2CX8A

Crystal structure of methyltransferase with ligand(sah)
Knot K +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 154-198 45 1-153, 199-225 153 27 knot
Chain Sequence
HRAFSPGLTGVLPLRETRHLVEVLRARVGDRFTVFDGEREALAEVVDLGPPLRYRVLEERRPEREVGVEVVLYVALLKGDKLAEVVRAATELGATRIQPLVTRHSVPKEMGEGKLRRLRAVALEAAKQSGRVVVPEVLPPIPLKAVPQVAQGLVAHVGATARVREVLDPEKPLALAVGPEGGFAEEEVALLEARGFTPVSLGRRILRAETAALALLALCTAGEGR
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 153-199 47 1-152, 200-225 152 26 knot
view details
2.1 150-196 47 1-149 203-225 197-202 149 23 slipknot
sequence length 225
structure length 225
publication title Crystal structure of methyltransferase with ligand(SAH)
rcsb
molecule tags Transferase
molecule keywords methyl transferase
source organism Thermus thermophilus
total genus Genus: 70
ec nomenclature
pdb deposition date 2005-06-28
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF04452 Methyltrans_RNA RNA methyltransferase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.240.20 Mainly Beta Beta Barrel Ribosomal Protein L25; Chain P Hypothetical PUA domain-like; domain 1 2cx8A01
3.40.1280.10 Alpha Beta 3-Layer(aba) Sandwich Alpha/beta knot Alpha/beta knot 2cx8A02
1V2XA 4CNFB 1V6ZA 1X7OA 3L8UA 3N4KA 2HA8A 3KTYA 1NXZA 4H3YA 2YY8A 1UAMA 2QWVA 1X7PA 4H3ZA 3AIAA 2O3AA 3ONPA 3KW2A 2I6DA 2QMMA 4E8BA 1MXIA 4FAKA 3N4JA 3NK6A 3NK7A 1VH0A 1UALA 3KNUA 3GYQA 4CNEB 3IEFA 3AXZA 1J85A 2Z0YA 4IG6A 1GZ0A 1ZJRA 2CX8A 1TO0A 3KY7A 4CNGB 1P9PA 1UAKA 1VHYA 3E5YA 3QUVA 3AI9X 1NS5A 3IC6A 3DCMX 1K3RA 1UAJA 3ILKA 1O6DA 1VHKA
chains in the KnotProt database with same CATH superfamily
1V2XA 4CNFB 1V6ZA 1X7OA 3L8UA 3N4KA 2HA8A 3KTYA 1NXZA 4H3YA 2YY8A 1UAMA 2QWVA 1X7PA 4H3ZA 3AIAA 2O3AA 3ONPA 3KW2A 2I6DA 2QMMA 4E8BA 1MXIA 4FAKA 3N4JA 3NK6A 3NK7A 1VH0A 1UALA 3KNUA 3GYQA 4CNEB 3IEFA 3AXZA 1J85A 2Z0YA 4IG6A 1GZ0A 1ZJRA 2CX8A 1TO0A 3KY7A 4CNGB 1P9PA 1UAKA 1VHYA 3E5YA 3QUVA 3AI9X 1NS5A 3IC6A 3DCMX 1K3RA 1UAJA 3ILKA 1O6DA 1VHKA
chains in the KnotProt database with same CATH topology
1V2XA 4CNFB 1V6ZA 1X7OA 3L8UA 3N4KA 2HA8A 3KTYA 1NXZA 4H3YA 2YY8A 1UAMA 2QWVA 1X7PA 4H3ZA 3AIAA 2O3AA 3ONPA 3KW2A 2I6DA 2QMMA 4E8BA 1MXIA 4FAKA 3N4JA 3NK6A 3NK7A 1VH0A 1UALA 3KNUA 3GYQA 4CNEB 3IEFA 3AXZA 1J85A 2Z0YA 4IG6A 1GZ0A 1ZJRA 2CX8A 1TO0A 3KY7A 4CNGB 1P9PA 1UAKA 1VHYA 3E5YA 3QUVA 3AI9X 1NS5A 3IC6A 3DCMX 1K3RA 1UAJA 3ILKA 1O6DA 1VHKA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1V2X A;  4CNF B;  1V6Z A;  1X7O A;  3L8U A;  3N4K A;  2HA8 A;  3KTY A;  1NXZ A;  4H3Y A;  2YY8 A;  1UAM A;  2QWV A;  1X7P A;  4H3Z A;  3AIA A;  2O3A A;  3ONP A;  3KW2 A;  2I6D A;  2QMM A;  4E8B A;  1MXI A;  4FAK A;  3N4J A;  3NK6 A;  3NK7 A;  1VH0 A;  1UAL A;  3KNU A;  3GYQ A;  4CNE B;  3IEF A;  3AXZ A;  1J85 A;  2Z0Y A;  4IG6 A;  1GZ0 A;  1ZJR A;  2CX8 A;  1TO0 A;  3KY7 A;  4CNG B;  1P9P A;  1UAK A;  1VHY A;  3E5Y A;  3QUV A;  3AI9 X;  1NS5 A;  3IC6 A;  3DCM X;  1K3R A;  1UAJ A;  3ILK A;  1O6D A;  1VHK A; 
#chains in the KnotProt database with same CATH topology
 1V2X A;  4CNF B;  1V6Z A;  1X7O A;  3L8U A;  3N4K A;  2HA8 A;  3KTY A;  1NXZ A;  4H3Y A;  2YY8 A;  1UAM A;  2QWV A;  1X7P A;  4H3Z A;  3AIA A;  2O3A A;  3ONP A;  3KW2 A;  2I6D A;  2QMM A;  4E8B A;  1MXI A;  4FAK A;  3N4J A;  3NK6 A;  3NK7 A;  1VH0 A;  1UAL A;  3KNU A;  3GYQ A;  4CNE B;  3IEF A;  3AXZ A;  1J85 A;  2Z0Y A;  4IG6 A;  1GZ0 A;  1ZJR A;  2CX8 A;  1TO0 A;  3KY7 A;  4CNG B;  1P9P A;  1UAK A;  1VHY A;  3E5Y A;  3QUV A;  3AI9 X;  1NS5 A;  3IC6 A;  3DCM X;  1K3R A;  1UAJ A;  3ILK A;  1O6D A;  1VHK A; 
#chains in the KnotProt database with same CATH homology
 1V2X A;  4CNF B;  1V6Z A;  1X7O A;  3L8U A;  3N4K A;  2HA8 A;  3KTY A;  1NXZ A;  4H3Y A;  2YY8 A;  1UAM A;  2QWV A;  1X7P A;  4H3Z A;  3AIA A;  2O3A A;  3ONP A;  3KW2 A;  2I6D A;  2QMM A;  4E8B A;  1MXI A;  4FAK A;  3N4J A;  3NK6 A;  3NK7 A;  1VH0 A;  1UAL A;  3KNU A;  3GYQ A;  4CNE B;  3IEF A;  3AXZ A;  1J85 A;  2Z0Y A;  4IG6 A;  1GZ0 A;  1ZJR A;  2CX8 A;  1TO0 A;  3KY7 A;  4CNG B;  1P9P A;  1UAK A;  1VHY A;  3E5Y A;  3QUV A;  3AI9 X;  1NS5 A;  3IC6 A;  3DCM X;  1K3R A;  1UAJ A;  3ILK A;  1O6D A;  1VHK A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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