1KH7A

E. coli alkaline phosphatase mutant (d153gd330n)
Genus: 151
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 41-363 323 1-40 414-444 364-413 40 31 slipknot
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSKTSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 39-362 324 1-38 370-444 363-369 38 75 slipknot
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3.1 44-365 322 1-43 383-444 366-382 43 62 slipknot
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3.1 44-382 339 1-43 407-444 383-406 43 38 slipknot
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3.1 44-406 363 1-43 412-444 407-411 43 33 slipknot
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2.1 39-411 373 1-38 416-444 412-415 38 29 slipknot
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2.1 40-411 372 1-38, 414-444 39-39, 412-413 38 31 slipknot
sequence length 444
structure length 444
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords alkaline phosphatase
source organism Escherichia coli
total genus Genus: 151
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29
KnotProt deposition date 2014-07-31
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh7A00
1AUKA 1E2SP 1HQAA 1AJCA 3M8WA 3BDGB 2IFYA 3BDGA 3IGYB 1ED8A 1E33P 3UN5A 3BDFA 1Y7AA 1KHLA 1O98A 3UO0A 3CMRA 2GA3A 1E1ZP 3MK2A 1N2LA 1KHNA 1Y6VA 3T01A 3ED4A 3M8YA 1ALIA 3SZYA 1ALKA 4FDJA 3MK0A 1ZEDA 3NVLA 3BDHA 1URAA 1EI6A 3MK1A 3TWZA 1URBA 1AJBA 1ELYA 1ED9A 1ZEFA 1KH5A 3TX0A 1O99A 3IGZB 1EJJA 3T02A 1P49A 1KH4A 1HDHA 3M7VA 3T00A 3UNYA 1SHQA 1ALHA 3DYCA 3DPCA 1N2KA 1KH9A 2QZUA 2GLQA 1ZEBA 1EW2A 1ANIA 3SZZA 1K7HA 3UN3A 1HJKA 1ALJA 1E3CP 1EW9A 1ANJA 1FSUA 1ELXA 1ELZA 1SHNA 1EQJA 1AJAA 2G9YA 1EW8A 3M8ZA 1AJDA 1KH7A 1KHKA 1B8JA 3UN2A 1KHJA 4FDIA 2ANHA 3OT9A
chains in the KnotProt database with same CATH superfamily
1AUKA 1E2SP 1HQAA 1AJCA 3M8WA 3BDGB 2IFYA 3BDGA 3IGYB 1ED8A 1E33P 3UN5A 3BDFA 1Y7AA 1KHLA 1O98A 3UO0A 3CMRA 2GA3A 1E1ZP 3MK2A 1N2LA 1KHNA 1Y6VA 3T01A 3ED4A 3M8YA 1ALIA 3SZYA 1ALKA 4FDJA 3MK0A 1ZEDA 3NVLA 3BDHA 1URAA 1EI6A 3MK1A 3TWZA 1URBA 1AJBA 1ELYA 1ED9A 1ZEFA 1KH5A 3TX0A 1O99A 3IGZB 1EJJA 3T02A 1P49A 1KH4A 1HDHA 3M7VA 3T00A 3UNYA 1SHQA 1ALHA 3DYCA 3DPCA 1N2KA 1KH9A 2QZUA 2GLQA 1ZEBA 1EW2A 1ANIA 3SZZA 1K7HA 3UN3A 1HJKA 1ALJA 1E3CP 1EW9A 1ANJA 1FSUA 1ELXA 1ELZA 1SHNA 1EQJA 1AJAA 2G9YA 1EW8A 3M8ZA 1AJDA 1KH7A 1KHKA 1B8JA 3UN2A 1KHJA 4FDIA 2ANHA 3OT9A
chains in the KnotProt database with same CATH topology
1AUKA 1E2SP 1HQAA 1AJCA 3M8WA 3BDGB 2IFYA 3BDGA 3IGYB 1ED8A 1E33P 3UN5A 3BDFA 1Y7AA 1KHLA 1O98A 3UO0A 3CMRA 2GA3A 1E1ZP 3MK2A 1N2LA 1KHNA 1Y6VA 3T01A 3ED4A 3M8YA 1ALIA 3SZYA 1ALKA 4FDJA 3MK0A 1ZEDA 3NVLA 3BDHA 1URAA 1EI6A 3MK1A 3TWZA 1URBA 1AJBA 1ELYA 1ED9A 1ZEFA 1KH5A 3TX0A 1O99A 3IGZB 1EJJA 3T02A 1P49A 1KH4A 1HDHA 3M7VA 3T00A 3UNYA 1SHQA 1ALHA 3DYCA 3DPCA 1N2KA 1KH9A 2QZUA 2GLQA 1ZEBA 1EW2A 1ANIA 3SZZA 1K7HA 3UN3A 1HJKA 1ALJA 1E3CP 1EW9A 1ANJA 1FSUA 1ELXA 1ELZA 1SHNA 1EQJA 1AJAA 2G9YA 1EW8A 3M8ZA 1AJDA 1KH7A 1KHKA 1B8JA 3UN2A 1KHJA 4FDIA 2ANHA 3OT9A
