2GD8A

Crystal structure analysis of the human carbonic anhydrase ii in complex with a 2-substituted estradiol bis-sulfamate
Genus: 80
Alphaknot: P00918
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 22-254 233 1-21, 255-258 21 4 knot
Chain Sequence
HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Note, that the numbers in the matrix denote the consecutive residues in the loop, not the index of amino acids in the chain!
Knot K 11x +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
+ 31 23-255 233 1-22, 256-258 22 3 knot
Fingerprint Knot forming loop Loop type
K +31 His4 ... His94 <->
Bridging ionZn262
<-> His96 ...
Chain closureLys261 <-> His4
 probabilistic
K +31
Chain closureHis4 <-> Lys261
... Cys206 <->
Bridging ionMbo266
<-> Gln137 ... His4		 probabilistic
K +31 His4 ... His96 <->
Bridging ionZn262
<-> His119 ...
Chain closureLys261 <-> His4
 probabilistic
K +31 His4 ... His94 <->
Bridging ionZn262
<-> His119 ...
Chain closureLys261 <-> His4
 probabilistic
K +31
Chain closureHis4 <-> Lys261
... Glu205 <->
Bridging ionMbo266
<-> Gln137 ... His4		 probabilistic
K +31
Chain closureHis4 <-> Lys261
... Cys206 <->
Bridging ionMbo266
<-> Gln137 ... His96 <->
Bridging ionZn262
<-> His94 ... His4		 probabilistic
K +31
Chain closureHis4 <-> Lys261
... Cys206 <->
Bridging ionMbo266
<-> Gln137 ... His119 <->
Bridging ionZn262
<-> His96 ... His4		 probabilistic
K +31
Chain closureHis4 <-> Lys261
... Cys206 <->
Bridging ionMbo266
<-> Gln137 ... His119 <->
Bridging ionZn262
<-> His94 ... His4		 probabilistic
K +31
Chain closureHis4 <-> Lys261
... Glu205 <->
Bridging ionMbo266
<-> Gln137 ... His96 <->
Bridging ionZn262
<-> His94 ... His4		 probabilistic
K +31
Chain closureHis4 <-> Lys261
... Glu205 <->
Bridging ionMbo266
<-> Gln137 ... His119 <->
Bridging ionZn262
<-> His96 ... His4		 probabilistic
K +31
Chain closureHis4 <-> Lys261
... Glu205 <->
Bridging ionMbo266
<-> Gln137 ... His119 <->
Bridging ionZn262
<-> His94 ... His4		 probabilistic
Chain Sequence
HWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 24-256 233 1-23, 257-257 23 1 knot
view details
2.1 25-251 227 1-24 257-257 252-256 24 1 slipknot
sequence length 257
structure length 257
publication title 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity.
pubmed doi rcsb
molecule tags Lyase
molecule keywords Carbonic anhydrase 2
total genus Genus: 80
ec nomenclature ec 4.2.1.1: Carbonate dehydratase.
pdb deposition date 2006-03-15
