1KH7A

E. coli alkaline phosphatase mutant (d153gd330n)
Genus: 151
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 41-363 323 1-40 414-444 364-413 40 31 slipknot
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSKTSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 39-362 324 1-38 370-444 363-369 38 75 slipknot
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3.1 44-365 322 1-43 383-444 366-382 43 62 slipknot
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3.1 44-382 339 1-43 407-444 383-406 43 38 slipknot
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3.1 44-406 363 1-43 412-444 407-411 43 33 slipknot
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2.1 39-411 373 1-38 416-444 412-415 38 29 slipknot
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2.1 40-411 372 1-38, 414-444 39-39, 412-413 38 31 slipknot
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
structure length 444
molecule tags Hydrolase
source organism Escherichia coli
sequence length 444
total genus Genus: 151
molecule keywords alkaline phosphatase
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29
KnotProt deposition date 2014-07-31
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh7A00
1EW8A 1ZEDA 1KHLA 1ED9A 4FDJA 1ANIA 2QZUA 1EI6A 1EW2A 3UNYA 3MK0A 1KHKA 3BDFA 1HDHA 1ALKA 3NVLA 1O98A 1Y7AA 1KH5A 3UN2A 1E33P 3OT9A 2ANHA 1AJBA 1N2KA 3UN5A 3T01A 1E1ZP 3M7VA 2GA3A 3M8ZA 1N2LA 3SZZA 3TWZA 1ANJA 3M8WA 1FSUA 1ALHA 1EQJA 3MK2A 1ZEFA 3UN3A 1URAA 1AJCA 3CMRA 1ELXA 2G9YA 1K7HA 1Y6VA 3IGZB 3TX0A 3UO0A 3SZYA 2GLQA 1AUKA 1ZEBA 1KHNA 1B8JA 3T02A 4FDIA 1EJJA 3DYCA 1HJKA 1ALIA 1EW9A 1ED8A 1HQAA 1KH7A 1P49A 3DPCA 3ED4A 3T00A 1URBA 1AJDA 3IGYB 3MK1A 1ELYA 1KHJA 3BDGA 1E3CP 1ALJA 1O99A 1KH4A 1E2SP 3BDHA 1SHQA 1SHNA 1AJAA 1ELZA 2IFYA 3M8YA 1KH9A 3BDGB
chains in the KnotProt database with same CATH superfamily
1EW8A 1ZEDA 1KHLA 1ED9A 4FDJA 1ANIA 2QZUA 1EI6A 1EW2A 3UNYA 3MK0A 1KHKA 3BDFA 1HDHA 1ALKA 3NVLA 1O98A 1Y7AA 1KH5A 3UN2A 1E33P 3OT9A 2ANHA 1AJBA 1N2KA 3UN5A 3T01A 1E1ZP 3M7VA 2GA3A 3M8ZA 1N2LA 3SZZA 3TWZA 1ANJA 3M8WA 1FSUA 1ALHA 1EQJA 3MK2A 1ZEFA 3UN3A 1URAA 1AJCA 3CMRA 1ELXA 2G9YA 1K7HA 1Y6VA 3IGZB 3TX0A 3UO0A 3SZYA 2GLQA 1AUKA 1ZEBA 1KHNA 1B8JA 3T02A 4FDIA 1EJJA 3DYCA 1HJKA 1ALIA 1EW9A 1ED8A 1HQAA 1KH7A 1P49A 3DPCA 3ED4A 3T00A 1URBA 1AJDA 3IGYB 3MK1A 1ELYA 1KHJA 3BDGA 1E3CP 1ALJA 1O99A 1KH4A 1E2SP 3BDHA 1SHQA 1SHNA 1AJAA 1ELZA 2IFYA 3M8YA 1KH9A 3BDGB
chains in the KnotProt database with same CATH topology
1EW8A 1ZEDA 1KHLA 1ED9A 4FDJA 1ANIA 2QZUA 1EI6A 1EW2A 3UNYA 3MK0A 1KHKA 3BDFA 1HDHA 1ALKA 3NVLA 1O98A 1Y7AA 1KH5A 3UN2A 1E33P 3OT9A 2ANHA 1AJBA 1N2KA 3UN5A 3T01A 1E1ZP 3M7VA 2GA3A 3M8ZA 1N2LA 3SZZA 3TWZA 1ANJA 3M8WA 1FSUA 1ALHA 1EQJA 3MK2A 1ZEFA 3UN3A 1URAA 1AJCA 3CMRA 1ELXA 2G9YA 1K7HA 1Y6VA 3IGZB 3TX0A 3UO0A 3SZYA 2GLQA 1AUKA 1ZEBA 1KHNA 1B8JA 3T02A 4FDIA 1EJJA 3DYCA 1HJKA 1ALIA 1EW9A 1ED8A 1HQAA 1KH7A 1P49A 3DPCA 3ED4A 3T00A 1URBA 1AJDA 3IGYB 3MK1A 1ELYA 1KHJA 3BDGA 1E3CP 1ALJA 1O99A 1KH4A 1E2SP 3BDHA 1SHQA 1SHNA 1AJAA 1ELZA 2IFYA 3M8YA 1KH9A 3BDGB
