1KHLA

E. coli alkaline phosphatase mutant (d153hd330n) complex with phosphate
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 42-364 323 1-41 414-444 365-413 41 31 slipknot
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 28-361 334 1-27 367-444 362-366 27 78 slipknot
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3.1 42-367 326 1-41 409-444 368-408 41 36 slipknot
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2.1 25-409 385 1-24 416-444 410-415 24 29 slipknot
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2.1 37-408 372 1-19, 416-444 20-36, 409-415 19 29 slipknot
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2.1 38-408 371 1-36, 416-444 37-37, 409-415 36 29 slipknot
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2.1 39-408 370 1-37, 414-444 38-38, 409-413 37 31 slipknot
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2.1 40-409 370 1-38, 416-444 39-39, 410-415 38 29 slipknot
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2.1 39-362 324 1-31, 368-444 32-38, 363-367 31 77 slipknot
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2.1 43-377 335 1-41, 384-444 42-42, 378-383 41 61 slipknot
sequence length 444
structure length 444
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline Phosphatase
source organism Escherichia coli
total genus Genus: 150
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-30
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1khlA00
1HDHA 2IFYA 1KH5A 1O99A 1KHNA 1URAA 2GA3A 1ELXA 1AJAA 3BDGB 1EW2A 1Y7AA 1HJKA 1URBA 1KHKA 1AUKA 2QZUA 3UNYA 1HQAA 3IGZB 2GLQA 1EQJA 3UN3A 1N2LA 1FSUA 1EI6A 1ALHA 3UO0A 1P49A 3SZZA 3MK2A 3T00A 1ZEDA 4FDIA 3M7VA 3TWZA 1ELZA 3BDHA 3BDGA 1KH4A 1AJDA 1B8JA 1KHJA 1ED8A 3ED4A 3NVLA 3SZYA 1E1ZP 3DYCA 3M8WA 3CMRA 3T01A 1K7HA 1ED9A 1O98A 1ZEBA 3M8ZA 1EW8A 1ANJA 1KH7A 1N2KA 4FDJA 1Y6VA 3BDFA 1AJCA 3OT9A 1ELYA 1KH9A 1KHLA 3UN5A 1ZEFA 2G9YA 1EJJA 1E2SP 3MK0A 1ANIA 1E3CP 1ALIA 3MK1A 3T02A 1EW9A 3UN2A 3M8YA 1ALKA 3DPCA 1SHQA 3IGYB 1ALJA 1SHNA 2ANHA 3TX0A 1AJBA 1E33P
chains in the KnotProt database with same CATH superfamily
1HDHA 2IFYA 1KH5A 1O99A 1KHNA 1URAA 2GA3A 1ELXA 1AJAA 3BDGB 1EW2A 1Y7AA 1HJKA 1URBA 1KHKA 1AUKA 2QZUA 3UNYA 1HQAA 3IGZB 2GLQA 1EQJA 3UN3A 1N2LA 1FSUA 1EI6A 1ALHA 3UO0A 1P49A 3SZZA 3MK2A 3T00A 1ZEDA 4FDIA 3M7VA 3TWZA 1ELZA 3BDHA 3BDGA 1KH4A 1AJDA 1B8JA 1KHJA 1ED8A 3ED4A 3NVLA 3SZYA 1E1ZP 3DYCA 3M8WA 3CMRA 3T01A 1K7HA 1ED9A 1O98A 1ZEBA 3M8ZA 1EW8A 1ANJA 1KH7A 1N2KA 4FDJA 1Y6VA 3BDFA 1AJCA 3OT9A 1ELYA 1KH9A 1KHLA 3UN5A 1ZEFA 2G9YA 1EJJA 1E2SP 3MK0A 1ANIA 1E3CP 1ALIA 3MK1A 3T02A 1EW9A 3UN2A 3M8YA 1ALKA 3DPCA 1SHQA 3IGYB 1ALJA 1SHNA 2ANHA 3TX0A 1AJBA 1E33P
chains in the KnotProt database with same CATH topology
1HDHA 2IFYA 1KH5A 1O99A 1KHNA 1URAA 2GA3A 1ELXA 1AJAA 3BDGB 1EW2A 1Y7AA 1HJKA 1URBA 1KHKA 1AUKA 2QZUA 3UNYA 1HQAA 3IGZB 2GLQA 1EQJA 3UN3A 1N2LA 1FSUA 1EI6A 1ALHA 3UO0A 1P49A 3SZZA 3MK2A 3T00A 1ZEDA 4FDIA 3M7VA 3TWZA 1ELZA 3BDHA 3BDGA 1KH4A 1AJDA 1B8JA 1KHJA 1ED8A 3ED4A 3NVLA 3SZYA 1E1ZP 3DYCA 3M8WA 3CMRA 3T01A 1K7HA 1ED9A 1O98A 1ZEBA 3M8ZA 1EW8A 1ANJA 1KH7A 1N2KA 4FDJA 1Y6VA 3BDFA 1AJCA 3OT9A 1ELYA 1KH9A 1KHLA 3UN5A 1ZEFA 2G9YA 1EJJA 1E2SP 3MK0A 1ANIA 1E3CP 1ALIA 3MK1A 3T02A 1EW9A 3UN2A 3M8YA 1ALKA 3DPCA 1SHQA 3IGYB 1ALJA 1SHNA 2ANHA 3TX0A 1AJBA 1E33P
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1HDH A;  2IFY A;  1KH5 A;  1O99 A;  1KHN A;  1URA A;  2GA3 A;  1ELX A;  1AJA A;  3BDG B;  1EW2 A;  1Y7A A;  1HJK A;  1URB A;  1KHK A;  1AUK A;  2QZU A;  3UNY A;  1HQA A;  3IGZ B;  2GLQ A;  1EQJ A;  3UN3 A;  1N2L A;  1FSU A;  1EI6 A;  1ALH A;  3UO0 A;  1P49 A;  3SZZ A;  3MK2 A;  3T00 A;  1ZED A;  4FDI A;  3M7V A;  3TWZ A;  1ELZ A;  3BDH A;  3BDG A;  1KH4 A;  1AJD A;  1B8J A;  1KHJ A;  1ED8 A;  3ED4 A;  3NVL A;  3SZY A;  1E1Z P;  3DYC A;  3M8W A;  3CMR A;  3T01 A;  1K7H A;  1ED9 A;  1O98 A;  1ZEB A;  3M8Z A;  1EW8 A;  1ANJ A;  1KH7 A;  1N2K A;  4FDJ A;  1Y6V A;  3BDF A;  1AJC A;  3OT9 A;  1ELY A;  1KH9 A;  1KHL A;  3UN5 A;  1ZEF A;  2G9Y A;  1EJJ A;  1E2S P;  3MK0 A;  1ANI A;  1E3C P;  1ALI A;  3MK1 A;  3T02 A;  1EW9 A;  3UN2 A;  3M8Y A;  1ALK A;  3DPC A;  1SHQ A;  3IGY B;  1ALJ A;  1SHN A;  2ANH A;  3TX0 A;  1AJB A;  1E33 P; 
#chains in the KnotProt database with same CATH topology
 1HDH A;  2IFY A;  1KH5 A;  1O99 A;  1KHN A;  1URA A;  2GA3 A;  1ELX A;  1AJA A;  3BDG B;  1EW2 A;  1Y7A A;  1HJK A;  1URB A;  1KHK A;  1AUK A;  2QZU A;  3UNY A;  1HQA A;  3IGZ B;  2GLQ A;  1EQJ A;  3UN3 A;  1N2L A;  1FSU A;  1EI6 A;  1ALH A;  3UO0 A;  1P49 A;  3SZZ A;  3MK2 A;  3T00 A;  1ZED A;  4FDI A;  3M7V A;  3TWZ A;  1ELZ A;  3BDH A;  3BDG A;  1KH4 A;  1AJD A;  1B8J A;  1KHJ A;  1ED8 A;  3ED4 A;  3NVL A;  3SZY A;  1E1Z P;  3DYC A;  3M8W A;  3CMR A;  3T01 A;  1K7H A;  1ED9 A;  1O98 A;  1ZEB A;  3M8Z A;  1EW8 A;  1ANJ A;  1KH7 A;  1N2K A;  4FDJ A;  1Y6V A;  3BDF A;  1AJC A;  3OT9 A;  1ELY A;  1KH9 A;  1KHL A;  3UN5 A;  1ZEF A;  2G9Y A;  1EJJ A;  1E2S P;  3MK0 A;  1ANI A;  1E3C P;  1ALI A;  3MK1 A;  3T02 A;  1EW9 A;  3UN2 A;  3M8Y A;  1ALK A;  3DPC A;  1SHQ A;  3IGY B;  1ALJ A;  1SHN A;  2ANH A;  3TX0 A;  1AJB A;  1E33 P; 
#chains in the KnotProt database with same CATH homology
 1HDH A;  2IFY A;  1KH5 A;  1O99 A;  1KHN A;  1URA A;  2GA3 A;  1ELX A;  1AJA A;  3BDG B;  1EW2 A;  1Y7A A;  1HJK A;  1URB A;  1KHK A;  1AUK A;  2QZU A;  3UNY A;  1HQA A;  3IGZ B;  2GLQ A;  1EQJ A;  3UN3 A;  1N2L A;  1FSU A;  1EI6 A;  1ALH A;  3UO0 A;  1P49 A;  3SZZ A;  3MK2 A;  3T00 A;  1ZED A;  4FDI A;  3M7V A;  3TWZ A;  1ELZ A;  3BDH A;  3BDG A;  1KH4 A;  1AJD A;  1B8J A;  1KHJ A;  1ED8 A;  3ED4 A;  3NVL A;  3SZY A;  1E1Z P;  3DYC A;  3M8W A;  3CMR A;  3T01 A;  1K7H A;  1ED9 A;  1O98 A;  1ZEB A;  3M8Z A;  1EW8 A;  1ANJ A;  1KH7 A;  1N2K A;  4FDJ A;  1Y6V A;  3BDF A;  1AJC A;  3OT9 A;  1ELY A;  1KH9 A;  1KHL A;  3UN5 A;  1ZEF A;  2G9Y A;  1EJJ A;  1E2S P;  3MK0 A;  1ANI A;  1E3C P;  1ALI A;  3MK1 A;  3T02 A;  1EW9 A;  3UN2 A;  3M8Y A;  1ALK A;  3DPC A;  1SHQ A;  3IGY B;  1ALJ A;  1SHN A;  2ANH A;  3TX0 A;  1AJB A;  1E33 P; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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