1AJBA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 46-369 324 1-45 420-449 370-419 45 30 slipknot
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 48-371 324 1-47 417-449 372-416 47 33 slipknot
view details
3.1 44-416 373 1-43 420-449 417-419 43 30 slipknot
view details
2.1 43-419 377 1-1, 421-449 2-42, 420-420 1 29 slipknot
view details
2.1 13-368 356 1-6, 372-449 7-12, 369-371 6 78 slipknot
view details
3.1 14-368 355 1-12, 372-449 13-13, 369-371 12 78 slipknot
view details
2.1 43-366 324 1-25, 372-449 26-42, 367-371 25 78 slipknot
view details
2.1 45-416 372 1-43, 419-449 44-44, 417-418 43 31 slipknot
sequence length 449
structure length 449
publication title 3-D structure of the D153G mutant of Escherichia coli alkaline phosphatase: an enzyme with weaker magnesium binding and increased catalytic activity.
pubmed doi rcsb
molecule tags Non specific mono-esterase
molecule keywords ALKALINE PHOSPHATASE
source organism Escherichia coli
total genus Genus: 162
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-08-19
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajbA00
1ELXA 1EW9A 1HQAA 1KHKA 1KH9A 1N2KA 1URAA 1ALKA 1SHQA 1K7HA 3IGYB 1AUKA 1AJDA 1AJBA 1KH7A 3M8ZA 1SHNA 1URBA 2GLQA 3MK1A 3M8YA 3T01A 1EQJA 3T00A 1E33P 3OT9A 3SZZA 1ALJA 1E2SP 3UN2A 1ELZA 3BDGA 1AJAA 1ALIA 1ZEFA 3NVLA 3T02A 1HJKA 1ED8A 1EJJA 3DPCA 1ZEBA 3TWZA 1E3CP 3BDHA 1Y6VA 2QZUA 2GA3A 1KHNA 1EW2A 1AJCA 1O98A 1O99A 1ED9A 1ANIA 1FSUA 3UNYA 3SZYA 3TX0A 1EI6A 1ZEDA 3MK2A 3CMRA 3UN5A 1ANJA 3DYCA 4FDIA 3M7VA 1HDHA 3MK0A 1N2LA 1KHJA 2ANHA 2IFYA 1KH5A 1P49A 4FDJA 3ED4A 3IGZB 1B8JA 3M8WA 3BDGB 3UN3A 1ELYA 1E1ZP 3UO0A 1EW8A 1KH4A 1Y7AA 2G9YA 1KHLA 3BDFA
chains in the KnotProt database with same CATH superfamily
1ELXA 1EW9A 1HQAA 1KHKA 1KH9A 1N2KA 1URAA 1ALKA 1SHQA 1K7HA 3IGYB 1AUKA 1AJDA 1AJBA 1KH7A 3M8ZA 1SHNA 1URBA 2GLQA 3MK1A 3M8YA 3T01A 1EQJA 3T00A 1E33P 3OT9A 3SZZA 1ALJA 1E2SP 3UN2A 1ELZA 3BDGA 1AJAA 1ALIA 1ZEFA 3NVLA 3T02A 1HJKA 1ED8A 1EJJA 3DPCA 1ZEBA 3TWZA 1E3CP 3BDHA 1Y6VA 2QZUA 2GA3A 1KHNA 1EW2A 1AJCA 1O98A 1O99A 1ED9A 1ANIA 1FSUA 3UNYA 3SZYA 3TX0A 1EI6A 1ZEDA 3MK2A 3CMRA 3UN5A 1ANJA 3DYCA 4FDIA 3M7VA 1HDHA 3MK0A 1N2LA 1KHJA 2ANHA 2IFYA 1KH5A 1P49A 4FDJA 3ED4A 3IGZB 1B8JA 3M8WA 3BDGB 3UN3A 1ELYA 1E1ZP 3UO0A 1EW8A 1KH4A 1Y7AA 2G9YA 1KHLA 3BDFA
chains in the KnotProt database with same CATH topology
1ELXA 1EW9A 1HQAA 1KHKA 1KH9A 1N2KA 1URAA 1ALKA 1SHQA 1K7HA 3IGYB 1AUKA 1AJDA 1AJBA 1KH7A 3M8ZA 1SHNA 1URBA 2GLQA 3MK1A 3M8YA 3T01A 1EQJA 3T00A 1E33P 3OT9A 3SZZA 1ALJA 1E2SP 3UN2A 1ELZA 3BDGA 1AJAA 1ALIA 1ZEFA 3NVLA 3T02A 1HJKA 1ED8A 1EJJA 3DPCA 1ZEBA 3TWZA 1E3CP 3BDHA 1Y6VA 2QZUA 2GA3A 1KHNA 1EW2A 1AJCA 1O98A 1O99A 1ED9A 1ANIA 1FSUA 3UNYA 3SZYA 3TX0A 1EI6A 1ZEDA 3MK2A 3CMRA 3UN5A 1ANJA 3DYCA 4FDIA 3M7VA 1HDHA 3MK0A 1N2LA 1KHJA 2ANHA 2IFYA 1KH5A 1P49A 4FDJA 3ED4A 3IGZB 1B8JA 3M8WA 3BDGB 