1KH7A

E. coli alkaline phosphatase mutant (d153gd330n)
Genus: 151
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 41-363 323 1-40 414-444 364-413 40 31 slipknot
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSKTSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 39-362 324 1-38 370-444 363-369 38 75 slipknot
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3.1 44-365 322 1-43 383-444 366-382 43 62 slipknot
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3.1 44-382 339 1-43 407-444 383-406 43 38 slipknot
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3.1 44-406 363 1-43 412-444 407-411 43 33 slipknot
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2.1 39-411 373 1-38 416-444 412-415 38 29 slipknot
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2.1 40-411 372 1-38, 414-444 39-39, 412-413 38 31 slipknot
sequence length 444
structure length 444
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords alkaline phosphatase
source organism Escherichia coli
total genus Genus: 151
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29
KnotProt deposition date 2014-07-31
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh7A00
2GLQA 1EJJA 3NVLA 3IGYB 3SZZA 3M8YA 2ANHA 1SHQA 1O98A 1ELYA 1E2SP 3OT9A 3BDGB 3DPCA 1KH4A 3ED4A 1E3CP 1EI6A 1EW2A 1AJBA 1KHNA 3SZYA 1ALIA 3TWZA 1HJKA 1KH5A 3UN3A 1ZEBA 1HQAA 3UN2A 3M8WA 1ALJA 2GA3A 4FDIA 1AUKA 3MK1A 1ED9A 3UNYA 1E1ZP 4FDJA 1EW9A 1Y7AA 1N2LA 1E33P 1KHJA 3BDFA 3MK0A 1ANJA 3M7VA 1K7HA 2QZUA 1HDHA 1AJDA 3M8ZA 1N2KA 1ANIA 2G9YA 3CMRA 3UN5A 1KHLA 1ELXA 3DYCA 3UO0A 1ELZA 1Y6VA 3BDGA 2IFYA 3IGZB 1ZEDA 3T01A 1KH7A 1EW8A 1URBA 1EQJA 1AJAA 1ALKA 1KHKA 1B8JA 3T00A 1ED8A 1ZEFA 1P49A 1FSUA 1AJCA 3BDHA 1O99A 1SHNA 3T02A 1URAA 3TX0A 3MK2A 1KH9A
chains in the KnotProt database with same CATH superfamily
2GLQA 1EJJA 3NVLA 3IGYB 3SZZA 3M8YA 2ANHA 1SHQA 1O98A 1ELYA 1E2SP 3OT9A 3BDGB 3DPCA 1KH4A 3ED4A 1E3CP 1EI6A 1EW2A 1AJBA 1KHNA 3SZYA 1ALIA 3TWZA 1HJKA 1KH5A 3UN3A 1ZEBA 1HQAA 3UN2A 3M8WA 1ALJA 2GA3A 4FDIA 1AUKA 3MK1A 1ED9A 3UNYA 1E1ZP 4FDJA 1EW9A 1Y7AA 1N2LA 1E33P 1KHJA 3BDFA 3MK0A 1ANJA 3M7VA 1K7HA 2QZUA 1HDHA 1AJDA 3M8ZA 1N2KA 1ANIA 2G9YA 3CMRA 3UN5A 1KHLA 1ELXA 3DYCA 3UO0A 1ELZA 1Y6VA 3BDGA 2IFYA 3IGZB 1ZEDA 3T01A 1KH7A 1EW8A 1URBA 1EQJA 1AJAA 1ALKA 1KHKA 1B8JA 3T00A 1ED8A 1ZEFA 1P49A 1FSUA 1AJCA 3BDHA 1O99A 1SHNA 3T02A 1URAA 3TX0A 3MK2A 1KH9A
chains in the KnotProt database with same CATH topology
2GLQA 1EJJA 3NVLA 3IGYB 3SZZA 3M8YA 2ANHA 1SHQA 1O98A 1ELYA 1E2SP 3OT9A 3BDGB 3DPCA 1KH4A 3ED4A 1E3CP 1EI6A 1EW2A 1AJBA 1KHNA 3SZYA 1ALIA 3TWZA 1HJKA 1KH5A 3UN3A 1ZEBA 1HQAA 3UN2A 3M8WA 1ALJA 2GA3A 4FDIA 1AUKA 3MK1A 1ED9A 3UNYA 1E1ZP 4FDJA 1EW9A 1Y7AA 1N2LA 1E33P 1KHJA 3BDFA 3MK0A 1ANJA 3M7VA 1K7HA 2QZUA 1HDHA 1AJDA 3M8ZA 1N2KA 1ANIA 2G9YA 3CMRA 3UN5A 1KHLA 1ELXA 3DYCA 3UO0A 1ELZA 1Y6VA 3BDGA 2IFYA 3IGZB 1ZEDA 3T01A 1KH7A 1EW8A 1URBA 1EQJA 1AJAA 1ALKA 1KHKA 1B8JA 3T00A 1ED8A 1ZEFA 1P49A 1FSUA 1AJCA 3BDHA 1O99A 1SHNA 3T02A 1URAA 3TX0A 3MK2A 1KH9A
