1AJBA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Genus: 162
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 46-369 324 1-45 420-449 370-419 45 30 slipknot
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 48-371 324 1-47 417-449 372-416 47 33 slipknot
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3.1 44-416 373 1-43 420-449 417-419 43 30 slipknot
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2.1 43-419 377 1-1, 421-449 2-42, 420-420 1 29 slipknot
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2.1 13-368 356 1-6, 372-449 7-12, 369-371 6 78 slipknot
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3.1 14-368 355 1-12, 372-449 13-13, 369-371 12 78 slipknot
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2.1 43-366 324 1-25, 372-449 26-42, 367-371 25 78 slipknot
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2.1 45-416 372 1-43, 419-449 44-44, 417-418 43 31 slipknot
sequence length 449
structure length 449
publication title 3-D structure of the D153G mutant of Escherichia coli alkaline phosphatase: an enzyme with weaker magnesium binding and increased catalytic activity.
pubmed doi rcsb
molecule tags Non specific mono-esterase
molecule keywords ALKALINE PHOSPHATASE
source organism Escherichia coli
total genus Genus: 162
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-08-19
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajbA00
1ANIA 1HDHA 1ED8A 1ALIA 1Y7AA 1FSUA 2GLQA 1AUKA 1ZEFA 3M8YA 1URAA 1ZEBA 1EQJA 1KHLA 1KHKA 3IGYB 1ELXA 3BDHA 1ALJA 3UO0A 3ED4A 3BDGB 3UN3A 1P49A 1KH7A 1ELZA 1KHJA 1KHNA 3SZYA 3M8ZA 3DYCA 1SHNA 1ELYA 1KH4A 1SHQA 1EW9A 1AJAA 2G9YA 1N2LA 3CMRA 1ED9A 3UN2A 1HJKA 4FDJA 1K7HA 1E2SP 4FDIA 1ANJA 3TWZA 3MK1A 1EW2A 1E33P 1E3CP 1KH9A 2IFYA 3SZZA 2GA3A 3OT9A 1ZEDA 1E1ZP 1O99A 3UN5A 1B8JA 2ANHA 3UNYA 3BDGA 1N2KA 3T00A 1KH5A 3T01A 1HQAA 3IGZB 3MK0A 2QZUA 3NVLA 3DPCA 1AJDA 1O98A 1EJJA 3M8WA 3T02A 1AJBA 1EI6A 3M7VA 1URBA 1Y6VA 3TX0A 1AJCA 3MK2A 1ALKA 1EW8A 3BDFA
chains in the KnotProt database with same CATH superfamily
1ANIA 1HDHA 1ED8A 1ALIA 1Y7AA 1FSUA 2GLQA 1AUKA 1ZEFA 3M8YA 1URAA 1ZEBA 1EQJA 1KHLA 1KHKA 3IGYB 1ELXA 3BDHA 1ALJA 3UO0A 3ED4A 3BDGB 3UN3A 1P49A 1KH7A 1ELZA 1KHJA 1KHNA 3SZYA 3M8ZA 3DYCA 1SHNA 1ELYA 1KH4A 1SHQA 1EW9A 1AJAA 2G9YA 1N2LA 3CMRA 1ED9A 3UN2A 1HJKA 4FDJA 1K7HA 1E2SP 4FDIA 1ANJA 3TWZA 3MK1A 1EW2A 1E33P 1E3CP 1KH9A 2IFYA 3SZZA 2GA3A 3OT9A 1ZEDA 1E1ZP 1O99A 3UN5A 1B8JA 2ANHA 3UNYA 3BDGA 1N2KA 3T00A 1KH5A 3T01A 1HQAA 3IGZB 3MK0A 2QZUA 3NVLA 3DPCA 1AJDA 1O98A 1EJJA 3M8WA 3T02A 1AJBA 1EI6A 3M7VA 1URBA 1Y6VA 3TX0A 1AJCA 3MK2A 1ALKA 1EW8A 3BDFA
chains in the KnotProt database with same CATH topology
