1KH7A

E. coli alkaline phosphatase mutant (d153gd330n)
Genus: 151
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 41-363 323 1-40 414-444 364-413 40 31 slipknot
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSKTSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 39-362 324 1-38 370-444 363-369 38 75 slipknot
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3.1 44-365 322 1-43 383-444 366-382 43 62 slipknot
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3.1 44-382 339 1-43 407-444 383-406 43 38 slipknot
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3.1 44-406 363 1-43 412-444 407-411 43 33 slipknot
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2.1 39-411 373 1-38 416-444 412-415 38 29 slipknot
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2.1 40-411 372 1-38, 414-444 39-39, 412-413 38 31 slipknot
sequence length 444
structure length 444
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords alkaline phosphatase
source organism Escherichia coli
total genus Genus: 151
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29
KnotProt deposition date 2014-07-31
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh7A00
3UN3A 3IGZB 1AUKA 1P49A 1EW2A 3TWZA 1FSUA 3T02A 3UN5A 1ED8A 1EI6A 1E3CP 1ALJA 1B8JA 1ELZA 1ALIA 1KHNA 3IGYB 1AJDA 1AJAA 1O99A 1E2SP 3UO0A 1N2LA 1Y7AA 1EQJA 1EW9A 3MK2A 1AJBA 4FDIA 3SZYA 1ZEDA 3M8YA 1SHNA 1E1ZP 3T01A 1HDHA 3DYCA 1ALHA 2ANHA 1KHJA 3ED4A 3OT9A 2QZUA 2IFYA 2GLQA 1ED9A 1ELXA 1KHKA 3NVLA 3UNYA 1KHLA 3UN2A 1ANJA 1KH4A 1Y6VA 1ZEBA 1URAA 3M8WA 1HJKA 1ELYA 1KH9A 3CMRA 1HQAA 1KH5A 1SHQA 3T00A 1EJJA 3SZZA 3M8ZA 1URBA 3M7VA 3MK1A 3TX0A 1ZEFA 3BDHA 3MK0A 1ALKA 3BDGB 4FDJA 1E33P 1K7HA 2G9YA 1ANIA 3BDGA 1N2KA 1EW8A 3BDFA 1KH7A 2GA3A 3DPCA 1O98A 1AJCA
chains in the KnotProt database with same CATH superfamily
3UN3A 3IGZB 1AUKA 1P49A 1EW2A 3TWZA 1FSUA 3T02A 3UN5A 1ED8A 1EI6A 1E3CP 1ALJA 1B8JA 1ELZA 1ALIA 1KHNA 3IGYB 1AJDA 1AJAA 1O99A 1E2SP 3UO0A 1N2LA 1Y7AA 1EQJA 1EW9A 3MK2A 1AJBA 4FDIA 3SZYA 1ZEDA 3M8YA 1SHNA 1E1ZP 3T01A 1HDHA 3DYCA 1ALHA 2ANHA 1KHJA 3ED4A 3OT9A 2QZUA 2IFYA 2GLQA 1ED9A 1ELXA 1KHKA 3NVLA 3UNYA 1KHLA 3UN2A 1ANJA 1KH4A 1Y6VA 1ZEBA 1URAA 3M8WA 1HJKA 1ELYA 1KH9A 3CMRA 1HQAA 1KH5A 1SHQA 3T00A 1EJJA 3SZZA 3M8ZA 1URBA 3M7VA 3MK1A 3TX0A 1ZEFA 3BDHA 3MK0A 1ALKA 3BDGB 4FDJA 1E33P 1K7HA 2G9YA 1ANIA 3BDGA 1N2KA 1EW8A 3BDFA 1KH7A 2GA3A 3DPCA 1O98A 1AJCA
chains in the KnotProt database with same CATH topology
3UN3A 3IGZB 1AUKA 1P49A 1EW2A 3TWZA 1FSUA 3T02A 3UN5A 1ED8A 1EI6A 1E3CP 1ALJA 1B8JA 1ELZA 1ALIA 1KHNA 3IGYB 1AJDA 1AJAA 1O99A 1E2SP 3UO0A 1N2LA 1Y7AA 1EQJA 1EW9A 3MK2A 1AJBA 4FDIA 3SZYA 1ZEDA 3M8YA 1SHNA 1E1ZP 3T01A 1HDHA 3DYCA 1ALHA 2ANHA 1KHJA 3ED4A 3OT9A 2QZUA 2IFYA 2GLQA 1ED9A 1ELXA 1KHKA 3NVLA 3UNYA 1KHLA 3UN2A 1ANJA 1KH4A 1Y6VA 1ZEBA 1URAA 3M8WA 1HJKA 1ELYA 1KH9A 3CMRA 1HQAA 1KH5A 1SHQA 3T00A 1EJJA 3SZZA 3M8ZA 1URBA 3M7VA 3MK1A 3TX0A 1ZEFA 3BDHA 3MK0A 