1ZEFA

Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 40-355 316 1-39 440-481 356-439 39 42 slipknot
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 35-355 321 1-34 362-481 356-361 34 120 slipknot
view details
3.1 39-358 320 1-38 437-481 359-436 38 45 slipknot
view details
2.1 36-436 401 1-35 441-481 437-440 35 41 slipknot
view details
2.1 40-404 365 1-38, 413-481 39-39, 405-412 38 69 slipknot
view details
2.1 41-403 363 1-39, 413-481 40-40, 404-412 39 69 slipknot
sequence length 481
structure length 481
publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus Genus: 176
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zefA00
1E1ZP 3DPCA 2G9YA 3UN2A 1P49A 3BDHA 3CMRA 3BDGB 2ANHA 3OT9A 1KH7A 3ED4A 1AJCA 1EW8A 2GA3A 3SZZA 1ED9A 2QZUA 3SZYA 1ALIA 1ALJA 1KHLA 1ANJA 3BDFA 1N2KA 3MK2A 1AJDA 1KH9A 1FSUA 3TX0A 1ELXA 1KH5A 1AJBA 1SHQA 1KHKA 3T00A 1E33P 1SHNA 1ZEBA 3BDGA 1Y6VA 1EW9A 1EI6A 1HJKA 1URBA 3TWZA 1E2SP 1ED8A 1ALHA 1AJAA 3MK1A 2IFYA 1ELYA 1HDHA 1EQJA 1ANIA 1ELZA 1AUKA 3M8ZA 1B8JA 3UNYA 1ALKA 3DYCA 3UO0A 1O99A 1N2LA 1KHNA 3NVLA 1E3CP 1HQAA 4FDJA 3T01A 3UN5A 1EJJA 1EW2A 1ZEDA 3T02A 3IGYB 1O98A 1URAA 3M8YA 1KH4A 3UN3A 3M7VA 3M8WA 2GLQA 3IGZB 4FDIA 1K7HA 1ZEFA 1KHJA 1Y7AA 3MK0A
chains in the KnotProt database with same CATH superfamily
1E1ZP 3DPCA 2G9YA 3UN2A 1P49A 3BDHA 3CMRA 3BDGB 2ANHA 3OT9A 1KH7A 3ED4A 1AJCA 1EW8A 2GA3A 3SZZA 1ED9A 2QZUA 3SZYA 1ALIA 1ALJA 1KHLA 1ANJA 3BDFA 1N2KA 3MK2A 1AJDA 1KH9A 1FSUA 3TX0A 1ELXA 1KH5A 1AJBA 1SHQA 1KHKA 3T00A 1E33P 1SHNA 1ZEBA 3BDGA 1Y6VA 1EW9A 1EI6A 1HJKA 1URBA 3TWZA 1E2SP 1ED8A 1ALHA 1AJAA 3MK1A 2IFYA 1ELYA 1HDHA 1EQJA 1ANIA 1ELZA 1AUKA 3M8ZA 1B8JA 3UNYA 1ALKA 3DYCA 3UO0A 1O99A 1N2LA 1KHNA 3NVLA 1E3CP 1HQAA 4FDJA 3T01A 3UN5A 1EJJA 1EW2A 1ZEDA 3T02A 3IGYB 1O98A 1URAA 3M8YA 1KH4A 3UN3A 3M7VA 3M8WA 2GLQA 3IGZB 4FDIA 1K7HA 1ZEFA 1KHJA 1Y7AA 3MK0A
chains in the KnotProt database with same CATH topology
1E1ZP 3DPCA 2G9YA 3UN2A 1P49A 3BDHA 3CMRA 3BDGB 2ANHA 3OT9A 1KH7A 3ED4A 1AJCA 1EW8A 2GA3A 3SZZA 1ED9A 2QZUA 3SZYA 1ALIA 1ALJA 1KHLA 1ANJA 3BDFA 1N2KA 3MK2A 1AJDA 1KH9A 1FSUA 3TX0A 1ELXA 1KH5A 1AJBA 1SHQA 1KHKA 3T00A 1E33P 1SHNA 1ZEBA 3BDGA 1Y6VA 1EW9A 1EI6A 1HJKA 1URBA 3TWZA 1E2SP 1ED8A 1ALHA 1AJAA 3MK1A 2IFYA 1ELYA 1HDHA 1EQJA 1ANIA 1ELZA 1AUKA 3M8ZA 1B8JA 3UNYA 1ALKA 3DYCA 3UO0A 1O99A 1N2LA 1KHNA 3NVLA 1E3CP 1HQAA 4FDJA 3T01A 3UN5A 1EJJA 1EW2A 1ZEDA 3T02A 3IGYB 1O98A 1URAA 3M8YA 1KH4A 3UN3A 3M7VA 3M8WA 2GLQA 3IGZB 4FDIA 1K7HA 1ZEFA 1KHJA 1Y7AA 3MK0A
