4FDJA

The molecular basis of mucopolysaccharidosis iv a, complex with galnac
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 171
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 7-261 255 1-6 294-493 262-293 6 200 slipknot
Chain Sequence
PQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLXSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIPKKCLW
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 7-264 258 1-6 277-493 265-276 6 217 slipknot
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3.1 6-277 272 1-5 291-493 278-290 5 203 slipknot
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2.1 6-290 285 1-5 296-493 291-295 5 198 slipknot
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3.1 9-285 277 1-5, 292-493 6-8, 286-291 5 202 slipknot
sequence length 493
structure length 493
publication title The Structure of Human GALNS Reveals the Molecular Basis for Mucopolysaccharidosis IV A.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords N-acetylgalactosamine-6-sulfatase
source organism Homo sapiens
total genus Genus: 171
ec nomenclature ec 3.1.6.4: N-acetylgalactosamine-6-sulfatase.
pdb deposition date 2012-05-28
KnotProt deposition date 2014-08-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.10 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 4fdjA02
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 4fdjA01
3BDHA 3MK2A 1N2KA 3DYCA 1ED8A 1ALKA 1KHNA 3TWZA 1AJAA 1B8JA 1Y6VA 1N2LA 3T00A 3DPCA 3T02A 4FDIA 1EW8A 3OT9A 3ED4A 1EW9A 3T01A 1O98A 3CMRA 1EQJA 1EI6A 1EJJA 1ZEDA 1ELXA 1P49A 1KH9A 3M7VA 1ZEFA 1E2SP 1KHJA 1E33P 1KH7A 1KH4A 1HDHA 1HJKA 1E1ZP 3UN2A 1KHKA 2G9YA 3M8ZA 3TX0A 3UN5A 1ZEBA 2QZUA 3SZYA 3BDGA 1HQAA 3SZZA 1ALJA 3UO0A 3M8YA 3MK1A 1AUKA 1K7HA 1ED9A 1EW2A 1SHNA 1ANIA 1ANJA 4FDJA 1URAA 1FSUA 1Y7AA 3MK0A 1SHQA 3IGYB 3BDGB 1ELYA 2GA3A 3M8WA 1KHLA 1AJDA 3IGZB 2GLQA 3BDFA 1AJBA 3NVLA 1E3CP 1ALIA 3UNYA 1O99A 3UN3A 2IFYA 1URBA 2ANHA 1KH5A 1AJCA 1ELZA
chains in the KnotProt database with same CATH superfamily
3BDHA 3MK2A 1N2KA 3DYCA 1ED8A 1ALKA 1KHNA 3TWZA 1AJAA 1B8JA 1Y6VA 1N2LA 3T00A 3DPCA 3T02A 4FDIA 1EW8A 3OT9A 3ED4A 1EW9A 3T01A 1O98A 3CMRA 1EQJA 1EI6A 1EJJA 1ZEDA 1ELXA 1P49A 1KH9A 3M7VA 1ZEFA 1E2SP 1KHJA 1E33P 1KH7A 1KH4A 1HDHA 1HJKA 1E1ZP 3UN2A 1KHKA 2G9YA 3M8ZA 3TX0A 3UN5A 1ZEBA 2QZUA 3SZYA 3BDGA 1HQAA 3SZZA 1ALJA 3UO0A 3M8YA 3MK1A 1AUKA 1K7HA 1ED9A 1EW2A 1SHNA 1ANIA 1ANJA 4FDJA 1URAA 1FSUA 1Y7AA 3MK0A 1SHQA 3IGYB 3BDGB 1ELYA 2GA3A 3M8WA 1KHLA 1AJDA 3IGZB 2GLQA 3BDFA 1AJBA 3NVLA 1E3CP 1ALIA 3UNYA 1O99A 3UN3A 2IFYA 1URBA 2ANHA 1KH5A 1AJCA 1ELZA
chains in the KnotProt database with same CATH topology
