1ZEFA

Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 40-355 316 1-39 440-481 356-439 39 42 slipknot
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 35-355 321 1-34 362-481 356-361 34 120 slipknot
view details
3.1 39-358 320 1-38 437-481 359-436 38 45 slipknot
view details
2.1 36-436 401 1-35 441-481 437-440 35 41 slipknot
view details
2.1 40-404 365 1-38, 413-481 39-39, 405-412 38 69 slipknot
view details
2.1 41-403 363 1-39, 413-481 40-40, 404-412 39 69 slipknot
sequence length 481
structure length 481
publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus Genus: 176
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zefA00
1ELYA 1ALKA 2GLQA 1SHQA 3M8YA 3BDGB 1EW9A 2IFYA 1AJDA 1ED9A 1ZEFA 3UN5A 1ALIA 3T01A 1ED8A 1ANJA 3UNYA 2ANHA 3BDFA 1KH9A 1ZEBA 1EW2A 3T02A 1HQAA 3TWZA 1P49A 3MK0A 1EJJA 1FSUA 1KH5A 3IGYB 1Y6VA 1B8JA 1ELXA 1AJAA 1AJCA 3SZZA 1E2SP 3IGZB 1HJKA 1O99A 3BDGA 3TX0A 1ELZA 2G9YA 1E1ZP 2QZUA 1N2LA 1HDHA 1URAA 1SHNA 3DPCA 1EW8A 3NVLA 3DYCA 4FDIA 3ED4A 3MK1A 3UN2A 3SZYA 3CMRA 1ANIA 1E3CP 1ZEDA 3M7VA 3BDHA 3OT9A 1Y7AA 1AUKA 1KH7A 1EI6A 1KHLA 3T00A 1N2KA 1KHJA 4FDJA 1AJBA 3M8WA 1ALJA 3UN3A 2GA3A 1K7HA 1URBA 1EQJA 1KHKA 3UO0A 1O98A 3M8ZA 3MK2A 1KHNA 1KH4A 1E33P
chains in the KnotProt database with same CATH superfamily
1ELYA 1ALKA 2GLQA 1SHQA 3M8YA 3BDGB 1EW9A 2IFYA 1AJDA 1ED9A 1ZEFA 3UN5A 1ALIA 3T01A 1ED8A 1ANJA 3UNYA 2ANHA 3BDFA 1KH9A 1ZEBA 1EW2A 3T02A 1HQAA 3TWZA 1P49A 3MK0A 1EJJA 1FSUA 1KH5A 3IGYB 1Y6VA 1B8JA 1ELXA 1AJAA 1AJCA 3SZZA 1E2SP 3IGZB 1HJKA 1O99A 3BDGA 3TX0A 1ELZA 2G9YA 1E1ZP 2QZUA 1N2LA 1HDHA 1URAA 1SHNA 3DPCA 1EW8A 3NVLA 3DYCA 4FDIA 3ED4A 3MK1A 3UN2A 3SZYA 3CMRA 1ANIA 1E3CP 1ZEDA 3M7VA 3BDHA 3OT9A 1Y7AA 1AUKA 1KH7A 1EI6A 1KHLA 3T00A 1N2KA 1KHJA 4FDJA 1AJBA 3M8WA 1ALJA 3UN3A 2GA3A 1K7HA 1URBA 1EQJA 1KHKA 3UO0A 1O98A 3M8ZA 3MK2A 1KHNA 1KH4A 1E33P
chains in the KnotProt database with same CATH topology
1ELYA 1ALKA 2GLQA 1SHQA 3M8YA 3BDGB 1EW9A 2IFYA 1AJDA 1ED9A 1ZEFA 3UN5A 1ALIA 3T01A 1ED8A 1ANJA 3UNYA 2ANHA 3BDFA 1KH9A 1ZEBA 1EW2A 3T02A 1HQAA 3TWZA 1P49A 3MK0A 1EJJA 1FSUA 1KH5A 3IGYB 1Y6VA 1B8JA 1ELXA 1AJAA 1AJCA 3SZZA 1E2SP 3IGZB 1HJKA 1O99A 3BDGA 3TX0A 1ELZA 2G9YA 1E1ZP 2QZUA 1N2LA 1HDHA 1URAA 1SHNA 3DPCA 1EW8A 3NVLA 3DYCA 4FDIA 3ED4A 3MK1A 3UN2A 3SZYA 3CMRA 1ANIA 1E3CP 1ZEDA 3M7VA 3BDHA 3OT9A 1Y7AA 1AUKA 1KH7A 1EI6A 1KHLA 3T00A 1N2KA 1KHJA 4FDJA 1AJBA 3M8WA 1ALJA 3UN3A 2GA3A 1K7HA 1URBA 1EQJA 1KHKA 3UO0A 1O98A 3M8ZA 3MK2A 1KHNA 1KH4A 1E33P