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1E1Z P;  3DPC A;  2G9Y A;  3UN2 A;  1P49 A;  3BDH A;  3CMR A;  3BDG B;  2ANH A;  3OT9 A;  1KH7 A;  3ED4 A;  1AJC A;  1EW8 A;  2GA3 A;  3SZZ A;  1ED9 A;  2QZU A;  3SZY A;  1ALI A;  1ALJ A;  1KHL A;  1ANJ A;  3BDF A;  1N2K A;  3MK2 A;  1AJD A;  1KH9 A;  1FSU A;  3TX0 A;  1ELX A;  1KH5 A;  1AJB A;  1SHQ A;  1KHK A;  3T00 A;  1E33 P;  1SHN A;  1ZEB A;  3BDG A;  1Y6V A;  1EW9 A;  1EI6 A;  1HJK A;  1URB A;  3TWZ A;  1E2S P;  1ED8 A;  1ALH A;  1AJA A;  3MK1 A;  2IFY A;  1ELY A;  1HDH A;  1EQJ A;  1ANI A;  1ELZ A;  1AUK A;  3M8Z A;  1B8J A;  3UNY A;  1ALK A;  3DYC A;  3UO0 A;  1O99 A;  1N2L A;  1KHN A;  3NVL A;  1E3C P;  1HQA A;  4FDJ A;  3T01 A;  3UN5 A;  1EJJ A;  1EW2 A;  1ZED A;  3T02 A;  3IGY B;  1O98 A;  1URA A;  3M8Y A;  1KH4 A;  3UN3 A;  3M7V A;  3M8W A;  2GLQ A;  3IGZ B;  4FDI A;  1K7H A;  1ZEF A;  1KHJ A;  1Y7A A;  3MK0 A; 
#chains in the KnotProt database with same CATH topology
 1E1Z P;  3DPC A;  2G9Y A;  3UN2 A;  1P49 A;  3BDH A;  3CMR A;  3BDG B;  2ANH A;  3OT9 A;  1KH7 A;  3ED4 A;  1AJC A;  1EW8 A;  2GA3 A;  3SZZ A;  1ED9 A;  2QZU A;  3SZY A;  1ALI A;  1ALJ A;  1KHL A;  1ANJ A;  3BDF A;  1N2K A;  3MK2 A;  1AJD A;  1KH9 A;  1FSU A;  3TX0 A;  1ELX A;  1KH5 A;  1AJB A;  1SHQ A;  1KHK A;  3T00 A;  1E33 P;  1SHN A;  1ZEB A;  3BDG A;  1Y6V A;  1EW9 A;  1EI6 A;  1HJK A;  1URB A;  3TWZ A;  1E2S P;  1ED8 A;  1ALH A;  1AJA A;  3MK1 A;  2IFY A;  1ELY A;  1HDH A;  1EQJ A;  1ANI A;  1ELZ A;  1AUK A;  3M8Z A;  1B8J A;  3UNY A;  1ALK A;  3DYC A;  3UO0 A;  1O99 A;  1N2L A;  1KHN A;  3NVL A;  1E3C P;  1HQA A;  4FDJ A;  3T01 A;  3UN5 A;  1EJJ A;  1EW2 A;  1ZED A;  3T02 A;  3IGY B;  1O98 A;  1URA A;  3M8Y A;  1KH4 A;  3UN3 A;  3M7V A;  3M8W A;  2GLQ A;  3IGZ B;  4FDI A;  1K7H A;  1ZEF A;  1KHJ A;  1Y7A A;  3MK0 A; 
#chains in the KnotProt database with same CATH homology
 1E1Z P;  3DPC A;  2G9Y A;  3UN2 A;  1P49 A;  3BDH A;  3CMR A;  3BDG B;  2ANH A;  3OT9 A;  1KH7 A;  3ED4 A;  1AJC A;  1EW8 A;  2GA3 A;  3SZZ A;  1ED9 A;  2QZU A;  3SZY A;  1ALI A;  1ALJ A;  1KHL A;  1ANJ A;  3BDF A;  1N2K A;  3MK2 A;  1AJD A;  1KH9 A;  1FSU A;  3TX0 A;  1ELX A;  1KH5 A;  1AJB A;  1SHQ A;  1KHK A;  3T00 A;  1E33 P;  1SHN A;  1ZEB A;  3BDG A;  1Y6V A;  1EW9 A;  1EI6 A;  1HJK A;  1URB A;  3TWZ A;  1E2S P;  1ED8 A;  1ALH A;  1AJA A;  3MK1 A;  2IFY A;  1ELY A;  1HDH A;  1EQJ A;  1ANI A;  1ELZ A;  1AUK A;  3M8Z A;  1B8J A;  3UNY A;  1ALK A;  3DYC A;  3UO0 A;  1O99 A;  1N2L A;  1KHN A;  3NVL A;  1E3C P;  1HQA A;  4FDJ A;  3T01 A;  3UN5 A;  1EJJ A;  1EW2 A;  1ZED A;  3T02 A;  3IGY B;  1O98 A;  1URA A;  3M8Y A;  1KH4 A;  3UN3 A;  3M7V A;  3M8W A;  2GLQ A;  3IGZ B;  4FDI A;  1K7H A;  1ZEF A;  1KHJ A;  1Y7A A;  3MK0 A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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