1ANIA 1HDHA 1ED8A 1ALIA 1Y7AA 1FSUA 2GLQA 1AUKA 1ZEFA 3M8YA 1URAA 1ZEBA 1EQJA 1KHLA 1KHKA 3IGYB 1ELXA 3BDHA 1ALJA 3UO0A 3ED4A 3BDGB 3UN3A 1P49A 1KH7A 1ELZA 1KHJA 1KHNA 3SZYA 3M8ZA 3DYCA 1SHNA 1ELYA 1KH4A 1SHQA 1EW9A 1AJAA 2G9YA 1N2LA 3CMRA 1ED9A 3UN2A 1HJKA 4FDJA 1K7HA 1E2SP 4FDIA 1ANJA 3TWZA 3MK1A 1EW2A 1E33P 1E3CP 1KH9A 2IFYA 3SZZA 2GA3A 3OT9A 1ZEDA 1E1ZP 1O99A 3UN5A 1B8JA 2ANHA 3UNYA 3BDGA 1N2KA 3T00A 1KH5A 3T01A 1HQAA 3IGZB 3MK0A 2QZUA 3NVLA 3DPCA 1AJDA 1O98A 1EJJA 3M8WA 3T02A 1AJBA 1EI6A 3M7VA 1URBA 1Y6VA 3TX0A 1AJCA 3MK2A 1ALKA 1EW8A 3BDFA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1ANI A;  1HDH A;  1ED8 A;  1ALI A;  1Y7A A;  1FSU A;  2GLQ A;  1AUK A;  1ZEF A;  3M8Y A;  1URA A;  1ZEB A;  1EQJ A;  1KHL A;  1KHK A;  3IGY B;  1ELX A;  3BDH A;  1ALJ A;  3UO0 A;  3ED4 A;  3BDG B;  3UN3 A;  1P49 A;  1KH7 A;  1ELZ A;  1KHJ A;  1KHN A;  3SZY A;  3M8Z A;  3DYC A;  1SHN A;  1ELY A;  1KH4 A;  1SHQ A;  1EW9 A;  1AJA A;  2G9Y A;  1N2L A;  3CMR A;  1ED9 A;  3UN2 A;  1HJK A;  4FDJ A;  1K7H A;  1E2S P;  4FDI A;  1ANJ A;  3TWZ A;  3MK1 A;  1EW2 A;  1E33 P;  1E3C P;  1KH9 A;  2IFY A;  3SZZ A;  2GA3 A;  3OT9 A;  1ZED A;  1E1Z P;  1O99 A;  3UN5 A;  1B8J A;  2ANH A;  3UNY A;  3BDG A;  1N2K A;  3T00 A;  1KH5 A;  3T01 A;  1HQA A;  3IGZ B;  3MK0 A;  2QZU A;  3NVL A;  3DPC A;  1AJD A;  1O98 A;  1EJJ A;  3M8W A;  3T02 A;  1AJB A;  1EI6 A;  3M7V A;  1URB A;  1Y6V A;  3TX0 A;  1AJC A;  3MK2 A;  1ALK A;  1EW8 A;  3BDF A; 
#chains in the KnotProt database with same CATH topology
 1ANI A;  1HDH A;  1ED8 A;  1ALI A;  1Y7A A;  1FSU A;  2GLQ A;  1AUK A;  1ZEF A;  3M8Y A;  1URA A;  1ZEB A;  1EQJ A;  1KHL A;  1KHK A;  3IGY B;  1ELX A;  3BDH A;  1ALJ A;  3UO0 A;  3ED4 A;  3BDG B;  3UN3 A;  1P49 A;  1KH7 A;  1ELZ A;  1KHJ A;  1KHN A;  3SZY A;  3M8Z A;  3DYC A;  1SHN A;  1ELY A;  1KH4 A;  1SHQ A;  1EW9 A;  1AJA A;  2G9Y A;  1N2L A;  3CMR A;  1ED9 A;  3UN2 A;  1HJK A;  4FDJ A;  1K7H A;  1E2S P;  4FDI A;  1ANJ A;  3TWZ A;  3MK1 A;  1EW2 A;  1E33 P;  1E3C P;  1KH9 A;  2IFY A;  3SZZ A;  2GA3 A;  3OT9 A;  1ZED A;  1E1Z P;  1O99 A;  3UN5 A;  1B8J A;  2ANH A;  3UNY A;  3BDG A;  1N2K A;  3T00 A;  1KH5 A;  3T01 A;  1HQA A;  3IGZ B;  3MK0 A;  2QZU A;  3NVL A;  3DPC A;  1AJD A;  1O98 A;  1EJJ A;  3M8W A;  3T02 A;  1AJB A;  1EI6 A;  3M7V A;  1URB A;  1Y6V A;  3TX0 A;  1AJC A;  3MK2 A;  1ALK A;  1EW8 A;  3BDF A; 
#chains in the KnotProt database with same CATH homology
 1ANI A;  1HDH A;  1ED8 A;  1ALI A;  1Y7A A;  1FSU A;  2GLQ A;  1AUK A;  1ZEF A;  3M8Y A;  1URA A;  1ZEB A;  1EQJ A;  1KHL A;  1KHK A;  3IGY B;  1ELX A;  3BDH A;  1ALJ A;  3UO0 A;  3ED4 A;  3BDG B;  3UN3 A;  1P49 A;  1KH7 A;  1ELZ A;  1KHJ A;  1KHN A;  3SZY A;  3M8Z A;  3DYC A;  1SHN A;  1ELY A;  1KH4 A;  1SHQ A;  1EW9 A;  1AJA A;  2G9Y A;  1N2L A;  3CMR A;  1ED9 A;  3UN2 A;  1HJK A;  4FDJ A;  1K7H A;  1E2S P;  4FDI A;  1ANJ A;  3TWZ A;  3MK1 A;  1EW2 A;  1E33 P;  1E3C P;  1KH9 A;  2IFY A;  3SZZ A;  2GA3 A;  3OT9 A;  1ZED A;  1E1Z P;  1O99 A;  3UN5 A;  1B8J A;  2ANH A;  3UNY A;  3BDG A;  1N2K A;  3T00 A;  1KH5 A;  3T01 A;  1HQA A;  3IGZ B;  3MK0 A;  2QZU A;  3NVL A;  3DPC A;  1AJD A;  1O98 A;  1EJJ A;  3M8W A;  3T02 A;  1AJB A;  1EI6 A;  3M7V A;  1URB A;  1Y6V A;  3TX0 A;  1AJC A;  3MK2 A;  1ALK A;  1EW8 A;  3BDF A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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