1KH7A

E. coli alkaline phosphatase mutant (d153gd330n)
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 41-363 323 1-40 414-444 364-413 40 31 slipknot
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSKTSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 39-362 324 1-38 370-444 363-369 38 75 slipknot
view details
3.1 44-365 322 1-43 383-444 366-382 43 62 slipknot
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3.1 44-382 339 1-43 407-444 383-406 43 38 slipknot
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3.1 44-406 363 1-43 412-444 407-411 43 33 slipknot
view details
2.1 39-411 373 1-38 416-444 412-415 38 29 slipknot
view details
2.1 40-411 372 1-38, 414-444 39-39, 412-413 38 31 slipknot
sequence length 444
structure length 444
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords alkaline phosphatase
source organism Escherichia coli
total genus Genus: 151
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29
KnotProt deposition date 2014-07-31
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh7A00
1ED9A 1N2LA 1E1ZP 1FSUA 3UO0A 3BDGB 1AUKA 3BDHA 1HJKA 3M8ZA 3MK1A 1ANJA 1E2SP 3TX0A 1ALKA 1HDHA 1KH7A 3T00A 1O99A 1ZEBA 3UNYA 1E33P 3BDFA 1ANIA 3M7VA 1O98A 1SHNA 3SZYA 3SZZA 3TWZA 3UN5A 3DPCA 3T01A 2G9YA 1AJAA 1URAA 1ZEDA 1EQJA 2GLQA 1P49A 1KH9A 1AJCA 1ALIA 1E3CP 1EW2A 1KH4A 3MK2A 1ZEFA 1AJBA 3IGYB 1ALJA 1Y6VA 1EI6A 1ELZA 3CMRA 3OT9A 1KHLA 4FDIA 1KHKA 1SHQA 4FDJA 2IFYA 3NVLA 1AJDA 1ELXA 2GA3A 1KHJA 3ED4A 3UN2A 2QZUA 3M8WA 3UN3A 1EJJA 1HQAA 1B8JA 3DYCA 1Y7AA 1N2KA 1K7HA 1EW8A 3M8YA 1EW9A 1ELYA 1KH5A 3MK0A 1URBA 3T02A 1ED8A 3IGZB 2ANHA 3BDGA 1KHNA
chains in the KnotProt database with same CATH superfamily
1ED9A 1N2LA 1E1ZP 1FSUA 3UO0A 3BDGB 1AUKA 3BDHA 1HJKA 3M8ZA 3MK1A 1ANJA 1E2SP 3TX0A 1ALKA 1HDHA 1KH7A 3T00A 1O99A 1ZEBA 3UNYA 1E33P 3BDFA 1ANIA 3M7VA 1O98A 1SHNA 3SZYA 3SZZA 3TWZA 3UN5A 3DPCA 3T01A 2G9YA 1AJAA 1URAA 1ZEDA 1EQJA 2GLQA 1P49A 1KH9A 1AJCA 1ALIA 1E3CP 1EW2A 1KH4A 3MK2A 1ZEFA 1AJBA 3IGYB 1ALJA 1Y6VA 1EI6A 1ELZA 3CMRA 3OT9A 1KHLA 4FDIA 1KHKA 1SHQA 4FDJA 2IFYA 3NVLA 1AJDA 1ELXA 2GA3A 1KHJA 3ED4A 3UN2A 2QZUA 3M8WA 3UN3A 1EJJA 1HQAA 1B8JA 3DYCA 1Y7AA 1N2KA 1K7HA 1EW8A 3M8YA 1EW9A 1ELYA 1KH5A 3MK0A 1URBA 3T02A 1ED8A 3IGZB 2ANHA 3BDGA 1KHNA
chains in the KnotProt database with same CATH topology
1ED9A 1N2LA 1E1ZP 1FSUA 3UO0A 3BDGB 1AUKA 3BDHA 1HJKA 3M8ZA 3MK1A 1ANJA 1E2SP 3TX0A 1ALKA 1HDHA 1KH7A 3T00A 1O99A 1ZEBA 3UNYA 1E33P 3BDFA 1ANIA 3M7VA 1O98A 1SHNA 3SZYA 3SZZA 3TWZA 3UN5A 3DPCA 3T01A 2G9YA 1AJAA 1URAA 1ZEDA 1EQJA 2GLQA 1P49A 1KH9A 1AJCA 1ALIA 1E3CP 1EW2A 1KH4A 3MK2A 1ZEFA 1AJBA 3IGYB 1ALJA 1Y6VA 1EI6A 1ELZA 3CMRA 3OT9A 1KHLA 4FDIA 1KHKA 1SHQA 4FDJA 2IFYA 3NVLA 1AJDA 1ELXA 2GA3A 1KHJA 3ED4A 3UN2A 2QZUA 3M8WA 3UN3A 1EJJA 1HQAA 1B8JA 3DYCA 1Y7AA 1N2KA 1K7HA 1EW8A 3M8YA 1EW9A 1ELYA 1KH5A 3MK0A 1URBA 