1E1ZP

Crystal structure of an arylsulfatase a mutant c69s
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 7-264 258 1-6 295-485 265-294 6 191 slipknot
Chain Sequence
RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLSTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLG----ATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCP
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 6-264 259 1-5 291-481 265-290 5 191 slipknot
view details
3.1 4-290 287 1-3 294-481 291-293 3 188 slipknot
view details
3.1 9-280 272 1-5, 288-481 6-8, 281-287 5 194 slipknot
sequence length 485
structure length 481
publication title Crystal Structure of an Enzyme-Substrate Complex Provides Insight Into the Interaction between Human Arylsulfatase a and its Substrates During Catalysis
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords ARYLSULFATASE A
missing residues 426-429
total genus Genus: 154
ec nomenclature ec 3.1.6.8: Cerebroside-sulfatase.
pdb deposition date 2000-05-12
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
P PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.10 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 1e1zP02
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1e1zP01
3ED4A 3TX0A 3MK2A 1ANJA 1ED9A 1HJKA 1KH9A 3UNYA 1O99A 1EJJA 1KH7A 1EQJA 1Y6VA 3M8YA 1EW9A 3TWZA 3OT9A 3T02A 1E2SP 1EW2A 2G9YA 1KH5A 1KHLA 1SHNA 1ALIA 3T00A 3CMRA 3M7VA 1N2LA 1URBA 1ELXA 3NVLA 1E1ZP 3DYCA 1N2KA 1K7HA 2GA3A 3BDGA 1AJBA 3M8ZA 1HDHA 4FDIA 1ALKA 3IGZB 1AJDA 1SHQA 3UO0A 1AJCA 1Y7AA 3UN5A 1E3CP 1ELZA 1ED8A 1URAA 1ZEFA 1E33P 1KHJA 3BDHA 1ALJA 1B8JA 4FDJA 1P49A 1KHNA 1AUKA 3MK0A 3SZYA 1HQAA 1KHKA 1AJAA 3UN3A 1ZEDA 1EI6A 1ZEBA 3SZZA 1O98A 3M8WA 1FSUA 3BDGB 1ANIA 1ELYA 1EW8A 2ANHA 1KH4A 2GLQA 3IGYB 2QZUA 2IFYA 3MK1A 3T01A 3UN2A 3BDFA 3DPCA
chains in the KnotProt database with same CATH superfamily
3ED4A 3TX0A 3MK2A 1ANJA 1ED9A 1HJKA 1KH9A 3UNYA 1O99A 1EJJA 1KH7A 1EQJA 1Y6VA 3M8YA 1EW9A 3TWZA 3OT9A 3T02A 1E2SP 1EW2A 2G9YA 1KH5A 1KHLA 1SHNA 1ALIA 3T00A 3CMRA 3M7VA 1N2LA 1URBA 1ELXA 3NVLA 1E1ZP 3DYCA 1N2KA 1K7HA 2GA3A 3BDGA 1AJBA 3M8ZA 1HDHA 4FDIA 1ALKA 3IGZB 1AJDA 1SHQA 3UO0A 1AJCA 1Y7AA 3UN5A 1E3CP 1ELZA 1ED8A 1URAA 1ZEFA 1E33P 1KHJA 3BDHA 1ALJA 1B8JA 4FDJA 1P49A 1KHNA 1AUKA 3MK0A 3SZYA 1HQAA 1KHKA 1AJAA 3UN3A 1ZEDA 1EI6A 1ZEBA 3SZZA 1O98A 3M8WA 1FSUA 3BDGB 1ANIA 1ELYA 1EW8A 2ANHA 1KH4A 2GLQA 3IGYB 2QZUA 2IFYA 3MK1A 3T01A 3UN2A 3BDFA 3DPCA
chains in the KnotProt database with same CATH topology
