1KHLA

E. coli alkaline phosphatase mutant (d153hd330n) complex with phosphate
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 42-364 323 1-41 414-444 365-413 41 31 slipknot
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 28-361 334 1-27 367-444 362-366 27 78 slipknot
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3.1 42-367 326 1-41 409-444 368-408 41 36 slipknot
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2.1 25-409 385 1-24 416-444 410-415 24 29 slipknot
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2.1 37-408 372 1-19, 416-444 20-36, 409-415 19 29 slipknot
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2.1 38-408 371 1-36, 416-444 37-37, 409-415 36 29 slipknot
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2.1 39-408 370 1-37, 414-444 38-38, 409-413 37 31 slipknot
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2.1 40-409 370 1-38, 416-444 39-39, 410-415 38 29 slipknot
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2.1 39-362 324 1-31, 368-444 32-38, 363-367 31 77 slipknot
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2.1 43-377 335 1-41, 384-444 42-42, 378-383 41 61 slipknot
sequence length 444
structure length 444
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline Phosphatase
source organism Escherichia coli
total genus Genus: 150
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-30
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1khlA00
1P49A 1ELXA 3TWZA 1ED8A 3T02A 1Y7AA 2G9YA 3ED4A 4FDIA 3DYCA 1EW9A 1HDHA 2IFYA 3BDFA 1ELZA 3M8ZA 1HQAA 1O99A 1AJCA 1ANJA 3MK2A 3UN2A 3M8YA 1ZEBA 2GLQA 4FDJA 1ED9A 3UN5A 1E33P 1FSUA 3UO0A 3DPCA 3NVLA 1KH4A 1URAA 1ZEDA 1KHKA 2ANHA 3BDHA 1O98A 1AJDA 1K7HA 2QZUA 3T00A 1ANIA 1SHQA 1ALKA 1ZEFA 3UNYA 3IGZB 3OT9A 1KH9A 1KHJA 1KH5A 1KHNA 1E2SP 1EI6A 3BDGA 1E1ZP 1EW8A 3TX0A 3IGYB 3CMRA 2GA3A 1AJAA 1EQJA 1AJBA 1ALIA 1KH7A 1AUKA 1ALHA 1ELYA 1HJKA 1SHNA 3M8WA 1B8JA 1URBA 1Y6VA 3SZZA 3UN3A 3T01A 1N2KA 3SZYA 3MK1A 1EJJA 1ALJA 3MK0A 3M7VA 3BDGB 1KHLA 1E3CP 1EW2A 1N2LA
chains in the KnotProt database with same CATH superfamily
1P49A 1ELXA 3TWZA 1ED8A 3T02A 1Y7AA 2G9YA 3ED4A 4FDIA 3DYCA 1EW9A 1HDHA 2IFYA 3BDFA 1ELZA 3M8ZA 1HQAA 1O99A 1AJCA 1ANJA 3MK2A 3UN2A 3M8YA 1ZEBA 2GLQA 4FDJA 1ED9A 3UN5A 1E33P 1FSUA 3UO0A 3DPCA 3NVLA 1KH4A 1URAA 1ZEDA 1KHKA 2ANHA 3BDHA 1O98A 1AJDA 1K7HA 2QZUA 3T00A 1ANIA 1SHQA 1ALKA 1ZEFA 3UNYA 3IGZB 3OT9A 1KH9A 1KHJA 1KH5A 1KHNA 1E2SP 1EI6A 3BDGA 1E1ZP 1EW8A 3TX0A 3IGYB 3CMRA 2GA3A 1AJAA 1EQJA 1AJBA 1ALIA 1KH7A 1AUKA 1ALHA 1ELYA 1HJKA 1SHNA 3M8WA 1B8JA 1URBA 1Y6VA 3SZZA 3UN3A 3T01A 1N2KA 3SZYA 3MK1A 1EJJA 1ALJA 3MK0A 3M7VA 3BDGB 1KHLA 1E3CP 1EW2A 1N2LA
chains in the KnotProt database with same CATH topology