3UN3A 1ELYA 1E1ZP 3UO0A 1EW8A 1KH4A 1Y7AA 2G9YA 1KHLA 3BDFA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1ELX A;  1EW9 A;  1HQA A;  1KHK A;  1KH9 A;  1N2K A;  1URA A;  1ALK A;  1SHQ A;  1K7H A;  3IGY B;  1AUK A;  1AJD A;  1AJB A;  1KH7 A;  3M8Z A;  1SHN A;  1URB A;  2GLQ A;  3MK1 A;  3M8Y A;  3T01 A;  1EQJ A;  3T00 A;  1E33 P;  3OT9 A;  3SZZ A;  1ALJ A;  1E2S P;  3UN2 A;  1ELZ A;  3BDG A;  1AJA A;  1ALI A;  1ZEF A;  3NVL A;  3T02 A;  1HJK A;  1ED8 A;  1EJJ A;  3DPC A;  1ZEB A;  3TWZ A;  1E3C P;  3BDH A;  1Y6V A;  2QZU A;  2GA3 A;  1KHN A;  1EW2 A;  1AJC A;  1O98 A;  1O99 A;  1ED9 A;  1ANI A;  1FSU A;  3UNY A;  3SZY A;  3TX0 A;  1EI6 A;  1ZED A;  3MK2 A;  3CMR A;  3UN5 A;  1ANJ A;  3DYC A;  4FDI A;  3M7V A;  1HDH A;  3MK0 A;  1N2L A;  1KHJ A;  2ANH A;  2IFY A;  1KH5 A;  1P49 A;  4FDJ A;  3ED4 A;  3IGZ B;  1B8J A;  3M8W A;  3BDG B;  3UN3 A;  1ELY A;  1E1Z P;  3UO0 A;  1EW8 A;  1KH4 A;  1Y7A A;  2G9Y A;  1KHL A;  3BDF A; 
#chains in the KnotProt database with same CATH topology
 1ELX A;  1EW9 A;  1HQA A;  1KHK A;  1KH9 A;  1N2K A;  1URA A;  1ALK A;  1SHQ A;  1K7H A;  3IGY B;  1AUK A;  1AJD A;  1AJB A;  1KH7 A;  3M8Z A;  1SHN A;  1URB A;  2GLQ A;  3MK1 A;  3M8Y A;  3T01 A;  1EQJ A;  3T00 A;  1E33 P;  3OT9 A;  3SZZ A;  1ALJ A;  1E2S P;  3UN2 A;  1ELZ A;  3BDG A;  1AJA A;  1ALI A;  1ZEF A;  3NVL A;  3T02 A;  1HJK A;  1ED8 A;  1EJJ A;  3DPC A;  1ZEB A;  3TWZ A;  1E3C P;  3BDH A;  1Y6V A;  2QZU A;  2GA3 A;  1KHN A;  1EW2 A;  1AJC A;  1O98 A;  1O99 A;  1ED9 A;  1ANI A;  1FSU A;  3UNY A;  3SZY A;  3TX0 A;  1EI6 A;  1ZED A;  3MK2 A;  3CMR A;  3UN5 A;  1ANJ A;  3DYC A;  4FDI A;  3M7V A;  1HDH A;  3MK0 A;  1N2L A;  1KHJ A;  2ANH A;  2IFY A;  1KH5 A;  1P49 A;  4FDJ A;  3ED4 A;  3IGZ B;  1B8J A;  3M8W A;  3BDG B;  3UN3 A;  1ELY A;  1E1Z P;  3UO0 A;  1EW8 A;  1KH4 A;  1Y7A A;  2G9Y A;  1KHL A;  3BDF A; 
#chains in the KnotProt database with same CATH homology
 1ELX A;  1EW9 A;  1HQA A;  1KHK A;  1KH9 A;  1N2K A;  1URA A;  1ALK A;  1SHQ A;  1K7H A;  3IGY B;  1AUK A;  1AJD A;  1AJB A;  1KH7 A;  3M8Z A;  1SHN A;  1URB A;  2GLQ A;  3MK1 A;  3M8Y A;  3T01 A;  1EQJ A;  3T00 A;  1E33 P;  3OT9 A;  3SZZ A;  1ALJ A;  1E2S P;  3UN2 A;  1ELZ A;  3BDG A;  1AJA A;  1ALI A;  1ZEF A;  3NVL A;  3T02 A;  1HJK A;  1ED8 A;  1EJJ A;  3DPC A;  1ZEB A;  3TWZ A;  1E3C P;  3BDH A;  1Y6V A;  2QZU A;  2GA3 A;  1KHN A;  1EW2 A;  1AJC A;  1O98 A;  1O99 A;  1ED9 A;  1ANI A;  1FSU A;  3UNY A;  3SZY A;  3TX0 A;  1EI6 A;  1ZED A;  3MK2 A;  3CMR A;  3UN5 A;  1ANJ A;  3DYC A;  4FDI A;  3M7V A;  1HDH A;  3MK0 A;  1N2L A;  1KHJ A;  2ANH A;  2IFY A;  1KH5 A;  1P49 A;  4FDJ A;  3ED4 A;  3IGZ B;  1B8J A;  3M8W A;  3BDG B;  3UN3 A;  1ELY A;  1E1Z P;  3UO0 A;  1EW8 A;  1KH4 A;  1Y7A A;  2G9Y A;  1KHL A;  3BDF A; 
...loading similar chains, please wait...
similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling