1KH7A

E. coli alkaline phosphatase mutant (d153gd330n)
Genus: 151
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 41-363 323 1-40 414-444 364-413 40 31 slipknot
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSKTSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 39-362 324 1-38 370-444 363-369 38 75 slipknot
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3.1 44-365 322 1-43 383-444 366-382 43 62 slipknot
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3.1 44-382 339 1-43 407-444 383-406 43 38 slipknot
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3.1 44-406 363 1-43 412-444 407-411 43 33 slipknot
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2.1 39-411 373 1-38 416-444 412-415 38 29 slipknot
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2.1 40-411 372 1-38, 414-444 39-39, 412-413 38 31 slipknot
sequence length 444
structure length 444
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords alkaline phosphatase
source organism Escherichia coli
total genus Genus: 151
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29
KnotProt deposition date 2014-07-31
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh7A00
3ED4A 3TX0A 3MK2A 1ANJA 1ED9A 1HJKA 1KH9A 3UNYA 1O99A 1EJJA 1KH7A 1EQJA 1Y6VA 3M8YA 1EW9A 3TWZA 3OT9A 3T02A 1E2SP 1EW2A 2G9YA 1KH5A 1KHLA 1SHNA 1ALIA 3T00A 3CMRA 3M7VA 1N2LA 1URBA 1ELXA 3NVLA 1E1ZP 3DYCA 1N2KA 1K7HA 2GA3A 3BDGA 1AJBA 3M8ZA 1HDHA 4FDIA 1ALKA 3IGZB 1AJDA 1SHQA 3UO0A 1AJCA 1Y7AA 3UN5A 1E3CP 1ELZA 1ED8A 1URAA 1ZEFA 1E33P 1KHJA 3BDHA 1ALJA 1B8JA 4FDJA 1P49A 1KHNA 1AUKA 3MK0A 3SZYA 1HQAA 1KHKA 1AJAA 3UN3A 1ZEDA 1EI6A 1ZEBA 3SZZA 1O98A 3M8WA 1FSUA 3BDGB 1ANIA 1ELYA 1EW8A 2ANHA 1KH4A 2GLQA 3IGYB 2IFYA 2QZUA 3MK1A 3T01A 3UN2A 3BDFA 3DPCA
chains in the KnotProt database with same CATH superfamily
3ED4A 3TX0A 3MK2A 1ANJA 1ED9A 1HJKA 1KH9A 3UNYA 1O99A 1EJJA 1KH7A 1EQJA 1Y6VA 3M8YA 1EW9A 3TWZA 3OT9A 3T02A 1E2SP 1EW2A 2G9YA 1KH5A 1KHLA 1SHNA 1ALIA 3T00A 3CMRA 3M7VA 1N2LA 1URBA 1ELXA 3NVLA 1E1ZP 3DYCA 1N2KA 1K7HA 2GA3A 3BDGA 1AJBA 3M8ZA 1HDHA 4FDIA 1ALKA 3IGZB 1AJDA 1SHQA 3UO0A 1AJCA 1Y7AA 3UN5A 1E3CP 1ELZA 1ED8A 1URAA 1ZEFA 1E33P 1KHJA 3BDHA 1ALJA 1B8JA 4FDJA 1P49A 1KHNA 1AUKA 3MK0A 3SZYA 1HQAA 1KHKA 1AJAA 3UN3A 1ZEDA 1EI6A 1ZEBA 3SZZA 1O98A 3M8WA 1FSUA 3BDGB 1ANIA 1ELYA 1EW8A 2ANHA 1KH4A 2GLQA 3IGYB 2IFYA 2QZUA 3MK1A 3T01A 3UN2A 3BDFA 3DPCA
chains in the KnotProt database with same CATH topology
3ED4A 3TX0A 3MK2A 1ANJA 1ED9A 1HJKA 1KH9A 3UNYA 1O99A 1EJJA 1KH7A 1EQJA 1Y6VA 3M8YA 1EW9A 3TWZA 3OT9A 3T02A 1E2SP 1EW2A 2G9YA 1KH5A 1KHLA 1SHNA 1ALIA 3T00A 3CMRA 3M7VA 1N2LA 1URBA 1ELXA 3NVLA 1E1ZP 3DYCA 1N2KA 1K7HA 2GA3A 3BDGA 1AJBA 3M8ZA 1HDHA 4FDIA 1ALKA 3IGZB 1AJDA 1SHQA 3UO0A 1AJCA 1Y7AA 3UN5A 1E3CP 1ELZA 1ED8A 1URAA 1ZEFA 1E33P 1KHJA 3BDHA 1ALJA 1B8JA 4FDJA 1P49A 1KHNA 1AUKA 3MK0A 3SZYA 1HQAA 1KHKA 1AJAA 3UN3A 1ZEDA 1EI6A 1ZEBA 3SZZA 1O98A 3M8WA 