1P49A 1ELXA 3TWZA 1ED8A 3T02A 1Y7AA 2G9YA 3ED4A 4FDIA 3DYCA 1EW9A 1HDHA 2IFYA 3BDFA 1ELZA 3M8ZA 1HQAA 1O99A 1AJCA 1ANJA 3MK2A 3UN2A 3M8YA 1ZEBA 2GLQA 4FDJA 1ED9A 3UN5A 1E33P 1FSUA 3UO0A 3DPCA 3NVLA 1KH4A 1URAA 1ZEDA 1KHKA 2ANHA 3BDHA 1O98A 1AJDA 1K7HA 2QZUA 3T00A 1ANIA 1SHQA 1ALKA 1ZEFA 3UNYA 3IGZB 3OT9A 1KH9A 1KHJA 1KH5A 1KHNA 1E2SP 1EI6A 3BDGA 1E1ZP 1EW8A 3TX0A 3IGYB 3CMRA 2GA3A 1AJAA 1EQJA 1AJBA 1ALIA 1KH7A 1AUKA 1ALHA 1ELYA 1HJKA 1SHNA 3M8WA 1B8JA 1URBA 1Y6VA 3SZZA 3UN3A 3T01A 1N2KA 3SZYA 3MK1A 1EJJA 1ALJA 3MK0A 3M7VA 3BDGB 1KHLA 1E3CP 1EW2A 1N2LA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1P49 A;  1ELX A;  3TWZ A;  1ED8 A;  3T02 A;  1Y7A A;  2G9Y A;  3ED4 A;  4FDI A;  3DYC A;  1EW9 A;  1HDH A;  2IFY A;  3BDF A;  1ELZ A;  3M8Z A;  1HQA A;  1O99 A;  1AJC A;  1ANJ A;  3MK2 A;  3UN2 A;  3M8Y A;  1ZEB A;  2GLQ A;  4FDJ A;  1ED9 A;  3UN5 A;  1E33 P;  1FSU A;  3UO0 A;  3DPC A;  3NVL A;  1KH4 A;  1URA A;  1ZED A;  1KHK A;  2ANH A;  3BDH A;  1O98 A;  1AJD A;  1K7H A;  2QZU A;  3T00 A;  1ANI A;  1SHQ A;  1ALK A;  1ZEF A;  3UNY A;  3IGZ B;  3OT9 A;  1KH9 A;  1KHJ A;  1KH5 A;  1KHN A;  1E2S P;  1EI6 A;  3BDG A;  1E1Z P;  1EW8 A;  3TX0 A;  3IGY B;  3CMR A;  2GA3 A;  1AJA A;  1EQJ A;  1AJB A;  1ALI A;  1KH7 A;  1AUK A;  1ALH A;  1ELY A;  1HJK A;  1SHN A;  3M8W A;  1B8J A;  1URB A;  1Y6V A;  3SZZ A;  3UN3 A;  3T01 A;  1N2K A;  3SZY A;  3MK1 A;  1EJJ A;  1ALJ A;  3MK0 A;  3M7V A;  3BDG B;  1KHL A;  1E3C P;  1EW2 A;  1N2L A; 
#chains in the KnotProt database with same CATH topology
 1P49 A;  1ELX A;  3TWZ A;  1ED8 A;  3T02 A;  1Y7A A;  2G9Y A;  3ED4 A;  4FDI A;  3DYC A;  1EW9 A;  1HDH A;  2IFY A;  3BDF A;  1ELZ A;  3M8Z A;  1HQA A;  1O99 A;  1AJC A;  1ANJ A;  3MK2 A;  3UN2 A;  3M8Y A;  1ZEB A;  2GLQ A;  4FDJ A;  1ED9 A;  3UN5 A;  1E33 P;  1FSU A;  3UO0 A;  3DPC A;  3NVL A;  1KH4 A;  1URA A;  1ZED A;  1KHK A;  2ANH A;  3BDH A;  1O98 A;  1AJD A;  1K7H A;  2QZU A;  3T00 A;  1ANI A;  1SHQ A;  1ALK A;  1ZEF A;  3UNY A;  3IGZ B;  3OT9 A;  1KH9 A;  1KHJ A;  1KH5 A;  1KHN A;  1E2S P;  1EI6 A;  3BDG A;  1E1Z P;  1EW8 A;  3TX0 A;  3IGY B;  3CMR A;  2GA3 A;  1AJA A;  1EQJ A;  1AJB A;  1ALI A;  1KH7 A;  1AUK A;  1ALH A;  1ELY A;  1HJK A;  1SHN A;  3M8W A;  1B8J A;  1URB A;  1Y6V A;  3SZZ A;  3UN3 A;  3T01 A;  1N2K A;  3SZY A;  3MK1 A;  1EJJ A;  1ALJ A;  3MK0 A;  3M7V A;  3BDG B;  1KHL A;  1E3C P;  1EW2 A;  1N2L A; 
#chains in the KnotProt database with same CATH homology
 1P49 A;  1ELX A;  3TWZ A;  1ED8 A;  3T02 A;  1Y7A A;  2G9Y A;  3ED4 A;  4FDI A;  3DYC A;  1EW9 A;  1HDH A;  2IFY A;  3BDF A;  1ELZ A;  3M8Z A;  1HQA A;  1O99 A;  1AJC A;  1ANJ A;  3MK2 A;  3UN2 A;  3M8Y A;  1ZEB A;  2GLQ A;  4FDJ A;  1ED9 A;  3UN5 A;  1E33 P;  1FSU A;  3UO0 A;  3DPC A;  3NVL A;  1KH4 A;  1URA A;  1ZED A;  1KHK A;  2ANH A;  3BDH A;  1O98 A;  1AJD A;  1K7H A;  2QZU A;  3T00 A;  1ANI A;  1SHQ A;  1ALK A;  1ZEF A;  3UNY A;  3IGZ B;  3OT9 A;  1KH9 A;  1KHJ A;  1KH5 A;  1KHN A;  1E2S P;  1EI6 A;  3BDG A;  1E1Z P;  1EW8 A;  3TX0 A;  3IGY B;  3CMR A;  2GA3 A;  1AJA A;  1EQJ A;  1AJB A;  1ALI A;  1KH7 A;  1AUK A;  1ALH A;  1ELY A;  1HJK A;  1SHN A;  3M8W A;  1B8J A;  1URB A;  1Y6V A;  3SZZ A;  3UN3 A;  3T01 A;  1N2K A;  3SZY A;  3MK1 A;  1EJJ A;  1ALJ A;  3MK0 A;  3M7V A;  3BDG B;  1KHL A;  1E3C P;  1EW2 A;  1N2L A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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