2CX8A

Crystal structure of methyltransferase with ligand(sah)
Genus: 70
Knot K +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 154-198 45 1-153, 199-225 153 27 knot
Chain Sequence
HRAFSPGLTGVLPLRETRHLVEVLRARVGDRFTVFDGEREALAEVVDLGPPLRYRVLEERRPEREVGVEVVLYVALLKGDKLAEVVRAATELGATRIQPLVTRHSVPKEMGEGKLRRLRAVALEAAKQSGRVVVPEVLPPIPLKAVPQVAQGLVAHVGATARVREVLDPEKPLALAVGPEGGFAEEEVALLEARGFTPVSLGRRILRAETAALALLALCTAGEGR
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 153-199 47 1-152, 200-225 152 26 knot
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2.1 150-196 47 1-149 203-225 197-202 149 23 slipknot
sequence length 225
structure length 225
publication title Crystal structure of methyltransferase with ligand(SAH)
rcsb
molecule tags Transferase
molecule keywords methyl transferase
source organism Thermus thermophilus
total genus Genus: 70
ec nomenclature
pdb deposition date 2005-06-28
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04452 Methyltrans_RNA RNA methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.20 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Hypothetical PUA domain-like; domain 1 2cx8A01
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 2cx8A02
3IEFA 3KW2A 2Z0YA 3KTYA 4CNGB 1GZ0A 1X7PA 3N4JA 1VHYA 1O6DA 4CNFB 2YY8A 1UAKA 1NXZA 2QWVA 4FAKA 1NS5A 1VH0A 3KNUA 1UALA 1UAMA 3QUVA 3AXZA 3NK7A 3N4KA 1V2XA 3ONPA 4IG6A 1MXIA 2HA8A 2CX8A 1VHKA 3ILKA 3AI9X 1J85A 3L8UA 4H3ZA 3DCMX 3NK6A 1ZJRA 2O3AA 4H3YA 1UAJA 4CNEB 3E5YA 1K3RA 1TO0A 1P9PA 1V6ZA 3AIAA 3GYQA 3KY7A 3IC6A 2I6DA 1X7OA 2QMMA 4E8BA
chains in the KnotProt database with same CATH superfamily
3IEFA 3KW2A 2Z0YA 3KTYA 4CNGB 1GZ0A 1X7PA 3N4JA 1VHYA 1O6DA 4CNFB 2YY8A 1UAKA 1NXZA 2QWVA 4FAKA 1NS5A 1VH0A 3KNUA 1UALA 1UAMA 3QUVA 3AXZA 3NK7A 3N4KA 1V2XA 3ONPA 4IG6A 1MXIA 2HA8A 2CX8A 1VHKA 3ILKA 3AI9X 1J85A 3L8UA 4H3ZA 3DCMX 3NK6A 1ZJRA 2O3AA 4H3YA 1UAJA 4CNEB 3E5YA 1K3RA 1TO0A 1P9PA 1V6ZA 3AIAA 3GYQA 3KY7A 3IC6A 2I6DA 1X7OA 2QMMA 4E8BA
chains in the KnotProt database with same CATH topology
3IEFA 3KW2A 2Z0YA 3KTYA 4CNGB 1GZ0A 1X7PA 3N4JA 1VHYA 1O6DA 4CNFB 2YY8A 1UAKA 1NXZA 2QWVA 4FAKA 1NS5A 1VH0A 3KNUA 1UALA 1UAMA 3QUVA 3AXZA 3NK7A 3N4KA 1V2XA 3ONPA 4IG6A 1MXIA 2HA8A 2CX8A 1VHKA 3ILKA 3AI9X 1J85A 3L8UA 4H3ZA 3DCMX 3NK6A 1ZJRA 2O3AA 4H3YA 1UAJA 4CNEB 3E5YA 1K3RA 1TO0A 1P9PA 1V6ZA 3AIAA 3GYQA 3KY7A 3IC6A 2I6DA 1X7OA 2QMMA 4E8BA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 3IEF A;  3KW2 A;  2Z0Y A;  3KTY A;  4CNG B;  1GZ0 A;  1X7P A;  3N4J A;  1VHY A;  1O6D A;  4CNF B;  2YY8 A;  1UAK A;  1NXZ A;  2QWV A;  4FAK A;  1NS5 A;  1VH0 A;  3KNU A;  1UAL A;  1UAM A;  3QUV A;  3AXZ A;  3NK7 A;  3N4K A;  1V2X A;  3ONP A;  4IG6 A;  1MXI A;  2HA8 A;  2CX8 A;  1VHK A;  3ILK A;  3AI9 X;  1J85 A;  3L8U A;  4H3Z A;  3DCM X;  3NK6 A;  1ZJR A;  2O3A A;  4H3Y A;  1UAJ A;  4CNE B;  3E5Y A;  1K3R A;  1TO0 A;  1P9P A;  1V6Z A;  3AIA A;  3GYQ A;  3KY7 A;  3IC6 A;  2I6D A;  1X7O A;  2QMM A;  4E8B A; 
#chains in the KnotProt database with same CATH topology
 3IEF A;  3KW2 A;  2Z0Y A;  3KTY A;  4CNG B;  1GZ0 A;  1X7P A;  3N4J A;  1VHY A;  1O6D A;  4CNF B;  2YY8 A;  1UAK A;  1NXZ A;  2QWV A;  4FAK A;  1NS5 A;  1VH0 A;  3KNU A;  1UAL A;  1UAM A;  3QUV A;  3AXZ A;  3NK7 A;  3N4K A;  1V2X A;  3ONP A;  4IG6 A;  1MXI A;  2HA8 A;  2CX8 A;  1VHK A;  3ILK A;  3AI9 X;  1J85 A;  3L8U A;  4H3Z A;  3DCM X;  3NK6 A;  1ZJR A;  2O3A A;  4H3Y A;  1UAJ A;  4CNE B;  3E5Y A;  1K3R A;  1TO0 A;  1P9P A;  1V6Z A;  3AIA A;  3GYQ A;  3KY7 A;  3IC6 A;  2I6D A;  1X7O A;  2QMM A;  4E8B A; 
#chains in the KnotProt database with same CATH homology
 3IEF A;  3KW2 A;  2Z0Y A;  3KTY A;  4CNG B;  1GZ0 A;  1X7P A;  3N4J A;  1VHY A;  1O6D A;  4CNF B;  2YY8 A;  1UAK A;  1NXZ A;  2QWV A;  4FAK A;  1NS5 A;  1VH0 A;  3KNU A;  1UAL A;  1UAM A;  3QUV A;  3AXZ A;  3NK7 A;  3N4K A;  1V2X A;  3ONP A;  4IG6 A;  1MXI A;  2HA8 A;  2CX8 A;  1VHK A;  3ILK A;  3AI9 X;  1J85 A;  3L8U A;  4H3Z A;  3DCM X;  3NK6 A;  1ZJR A;  2O3A A;  4H3Y A;  1UAJ A;  4CNE B;  3E5Y A;  1K3R A;  1TO0 A;  1P9P A;  1V6Z A;  3AIA A;  3GYQ A;  3KY7 A;  3IC6 A;  2I6D A;  1X7O A;  2QMM A;  4E8B A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling