1ZEFA

Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 40-355 316 1-39 440-481 356-439 39 42 slipknot
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 35-355 321 1-34 362-481 356-361 34 120 slipknot
view details
3.1 39-358 320 1-38 437-481 359-436 38 45 slipknot
view details
2.1 36-436 401 1-35 441-481 437-440 35 41 slipknot
view details
2.1 40-404 365 1-38, 413-481 39-39, 405-412 38 69 slipknot
view details
2.1 41-403 363 1-39, 413-481 40-40, 404-412 39 69 slipknot
sequence length 481
structure length 481
publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus Genus: 176
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zefA00
1P49A 1ELXA 3TWZA 1ED8A 3T02A 1Y7AA 2G9YA 3ED4A 4FDIA 3DYCA 1EW9A 1HDHA 2IFYA 3BDFA 1ELZA 3M8ZA 1HQAA 1O99A 1AJCA 1ANJA 3MK2A 3UN2A 3M8YA 1ZEBA 2GLQA 4FDJA 1ED9A 3UN5A 1E33P 1FSUA 3UO0A 3DPCA 3NVLA 1KH4A 1URAA 1ZEDA 1KHKA 2ANHA 3BDHA 1O98A 1AJDA 1K7HA 2QZUA 3T00A 1ANIA 1SHQA 1ALKA 1ZEFA 3UNYA 3IGZB 3OT9A 1KH9A 1KHJA 1KH5A 1KHNA 1E2SP 1EI6A 3BDGA 1E1ZP 1EW8A 3TX0A 3IGYB 3CMRA 2GA3A 1AJAA 1EQJA 1AJBA 1ALIA 1KH7A 1AUKA 1ALHA 1ELYA 1HJKA 1SHNA 3M8WA 1B8JA 1URBA 1Y6VA 3SZZA 3UN3A 3T01A 1N2KA 3SZYA 3MK1A 1EJJA 1ALJA 3MK0A 3M7VA 3BDGB 1KHLA 1E3CP 1EW2A 1N2LA
chains in the KnotProt database with same CATH superfamily
1P49A 1ELXA 3TWZA 1ED8A 3T02A 1Y7AA 2G9YA 3ED4A 4FDIA 3DYCA 1EW9A 1HDHA 2IFYA 3BDFA 1ELZA 3M8ZA 1HQAA 1O99A 1AJCA 1ANJA 3MK2A 3UN2A 3M8YA 1ZEBA 2GLQA 4FDJA 1ED9A 3UN5A 1E33P 1FSUA 3UO0A 3DPCA 3NVLA 1KH4A 1URAA 1ZEDA 1KHKA 2ANHA 3BDHA 1O98A 1AJDA 1K7HA 2QZUA 3T00A 1ANIA 1SHQA 1ALKA 1ZEFA 3UNYA 3IGZB 3OT9A 1KH9A 1KHJA 1KH5A 1KHNA 1E2SP 1EI6A 3BDGA 1E1ZP 1EW8A 3TX0A 3IGYB 3CMRA 2GA3A 1AJAA 1EQJA 1AJBA 1ALIA 1KH7A 1AUKA 1ALHA 1ELYA 1HJKA 1SHNA 3M8WA 1B8JA 1URBA 1Y6VA 3SZZA 3UN3A 3T01A 1N2KA 3SZYA 3MK1A 1EJJA 1ALJA 3MK0A 3M7VA 3BDGB 1KHLA 1E3CP 1EW2A 1N2LA
chains in the KnotProt database with same CATH topology
1P49A 1ELXA 3TWZA 1ED8A 3T02A 1Y7AA 2G9YA 3ED4A 4FDIA 3DYCA 1EW9A 1HDHA 2IFYA 3BDFA 1ELZA 3M8ZA 1HQAA 1O99A 1AJCA 1ANJA 3MK2A 3UN2A 3M8YA 1ZEBA 2GLQA 4FDJA 1ED9A 3UN5A 1E33P 1FSUA 3UO0A 3DPCA 3NVLA 1KH4A 1URAA 1ZEDA 1KHKA 2ANHA 3BDHA 1O98A 1AJDA 1K7HA 2QZUA 3T00A 1ANIA 1SHQA 1ALKA 1ZEFA 3UNYA 3IGZB 3OT9A 1KH9A 1KHJA 1KH5A 1KHNA 1E2SP 1EI6A 3BDGA 1E1ZP 1EW8A 3TX0A 3IGYB 3CMRA 2GA3A 1AJAA 1EQJA 1AJBA 1ALIA 1KH7A 1AUKA 1ALHA 1ELYA 1HJKA 1SHNA 3M8WA 1B8JA 1URBA 1Y6VA 3SZZA 3UN3A 3T01A 1N2KA 3SZYA 3MK1A 1EJJA 1ALJA 3MK0A 3M7VA 3BDGB 1KHLA 1E3CP 1EW2A 1N2LA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1P49 A;  1ELX A;  3TWZ A;  1ED8 A;  3T02 A;  1Y7A A;  2G9Y A;  3ED4 A;  4FDI A;  3DYC A;  1EW9 A;  1HDH A;  2IFY A;  