1FSUA 3BDGB 1ANIA 1ELYA 1EW8A 2ANHA 1KH4A 2GLQA 3IGYB 2IFYA 2QZUA 3MK1A 3T01A 3UN2A 3BDFA 3DPCA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 3ED4 A;  3TX0 A;  3MK2 A;  1ANJ A;  1ED9 A;  1HJK A;  1KH9 A;  3UNY A;  1O99 A;  1EJJ A;  1KH7 A;  1EQJ A;  1Y6V A;  3M8Y A;  1EW9 A;  3TWZ A;  3OT9 A;  3T02 A;  1E2S P;  1EW2 A;  2G9Y A;  1KH5 A;  1KHL A;  1SHN A;  1ALI A;  3T00 A;  3CMR A;  3M7V A;  1N2L A;  1URB A;  1ELX A;  3NVL A;  1E1Z P;  3DYC A;  1N2K A;  1K7H A;  2GA3 A;  3BDG A;  1AJB A;  3M8Z A;  1HDH A;  4FDI A;  1ALK A;  3IGZ B;  1AJD A;  1SHQ A;  3UO0 A;  1AJC A;  1Y7A A;  3UN5 A;  1E3C P;  1ELZ A;  1ED8 A;  1URA A;  1ZEF A;  1E33 P;  1KHJ A;  3BDH A;  1ALJ A;  1B8J A;  4FDJ A;  1P49 A;  1KHN A;  1AUK A;  3MK0 A;  3SZY A;  1HQA A;  1KHK A;  1AJA A;  3UN3 A;  1ZED A;  1EI6 A;  1ZEB A;  3SZZ A;  1O98 A;  3M8W A;  1FSU A;  3BDG B;  1ANI A;  1ELY A;  1EW8 A;  2ANH A;  1KH4 A;  2GLQ A;  3IGY B;  2IFY A;  2QZU A;  3MK1 A;  3T01 A;  3UN2 A;  3BDF A;  3DPC A; 
#chains in the KnotProt database with same CATH topology
 3ED4 A;  3TX0 A;  3MK2 A;  1ANJ A;  1ED9 A;  1HJK A;  1KH9 A;  3UNY A;  1O99 A;  1EJJ A;  1KH7 A;  1EQJ A;  1Y6V A;  3M8Y A;  1EW9 A;  3TWZ A;  3OT9 A;  3T02 A;  1E2S P;  1EW2 A;  2G9Y A;  1KH5 A;  1KHL A;  1SHN A;  1ALI A;  3T00 A;  3CMR A;  3M7V A;  1N2L A;  1URB A;  1ELX A;  3NVL A;  1E1Z P;  3DYC A;  1N2K A;  1K7H A;  2GA3 A;  3BDG A;  1AJB A;  3M8Z A;  1HDH A;  4FDI A;  1ALK A;  3IGZ B;  1AJD A;  1SHQ A;  3UO0 A;  1AJC A;  1Y7A A;  3UN5 A;  1E3C P;  1ELZ A;  1ED8 A;  1URA A;  1ZEF A;  1E33 P;  1KHJ A;  3BDH A;  1ALJ A;  1B8J A;  4FDJ A;  1P49 A;  1KHN A;  1AUK A;  3MK0 A;  3SZY A;  1HQA A;  1KHK A;  1AJA A;  3UN3 A;  1ZED A;  1EI6 A;  1ZEB A;  3SZZ A;  1O98 A;  3M8W A;  1FSU A;  3BDG B;  1ANI A;  1ELY A;  1EW8 A;  2ANH A;  1KH4 A;  2GLQ A;  3IGY B;  2IFY A;  2QZU A;  3MK1 A;  3T01 A;  3UN2 A;  3BDF A;  3DPC A; 
#chains in the KnotProt database with same CATH homology
 3ED4 A;  3TX0 A;  3MK2 A;  1ANJ A;  1ED9 A;  1HJK A;  1KH9 A;  3UNY A;  1O99 A;  1EJJ A;  1KH7 A;  1EQJ A;  1Y6V A;  3M8Y A;  1EW9 A;  3TWZ A;  3OT9 A;  3T02 A;  1E2S P;  1EW2 A;  2G9Y A;  1KH5 A;  1KHL A;  1SHN A;  1ALI A;  3T00 A;  3CMR A;  3M7V A;  1N2L A;  1URB A;  1ELX A;  3NVL A;  1E1Z P;  3DYC A;  1N2K A;  1K7H A;  2GA3 A;  3BDG A;  1AJB A;  3M8Z A;  1HDH A;  4FDI A;  1ALK A;  3IGZ B;  1AJD A;  1SHQ A;  3UO0 A;  1AJC A;  1Y7A A;  3UN5 A;  1E3C P;  1ELZ A;  1ED8 A;  1URA A;  1ZEF A;  1E33 P;  1KHJ A;  3BDH A;  1ALJ A;  1B8J A;  4FDJ A;  1P49 A;  1KHN A;  1AUK A;  3MK0 A;  3SZY A;  1HQA A;  1KHK A;  1AJA A;  3UN3 A;  1ZED A;  1EI6 A;  1ZEB A;  3SZZ A;  1O98 A;  3M8W A;  1FSU A;  3BDG B;  1ANI A;  1ELY A;  1EW8 A;  2ANH A;  1KH4 A;  2GLQ A;  3IGY B;  2IFY A;  2QZU A;  3MK1 A;  3T01 A;  3UN2 A;  3BDF A;  3DPC A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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