2CX8A

Crystal structure of methyltransferase with ligand(sah)
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 154-198 45 1-153, 199-225 153 27 knot
Chain Sequence
HRAFSPGLTGVLPLRETRHLVEVLRARVGDRFTVFDGEREALAEVVDLGPPLRYRVLEERRPEREVGVEVVLYVALLKGDKLAEVVRAATELGATRIQPLVTRHSVPKEMGEGKLRRLRAVALEAAKQSGRVVVPEVLPPIPLKAVPQVAQGLVAHVGATARVREVLDPEKPLALAVGPEGGFAEEEVALLEARGFTPVSLGRRILRAETAALALLALCTAGEGR
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 153-199 47 1-152, 200-225 152 26 knot
view details
2.1 150-196 47 1-149 203-225 197-202 149 23 slipknot
sequence length 225
structure length 225
publication title Crystal structure of methyltransferase with ligand(SAH)
rcsb
molecule tags Transferase
molecule keywords methyl transferase
source organism Thermus thermophilus
total genus Genus: 70
ec nomenclature
pdb deposition date 2005-06-28
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04452 Methyltrans_RNA RNA methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.20 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Hypothetical PUA domain-like; domain 1 2cx8A01
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 2cx8A02
4CNEB 1UALA 2QMMA 3AIAA 3NK6A 3ONPA 2O3AA 1J85A 1VH0A 1P9PA 1GZ0A 3KTYA 4H3ZA 1VHYA 1NXZA 3NK7A 3IEFA 3KW2A 4CNGB 3AI9X 2I6DA 1VHKA 2HA8A 3AXZA 1MXIA 1X7OA 3GYQA 4IG6A 2YY8A 3KNUA 1O6DA 1UAMA 3DCMX 4H3YA 3QUVA 3N4KA 1NS5A 1K3RA 3L8UA 3E5YA 1V2XA 3IC6A 1UAKA 3ILKA 3KY7A 1UAJA 1TO0A 1ZJRA 4CNFB 1V6ZA 4E8BA 2QWVA 2Z0YA 3N4JA 1X7PA 2CX8A 4FAKA
chains in the KnotProt database with same CATH superfamily
4CNEB 1UALA 2QMMA 3AIAA 3NK6A 3ONPA 2O3AA 1J85A 1VH0A 1P9PA 1GZ0A 3KTYA 4H3ZA 1VHYA 1NXZA 3NK7A 3IEFA 3KW2A 4CNGB 3AI9X 2I6DA 1VHKA 2HA8A 3AXZA 1MXIA 1X7OA 3GYQA 4IG6A 2YY8A 3KNUA 1O6DA 1UAMA 3DCMX 4H3YA 3QUVA 3N4KA 1NS5A 1K3RA 3L8UA 3E5YA 1V2XA 3IC6A 1UAKA 3ILKA 3KY7A 1UAJA 1TO0A 1ZJRA 4CNFB 1V6ZA 4E8BA 2QWVA 2Z0YA 3N4JA 1X7PA 2CX8A 4FAKA
chains in the KnotProt database with same CATH topology
4CNEB 1UALA 2QMMA 3AIAA 3NK6A 3ONPA 2O3AA 1J85A 1VH0A 1P9PA 1GZ0A 3KTYA 4H3ZA 1VHYA 1NXZA 3NK7A 3IEFA 3KW2A 4CNGB 3AI9X 2I6DA 1VHKA 2HA8A 3AXZA 1MXIA 1X7OA 3GYQA 4IG6A 2YY8A 3KNUA 1O6DA 1UAMA 3DCMX 4H3YA 3QUVA 3N4KA 1NS5A 1K3RA 3L8UA 3E5YA 1V2XA 3IC6A 1UAKA 3ILKA 3KY7A 1UAJA 1TO0A 1ZJRA 4CNFB 1V6ZA 4E8BA 2QWVA 2Z0YA 3N4JA 1X7PA 2CX8A 4FAKA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 4CNE B;  1UAL A;  2QMM A;  3AIA A;  3NK6 A;  3ONP A;  2O3A A;  1J85 A;  1VH0 A;  1P9P A;  1GZ0 A;  3KTY A;  4H3Z A;  1VHY A;  1NXZ A;  3NK7 A;  3IEF A;  3KW2 A;  4CNG B;  3AI9 X;  2I6D A;  1VHK A;  2HA8 A;  3AXZ A;  1MXI A;  1X7O A;  3GYQ A;  4IG6 A;  2YY8 A;  3KNU A;  1O6D A;  1UAM A;  3DCM X;  4H3Y A;  3QUV A;  3N4K A;  1NS5 A;  1K3R A;  3L8U A;  3E5Y A;  1V2X A;  3IC6 A;  1UAK A;  3ILK A;  3KY7 A;  1UAJ A;  1TO0 A;  1ZJR A;  4CNF B;  1V6Z A;  4E8B A;  2QWV A;  2Z0Y A;  3N4J A;  1X7P A;  2CX8 A;  4FAK A; 
#chains in the KnotProt database with same CATH topology
 4CNE B;  1UAL A;  2QMM A;  3AIA A;  3NK6 A;  3ONP A;  2O3A A;  1J85 A;  1VH0 A;  1P9P A;  1GZ0 A;  3KTY A;  4H3Z A;  1VHY A;  1NXZ A;  3NK7 A;  3IEF A;  3KW2 A;  4CNG B;  3AI9 X;  2I6D A;  1VHK A;  2HA8 A;  3AXZ A;  1MXI A;  1X7O A;  3GYQ A;  4IG6 A;  2YY8 A;  3KNU A;  1O6D A;  1UAM A;  3DCM X;  4H3Y A;  3QUV A;  3N4K A;  1NS5 A;  1K3R A;  3L8U A;  3E5Y A;  1V2X A;  3IC6 A;  1UAK A;  3ILK A;  3KY7 A;  1UAJ A;  1TO0 A;  1ZJR A;  4CNF B;  1V6Z A;  4E8B A;  2QWV A;  2Z0Y A;  3N4J A;  1X7P A;  2CX8 A;  4FAK A; 
#chains in the KnotProt database with same CATH homology
 4CNE B;  1UAL A;  2QMM A;  3AIA A;  3NK6 A;  3ONP A;  2O3A A;  1J85 A;  1VH0 A;  1P9P A;  1GZ0 A;  3KTY A;  4H3Z A;  1VHY A;  1NXZ A;  3NK7 A;  3IEF A;  3KW2 A;  4CNG B;  3AI9 X;  2I6D A;  1VHK A;  2HA8 A;  3AXZ A;  1MXI A;  1X7O A;  3GYQ A;  4IG6 A;  2YY8 A;  3KNU A;  1O6D A;  1UAM A;  3DCM X;  4H3Y A;  3QUV A;  3N4K A;  1NS5 A;  1K3R A;  3L8U A;  3E5Y A;  1V2X A;  3IC6 A;  1UAK A;  3ILK A;  3KY7 A;  1UAJ A;  1TO0 A;  1ZJR A;  4CNF B;  1V6Z A;  4E8B A;  2QWV A;  2Z0Y A;  3N4J A;  1X7P A;  2CX8 A;  4FAK A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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