KnotProt deposition date 2018-10-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00194 Carb_anhydrase Eukaryotic-type carbonic anhydrase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.200.10 Alpha Beta Roll Carbonic Anhydrase II Carbonic Anhydrase II 2gd8A00
3.10.200.10 Alpha Beta Roll Carbonic Anhydrase II Carbonic Anhydrase II 2gd8A00
1FSQA 1I9LA 1BNVA 1CRAA 2Q1QA 2OSFA 3ML2A 1I9MA 3K34A 1EOUA 3FE4A 2NWPA 3OILA 1YDCA 3HLJA 2WEOA 1BN4A 3MMFA 1G45A 3D0NA 7CA2A 3MHCA 1HUGA 1CAOA 3B4FA 1HCBA 1IF4A 1MUAA 3D9ZA 1G53A 2WD3A 4PYYA 2HKKA 3HKTA 3D92A 3N4BA 1RAZA 3BETA 3EFTA 2X7UA 3KWAA 1TTMA 1BNTA 1HVAA 1CA2A 3IBIA 1F2WA 3F7UA 2FNNA 1FQNA 1G0FA 3ML5A 1CRMA 1OKNA 3IGPA 1G1DA 1CAJA 2HFXA 1ZE8A 3JXHC 1CZMA 1I9OA 1CAMA 1HEBA 2IT4A 2WEGA 2CBBA 4CACA 3M2NA 2FOUA 3C7PA 1CA3A 3MNIA 3N0NA 1CILA 1HCAA 2EU3A 3MNKA 1BNUA 3DV7A 2FMZA 1YDAA 1CNCA 3MNUA 2POWA 3DD0A 3F4XA 3DC3A 1G48A 2HOCA 1RZEA 1BCDA 1CAIA 1CNGA 1FR4A 1BN3A 2EZ7A 1CVAA 3D8WA 1LUGA 3MHLA 3CAJA 3LXEA 1RJ5A 1XPZA 1ZSBA 3M5TA 4CA2A 3DVCA 1YO1A 1I91A 1BV3A 2NNOA 3F7BA 3FFPX 1H9QA 1TEUX 2NWZA 1IF6A 3KONA 1AZMA 1G6VA 3ZNCA 1YDBA 1FQLA 3MZCA 3K2FA 3N3JA 3KKXA 1KWRA 2NXTA 3MHIA 1URTA 1HECA 3DCCA 2CABA 3IEOA 2GEHA 1CVEA 3MHMA 3IAIA 1V9EA 1TH9A 2X7SA 1CCTA 3CA2A 1CVDA 1CIMA 1TBTX 1I9NA 1CINA 3EFIA 1ZNCA 3M98A 3MDZA 3JXGA 3CZVA 1IF8A 2POUA 1RZAA 2NWOA 2NMXA 1CAHA 3R17B 1THKA 1HUHA 1AVNA 1UGAA 1G46A 2NN7A 1H4NA 1XEVA 3JXFA 2CBAA 1RZBA 3FW3A 1OKMA 1BNNA 1G4OA 3KIGA 1KOPA 3KOKA 5CACA 2ILIA 2HNCA 1FQMA 1G52A 1UGBA 1TE3X 2NNVA 1CNIA 6CA2A 3DAZA 2CBEA 2AW1A 1IF5A 3DBUA 1BNQA 1DCAA 2ABEA 1CNXA 1IF7A 1CCUA 3DC9A 3NI5A 3OIKA 3DD8A 2NN1A 3HKUA 1BNWA 1BZMA 3IBLA 1Y7WA 1CANA 1G3ZA 1I90A 1YDDA 3PYKA 1RZCA 9CA2A 2FNKA 2Q1BA 1TG3A 3MNAA 1KEQA 3DA2A 2FMGA 3OKUA 3R16A 1KOQA 3M96A 1V9IC 1CVHA 1LG6A 2HL4A 2W2JA 1I9QA 2NNGA 1IF9A 3HKQA 1CAYA 1FLJA 1CNHA 3DCSA 2GD8A 2WD2A 1CCSA 3MNJA 1BN1A 1HEAA 1LG5A 2HFWA 3IBUA 3M1WA 3GZ0A 1YO0A 1RAYA 3DVBA 1TG9A 1LZVA 1ZSCA 3NJ9A 3M1QA 3MHOA 2HFYA 3M3XA 1I8ZA 3M2YA 2AX2A 3HFPA 3BL0A 1CNJA 2X7TA 1LGDA 2WEJA 3N2PA 3OIMA 1DCBA 2NNSA 1FR7A 2Q38A 1T9NA 3M5EA 1ZSAA 2FW4A 2H15A 1J9WA 1CNYA 1CNWA 3L14A 1CVBA 1UGDA 3BL1A 2FNMA 2NWYA 3K7KA 3M2ZA 1JD0A 3D93A 3P4VA 1FSNA 2HD6A 1DMYA 1UGFA 2O4ZA 1G0EA 1A42A 1Z97A 1CAKA 1RZDA 3B1BA 1I9PA 1UGEA 12CAA 1KWQA 1CVFA 3OKVA 1H9NA 3MYQA 8CA2A 1HEDA 2FOSA 3MWOA 1BNMA 1CVCA 1BICA 2POVA 1JV0A 1FQRA 3M40A 3PO6A 3M67A 1OQ5A 1RJ6A 2CBCA 2EU2A 2OSMA 3IQKA 1XQ0A 3F8EA 1XEGA 1FSRA 2CA2A 1AM6A 2FOQA 3KS3A 2VVBX 2CBDA 2WEHA 3DVDA 1CAZA 3M1JA 2VVAX 2F14A 1G4JA 1Z93A 3IBNA 3HKNA 2NXSA 2ZNCA 3M5SA 5CA2A 1CALA 3HS4A 2NXRA 3DCWA 1YO2A 3MNHA
