0 A;  1ZNC A;  1KWR A;  1UGA A;  1I90 A;  3F7U A;  3M5E A;  1A42 A;  3DCC A;  3MDZ A;  3FW3 A;  2NWY A;  2Q1B A;  3MHI A;  1YDB A;  1HUH A;  1G48 A;  3HKN A;  2O4Z A;  1BN1 A;  3BL1 A;  1I9Q A;  1AM6 A;  1CAL A;  2NWO A;  3MNA A;  3IBU A;  1ZE8 A;  1I9O A;  1HEC A;  1OKN A;  3HFP A;  1G0E A;  1HEA A;  3DC9 A;  2NNO A;  3M2Z A;  5CAC A;  1HEB A;  1URT A;  1BNU A;  5CA2 A;  2FMG A;  1FQR A;  1TTM A;  1TG3 A;  2Q1Q A;  2X7S A;  3CZV A;  1XEG A;  3OIK A;  1G4J A;  3F4X A;  2CAB A;  2CBA A;  2EU3 A;  1CZM A;  2NNS A;  3NJ9 A;  3MNU A;  1UGE A;  2CBB A;  1HED A;  3B1B A;  3MYQ A;  2FOU A;  1CNW A;  1I8Z A;  1OQ5 A;  1CIL A;  1I9P A;  1CAM A;  2CBD A;  2CBC A;  1F2W A;  1I9L A;  3P4V A;  2NN7 A;  3K2F A;  1FLJ A;  1H4N A;  3OIL A;  2ABE A;  3MHC A;  1BCD A;  3DVC A;  1DCB A;  3PO6 A;  1CVC A;  1YO1 A;  1CVH A;  1CAN A;  1CAZ A;  2NXR A;  3B4F A;  3F8E A;  2X7T A;  1Y7W A;  1XEV A;  1TH9 A;  6CA2 A;  3MNI A;  3MNJ A;  2CBE A;  2HOC A;  3N2P A;  3D93 A;  2HKK A;  1FSR A;  2FNN A;  1CNH A;  1CNX A;  1TEU X;  3EFI A;  1BZM A;  3C7P A;  2GEH A;  1Z97 A;  3NI5 A;  1HCB A;  3JXF A;  1BN4 A;  2Q38 A;  1ZSB A;  2ILI A;  1YDA A;  1RZE A;  2HFX A;  1YDD A;  1FR7 A;  4CA2 A;  3N3J A;  3HKT A;  1XPZ A;  3EFT A;  2WEO A;  1CVE A;  3MNH A;  3BL0 A;  3M98 A;  1EOU A;  3CA2 A;  1BNW A;  1HVA A;  3DC3 A;  2OSM A;  2POW A;  1CCS A;  1IF5 A;  3CAJ A;  3DCW A;  1CCU A;  3OIM A;  1HCA A;  1YDC A;  4PYY A;  2W2J A;  1CRM A;  2F14 A;  1OKM A;  1TE3 X;  1G53 A;  3M1W A;  2WD3 A;  3GZ0 A;  3DD8 A;  1RZB A;  2HFW A;  2NMX A;  1CNI A;  1CAJ A;  2FW4 A;  3FE4 A;  3OKU A;  2NWZ A;  1CVA A;  3MHM A;  1CRA A;  1IF6 A;  3DVD A;  1UGD A;  1CAY A;  1CAI A;  3DV7 A;  3N0N A;  1CNG A;  4CAC A;  1CVD A;  3M3X A;  2H15 A;  3R16 A;  1CVB A;  1DCA A;  3KIG A;  3M1J A;  1LUG A;  2NN1 A;  1FSN A;  2FNK A;  3HKQ A;  3N4B A;  2NWP A;  3MHL A;  3ML2 A;  3M2N A;  1JD0 A;  3ZNC A;  1LGD A;  3DAZ A;  3D8W A;  1J9W A;  3HS4 A;  7CA2 A;  3MNK A;  1CIM A;  3K34 A;  3D0N A;  1IF7 A;  1V9E A;  3JXG A;  2POV A;  1CNJ A;  1H9N A;  2HL4 A;  1KOP A;  3IBI A;  1CNC A;  3IEO A;  3HKU A;  3IQK A;  1LG5 A;  1XQ0 A;  3DD0 A;  1CA3 A;  3OKV A;  3FFP