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1AUK A;  1E2S P;  1HQA A;  1AJC A;  3M8W A;  3BDG B;  2IFY A;  3BDG A;  3IGY B;  1ED8 A;  1E33 P;  3UN5 A;  3BDF A;  1Y7A A;  1KHL A;  1O98 A;  3UO0 A;  3CMR A;  2GA3 A;  1E1Z P;  3MK2 A;  1N2L A;  1KHN A;  1Y6V A;  3T01 A;  3ED4 A;  3M8Y A;  1ALI A;  3SZY A;  1ALK A;  4FDJ A;  3MK0 A;  1ZED A;  3NVL A;  3BDH A;  1URA A;  1EI6 A;  3MK1 A;  3TWZ A;  1URB A;  1AJB A;  1ELY A;  1ED9 A;  1ZEF A;  1KH5 A;  3TX0 A;  1O99 A;  3IGZ B;  1EJJ A;  3T02 A;  1P49 A;  1KH4 A;  1HDH A;  3M7V A;  3T00 A;  3UNY A;  1SHQ A;  1ALH A;  3DYC A;  3DPC A;  1N2K A;  1KH9 A;  2QZU A;  2GLQ A;  1ZEB A;  1EW2 A;  1ANI A;  3SZZ A;  1K7H A;  3UN3 A;  1HJK A;  1ALJ A;  1E3C P;  1EW9 A;  1ANJ A;  1FSU A;  1ELX A;  1ELZ A;  1SHN A;  1EQJ A;  1AJA A;  2G9Y A;  1EW8 A;  3M8Z A;  1AJD A;  1KH7 A;  1KHK A;  1B8J A;  3UN2 A;  1KHJ A;  4FDI A;  2ANH A;  3OT9 A; 
#chains in the KnotProt database with same CATH topology
 1AUK A;  1E2S P;  1HQA A;  1AJC A;  3M8W A;  3BDG B;  2IFY A;  3BDG A;  3IGY B;  1ED8 A;  1E33 P;  3UN5 A;  3BDF A;  1Y7A A;  1KHL A;  1O98 A;  3UO0 A;  3CMR A;  2GA3 A;  1E1Z P;  3MK2 A;  1N2L A;  1KHN A;  1Y6V A;  3T01 A;  3ED4 A;  3M8Y A;  1ALI A;  3SZY A;  1ALK A;  4FDJ A;  3MK0 A;  1ZED A;  3NVL A;  3BDH A;  1URA A;  1EI6 A;  3MK1 A;  3TWZ A;  1URB A;  1AJB A;  1ELY A;  1ED9 A;  1ZEF A;  1KH5 A;  3TX0 A;  1O99 A;  3IGZ B;  1EJJ A;  3T02 A;  1P49 A;  1KH4 A;  1HDH A;  3M7V A;  3T00 A;  3UNY A;  1SHQ A;  1ALH A;  3DYC A;  3DPC A;  1N2K A;  1KH9 A;  2QZU A;  2GLQ A;  1ZEB A;  1EW2 A;  1ANI A;  3SZZ A;  1K7H A;  3UN3 A;  1HJK A;  1ALJ A;  1E3C P;  1EW9 A;  1ANJ A;  1FSU A;  1ELX A;  1ELZ A;  1SHN A;  1EQJ A;  1AJA A;  2G9Y A;  1EW8 A;  3M8Z A;  1AJD A;  1KH7 A;  1KHK A;  1B8J A;  3UN2 A;  1KHJ A;  4FDI A;  2ANH A;  3OT9 A; 
#chains in the KnotProt database with same CATH homology
 1AUK A;  1E2S P;  1HQA A;  1AJC A;  3M8W A;  3BDG B;  2IFY A;  3BDG A;  3IGY B;  1ED8 A;  1E33 P;  3UN5 A;  3BDF A;  1Y7A A;  1KHL A;  1O98 A;  3UO0 A;  3CMR A;  2GA3 A;  1E1Z P;  3MK2 A;  1N2L A;  1KHN A;  1Y6V A;  3T01 A;  3ED4 A;  3M8Y A;  1ALI A;  3SZY A;  1ALK A;  4FDJ A;  3MK0 A;  1ZED A;  3NVL A;  3BDH A;  1URA A;  1EI6 A;  3MK1 A;  3TWZ A;  1URB A;  1AJB A;  1ELY A;  1ED9 A;  1ZEF A;  1KH5 A;  3TX0 A;  1O99 A;  3IGZ B;  1EJJ A;  3T02 A;  1P49 A;  1KH4 A;  1HDH A;  3M7V A;  3T00 A;  3UNY A;  1SHQ A;  1ALH A;  3DYC A;  3DPC A;  1N2K A;  1KH9 A;  2QZU A;  2GLQ A;  1ZEB A;  1EW2 A;  1ANI A;  3SZZ A;  1K7H A;  3UN3 A;  1HJK A;  1ALJ A;  1E3C P;  1EW9 A;  1ANJ A;  1FSU A;  1ELX A;  1ELZ A;  1SHN A;  1EQJ A;  1AJA A;  2G9Y A;  1EW8 A;  3M8Z A;  1AJD A;  1KH7 A;  1KHK A;  1B8J A;  3UN2 A;  1KHJ A;  4FDI A;  2ANH A;  3OT9 A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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