chains in the KnotProt database with same CATH superfamily
1FSQA 1I9LA 1BNVA 1CRAA 2Q1QA 2OSFA 3ML2A 1I9MA 3K34A 1EOUA 3FE4A 2NWPA 3OILA 1YDCA 3HLJA 2WEOA 1BN4A 3MMFA 1G45A 3D0NA 7CA2A 3MHCA 1HUGA 1CAOA 3B4FA 1HCBA 1IF4A 1MUAA 3D9ZA 1G53A 2WD3A 4PYYA 2HKKA 3HKTA 3D92A 3N4BA 1RAZA 3BETA 3EFTA 2X7UA 3KWAA 1TTMA 1BNTA 1HVAA 1CA2A 3IBIA 1F2WA 3F7UA 2FNNA 1FQNA 1G0FA 3ML5A 1CRMA 1OKNA 3IGPA 1G1DA 1CAJA 2HFXA 1ZE8A 3JXHC 1CZMA 1I9OA 1CAMA 1HEBA 2IT4A 2WEGA 2CBBA 4CACA 3M2NA 2FOUA 3C7PA 1CA3A 3MNIA 3N0NA 1CILA 1HCAA 2EU3A 3MNKA 1BNUA 3DV7A 2FMZA 1YDAA 1CNCA 3MNUA 2POWA 3DD0A 3F4XA 3DC3A 1G48A 2HOCA 1RZEA 1BCDA 1CAIA 1CNGA 1FR4A 1BN3A 2EZ7A 1CVAA 3D8WA 1LUGA 3MHLA 3CAJA 3LXEA 1RJ5A 1XPZA 1ZSBA 3M5TA 4CA2A 3DVCA 1YO1A 1I91A 1BV3A 2NNOA 3F7BA 3FFPX 1H9QA 1TEUX 2NWZA 1IF6A 3KONA 1AZMA 1G6VA 3ZNCA 1YDBA 1FQLA 3MZCA 3K2FA 3N3JA 3KKXA 1KWRA 2NXTA 3MHIA 1URTA 1HECA 3DCCA 2CABA 3IEOA 2GEHA 1CVEA 3MHMA 3IAIA 1V9EA 1TH9A 2X7SA 1CCTA 3CA2A 1CVDA 1CIMA 1TBTX 1I9NA 1CINA 3EFIA 1ZNCA 3M98A 3MDZA 3JXGA 3CZVA 1IF8A 2POUA 1RZAA 2NWOA 2NMXA 1CAHA 3R17B 1THKA 1HUHA 1AVNA 1UGAA 1G46A 2NN7A 1H4NA 1XEVA 3JXFA 2CBAA 1RZBA 3FW3A 1OKMA 1BNNA 1G4OA 3KIGA 1KOPA 3KOKA 5CACA 2ILIA 2HNCA 1FQMA 1G52A 1UGBA 1TE3X 2NNVA 1CNIA 6CA2A 3DAZA 2CBEA 2AW1A 1IF5A 3DBUA 1BNQA 1DCAA 2ABEA 1CNXA 1IF7A 1CCUA 3DC9A 3NI5A 3OIKA 3DD8A 2NN1A 3HKUA 1BNWA 1BZMA 3IBLA 1Y7WA 1CANA 1G3ZA 1I90A 1YDDA 3PYKA 1RZCA 9CA2A 2FNKA 2Q1BA 1TG3A 3MNAA 1KEQA 3DA2A 2FMGA 3OKUA 3R16A 1KOQA 3M96A 1V9IC 1CVHA 1LG6A 2HL4A 2W2JA 1I9QA 2NNGA 1IF9A 3HKQA 1CAYA 1FLJA 1CNHA 3DCSA 2GD8A 2WD2A 1CCSA 3MNJA 1BN1A 1HEAA 1LG5A 2HFWA 3IBUA 3M1WA 3GZ0A 1YO0A 1RAYA 3DVBA 1TG9A 1LZVA 1ZSCA 3NJ9A 3M1QA 3MHOA 2HFYA 3M3XA 1I8ZA 3M2YA 2AX2A 3HFPA 3BL0A 1CNJA 2X7TA 1LGDA 2WEJA 3N2PA 3OIMA 1DCBA 2NNSA 1FR7A 2Q38A 1T9NA 3M5EA 1ZSAA 2FW4A 2H15A 1J9WA 1CNYA 1CNWA 3L14A 1CVBA 1UGDA 3BL1A 2FNMA 2NWYA 3K7KA 3M2ZA 1JD0A 3D93A 3P4VA 1FSNA 2HD6A 1DMYA 1UGFA 2O4ZA 1G0EA 1A42A 1Z97A 1CAKA 1RZDA 3B1BA 1I9PA 1UGEA 12CAA 1KWQA 1CVFA 3OKVA 1H9NA 3MYQA 8CA2A 1HEDA 2FOSA 3MWOA 1BNMA 1CVCA 1BICA 2POVA 1JV0A 1FQRA 3M40A 3PO6A 3M67A 1OQ5A 1RJ6A 2CBCA 2EU2A 2OSMA 3IQKA 1XQ0A 3F8EA 1XEGA 1FSRA 2CA2A 1AM6A 2FOQA 3KS3A 2VVBX 2CBDA 2WEHA 3DVDA 1CAZA 3M1JA 2VVAX 2F14A 1G4JA 1Z93A 3IBNA 3HKNA 2NXSA 2ZNCA 3M5SA 5CA2A 1CALA 3HS4A 2NXRA 3DCWA 1YO2A 3MNHA
chains in the KnotProt database with same CATH topology