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 2GLQ A;  1EJJ A;  3NVL A;  3IGY B;  3SZZ A;  3M8Y A;  2ANH A;  1SHQ A;  1O98 A;  1ELY A;  1E2S P;  3OT9 A;  3BDG B;  3DPC A;  1KH4 A;  3ED4 A;  1E3C P;  1EI6 A;  1EW2 A;  1AJB A;  1KHN A;  3SZY A;  1ALI A;  3TWZ A;  1HJK A;  1KH5 A;  3UN3 A;  1ZEB A;  1HQA A;  3UN2 A;  3M8W A;  1ALJ A;  2GA3 A;  4FDI A;  1AUK A;  3MK1 A;  1ED9 A;  3UNY A;  1E1Z P;  4FDJ A;  1EW9 A;  1Y7A A;  1N2L A;  1E33 P;  1KHJ A;  3BDF A;  3MK0 A;  1ANJ A;  3M7V A;  1K7H A;  2QZU A;  1HDH A;  1AJD A;  3M8Z A;  1N2K A;  1ANI A;  2G9Y A;  3CMR A;  3UN5 A;  1KHL A;  1ELX A;  3DYC A;  3UO0 A;  1ELZ A;  1Y6V A;  3BDG A;  2IFY A;  3IGZ B;  1ZED A;  3T01 A;  1KH7 A;  1EW8 A;  1URB A;  1EQJ A;  1AJA A;  1ALK A;  1KHK A;  1B8J A;  3T00 A;  1ED8 A;  1ZEF A;  1P49 A;  1FSU A;  1AJC A;  3BDH A;  1O99 A;  1SHN A;  3T02 A;  1URA A;  3TX0 A;  3MK2 A;  1KH9 A; 
#chains in the KnotProt database with same CATH topology
 2GLQ A;  1EJJ A;  3NVL A;  3IGY B;  3SZZ A;  3M8Y A;  2ANH A;  1SHQ A;  1O98 A;  1ELY A;  1E2S P;  3OT9 A;  3BDG B;  3DPC A;  1KH4 A;  3ED4 A;  1E3C P;  1EI6 A;  1EW2 A;  1AJB A;  1KHN A;  3SZY A;  1ALI A;  3TWZ A;  1HJK A;  1KH5 A;  3UN3 A;  1ZEB A;  1HQA A;  3UN2 A;  3M8W A;  1ALJ A;  2GA3 A;  4FDI A;  1AUK A;  3MK1 A;  1ED9 A;  3UNY A;  1E1Z P;  4FDJ A;  1EW9 A;  1Y7A A;  1N2L A;  1E33 P;  1KHJ A;  3BDF A;  3MK0 A;  1ANJ A;  3M7V A;  1K7H A;  2QZU A;  1HDH A;  1AJD A;  3M8Z A;  1N2K A;  1ANI A;  2G9Y A;  3CMR A;  3UN5 A;  1KHL A;  1ELX A;  3DYC A;  3UO0 A;  1ELZ A;  1Y6V A;  3BDG A;  2IFY A;  3IGZ B;  1ZED A;  3T01 A;  1KH7 A;  1EW8 A;  1URB A;  1EQJ A;  1AJA A;  1ALK A;  1KHK A;  1B8J A;  3T00 A;  1ED8 A;  1ZEF A;  1P49 A;  1FSU A;  1AJC A;  3BDH A;  1O99 A;  1SHN A;  3T02 A;  1URA A;  3TX0 A;  3MK2 A;  1KH9 A; 
#chains in the KnotProt database with same CATH homology
 2GLQ A;  1EJJ A;  3NVL A;  3IGY B;  3SZZ A;  3M8Y A;  2ANH A;  1SHQ A;  1O98 A;  1ELY A;  1E2S P;  3OT9 A;  3BDG B;  3DPC A;  1KH4 A;  3ED4 A;  1E3C P;  1EI6 A;  1EW2 A;  1AJB A;  1KHN A;  3SZY A;  1ALI A;  3TWZ A;  1HJK A;  1KH5 A;  3UN3 A;  1ZEB A;  1HQA A;  3UN2 A;  3M8W A;  1ALJ A;  2GA3 A;  4FDI A;  1AUK A;  3MK1 A;  1ED9 A;  3UNY A;  1E1Z P;  4FDJ A;  1EW9 A;  1Y7A A;  1N2L A;  1E33 P;  1KHJ A;  3BDF A;  3MK0 A;  1ANJ A;  3M7V A;  1K7H A;  2QZU A;  1HDH A;  1AJD A;  3M8Z A;  1N2K A;  1ANI A;  2G9Y A;  3CMR A;  3UN5 A;  1KHL A;  1ELX A;  3DYC A;  3UO0 A;  1ELZ A;  1Y6V A;  3BDG A;  2IFY A;  3IGZ B;  1ZED A;  3T01 A;  1KH7 A;  1EW8 A;  1URB A;  1EQJ A;  1AJA A;  1ALK A;  1KHK A;  1B8J A;  3T00 A;  1ED8 A;  1ZEF A;  1P49 A;  1FSU A;  1AJC A;  3BDH A;  1O99 A;  1SHN A;  3T02 A;  1URA A;  3TX0 A;  3MK2 A;  1KH9 A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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