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1ELY A;  1ALK A;  2GLQ A;  1SHQ A;  3M8Y A;  3BDG B;  1EW9 A;  2IFY A;  1AJD A;  1ED9 A;  1ZEF A;  3UN5 A;  1ALI A;  3T01 A;  1ED8 A;  1ANJ A;  3UNY A;  2ANH A;  3BDF A;  1KH9 A;  1ZEB A;  1EW2 A;  3T02 A;  1HQA A;  3TWZ A;  1P49 A;  3MK0 A;  1EJJ A;  1FSU A;  1KH5 A;  3IGY B;  1Y6V A;  1B8J A;  1ELX A;  1AJA A;  1AJC A;  3SZZ A;  1E2S P;  3IGZ B;  1HJK A;  1O99 A;  3BDG A;  3TX0 A;  1ELZ A;  2G9Y A;  1E1Z P;  2QZU A;  1N2L A;  1HDH A;  1URA A;  1SHN A;  3DPC A;  1EW8 A;  3NVL A;  3DYC A;  4FDI A;  3ED4 A;  3MK1 A;  3UN2 A;  3SZY A;  3CMR A;  1ANI A;  1E3C P;  1ZED A;  3M7V A;  3BDH A;  3OT9 A;  1Y7A A;  1AUK A;  1KH7 A;  1EI6 A;  1KHL A;  3T00 A;  1N2K A;  1KHJ A;  4FDJ A;  1AJB A;  3M8W A;  1ALJ A;  3UN3 A;  2GA3 A;  1K7H A;  1URB A;  1EQJ A;  1KHK A;  3UO0 A;  1O98 A;  3M8Z A;  3MK2 A;  1KHN A;  1KH4 A;  1E33 P; 
#chains in the KnotProt database with same CATH topology
 1ELY A;  1ALK A;  2GLQ A;  1SHQ A;  3M8Y A;  3BDG B;  1EW9 A;  2IFY A;  1AJD A;  1ED9 A;  1ZEF A;  3UN5 A;  1ALI A;  3T01 A;  1ED8 A;  1ANJ A;  3UNY A;  2ANH A;  3BDF A;  1KH9 A;  1ZEB A;  1EW2 A;  3T02 A;  1HQA A;  3TWZ A;  1P49 A;  3MK0 A;  1EJJ A;  1FSU A;  1KH5 A;  3IGY B;  1Y6V A;  1B8J A;  1ELX A;  1AJA A;  1AJC A;  3SZZ A;  1E2S P;  3IGZ B;  1HJK A;  1O99 A;  3BDG A;  3TX0 A;  1ELZ A;  2G9Y A;  1E1Z P;  2QZU A;  1N2L A;  1HDH A;  1URA A;  1SHN A;  3DPC A;  1EW8 A;  3NVL A;  3DYC A;  4FDI A;  3ED4 A;  3MK1 A;  3UN2 A;  3SZY A;  3CMR A;  1ANI A;  1E3C P;  1ZED A;  3M7V A;  3BDH A;  3OT9 A;  1Y7A A;  1AUK A;  1KH7 A;  1EI6 A;  1KHL A;  3T00 A;  1N2K A;  1KHJ A;  4FDJ A;  1AJB A;  3M8W A;  1ALJ A;  3UN3 A;  2GA3 A;  1K7H A;  1URB A;  1EQJ A;  1KHK A;  3UO0 A;  1O98 A;  3M8Z A;  3MK2 A;  1KHN A;  1KH4 A;  1E33 P; 
#chains in the KnotProt database with same CATH homology
 1ELY A;  1ALK A;  2GLQ A;  1SHQ A;  3M8Y A;  3BDG B;  1EW9 A;  2IFY A;  1AJD A;  1ED9 A;  1ZEF A;  3UN5 A;  1ALI A;  3T01 A;  1ED8 A;  1ANJ A;  3UNY A;  2ANH A;  3BDF A;  1KH9 A;  1ZEB A;  1EW2 A;  3T02 A;  1HQA A;  3TWZ A;  1P49 A;  3MK0 A;  1EJJ A;  1FSU A;  1KH5 A;  3IGY B;  1Y6V A;  1B8J A;  1ELX A;  1AJA A;  1AJC A;  3SZZ A;  1E2S P;  3IGZ B;  1HJK A;  1O99 A;  3BDG A;  3TX0 A;  1ELZ A;  2G9Y A;  1E1Z P;  2QZU A;  1N2L A;  1HDH A;  1URA A;  1SHN A;  3DPC A;  1EW8 A;  3NVL A;  3DYC A;  4FDI A;  3ED4 A;  3MK1 A;  3UN2 A;  3SZY A;  3CMR A;  1ANI A;  1E3C P;  1ZED A;  3M7V A;  3BDH A;  3OT9 A;  1Y7A A;  1AUK A;  1KH7 A;  1EI6 A;  1KHL A;  3T00 A;  1N2K A;  1KHJ A;  4FDJ A;  1AJB A;  3M8W A;  1ALJ A;  3UN3 A;  2GA3 A;  1K7H A;  1URB A;  1EQJ A;  1KHK A;  3UO0 A;  1O98 A;  3M8Z A;  3MK2 A;  1KHN A;  1KH4 A;  1E33 P; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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