1FSQA 1I9LA 1BNVA 1CRAA 2Q1QA 2OSFA 3ML2A 1I9MA 3K34A 1EOUA 3FE4A 2NWPA 3OILA 1YDCA 3HLJA 2WEOA 1BN4A 3MMFA 1G45A 3D0NA 7CA2A 3MHCA 1HUGA 1CAOA 3B4FA 1HCBA 1IF4A 1MUAA 3D9ZA 1G53A 2WD3A 2HKKA 3HKTA 3D92A 3N4BA 1RAZA 3BETA 3EFTA 2X7UA 3KWAA 1TTMA 1BNTA 1HVAA 1CA2A 3IBIA 1F2WA 3F7UA 2FNNA 1FQNA 1G0FA 3ML5A 1CRMA 1OKNA 3IGPA 1G1DA 1CAJA 2HFXA 1ZE8A 3JXHC 1CZMA 1I9OA 1CAMA 1HEBA 2IT4A 2WEGA 2CBBA 4CACA 3M2NA 2FOUA 3C7PA 1CA3A 3MNIA 3N0NA 1CILA 1HCAA 2EU3A 3MNKA 1BNUA 3DV7A 2FMZA 1YDAA 1CNCA 3MNUA 2POWA 3DD0A 3F4XA 3DC3A 1G48A 2HOCA 1RZEA 1BCDA 1CAIA 1CNGA 1FR4A 1BN3A 2EZ7A 1CVAA 3D8WA 1LUGA 3MHLA 3CAJA 3LXEA 1RJ5A 1XPZA 1ZSBA 3M5TA 4CA2A 3DVCA 1YO1A 1I91A 1BV3A 2NNOA 3F7BA 3FFPX 1H9QA 1TEUX 2NWZA 1IF6A 3KONA 1AZMA 1G6VA 3ZNCA 1YDBA 1FQLA 3MZCA 3K2FA 3N3JA 3KKXA 1KWRA 2NXTA 3MHIA 1URTA 1HECA 3DCCA 2CABA 3IEOA 2GEHA 1CVEA 3MHMA 3IAIA 1V9EA 1TH9A 2X7SA 1CCTA 3CA2A 1CVDA 1CIMA 1TBTX 1I9NA 1CINA 3EFIA 1ZNCA 3M98A 3MDZA 3JXGA 3CZVA 1IF8A 2POUA 1RZAA 2NWOA 2NMXA 1CAHA 3R17B 1THKA 1HUHA 1AVNA 1UGAA 1G46A 2NN7A 1H4NA 1XEVA 3JXFA 2CBAA 1RZBA 3FW3A 1OKMA 1BNNA 1G4OA 3KIGA 1KOPA 3KOKA 5CACA 2ILIA 2HNCA 1FQMA 1G52A 1UGBA 1TE3X 2NNVA 1CNIA 6CA2A 3DAZA 2CBEA 2AW1A 1IF5A 3DBUA 1BNQA 1DCAA 2ABEA 1CNXA 1IF7A 1CCUA 3DC9A 3NI5A 3OIKA 3DD8A 2NN1A 3HKUA 1BNWA 1BZMA 3IBLA 1Y7WA 1CANA 1G3ZA 1I90A 1YDDA 3PYKA 1RZCA 9CA2A 2FNKA 2Q1BA 1TG3A 3MNAA 1KEQA 3DA2A 2FMGA 3OKUA 3R16A 1KOQA 3M96A 1V9IC 1CVHA 1LG6A 2HL4A 2W2JA 1I9QA 2NNGA 1IF9A 3HKQA 1CAYA 1FLJA 1CNHA 3DCSA 2GD8A 2WD2A 1CCSA 3MNJA 1BN1A 1HEAA 1LG5A 2HFWA 3IBUA 3M1WA 3GZ0A 1YO0A 1RAYA 3DVBA 1TG9A 1LZVA 1ZSCA 3NJ9A 3M1QA 3MHOA 2HFYA 3M3XA 1I8ZA 3M2YA 2AX2A 3HFPA 3BL0A 1CNJA 2X7TA 1LGDA 2WEJA 3N2PA 3OIMA 1DCBA 2NNSA 1FR7A 2Q38A 1T9NA 3M5EA 1ZSAA 2FW4A 2H15A 1J9WA 1CNYA 1CNWA 3L14A 1CVBA 1UGDA 3BL1A 2FNMA 2NWYA 3K7KA 3M2ZA 1JD0A 3D93A 3P4VA 1FSNA 2HD6A 1DMYA 1UGFA 2O4ZA 1G0EA 1A42A 1Z97A 1CAKA 1RZDA 3B1BA 1I9PA 1UGEA 12CAA 1KWQA 1CVFA 3OKVA 1H9NA 3MYQA 8CA2A 1HEDA 2FOSA 3MWOA 1BNMA 1CVCA 1BICA 2POVA 1JV0A 1FQRA 3M40A 3PO6A 3M67A 1OQ5A 1RJ6A 2CBCA 2EU2A 2OSMA 3IQKA 1XQ0A 3F8EA 1XEGA 1FSRA 2CA2A 1AM6A 2FOQA 3KS3A 2VVBX 2CBDA 2WEHA 3DVDA 1CAZA 3M1JA 2VVAX 2F14A 1G4JA 1Z93A 3IBNA 3HKNA 2NXSA 2ZNCA 3M5SA 5CA2A 1CALA 3HS4A 2NXRA 3DCWA 1YO2A 3MNHA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1FSQ A;  1I9L A;  1BNV A;  1CRA A;  2Q1Q A;  2OSF A;  3ML2 A;  1I9M A;  3K34 A;  1EOU A;  3FE4 A;  2NWP A;  3OIL A;  1YDC A;  3HLJ A;  2WEO A;  1BN4 A;  3MMF A;  1G45 A;  3D0N A;  7CA2 A;  3MHC A;  1HUG A;  1CAO A;  3B4F A;  1HCB A;  1IF4 A;  1MUA A;  3D9Z A;  1G53 A;  2WD3 A;  4PYY A;  2HKK A;  3HKT A;  3D92 A;  3N4B A;  1RAZ A;  3BET A;  3EFT A;  2X7U A;  3KWA A;  1TTM A;  1BNT A;  1HVA A;  1CA2 A;  3IBI A;  1F2W A;  3F7U A;  2FNN A;  1FQN A;  1G0F A;  3ML5 A;  1CRM A;  1OKN A;  3IGP A;  1G1D A;  1CAJ A;  2HFX A;  1ZE8 A;  3JXH C;  1CZM A;  1I9O A;  1CAM A;  1HEB A;  2IT4 A;  2WEG A;  2CBB A;  4CAC A;  3M2N A;  2FOU A;  3C7P A;  1CA3 A;  3MNI A;  3N0N A;  1CIL A;  1HCA A;  2EU3 A;  3MNK A;  1BNU A;  3DV7 A;  2FMZ A;  1YDA A;  1CNC A;  3MNU A;  2POW A;  3DD0 A;  3F4X A;  3DC3 A;  1G48 A;  2HOC A;  1RZE A;  1BCD A;  1CAI A;  1CNG A;  1FR4 A;  1BN3 A;  2EZ7 A;  1CVA A;  3D8W A;  1LUG A;  3MHL A;  3CAJ A;  3LXE A;  1RJ5 A;  1XPZ A;  1ZSB A;  3M5T A;  4CA2 A;  3DVC A;  1YO1 A;  1I91 A;  1BV3 A;  2NNO A;  3F7B A;  3FFP X;  1H9Q A;  1TEU X;  2NWZ A;  1IF6 A;  3KON A;  1AZM A;  1G6V A;  3ZNC A;  1YDB A;  1FQL A;  3MZC A;  3K2F A;  3N3J A;  3KKX A;  1KWR A;  2NXT A;  3MHI A;  1URT A;  1HEC A;  3DCC A;  2CAB A;  3IEO A;  2GEH A;  1CVE A;  3MHM A;  3IAI A;  1V9E A;  1TH9 A;  2X7S A;  1CCT A;  3CA2 A;  1CVD A;  1CIM A;  1TBT X;  1I9N A;  1CIN A;  3EFI A;  1ZNC A;  3M98 A;  3MDZ A;  3JXG A;  3CZV A;  1IF8 A;  2POU A;  1RZA A;  2NWO A;  2NMX A;  1CAH A;  3R17 B;  1THK A;  1HUH A;  1AVN A;  1UGA A;  1G46 A;  2NN7 A;  1H4N A;  1XEV A;  3JXF A;  2CBA A;  1RZB A;  3FW3 A;  1OKM A;  1BNN A;  1G4O A;  3KIG A;  1KOP A;  3KOK A;  5CAC A;  2ILI A;  2HNC A;  1FQM A;  1G52 A;  1UGB A;  1TE3 X;  2NNV A;  1CNI A;  6CA2 A;  3DAZ A;  2CBE A;  2AW1 A;  1IF5 A;  3DBU A;  1BNQ A;  1DCA A;  2ABE A;  1CNX A;  1IF7 A;  1CCU A;  3DC9 A;  3NI5 A;  3OIK A;  3DD8 A;  2NN1 A;  3HKU A;  1BNW A;  1BZM A;  3IBL A;  1Y7W A;  1CAN A;  1G3Z A;  1I90 A;  1YDD A;  3PYK A;  1RZC A;  9CA2 A;  2FNK A;  2Q1B A;  1TG3 A;  3MNA A;  1KEQ A;  3DA2 A;  2FMG A;  3OKU A;  3R16 A;  1KOQ A;  3M96 A;  1V9I C;  1CVH A;  1LG6 A;  2HL4 A;  2W2J A;  1I9Q A;  2NNG A;  1IF9 A;  3HKQ A;  1CAY A;  1FLJ A;  1CNH A;  3DCS A;  2GD8 A;  2WD2 A;  1CCS A;  3MNJ A;  1BN1 A;  1HEA A;  1LG5 A;  2HFW A;  3IBU A;  3M1W A;  3GZ0 A;  1YO0 A;  1RAY A;  3DVB A;  1TG9 A;  1LZV A;  1ZSC A;  3NJ9 A;  3M1Q A;  3MHO A;  2HFY A;  3M3X A;  1I8Z A;  3M2Y A;  2AX2 A;  3HFP A;  3BL0 A;  1CNJ A;  2X7T A;  1LGD A;  2WEJ A;  3N2P A;  3OIM A;  1DCB A;  2NNS A;  1FR7 A;  2Q38 A;  1T9N A;  3M5E A;  1ZSA A;  2FW4 A;  2H15 A;  1J9W A;  1CNY A;  1CNW A;  3L14 A;  1CVB A;  1UGD A;  3BL1 A;  2FNM A;  2NWY A;  3K7K A;  3M2Z A;  1JD0 A;  3D93 A;  3P4V A;  1FSN A;  2HD6 A;  1DMY A;  1UGF A;  2O4Z A;  1G0E