3BDHA 3MK2A 1N2KA 3DYCA 1ED8A 1ALKA 1KHNA 3TWZA 1AJAA 1B8JA 1Y6VA 1N2LA 3T00A 3DPCA 3T02A 4FDIA 1EW8A 3OT9A 3ED4A 1EW9A 3T01A 1O98A 3CMRA 1EQJA 1EI6A 1EJJA 1ZEDA 1ELXA 1P49A 1KH9A 3M7VA 1ZEFA 1E2SP 1KHJA 1E33P 1KH7A 1KH4A 1HDHA 1HJKA 1E1ZP 3UN2A 1KHKA 2G9YA 3M8ZA 3TX0A 3UN5A 1ZEBA 2QZUA 3SZYA 3BDGA 1HQAA 3SZZA 1ALJA 3UO0A 3M8YA 3MK1A 1AUKA 1K7HA 1ED9A 1EW2A 1SHNA 1ANIA 1ANJA 4FDJA 1URAA 1FSUA 1Y7AA 3MK0A 1SHQA 3IGYB 3BDGB 1ELYA 2GA3A 3M8WA 1KHLA 1AJDA 3IGZB 2GLQA 3BDFA 1AJBA 3NVLA 1E3CP 1ALIA 3UNYA 1O99A 3UN3A 2IFYA 1URBA 2ANHA 1KH5A 1AJCA 1ELZA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 3BDH A;  3MK2 A;  1N2K A;  3DYC A;  1ED8 A;  1ALK A;  1KHN A;  3TWZ A;  1AJA A;  1B8J A;  1Y6V A;  1N2L A;  3T00 A;  3DPC A;  3T02 A;  4FDI A;  1EW8 A;  3OT9 A;  3ED4 A;  1EW9 A;  3T01 A;  1O98 A;  3CMR A;  1EQJ A;  1EI6 A;  1EJJ A;  1ZED A;  1ELX A;  1P49 A;  1KH9 A;  3M7V A;  1ZEF A;  1E2S P;  1KHJ A;  1E33 P;  1KH7 A;  1KH4 A;  1HDH A;  1HJK A;  1E1Z P;  3UN2 A;  1KHK A;  2G9Y A;  3M8Z A;  3TX0 A;  3UN5 A;  1ZEB A;  2QZU A;  3SZY A;  3BDG A;  1HQA A;  3SZZ A;  1ALJ A;  3UO0 A;  3M8Y A;  3MK1 A;  1AUK A;  1K7H A;  1ED9 A;  1EW2 A;  1SHN A;  1ANI A;  1ANJ A;  4FDJ A;  1URA A;  1FSU A;  1Y7A A;  3MK0 A;  1SHQ A;  3IGY B;  3BDG B;  1ELY A;  2GA3 A;  3M8W A;  1KHL A;  1AJD A;  3IGZ B;  2GLQ A;  3BDF A;  1AJB A;  3NVL A;  1E3C P;  1ALI A;  3UNY A;  1O99 A;  3UN3 A;  2IFY A;  1URB A;  2ANH A;  1KH5 A;  1AJC A;  1ELZ A; 
#chains in the KnotProt database with same CATH topology
 3BDH A;  3MK2 A;  1N2K A;  3DYC A;  1ED8 A;  1ALK A;  1KHN A;  3TWZ A;  1AJA A;  1B8J A;  1Y6V A;  1N2L A;  3T00 A;  3DPC A;  3T02 A;  4FDI A;  1EW8 A;  3OT9 A;  3ED4 A;  1EW9 A;  3T01 A;  1O98 A;  3CMR A;  1EQJ A;  1EI6 A;  1EJJ A;  1ZED A;  1ELX A;  1P49 A;  1KH9 A;  3M7V A;  1ZEF A;  1E2S P;  1KHJ A;  1E33 P;  1KH7 A;  1KH4 A;  1HDH A;  1HJK A;  1E1Z P;  3UN2 A;  1KHK A;  2G9Y A;  3M8Z A;  3TX0 A;  3UN5 A;  1ZEB A;  2QZU A;  3SZY A;  3BDG A;  1HQA A;  3SZZ A;  1ALJ A;  3UO0 A;  3M8Y A;  3MK1 A;  1AUK A;  1K7H A;  1ED9 A;  1EW2 A;  1SHN A;  1ANI A;  1ANJ A;  4FDJ A;  1URA A;  1FSU A;  1Y7A A;  3MK0 A;  1SHQ A;  3IGY B;  3BDG B;  1ELY A;  2GA3 A;  3M8W A;  1KHL A;  1AJD A;  3IGZ B;  2GLQ A;  3BDF A;  1AJB A;  3NVL A;  1E3C P;  1ALI A;  3UNY A;  1O99 A;  3UN3 A;  2IFY A;  1URB A;  2ANH A;  1KH5 A;  1AJC A;  1ELZ A; 
#chains in the KnotProt database with same CATH homology
 3BDH A;  3MK2 A;  1N2K A;  3DYC A;  1ED8 A;  1ALK A;  1KHN A;  3TWZ A;  1AJA A;  1B8J A;  1Y6V A;  1N2L A;  3T00 A;  3DPC A;  3T02 A;  4FDI A;  1EW8 A;  3OT9 A;  3ED4 A;  1EW9 A;  3T01 A;  1O98 A;  3CMR A;  1EQJ A;  1EI6 A;  1EJJ A;  1ZED A;  1ELX A;  1P49 A;  1KH9 A;  3M7V A;  1ZEF A;  1E2S P;  1KHJ A;  1E33 P;  1KH7 A;  1KH4 A;  1HDH A;  1HJK A;  1E1Z P;  3UN2 A;  1KHK A;  2G9Y A;  3M8Z A;  3TX0 A;  3UN5 A;  1ZEB A;  2QZU A;  3SZY A;  3BDG A;  1HQA A;  3SZZ A;  1ALJ A;  3UO0 A;  3M8Y A;  3MK1 A;  1AUK A;  1K7H A;  1ED9 A;  1EW2 A;  1SHN A;  1ANI A;  1ANJ A;  4FDJ A;  1URA A;  1FSU A;  1Y7A A;  3MK0 A;  1SHQ A;  3IGY B;  3BDG B;  1ELY A;  2GA3 A;  3M8W A;  1KHL A;  1AJD A;  3IGZ B;  2GLQ A;  3BDF A;  1AJB A;  3NVL A;  1E3C P;  1ALI A;  3UNY A;  1O99 A;  3UN3 A;  2IFY A;  1URB A;  2ANH A;  1KH5 A;  1AJC A;  1ELZ A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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