3ED4A 3TX0A 3MK2A 1ANJA 1ED9A 1HJKA 1KH9A 3UNYA 1O99A 1EJJA 1KH7A 1EQJA 1Y6VA 3M8YA 1EW9A 3TWZA 3OT9A 3T02A 1E2SP 1EW2A 2G9YA 1KH5A 1KHLA 1SHNA 1ALIA 3T00A 3CMRA 3M7VA 1N2LA 1URBA 1ELXA 3NVLA 1E1ZP 3DYCA 1N2KA 1K7HA 2GA3A 3BDGA 1AJBA 3M8ZA 1HDHA 4FDIA 1ALKA 3IGZB 1AJDA 1SHQA 3UO0A 1AJCA 1Y7AA 3UN5A 1E3CP 1ELZA 1ED8A 1URAA 1ZEFA 1E33P 1KHJA 3BDHA 1ALJA 1B8JA 4FDJA 1P49A 1KHNA 1AUKA 3MK0A 3SZYA 1HQAA 1KHKA 1AJAA 3UN3A 1ZEDA 1EI6A 1ZEBA 3SZZA 1O98A 3M8WA 1FSUA 3BDGB 1ANIA 1ELYA 1EW8A 2ANHA 1KH4A 2GLQA 3IGYB 2QZUA 2IFYA 3MK1A 3T01A 3UN2A 3BDFA 3DPCA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 3ED4 A;  3TX0 A;  3MK2 A;  1ANJ A;  1ED9 A;  1HJK A;  1KH9 A;  3UNY A;  1O99 A;  1EJJ A;  1KH7 A;  1EQJ A;  1Y6V A;  3M8Y A;  1EW9 A;  3TWZ A;  3OT9 A;  3T02 A;  1E2S P;  1EW2 A;  2G9Y A;  1KH5 A;  1KHL A;  1SHN A;  1ALI A;  3T00 A;  3CMR A;  3M7V A;  1N2L A;  1URB A;  1ELX A;  3NVL A;  1E1Z P;  3DYC A;  1N2K A;  1K7H A;  2GA3 A;  3BDG A;  1AJB A;  3M8Z A;  1HDH A;  4FDI A;  1ALK A;  3IGZ B;  1AJD A;  1SHQ A;  3UO0 A;  1AJC A;  1Y7A A;  3UN5 A;  1E3C P;  1ELZ A;  1ED8 A;  1URA A;  1ZEF A;  1E33 P;  1KHJ A;  3BDH A;  1ALJ A;  1B8J A;  4FDJ A;  1P49 A;  1KHN A;  1AUK A;  3MK0 A;  3SZY A;  1HQA A;  1KHK A;  1AJA A;  3UN3 A;  1ZED A;  1EI6 A;  1ZEB A;  3SZZ A;  1O98 A;  3M8W A;  1FSU A;  3BDG B;  1ANI A;  1ELY A;  1EW8 A;  2ANH A;  1KH4 A;  2GLQ A;  3IGY B;  2QZU A;  2IFY A;  3MK1 A;  3T01 A;  3UN2 A;  3BDF A;  3DPC A; 
#chains in the KnotProt database with same CATH topology
 3ED4 A;  3TX0 A;  3MK2 A;  1ANJ A;  1ED9 A;  1HJK A;  1KH9 A;  3UNY A;  1O99 A;  1EJJ A;  1KH7 A;  1EQJ A;  1Y6V A;  3M8Y A;  1EW9 A;  3TWZ A;  3OT9 A;  3T02 A;  1E2S P;  1EW2 A;  2G9Y A;  1KH5 A;  1KHL A;  1SHN A;  1ALI A;  3T00 A;  3CMR A;  3M7V A;  1N2L A;  1URB A;  1ELX A;  3NVL A;  1E1Z P;  3DYC A;  1N2K A;  1K7H A;  2GA3 A;  3BDG A;  1AJB A;  3M8Z A;  1HDH A;  4FDI A;  1ALK A;  3IGZ B;  1AJD A;  1SHQ A;  3UO0 A;  1AJC A;  1Y7A A;  3UN5 A;  1E3C P;  1ELZ A;  1ED8 A;  1URA A;  1ZEF A;  1E33 P;  1KHJ A;  3BDH A;  1ALJ A;  1B8J A;  4FDJ A;  1P49 A;  1KHN A;  1AUK A;  3MK0 A;  3SZY A;  1HQA A;  1KHK A;  1AJA A;  3UN3 A;  1ZED A;  1EI6 A;  1ZEB A;  3SZZ A;  1O98 A;  3M8W A;  1FSU A;  3BDG B;  1ANI A;  1ELY A;  1EW8 A;  2ANH A;  1KH4 A;  2GLQ A;  3IGY B;  2QZU A;  2IFY A;  3MK1 A;  3T01 A;  3UN2 A;  3BDF A;  3DPC A; 
#chains in the KnotProt database with same CATH homology
 3ED4 A;  3TX0 A;  3MK2 A;  1ANJ A;  1ED9 A;  1HJK A;  1KH9 A;  3UNY A;  1O99 A;  1EJJ A;  1KH7 A;  1EQJ A;  1Y6V A;  3M8Y A;  1EW9 A;  3TWZ A;  3OT9 A;  3T02 A;  1E2S P;  1EW2 A;  2G9Y A;  1KH5 A;  1KHL A;  1SHN A;  1ALI A;  3T00 A;  3CMR A;  3M7V A;  1N2L A;  1URB A;  1ELX A;  3NVL A;  1E1Z P;  3DYC A;  1N2K A;  1K7H A;  2GA3 A;  3BDG A;  1AJB A;  3M8Z A;  1HDH A;  4FDI A;  1ALK A;  3IGZ B;  1AJD A;  1SHQ A;  3UO0 A;  1AJC A;  1Y7A A;  3UN5 A;  1E3C P;  1ELZ A;  1ED8 A;  1URA A;  1ZEF A;  1E33 P;  1KHJ A;  3BDH A;  1ALJ A;  1B8J A;  4FDJ A;  1P49 A;  1KHN A;  1AUK A;  3MK0 A;  3SZY A;  1HQA A;  1KHK A;  1AJA A;  3UN3 A;  1ZED A;  1EI6 A;  1ZEB A;  3SZZ A;  1O98 A;  3M8W A;  1FSU A;  3BDG B;  1ANI A;  1ELY A;  1EW8 A;  2ANH A;  1KH4 A;  2GLQ A;  3IGY B;  2QZU A;  2IFY A;  3MK1 A;  3T01 A;  3UN2 A;  3BDF A;  3DPC A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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