A;  1A42 A;  1Z97 A;  1CAK A;  1RZD A;  3B1B A;  1I9P A;  1UGE A;  12CA A;  1KWQ A;  1CVF A;  3OKV A;  1H9N A;  3MYQ A;  8CA2 A;  1HED A;  2FOS A;  3MWO A;  1BNM A;  1CVC A;  1BIC A;  2POV A;  1JV0 A;  1FQR A;  3M40 A;  3PO6 A;  3M67 A;  1OQ5 A;  1RJ6 A;  2CBC A;  2EU2 A;  2OSM A;  3IQK A;  1XQ0 A;  3F8E A;  1XEG A;  1FSR A;  2CA2 A;  1AM6 A;  2FOQ A;  3KS3 A;  2VVB X;  2CBD A;  2WEH A;  3DVD A;  1CAZ A;  3M1J A;  2VVA X;  2F14 A;  1G4J A;  1Z93 A;  3IBN A;  3HKN A;  2NXS A;  2ZNC A;  3M5S A;  5CA2 A;  1CAL A;  3HS4 A;  2NXR A;  3DCW A;  1YO2 A;  3MNH A; 
#chains in the KnotProt database with same CATH topology
 1FSQ A;  1I9L A;  1BNV A;  1CRA A;  2Q1Q A;  2OSF A;  3ML2 A;  1I9M A;  3K34 A;  1EOU A;  3FE4 A;  2NWP A;  3OIL A;  1YDC A;  3HLJ A;  2WEO A;  1BN4 A;  3MMF A;  1G45 A;  3D0N A;  7CA2 A;  3MHC A;  1HUG A;  1CAO A;  3B4F A;  1HCB A;  1IF4 A;  1MUA A;  3D9Z A;  1G53 A;  2WD3 A;  4PYY A;  2HKK A;  3HKT A;  3D92 A;  3N4B A;  1RAZ A;  3BET A;  3EFT A;  2X7U A;  3KWA A;  1TTM A;  1BNT A;  1HVA A;  1CA2 A;  3IBI A;  1F2W A;  3F7U A;  2FNN A;  1FQN A;  1G0F A;  3ML5 A;  1CRM A;  1OKN A;  3IGP A;  1G1D A;  1CAJ A;  2HFX A;  1ZE8 A;  3JXH C;  1CZM A;  1I9O A;  1CAM A;  1HEB A;  2IT4 A;  2WEG A;  2CBB A;  4CAC A;  3M2N A;  2FOU A;  3C7P A;  1CA3 A;  3MNI A;  3N0N A;  1CIL A;  1HCA A;  2EU3 A;  3MNK A;  1BNU A;  3DV7 A;  2FMZ A;  1YDA A;  1CNC A;  3MNU A;  2POW A;  3DD0 A;  3F4X A;  3DC3 A;  1G48 A;  2HOC A;  1RZE A;  1BCD A;  1CAI A;  1CNG A;  1FR4 A;  1BN3 A;  2EZ7 A;  1CVA A;  3D8W A;  1LUG A;  3MHL A;  3CAJ A;  3LXE A;  1RJ5 A;  1XPZ A;  1ZSB A;  3M5T A;  4CA2 A;  3DVC A;  1YO1 A;  1I91 A;  1BV3 A;  2NNO A;  3F7B A;  3FFP X;  1H9Q A;  1TEU X;  2NWZ A;  1IF6 A;  3KON A;  1AZM A;  1G6V A;  3ZNC A;  1YDB A;  1FQL A;  3MZC A;  3K2F A;  3N3J A;  3KKX A;  1KWR A;  2NXT A;  3MHI A;  1URT A;  1HEC A;  3DCC A;  2CAB A;  3IEO A;  2GEH A;  1CVE A;  3MHM A;  3IAI A;  1V9E A;  1TH9 A;  2X7S A;  1CCT A;  3CA2 A;  1CVD A;  1CIM A;  1TBT X;  1I9N A;  1CIN A;  3EFI A;  1ZNC A;  3M98 A;  3MDZ A;  3JXG A;  3CZV A;  1IF8 A;  2POU A;  1RZA A;  2NWO A;  2NMX A;  1CAH A;  3R17 B;  1THK A;  1HUH A;  1AVN A;  1UGA A;  1G46 A;  2NN7 A;  1H4N A;  1XEV A;  3JXF A;  2CBA A;  1RZB A;  3FW3 A;  1OKM A;  1BNN A;  1G4O A;  3KIG A;  1KOP A;  3KOK A;  5CAC A;  2ILI A;  2HNC A;  1FQM A;  1G52 A;  1UGB A;  1TE3 X;  2NNV A;  1CNI A;  6CA2 A;  3DAZ A;  2CBE A;  2AW1 A;  1IF5 A;  3DBU A;  1BNQ A;  1DCA A;  2ABE A;  1CNX A;  1IF7 A;  1CCU A;  3DC9 A;  3NI5 A;  