1ALKA 3BDGB 4FDJA 1E33P 1K7HA 2G9YA 1ANIA 3BDGA 1N2KA 1EW8A 3BDFA 1KH7A 2GA3A 3DPCA 1O98A 1AJCA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 3UN3 A;  3IGZ B;  1AUK A;  1P49 A;  1EW2 A;  3TWZ A;  1FSU A;  3T02 A;  3UN5 A;  1ED8 A;  1EI6 A;  1E3C P;  1ALJ A;  1B8J A;  1ELZ A;  1ALI A;  1KHN A;  3IGY B;  1AJD A;  1AJA A;  1O99 A;  1E2S P;  3UO0 A;  1N2L A;  1Y7A A;  1EQJ A;  1EW9 A;  3MK2 A;  1AJB A;  4FDI A;  3SZY A;  1ZED A;  3M8Y A;  1SHN A;  1E1Z P;  3T01 A;  1HDH A;  3DYC A;  1ALH A;  2ANH A;  1KHJ A;  3ED4 A;  3OT9 A;  2QZU A;  2IFY A;  2GLQ A;  1ED9 A;  1ELX A;  1KHK A;  3NVL A;  3UNY A;  1KHL A;  3UN2 A;  1ANJ A;  1KH4 A;  1Y6V A;  1ZEB A;  1URA A;  3M8W A;  1HJK A;  1ELY A;  1KH9 A;  3CMR A;  1HQA A;  1KH5 A;  1SHQ A;  3T00 A;  1EJJ A;  3SZZ A;  3M8Z A;  1URB A;  3M7V A;  3MK1 A;  3TX0 A;  1ZEF A;  3BDH A;  3MK0 A;  1ALK A;  3BDG B;  4FDJ A;  1E33 P;  1K7H A;  2G9Y A;  1ANI A;  3BDG A;  1N2K A;  1EW8 A;  3BDF A;  1KH7 A;  2GA3 A;  3DPC A;  1O98 A;  1AJC A; 
#chains in the KnotProt database with same CATH topology
 3UN3 A;  3IGZ B;  1AUK A;  1P49 A;  1EW2 A;  3TWZ A;  1FSU A;  3T02 A;  3UN5 A;  1ED8 A;  1EI6 A;  1E3C P;  1ALJ A;  1B8J A;  1ELZ A;  1ALI A;  1KHN A;  3IGY B;  1AJD A;  1AJA A;  1O99 A;  1E2S P;  3UO0 A;  1N2L A;  1Y7A A;  1EQJ A;  1EW9 A;  3MK2 A;  1AJB A;  4FDI A;  3SZY A;  1ZED A;  3M8Y A;  1SHN A;  1E1Z P;  3T01 A;  1HDH A;  3DYC A;  1ALH A;  2ANH A;  1KHJ A;  3ED4 A;  3OT9 A;  2QZU A;  2IFY A;  2GLQ A;  1ED9 A;  1ELX A;  1KHK A;  3NVL A;  3UNY A;  1KHL A;  3UN2 A;  1ANJ A;  1KH4 A;  1Y6V A;  1ZEB A;  1URA A;  3M8W A;  1HJK A;  1ELY A;  1KH9 A;  3CMR A;  1HQA A;  1KH5 A;  1SHQ A;  3T00 A;  1EJJ A;  3SZZ A;  3M8Z A;  1URB A;  3M7V A;  3MK1 A;  3TX0 A;  1ZEF A;  3BDH A;  3MK0 A;  1ALK A;  3BDG B;  4FDJ A;  1E33 P;  1K7H A;  2G9Y A;  1ANI A;  3BDG A;  1N2K A;  1EW8 A;  3BDF A;  1KH7 A;  2GA3 A;  3DPC A;  1O98 A;  1AJC A; 
#chains in the KnotProt database with same CATH homology
 3UN3 A;  3IGZ B;  1AUK A;  1P49 A;  1EW2 A;  3TWZ A;  1FSU A;  3T02 A;  3UN5 A;  1ED8 A;  1EI6 A;  1E3C P;  1ALJ A;  1B8J A;  1ELZ A;  1ALI A;  1KHN A;  3IGY B;  1AJD A;  1AJA A;  1O99 A;  1E2S P;  3UO0 A;  1N2L A;  1Y7A A;  1EQJ A;  1EW9 A;  3MK2 A;  1AJB A;  4FDI A;  3SZY A;  1ZED A;  3M8Y A;  1SHN A;  1E1Z P;  3T01 A;  1HDH A;  3DYC A;  1ALH A;  2ANH A;  1KHJ A;  3ED4 A;  3OT9 A;  2QZU A;  2IFY A;  2GLQ A;  1ED9 A;  1ELX A;  1KHK A;  3NVL A;  3UNY A;  1KHL A;  3UN2 A;  1ANJ A;  1KH4 A;  1Y6V A;  1ZEB A;  1URA A;  3M8W A;  1HJK A;  1ELY A;  1KH9 A;  3CMR A;  1HQA A;  1KH5 A;  1SHQ A;  3T00 A;  1EJJ A;  3SZZ A;  3M8Z A;  1URB A;  3M7V A;  3MK1 A;  3TX0 A;  1ZEF A;  3BDH A;  3MK0 A;  1ALK A;  3BDG B;  4FDJ A;  1E33 P;  1K7H A;  2G9Y A;  1ANI A;  3BDG A;  1N2K A;  1EW8 A;  3BDF A;  1KH7 A;  2GA3 A;  3DPC A;  1O98 A;  1AJC A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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