X;  1RZA A;  1G52 A;  1I9N A;  3IBL A;  1RJ6 A;  1G3Z A;  1IF9 A;  1CAK A;  2AW1 A;  3M96 A;  3PYK A;  1BIC A;  3M5T A;  3DCS A;  3K7K A;  3ML5 A;  1JV0 A;  2FOQ A;  3MMF A;  3KS3 A;  1H9Q A;  1T9N A;  2FOS A;  2HFY A;  3KKX A;  1RZC A;  3MZC A;  1AVN A;  1CVF A;  1G6V A;  1RJ5 A;  12CA A;  1HUG A;  1MUA A;  3IGP A;  1Z93 A;  3M5S A;  3D9Z A;  3F7B A;  2NNV A;  3IAI A;  3L14 A;  1G0F A;  1I9M A;  1G45 A;  1BNV A;  1CAO A;  2OSF A;  2NNG A;  1AZM A;  1CAH A;  1BNN A;  2VVA X;  2HD6 A;  2FNM A;  1G1D A;  1CCT A;  1ZSC A;  2WD2 A;  2EU2 A;  3M2Y A;  8CA2 A;  1KOQ A;  3M40 A;  3JXH C;  1RAY A;  2GD8 A;  1FQN A;  3R17 B;  1BNT A;  1THK A;  2FMZ A;  1DMY A;  3MHO A;  2VVB X;  1RZD A;  1UGB A;  1IF8 A;  1BV3 A;  1CIN A;  3KON A;  3M1Q A;  2EZ7 A;  3MWO A;  1LZV A;  1FR4 A;  2WEJ A;  3KWA A;  1RAZ A;  2X7U A; 
#chains in the KnotProt database with same CATH homology
 2NXS A;  1LG6 A;  3LXE A;  1CA2 A;  3DA2 A;  3IBN A;  1UGF A;  1FQM A;  3KOK A;  2WEH A;  9CA2 A;  3M67 A;  1IF4 A;  1TBT X;  1CNY A;  3DVB A;  3DBU A;  1KWQ A;  1BNM A;  1V9I C;  3HLJ A;  2ZNC A;  1KEQ A;  1FSQ A;  3BET A;  3D92 A;  2POU A;  2NXT A;  1FQL A;  2HNC A;  1G4O A;  1I91 A;  2CA2 A;  1BN3 A;  2WEG A;  1ZSA A;  2AX2 A;  1YO2 A;  1TG9 A;  1BNQ A;  1G46 A;  2IT4 A;  1YO0 A;  1ZNC A;  1KWR A;  1UGA A;  1I90 A;  3F7U A;  3M5E A;  1A42 A;  3DCC A;  3MDZ A;  3FW3 A;  2NWY A;  2Q1B A;  3MHI A;  1YDB A;  1HUH A;  1G48 A;  3HKN A;  2O4Z A;  1BN1 A;  3BL1 A;  1I9Q A;  1AM6 A;  1CAL A;  2NWO A;  3MNA A;  3IBU A;  1ZE8 A;  1I9O A;  1HEC A;  1OKN A;  3HFP A;  1G0E A;  1HEA A;  3DC9 A;  2NNO A;  3M2Z A;  5CAC A;  1HEB A;  1URT A;  1BNU A;  5CA2 A;  2FMG A;  1FQR A;  1TTM A;  1TG3 A;  2Q1Q A;  2X7S A;  3CZV A;  1XEG A;  3OIK A;  1G4J A;  3F4X A;  2CAB A;  2CBA A;  2EU3 A;  1CZM A;  2NNS A;  3NJ9 A;  3MNU A;  1UGE A;  2CBB A;  1HED A;  3B1B A;  3MYQ A;  2FOU A;  1CNW A;  1I8Z A;  1OQ5 A;  1CIL A;  1I9P A;  1CAM A;  2CBD A;  2CBC A;  1F2W A;  1I9L A;  3P4V A;  2NN7 A;  3K2F A;  1FLJ A;  1H4N A;  3OIL A;  2ABE A;  3MHC A;  1BCD A;  3DVC A;  1DCB A;  3PO6 A;  1CVC A;  1YO1 A;  1CVH A;  1CAN A;  1CAZ A;  2NXR A;  3B4F A;  3F8E A;  