3OIK A;  3DD8 A;  2NN1 A;  3HKU A;  1BNW A;  1BZM A;  3IBL A;  1Y7W A;  1CAN A;  1G3Z A;  1I90 A;  1YDD A;  3PYK A;  1RZC A;  9CA2 A;  2FNK A;  2Q1B A;  1TG3 A;  3MNA A;  1KEQ A;  3DA2 A;  2FMG A;  3OKU A;  3R16 A;  1KOQ A;  3M96 A;  1V9I C;  1CVH A;  1LG6 A;  2HL4 A;  2W2J A;  1I9Q A;  2NNG A;  1IF9 A;  3HKQ A;  1CAY A;  1FLJ A;  1CNH A;  3DCS A;  2GD8 A;  2WD2 A;  1CCS A;  3MNJ A;  1BN1 A;  1HEA A;  1LG5 A;  2HFW A;  3IBU A;  3M1W A;  3GZ0 A;  1YO0 A;  1RAY A;  3DVB A;  1TG9 A;  1LZV A;  1ZSC A;  3NJ9 A;  3M1Q A;  3MHO A;  2HFY A;  3M3X A;  1I8Z A;  3M2Y A;  2AX2 A;  3HFP A;  3BL0 A;  1CNJ A;  2X7T A;  1LGD A;  2WEJ A;  3N2P A;  3OIM A;  1DCB A;  2NNS A;  1FR7 A;  2Q38 A;  1T9N A;  3M5E A;  1ZSA A;  2FW4 A;  2H15 A;  1J9W A;  1CNY A;  1CNW A;  3L14 A;  1CVB A;  1UGD A;  3BL1 A;  2FNM A;  2NWY A;  3K7K A;  3M2Z A;  1JD0 A;  3D93 A;  3P4V A;  1FSN A;  2HD6 A;  1DMY A;  1UGF A;  2O4Z A;  1G0E A;  1A42 A;  1Z97 A;  1CAK A;  1RZD A;  3B1B A;  1I9P A;  1UGE A;  12CA A;  1KWQ A;  1CVF A;  3OKV A;  1H9N A;  3MYQ A;  8CA2 A;  1HED A;  2FOS A;  3MWO A;  1BNM A;  1CVC A;  1BIC A;  2POV A;  1JV0 A;  1FQR A;  3M40 A;  3PO6 A;  3M67 A;  1OQ5 A;  1RJ6 A;  2CBC A;  2EU2 A;  2OSM A;  3IQK A;  1XQ0 A;  3F8E A;  1XEG A;  1FSR A;  2CA2 A;  1AM6 A;  2FOQ A;  3KS3 A;  2VVB X;  2CBD A;  2WEH A;  3DVD A;  1CAZ A;  3M1J A;  2VVA X;  2F14 A;  1G4J A;  1Z93 A;  3IBN A;  3HKN A;  2NXS A;  2ZNC A;  3M5S A;  5CA2 A;  1CAL A;  3HS4 A;  2NXR A;  3DCW A;  1YO2 A;  3MNH A; 
#chains in the KnotProt database with same CATH homology
 1FSQ A;  1I9L A;  1BNV A;  1CRA A;  2Q1Q A;  2OSF A;  3ML2 A;  1I9M A;  3K34 A;  1EOU A;  3FE4 A;  2NWP A;  3OIL A;  1YDC A;  3HLJ A;  2WEO A;  1BN4 A;  3MMF A;  1G45 A;  3D0N A;  7CA2 A;  3MHC A;  1HUG A;  1CAO A;  3B4F A;  1HCB A;  1IF4 A;  1MUA A;  3D9Z A;  1G53 A;  2WD3 A;  2HKK A;  3HKT A;  3D92 A;  3N4B A;  1RAZ A;  3BET A;  3EFT A;  2X7U A;  3KWA A;  1TTM A;  1BNT A;  1HVA A;  1CA2 A;  3IBI A;  1F2W A;  3F7U A;  2FNN A;  1FQN A;  1G0F A;  3ML5 A;  1CRM A;  1OKN A;  3IGP A;  1G1D A;  1CAJ A;  2HFX A;  1ZE8 A;  3JXH C;  1CZM A;  1I9O A;  1CAM A;  1HEB A;  2IT4 A;  2WEG A;  2CBB A;  4CAC A;  3M2N A;  2FOU A;  3C7P A;  1CA3 A;  3MNI A;  3N0N A;  1CIL A;  1HCA A;  2EU3 A;  3MNK A;  1BNU A;  3DV7 A;  2FMZ A;  1YDA A;  1CNC A;  3MNU A;  2POW A;  3DD0 A;  3F4X A;  3DC3 A;  1G48 A;  2HOC A;  1RZE A;  1BCD A;  1CAI A;  1CNG A;  1FR4 A;  1BN3 A;  2EZ7 A;  1CVA A;  3D8W A;  1LUG A;  3MHL A;  3CAJ A;  3LXE A;  1RJ5 A;  1XPZ A;  1ZSB A;  3M5T A;  4CA2 A;  3DVC A;  1YO1 A;  1I91 A;  1BV3 A;  2NNO A;  3F7B A;  3FFP X;  1H9Q A;  1TEU X;  2NWZ A;  1IF6 A;  3KON A;  1AZM A;  1G6V A;  3ZNC A;  1YDB A;  1FQL A;  3MZC A;  3K2F A;  3N3J A;  3KKX A;  1KWR A;  2NXT A;  3MHI A;  1URT A;  1HEC A;  3DCC A;  2CAB A;  3IEO A;  2GEH A;  1CVE A;  3MHM A;  3IAI A;  1V9E A;  1TH9 A;  2X7S A;  1CCT A;  3CA2 A;  1CVD A;  1CIM A;  1TBT X;  1I9N A;  1CIN A;  3EFI A;  1ZNC A;  3M98 A;  3MDZ A;  3JXG A;  3CZV A;  1IF8 A;  2POU A;  1RZA A;  2NWO A;  2NMX A;  1CAH A;  3R17 B;  1THK A;  1HUH A;  1AVN A;  1UGA A;  1G46 A;  2NN7 A;  1H4N A;  1XEV A;  3JXF A;  2CBA A;  1RZB A;  3FW3 A;  1OKM A;  1BNN A;  1G4O A;  3KIG A;  1KOP A;  3KOK A;  5CAC A;  2ILI A;  2HNC A;  1FQM A;  1G52 A;  1UGB A;  1TE3 X;  2NNV A;  1CNI A;  6CA2 A;  3DAZ A;  2CBE A;  2AW1 A;  1IF5 A;  3DBU A;  1BNQ A;  1DCA A;  2ABE A;  1CNX A;  1IF7 A;  1CCU A;  3DC9 A;  3NI5 A;  3OIK A;  3DD8 A;  2NN1 A;  3HKU A;  1BNW A;  1BZM A;  3IBL A;  1Y7W A;  1CAN A;  1G3Z A;  1I90 A;  1YDD A;  3PYK A;  1RZC A;  9CA2 A;  2FNK A;  2Q1B A;  1TG3 A;  3MNA A;  1KEQ A;  3DA2 A;  2FMG A;  3OKU A;  3R16 A;  1KOQ A;  3M96 A;  1V9I C;  1CVH A;  1LG6 A;  2HL4 A;  2W2J A;  1I9Q A;  2NNG A;  1IF9 A;  3HKQ A;  1CAY A;  1FLJ A;  1CNH A;  3DCS A;  2GD8 A;  2WD2 A;  1CCS A;  3MNJ A;  1BN1 A;  1HEA A;  1LG5 A;  2HFW A;  3IBU A;  3M1W A;  3GZ0 A;  1YO0 A;  1RAY A;  3DVB A;  1TG9 A;  1LZV A;  1ZSC A;  3NJ9 A;  3M1Q A;  3MHO A;  2HFY A;  3M3X A;  1I8Z A;  3M2Y A;  2AX2 A;  3HFP A;  3BL0 A;  1CNJ A;  2X7T A;  1LGD A;  2WEJ A;  3N2P A;  3OIM A;  1DCB A;  2NNS A;  1FR7 A;  2Q38 A;  1T9N A;  3M5E A;  1ZSA A;  2FW4 A;  2H15 A;  1J9W A;  1CNY A;  1CNW A;  3L14 A;  1CVB A;  1UGD A;  3BL1 A;  2FNM A;  2NWY A;  3K7K A;  3M2Z A;  1JD0 A;  3D93 A;  3P4V A;  1FSN A;  2HD6 A;  1DMY A;  1UGF A;  2O4Z A;  1G0E A;  1A42 A;  1Z97 A;  1CAK A;  1RZD A;  3B1B A;  1I9P A;  1UGE A;  12CA A;  1KWQ A;  1CVF A;  3OKV A;  1H9N A;  3MYQ A;  8CA2 A;  1HED A;  2FOS A;  3MWO A;  1BNM A;  1CVC A;  1BIC A;  2POV A;  1JV0 A;  1FQR A;  3M40 A;  3PO6 A;  3M67 A;  1OQ5 A;  1RJ6 A;  2CBC A;  2EU2 A;  2OSM A;  3IQK A;  1XQ0 A;  3F8E A;  1XEG A;  1FSR A;  2CA2 A;  1AM6 A;  2FOQ A;  3KS3 A;  2VVB X;  2CBD A;  2WEH A;  3DVD A;  1CAZ A;  3M1J A;  2VVA X;  2F14 A;  1G4J A;  1Z93 A;  3IBN A;  3HKN A;  2NXS A;  2ZNC A;  3M5S A;  5CA2 A;  1CAL A;  3HS4 A;  2NXR A;  3DCW A;  1YO2 A;  3MNH A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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