3BDF A;  1ELZ A;  3M8Z A;  1HQA A;  1O99 A;  1AJC A;  1ANJ A;  3MK2 A;  3UN2 A;  3M8Y A;  1ZEB A;  2GLQ A;  4FDJ A;  1ED9 A;  3UN5 A;  1E33 P;  1FSU A;  3UO0 A;  3DPC A;  3NVL A;  1KH4 A;  1URA A;  1ZED A;  1KHK A;  2ANH A;  3BDH A;  1O98 A;  1AJD A;  1K7H A;  2QZU A;  3T00 A;  1ANI A;  1SHQ A;  1ALK A;  1ZEF A;  3UNY A;  3IGZ B;  3OT9 A;  1KH9 A;  1KHJ A;  1KH5 A;  1KHN A;  1E2S P;  1EI6 A;  3BDG A;  1E1Z P;  1EW8 A;  3TX0 A;  3IGY B;  3CMR A;  2GA3 A;  1AJA A;  1EQJ A;  1AJB A;  1ALI A;  1KH7 A;  1AUK A;  1ALH A;  1ELY A;  1HJK A;  1SHN A;  3M8W A;  1B8J A;  1URB A;  1Y6V A;  3SZZ A;  3UN3 A;  3T01 A;  1N2K A;  3SZY A;  3MK1 A;  1EJJ A;  1ALJ A;  3MK0 A;  3M7V A;  3BDG B;  1KHL A;  1E3C P;  1EW2 A;  1N2L A; 
#chains in the KnotProt database with same CATH topology
 1P49 A;  1ELX A;  3TWZ A;  1ED8 A;  3T02 A;  1Y7A A;  2G9Y A;  3ED4 A;  4FDI A;  3DYC A;  1EW9 A;  1HDH A;  2IFY A;  3BDF A;  1ELZ A;  3M8Z A;  1HQA A;  1O99 A;  1AJC A;  1ANJ A;  3MK2 A;  3UN2 A;  3M8Y A;  1ZEB A;  2GLQ A;  4FDJ A;  1ED9 A;  3UN5 A;  1E33 P;  1FSU A;  3UO0 A;  3DPC A;  3NVL A;  1KH4 A;  1URA A;  1ZED A;  1KHK A;  2ANH A;  3BDH A;  1O98 A;  1AJD A;  1K7H A;  2QZU A;  3T00 A;  1ANI A;  1SHQ A;  1ALK A;  1ZEF A;  3UNY A;  3IGZ B;  3OT9 A;  1KH9 A;  1KHJ A;  1KH5 A;  1KHN A;  1E2S P;  1EI6 A;  3BDG A;  1E1Z P;  1EW8 A;  3TX0 A;  3IGY B;  3CMR A;  2GA3 A;  1AJA A;  1EQJ A;  1AJB A;  1ALI A;  1KH7 A;  1AUK A;  1ALH A;  1ELY A;  1HJK A;  1SHN A;  3M8W A;  1B8J A;  1URB A;  1Y6V A;  3SZZ A;  3UN3 A;  3T01 A;  1N2K A;  3SZY A;  3MK1 A;  1EJJ A;  1ALJ A;  3MK0 A;  3M7V A;  3BDG B;  1KHL A;  1E3C P;  1EW2 A;  1N2L A; 
#chains in the KnotProt database with same CATH homology
 1P49 A;  1ELX A;  3TWZ A;  1ED8 A;  3T02 A;  1Y7A A;  2G9Y A;  3ED4 A;  4FDI A;  3DYC A;  1EW9 A;  1HDH A;  2IFY A;  3BDF A;  1ELZ A;  3M8Z A;  1HQA A;  1O99 A;  1AJC A;  1ANJ A;  3MK2 A;  3UN2 A;  3M8Y A;  1ZEB A;  2GLQ A;  4FDJ A;  1ED9 A;  3UN5 A;  1E33 P;  1FSU A;  3UO0 A;  3DPC A;  3NVL A;  1KH4 A;  1URA A;  1ZED A;  1KHK A;  2ANH A;  3BDH A;  1O98 A;  1AJD A;  1K7H A;  2QZU A;  3T00 A;  1ANI A;  1SHQ A;  1ALK A;  1ZEF A;  3UNY A;  3IGZ B;  3OT9 A;  1KH9 A;  1KHJ A;  1KH5 A;  1KHN A;  1E2S P;  1EI6 A;  3BDG A;  1E1Z P;  1EW8 A;  3TX0 A;  3IGY B;  3CMR A;  2GA3 A;  1AJA A;  1EQJ A;  1AJB A;  1ALI A;  1KH7 A;  1AUK A;  1ALH A;  1ELY A;  1HJK A;  1SHN A;  3M8W A;  1B8J A;  1URB A;  1Y6V A;  3SZZ A;  3UN3 A;  3T01 A;  1N2K A;  3SZY A;  3MK1 A;  1EJJ A;  1ALJ A;  3MK0 A;  3M7V A;  3BDG B;  1KHL A;  1E3C P;  1EW2 A;  1N2L A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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