1ZEFA

Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 40-355 316 1-39 440-481 356-439 39 42 slipknot
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 35-355 321 1-34 362-481 356-361 34 120 slipknot
view details
3.1 39-358 320 1-38 437-481 359-436 38 45 slipknot
view details
2.1 36-436 401 1-35 441-481 437-440 35 41 slipknot
view details
2.1 40-404 365 1-38, 413-481 39-39, 405-412 38 69 slipknot
view details
2.1 41-403 363 1-39, 413-481 40-40, 404-412 39 69 slipknot
sequence length 481
structure length 481
publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus Genus: 176
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zefA00
1E3CP 1ED9A 1HDHA 1Y7AA 2QZUA 3DPCA 3SZZA 3M8WA 1URAA 3T01A 1Y6VA 1ZEDA 1B8JA 1O98A 3BDGB 3BDFA 2ANHA 1KH7A 1K7HA 1ALIA 3BDGA 3UN3A 3MK0A 1AJAA 1EW8A 3IGYB 1AJCA 1E1ZP 1N2KA 1E33P 1AUKA 1ALJA 1ELZA 3M8ZA 1KH4A 1ZEFA 1URBA 1EI6A 3UNYA 1ANJA 4FDJA 1P49A 1EQJA 3NVLA 3UN5A 3UN2A 1AJBA 3ED4A 1ANIA 1EW9A 1EJJA 3T02A 1KHKA 4FDIA 1SHNA 2IFYA 1ALKA 3OT9A 2G9YA 3SZYA 1N2LA 3DYCA 3M8YA 3UO0A 3TX0A 1ELXA 3M7VA 3BDHA 1ED8A 1KHLA 1O99A 1FSUA 1HJKA 3IGZB 1KHJA 3MK1A 1KH5A 1HQAA 1EW2A 1KHNA 2GA3A 3T00A 2GLQA 1E2SP 1KH9A 1SHQA 3TWZA 3CMRA 3MK2A 1ZEBA 1ELYA 1AJDA
chains in the KnotProt database with same CATH superfamily
1E3CP 1ED9A 1HDHA 1Y7AA 2QZUA 3DPCA 3SZZA 3M8WA 1URAA 3T01A 1Y6VA 1ZEDA 1B8JA 1O98A 3BDGB 3BDFA 2ANHA 1KH7A 1K7HA 1ALIA 3BDGA 3UN3A 3MK0A 1AJAA 1EW8A 3IGYB 1AJCA 1E1ZP 1N2KA 1E33P 1AUKA 1ALJA 1ELZA 3M8ZA 1KH4A 1ZEFA 1URBA 1EI6A 3UNYA 1ANJA 4FDJA 1P49A 1EQJA 3NVLA 3UN5A 3UN2A 1AJBA 3ED4A 1ANIA 1EW9A 1EJJA 3T02A 1KHKA 4FDIA 1SHNA 2IFYA 1ALKA 3OT9A 2G9YA 3SZYA 1N2LA 3DYCA 3M8YA 3UO0A 3TX0A 1ELXA 3M7VA 3BDHA 1ED8A 1KHLA 1O99A 1FSUA 1HJKA 3IGZB 1KHJA 3MK1A 1KH5A 1HQAA 1EW2A 1KHNA 2GA3A 3T00A 2GLQA 1E2SP 1KH9A 1SHQA 3TWZA 3CMRA 3MK2A 1ZEBA 1ELYA 1AJDA
chains in the KnotProt database with same CATH topology
1E3CP 1ED9A 1HDHA 1Y7AA 2QZUA 3DPCA 3SZZA 3M8WA 1URAA 3T01A 1Y6VA 1ZEDA 1B8JA 1O98A 3BDGB 3BDFA 2ANHA 1KH7A 1K7HA 1ALIA 3BDGA 3UN3A 3MK0A 1AJAA 1EW8A 3IGYB 1AJCA 1E1ZP 1N2KA 1E33P 1AUKA 1ALJA 1ELZA 3M8ZA 1KH4A 1ZEFA 1URBA 1EI6A 3UNYA 1ANJA 4FDJA 1P49A 1EQJA 3NVLA 3UN5A 3UN2A 1AJBA 3ED4A 1ANIA 1EW9A 1EJJA 3T02A 1KHKA 4FDIA 1SHNA 2IFYA 1ALKA 3OT9A 2G9YA 3SZYA 1N2LA 3DYCA 3M8YA 3UO0A 3TX0A 1ELXA 3M7VA 3BDHA 1ED8A 1KHLA 1O99A 1FSUA 1HJKA 3IGZB 1KHJA 3MK1A 1KH5A 1HQAA 1EW2A 1KHNA 2GA3A 3T00A 2GLQA 1E2SP 1KH9A 1SHQA 3TWZA 3CMRA 3MK2A 1ZEBA 1ELYA 1AJDA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1E3C P;  1ED9 A;  1HDH A;  1Y7A A;  2QZU A;  3DPC A;  3SZZ A;  3M8W A;  1URA A;  3T01 A;  1Y6V A;  1ZED A;  1B8J