3T02A 1ED8A 3IGZB 2ANHA 3BDGA 1KHNA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1ED9 A;  1N2L A;  1E1Z P;  1FSU A;  3UO0 A;  3BDG B;  1AUK A;  3BDH A;  1HJK A;  3M8Z A;  3MK1 A;  1ANJ A;  1E2S P;  3TX0 A;  1ALK A;  1HDH A;  1KH7 A;  3T00 A;  1O99 A;  1ZEB A;  3UNY A;  1E33 P;  3BDF A;  1ANI A;  3M7V A;  1O98 A;  1SHN A;  3SZY A;  3SZZ A;  3TWZ A;  3UN5 A;  3DPC A;  3T01 A;  2G9Y A;  1AJA A;  1URA A;  1ZED A;  1EQJ A;  2GLQ A;  1P49 A;  1KH9 A;  1AJC A;  1ALI A;  1E3C P;  1EW2 A;  1KH4 A;  3MK2 A;  1ZEF A;  1AJB A;  3IGY B;  1ALJ A;  1Y6V A;  1EI6 A;  1ELZ A;  3CMR A;  3OT9 A;  1KHL A;  4FDI A;  1KHK A;  1SHQ A;  4FDJ A;  2IFY A;  3NVL A;  1AJD A;  1ELX A;  2GA3 A;  1KHJ A;  3ED4 A;  3UN2 A;  2QZU A;  3M8W A;  3UN3 A;  1EJJ A;  1HQA A;  1B8J A;  3DYC A;  1Y7A A;  1N2K A;  1K7H A;  1EW8 A;  3M8Y A;  1EW9 A;  1ELY A;  1KH5 A;  3MK0 A;  1URB A;  3T02 A;  1ED8 A;  3IGZ B;  2ANH A;  3BDG A;  1KHN A; 
#chains in the KnotProt database with same CATH topology
 1ED9 A;  1N2L A;  1E1Z P;  1FSU A;  3UO0 A;  3BDG B;  1AUK A;  3BDH A;  1HJK A;  3M8Z A;  3MK1 A;  1ANJ A;  1E2S P;  3TX0 A;  1ALK A;  1HDH A;  1KH7 A;  3T00 A;  1O99 A;  1ZEB A;  3UNY A;  1E33 P;  3BDF A;  1ANI A;  3M7V A;  1O98 A;  1SHN A;  3SZY A;  3SZZ A;  3TWZ A;  3UN5 A;  3DPC A;  3T01 A;  2G9Y A;  1AJA A;  1URA A;  1ZED A;  1EQJ A;  2GLQ A;  1P49 A;  1KH9 A;  1AJC A;  1ALI A;  1E3C P;  1EW2 A;  1KH4 A;  3MK2 A;  1ZEF A;  1AJB A;  3IGY B;  1ALJ A;  1Y6V A;  1EI6 A;  1ELZ A;  3CMR A;  3OT9 A;  1KHL A;  4FDI A;  1KHK A;  1SHQ A;  4FDJ A;  2IFY A;  3NVL A;  1AJD A;  1ELX A;  2GA3 A;  1KHJ A;  3ED4 A;  3UN2 A;  2QZU A;  3M8W A;  3UN3 A;  1EJJ A;  1HQA A;  1B8J A;  3DYC A;  1Y7A A;  1N2K A;  1K7H A;  1EW8 A;  3M8Y A;  1EW9 A;  1ELY A;  1KH5 A;  3MK0 A;  1URB A;  3T02 A;  1ED8 A;  3IGZ B;  2ANH A;  3BDG A;  1KHN A; 
#chains in the KnotProt database with same CATH homology
 1ED9 A;  1N2L A;  1E1Z P;  1FSU A;  3UO0 A;  3BDG B;  1AUK A;  3BDH A;  1HJK A;  3M8Z A;  3MK1 A;  1ANJ A;  1E2S P;  3TX0 A;  1ALK A;  1HDH A;  1KH7 A;  3T00 A;  1O99 A;  1ZEB A;  3UNY A;  1E33 P;  3BDF A;  1ANI A;  3M7V A;  1O98 A;  1SHN A;  3SZY A;  3SZZ A;  3TWZ A;  3UN5 A;  3DPC A;  3T01 A;  2G9Y A;  1AJA A;  1URA A;  1ZED A;  1EQJ A;  2GLQ A;  1P49 A;  1KH9 A;  1AJC A;  1ALI A;  1E3C P;  1EW2 A;  1KH4 A;  3MK2 A;  1ZEF A;  1AJB A;  3IGY B;  1ALJ A;  1Y6V A;  1EI6 A;  1ELZ A;  3CMR A;  3OT9 A;  1KHL A;  4FDI A;  1KHK A;  1SHQ A;  4FDJ A;  2IFY A;  3NVL A;  1AJD A;  1ELX A;  2GA3 A;  1KHJ A;  3ED4 A;  3UN2 A;  2QZU A;  3M8W A;  3UN3 A;  1EJJ A;  1HQA A;  1B8J A;  3DYC A;  1Y7A A;  1N2K A;  1K7H A;  1EW8 A;  3M8Y A;  1EW9 A;  1ELY A;  1KH5 A;  3MK0 A;  1URB A;  3T02 A;  1ED8 A;  3IGZ B;  2ANH A;  3BDG A;  1KHN A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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