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1EW8 A;  1ZED A;  1KHL A;  1ED9 A;  4FDJ A;  1ANI A;  2QZU A;  1EI6 A;  1EW2 A;  3UNY A;  3MK0 A;  1KHK A;  3BDF A;  1HDH A;  1ALK A;  3NVL A;  1O98 A;  1Y7A A;  1KH5 A;  3UN2 A;  1E33 P;  3OT9 A;  2ANH A;  1AJB A;  1N2K A;  3UN5 A;  3T01 A;  1E1Z P;  3M7V A;  2GA3 A;  3M8Z A;  1N2L A;  3SZZ A;  3TWZ A;  1ANJ A;  3M8W A;  1FSU A;  1ALH A;  1EQJ A;  3MK2 A;  1ZEF A;  3UN3 A;  1URA A;  1AJC A;  3CMR A;  1ELX A;  2G9Y A;  1K7H A;  1Y6V A;  3IGZ B;  3TX0 A;  3UO0 A;  3SZY A;  2GLQ A;  1AUK A;  1ZEB A;  1KHN A;  1B8J A;  3T02 A;  4FDI A;  1EJJ A;  3DYC A;  1HJK A;  1ALI A;  1EW9 A;  1ED8 A;  1HQA A;  1KH7 A;  1P49 A;  3DPC A;  3ED4 A;  3T00 A;  1URB A;  1AJD A;  3IGY B;  3MK1 A;  1ELY A;  1KHJ A;  3BDG A;  1E3C P;  1ALJ A;  1O99 A;  1KH4 A;  1E2S P;  3BDH A;  1SHQ A;  1SHN A;  1AJA A;  1ELZ A;  2IFY A;  3M8Y A;  1KH9 A;  3BDG B; 
#chains in the KnotProt database with same CATH topology
 1EW8 A;  1ZED A;  1KHL A;  1ED9 A;  4FDJ A;  1ANI A;  2QZU A;  1EI6 A;  1EW2 A;  3UNY A;  3MK0 A;  1KHK A;  3BDF A;  1HDH A;  1ALK A;  3NVL A;  1O98 A;  1Y7A A;  1KH5 A;  3UN2 A;  1E33 P;  3OT9 A;  2ANH A;  1AJB A;  1N2K A;  3UN5 A;  3T01 A;  1E1Z P;  3M7V A;  2GA3 A;  3M8Z A;  1N2L A;  3SZZ A;  3TWZ A;  1ANJ A;  3M8W A;  1FSU A;  1ALH A;  1EQJ A;  3MK2 A;  1ZEF A;  3UN3 A;  1URA A;  1AJC A;  3CMR A;  1ELX A;  2G9Y A;  1K7H A;  1Y6V A;  3IGZ B;  3TX0 A;  3UO0 A;  3SZY A;  2GLQ A;  1AUK A;  1ZEB A;  1KHN A;  1B8J A;  3T02 A;  4FDI A;  1EJJ A;  3DYC A;  1HJK A;  1ALI A;  1EW9 A;  1ED8 A;  1HQA A;  1KH7 A;  1P49 A;  3DPC A;  3ED4 A;  3T00 A;  1URB A;  1AJD A;  3IGY B;  3MK1 A;  1ELY A;  1KHJ A;  3BDG A;  1E3C P;  1ALJ A;  1O99 A;  1KH4 A;  1E2S P;  3BDH A;  1SHQ A;  1SHN A;  1AJA A;  1ELZ A;  2IFY A;  3M8Y A;  1KH9 A;  3BDG B; 
#chains in the KnotProt database with same CATH homology
 1EW8 A;  1ZED A;  1KHL A;  1ED9 A;  4FDJ A;  1ANI A;  2QZU A;  1EI6 A;  1EW2 A;  3UNY A;  3MK0 A;  1KHK A;  3BDF A;  1HDH A;  1ALK A;  3NVL A;  1O98 A;  1Y7A A;  1KH5 A;  3UN2 A;  1E33 P;  3OT9 A;  2ANH A;  1AJB A;  1N2K A;  3UN5 A;  3T01 A;  1E1Z P;  3M7V A;  2GA3 A;  3M8Z A;  1N2L A;  3SZZ A;  3TWZ A;  1ANJ A;  3M8W A;  1FSU A;  1ALH A;  1EQJ A;  3MK2 A;  1ZEF A;  3UN3 A;  1URA A;  1AJC A;  3CMR A;  1ELX A;  2G9Y A;  1K7H A;  1Y6V A;  3IGZ B;  3TX0 A;  3UO0 A;  3SZY A;  2GLQ A;  1AUK A;  1ZEB A;  1KHN A;  1B8J A;  3T02 A;  4FDI A;  1EJJ A;  3DYC A;  1HJK A;  1ALI A;  1EW9 A;  1ED8 A;  1HQA A;  1KH7 A;  1P49 A;  3DPC A;  3ED4 A;  3T00 A;  1URB A;  1AJD A;  3IGY B;  3MK1 A;  1ELY A;  1KHJ A;  3BDG A;  1E3C P;  1ALJ A;  1O99 A;  1KH4 A;  1E2S P;  3BDH A;  1SHQ A;  1SHN A;  1AJA A;  1ELZ A;  2IFY A;  3M8Y A;  1KH9 A;  3BDG B;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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