A;  1O98 A;  3BDG B;  3BDF A;  2ANH A;  1KH7 A;  1K7H A;  1ALI A;  3BDG A;  3UN3 A;  3MK0 A;  1AJA A;  1EW8 A;  3IGY B;  1AJC A;  1E1Z P;  1N2K A;  1E33 P;  1AUK A;  1ALJ A;  1ELZ A;  3M8Z A;  1KH4 A;  1ZEF A;  1URB A;  1EI6 A;  3UNY A;  1ANJ A;  4FDJ A;  1P49 A;  1EQJ A;  3NVL A;  3UN5 A;  3UN2 A;  1AJB A;  3ED4 A;  1ANI A;  1EW9 A;  1EJJ A;  3T02 A;  1KHK A;  4FDI A;  1SHN A;  2IFY A;  1ALK A;  3OT9 A;  2G9Y A;  3SZY A;  1N2L A;  3DYC A;  3M8Y A;  3UO0 A;  3TX0 A;  1ELX A;  3M7V A;  3BDH A;  1ED8 A;  1KHL A;  1O99 A;  1FSU A;  1HJK A;  3IGZ B;  1KHJ A;  3MK1 A;  1KH5 A;  1HQA A;  1EW2 A;  1KHN A;  2GA3 A;  3T00 A;  2GLQ A;  1E2S P;  1KH9 A;  1SHQ A;  3TWZ A;  3CMR A;  3MK2 A;  1ZEB A;  1ELY A;  1AJD A; 
#chains in the KnotProt database with same CATH topology
 1E3C P;  1ED9 A;  1HDH A;  1Y7A A;  2QZU A;  3DPC A;  3SZZ A;  3M8W A;  1URA A;  3T01 A;  1Y6V A;  1ZED A;  1B8J A;  1O98 A;  3BDG B;  3BDF A;  2ANH A;  1KH7 A;  1K7H A;  1ALI A;  3BDG A;  3UN3 A;  3MK0 A;  1AJA A;  1EW8 A;  3IGY B;  1AJC A;  1E1Z P;  1N2K A;  1E33 P;  1AUK A;  1ALJ A;  1ELZ A;  3M8Z A;  1KH4 A;  1ZEF A;  1URB A;  1EI6 A;  3UNY A;  1ANJ A;  4FDJ A;  1P49 A;  1EQJ A;  3NVL A;  3UN5 A;  3UN2 A;  1AJB A;  3ED4 A;  1ANI A;  1EW9 A;  1EJJ A;  3T02 A;  1KHK A;  4FDI A;  1SHN A;  2IFY A;  1ALK A;  3OT9 A;  2G9Y A;  3SZY A;  1N2L A;  3DYC A;  3M8Y A;  3UO0 A;  3TX0 A;  1ELX A;  3M7V A;  3BDH A;  1ED8 A;  1KHL A;  1O99 A;  1FSU A;  1HJK A;  3IGZ B;  1KHJ A;  3MK1 A;  1KH5 A;  1HQA A;  1EW2 A;  1KHN A;  2GA3 A;  3T00 A;  2GLQ A;  1E2S P;  1KH9 A;  1SHQ A;  3TWZ A;  3CMR A;  3MK2 A;  1ZEB A;  1ELY A;  1AJD A; 
#chains in the KnotProt database with same CATH homology
 1E3C P;  1ED9 A;  1HDH A;  1Y7A A;  2QZU A;  3DPC A;  3SZZ A;  3M8W A;  1URA A;  3T01 A;  1Y6V A;  1ZED A;  1B8J A;  1O98 A;  3BDG B;  3BDF A;  2ANH A;  1KH7 A;  1K7H A;  1ALI A;  3BDG A;  3UN3 A;  3MK0 A;  1AJA A;  1EW8 A;  3IGY B;  1AJC A;  1E1Z P;  1N2K A;  1E33 P;  1AUK A;  1ALJ A;  1ELZ A;  3M8Z A;  1KH4 A;  1ZEF A;  1URB A;  1EI6 A;  3UNY A;  1ANJ A;  4FDJ A;  1P49 A;  1EQJ A;  3NVL A;  3UN5 A;  3UN2 A;  1AJB A;  3ED4 A;  1ANI A;  1EW9 A;  1EJJ A;  3T02 A;  1KHK A;  4FDI A;  1SHN A;  2IFY A;  1ALK A;  3OT9 A;  2G9Y A;  3SZY A;  1N2L A;  3DYC A;  3M8Y A;  3UO0 A;  3TX0 A;  1ELX A;  3M7V A;  3BDH A;  1ED8 A;  1KHL A;  1O99 A;  1FSU A;  1HJK A;  3IGZ B;  1KHJ A;  3MK1 A;  1KH5 A;  1HQA A;  1EW2 A;  1KHN A;  2GA3 A;  3T00 A;  2GLQ A;  1E2S P;  1KH9 A;  1SHQ A;  3TWZ A;  3CMR A;  3MK2 A;  1ZEB A;  1ELY A;  1AJD A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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