2X7T A;  1Y7W A;  1XEV A;  1TH9 A;  6CA2 A;  3MNI A;  3MNJ A;  2CBE A;  2HOC A;  3N2P A;  3D93 A;  2HKK A;  1FSR A;  2FNN A;  1CNH A;  1CNX A;  1TEU X;  3EFI A;  1BZM A;  3C7P A;  2GEH A;  1Z97 A;  3NI5 A;  1HCB A;  3JXF A;  1BN4 A;  2Q38 A;  1ZSB A;  2ILI A;  1YDA A;  1RZE A;  2HFX A;  1YDD A;  1FR7 A;  4CA2 A;  3N3J A;  3HKT A;  1XPZ A;  3EFT A;  2WEO A;  1CVE A;  3MNH A;  3BL0 A;  3M98 A;  1EOU A;  3CA2 A;  1BNW A;  1HVA A;  3DC3 A;  2OSM A;  2POW A;  1CCS A;  1IF5 A;  3CAJ A;  3DCW A;  1CCU A;  3OIM A;  1HCA A;  1YDC A;  2W2J A;  1CRM A;  2F14 A;  1OKM A;  1TE3 X;  1G53 A;  3M1W A;  2WD3 A;  3GZ0 A;  3DD8 A;  1RZB A;  2HFW A;  2NMX A;  1CNI A;  1CAJ A;  2FW4 A;  3FE4 A;  3OKU A;  2NWZ A;  1CVA A;  3MHM A;  1CRA A;  1IF6 A;  3DVD A;  1UGD A;  1CAY A;  1CAI A;  3DV7 A;  3N0N A;  1CNG A;  4CAC A;  1CVD A;  3M3X A;  2H15 A;  3R16 A;  1CVB A;  1DCA A;  3KIG A;  3M1J A;  1LUG A;  2NN1 A;  1FSN A;  2FNK A;  3HKQ A;  3N4B A;  2NWP A;  3MHL A;  3ML2 A;  3M2N A;  1JD0 A;  3ZNC A;  1LGD A;  3DAZ A;  3D8W A;  1J9W A;  3HS4 A;  7CA2 A;  3MNK A;  1CIM A;  3K34 A;  3D0N A;  1IF7 A;  1V9E A;  3JXG A;  2POV A;  1CNJ A;  1H9N A;  2HL4 A;  1KOP A;  3IBI A;  1CNC A;  3IEO A;  3HKU A;  3IQK A;  1LG5 A;  1XQ0 A;  3DD0 A;  1CA3 A;  3OKV A;  3FFP X;  1RZA A;  1G52 A;  1I9N A;  3IBL A;  1RJ6 A;  1G3Z A;  1IF9 A;  1CAK A;  2AW1 A;  3M96 A;  3PYK A;  1BIC A;  3M5T A;  3DCS A;  3K7K A;  3ML5 A;  1JV0 A;  2FOQ A;  3MMF A;  3KS3 A;  1H9Q A;  1T9N A;  2FOS A;  2HFY A;  3KKX A;  1RZC A;  3MZC A;  1AVN A;  1CVF A;  1G6V A;  1RJ5 A;  12CA A;  1HUG A;  1MUA A;  3IGP A;  1Z93 A;  3M5S A;  3D9Z A;  3F7B A;  2NNV A;  3IAI A;  3L14 A;  1G0F A;  1I9M A;  1G45 A;  1BNV A;  1CAO A;  2OSF A;  2NNG A;  1AZM A;  1CAH A;  1BNN A;  2VVA X;  2HD6 A;  2FNM A;  1G1D A;  1CCT A;  1ZSC A;  2WD2 A;  2EU2 A;  3M2Y A;  8CA2 A;  1KOQ A;  3M40 A;  3JXH C;  1RAY A;  2GD8 A;  1FQN A;  3R17 B;  1BNT A;  1THK A;  2FMZ A;  1DMY A;  3MHO A;  2VVB X;  1RZD A;  1UGB A;  1IF8 A;  1BV3 A;  1CIN A;  3KON A;  3M1Q A;  2EZ7 A;  3MWO A;  1LZV A;  1FR4 A;  2WEJ A;  3KWA A;  1RAZ A;  2X7U A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling