2CX8A

Crystal structure of methyltransferase with ligand(sah)
Genus: 70
Knot K +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 154-198 45 1-153, 199-225 153 27 knot
Chain Sequence
HRAFSPGLTGVLPLRETRHLVEVLRARVGDRFTVFDGEREALAEVVDLGPPLRYRVLEERRPEREVGVEVVLYVALLKGDKLAEVVRAATELGATRIQPLVTRHSVPKEMGEGKLRRLRAVALEAAKQSGRVVVPEVLPPIPLKAVPQVAQGLVAHVGATARVREVLDPEKPLALAVGPEGGFAEEEVALLEARGFTPVSLGRRILRAETAALALLALCTAGEGR
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 153-199 47 1-152, 200-225 152 26 knot
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2.1 150-196 47 1-149 203-225 197-202 149 23 slipknot
sequence length 225
structure length 225
publication title Crystal structure of methyltransferase with ligand(SAH)
rcsb
molecule tags Transferase
molecule keywords methyl transferase
source organism Thermus thermophilus
total genus Genus: 70
ec nomenclature
pdb deposition date 2005-06-28
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04452 Methyltrans_RNA RNA methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.20 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Hypothetical PUA domain-like; domain 1 2cx8A01
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 2cx8A02
2CX8A 3QUVA 2O3AA 3AXZA 3IC6A 1O6DA 2I6DA 1V2XA 1VH0A 3AIAA 3NK6A 1UAMA 3E5YA 1UALA 1IPAA 3KW2A 1X7OA 1V6ZA 3ILKA 4H3ZA 1VHKA 1UAJA 1VHYA 4CNFB 1P9PA 2Z0YA 3GYQA 3AI9X 3IEFA 4CNGB 1K3RA 3DCMX 3KTYA 4CNEB 1X7PA 2YY8A 1ZJRA 2QMMA 3L8UA 1NS5A 4IG6A 1MXIA 1GZ0A 3ONPA 3KNUA 3N4KA 3NK7A 4E8BA 1NXZA 3KY7A 2QWVA 1TO0A 4H3YA 2HA8A 4FAKA 1UAKA 1J85A 3N4JA
chains in the KnotProt database with same CATH superfamily
2CX8A 3QUVA 2O3AA 3AXZA 3IC6A 1O6DA 2I6DA 1V2XA 1VH0A 3AIAA 3NK6A 1UAMA 3E5YA 1UALA 1IPAA 3KW2A 1X7OA 1V6ZA 3ILKA 4H3ZA 1VHKA 1UAJA 1VHYA 4CNFB 1P9PA 2Z0YA 3GYQA 3AI9X 3IEFA 4CNGB 1K3RA 3DCMX 3KTYA 4CNEB 1X7PA 2YY8A 1ZJRA 2QMMA 3L8UA 1NS5A 4IG6A 1MXIA 1GZ0A 3ONPA 3KNUA 3N4KA 3NK7A 4E8BA 1NXZA 3KY7A 2QWVA 1TO0A 4H3YA 2HA8A 4FAKA 1UAKA 1J85A 3N4JA
chains in the KnotProt database with same CATH topology
2CX8A 3QUVA 2O3AA 3AXZA 3IC6A 1O6DA 2I6DA 1V2XA 1VH0A 3AIAA 3NK6A 1UAMA 3E5YA 1UALA 1IPAA 3KW2A 1X7OA 1V6ZA 3ILKA 4H3ZA 1VHKA 1UAJA 1VHYA 4CNFB 1P9PA 2Z0YA 3GYQA 3AI9X 3IEFA 4CNGB 1K3RA 3DCMX 3KTYA 4CNEB 1X7PA 2YY8A 1ZJRA 2QMMA 3L8UA 1NS5A 4IG6A 1MXIA 1GZ0A 3ONPA 3KNUA 3N4KA 3NK7A 4E8BA 1NXZA 3KY7A 2QWVA 1TO0A 4H3YA 2HA8A 4FAKA 1UAKA 1J85A 3N4JA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 2CX8 A;  3QUV A;  2O3A A;  3AXZ A;  3IC6 A;  1O6D A;  2I6D A;  1V2X A;  1VH0 A;  3AIA A;  3NK6 A;  1UAM A;  3E5Y A;  1UAL A;  1IPA A;  3KW2 A;  1X7O A;  1V6Z A;  3ILK A;  4H3Z A;  1VHK A;  1UAJ A;  1VHY A;  4CNF B;  1P9P A;  2Z0Y A;  3GYQ A;  3AI9 X;  3IEF A;  4CNG B;  1K3R A;  3DCM X;  3KTY A;  4CNE B;  1X7P A;  2YY8 A;  1ZJR A;  2QMM A;  3L8U A;  1NS5 A;  4IG6 A;  1MXI A;  1GZ0 A;  3ONP A;  3KNU A;  3N4K A;  3NK7 A;  4E8B A;  1NXZ A;  3KY7 A;  2QWV A;  1TO0 A;  4H3Y A;  2HA8 A;  4FAK A;  1UAK A;  1J85 A;  3N4J A; 
#chains in the KnotProt database with same CATH topology
 2CX8 A;  3QUV A;  2O3A A;  3AXZ A;  3IC6 A;  1O6D A;  2I6D A;  1V2X A;  1VH0 A;  3AIA A;  3NK6 A;  1UAM A;  3E5Y A;  1UAL A;  1IPA A;  3KW2 A;  1X7O A;  1V6Z A;  3ILK A;  4H3Z A;  1VHK A;  1UAJ A;  1VHY A;  4CNF B;  1P9P A;  2Z0Y A;  3GYQ A;  3AI9 X;  3IEF A;  4CNG B;  1K3R A;  3DCM X;  3KTY A;  4CNE B;  1X7P A;  2YY8 A;  1ZJR A;  2QMM A;  3L8U A;  1NS5 A;  4IG6 A;  1MXI A;  1GZ0 A;  3ONP A;  3KNU A;  3N4K A;  3NK7 A;  4E8B A;  1NXZ A;  3KY7 A;  2QWV A;  1TO0 A;  4H3Y A;  2HA8 A;  4FAK A;  1UAK A;  1J85 A;  3N4J A; 
#chains in the KnotProt database with same CATH homology
 2CX8 A;  3QUV A;  2O3A A;  3AXZ A;  3IC6 A;  1O6D A;  2I6D A;  1V2X A;  1VH0 A;  3AIA A;  3NK6 A;  1UAM A;  3E5Y A;  1UAL A;  1IPA A;  3KW2 A;  1X7O A;  1V6Z A;  3ILK A;  4H3Z A;  1VHK A;  1UAJ A;  1VHY A;  4CNF B;  1P9P A;  2Z0Y A;  3GYQ A;  3AI9 X;  3IEF A;  4CNG B;  1K3R A;  3DCM X;  3KTY A;  4CNE B;  1X7P A;  2YY8 A;  1ZJR A;  2QMM A;  3L8U A;  1NS5 A;  4IG6 A;  1MXI A;  1GZ0 A;  3ONP A;  3KNU A;  3N4K A;  3NK7 A;  4E8B A;  1NXZ A;  3KY7 A;  2QWV A;  1TO0 A;  4H3Y A;  2HA8 A;  4FAK A;  1UAK A;  1J85 A;  3N4J A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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