1P49A

Structure of human placental estrone/dhea sulfatase
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 10-320 311 1-9 357-553 321-356 9 197 slipknot
Chain Sequence
AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPL-TPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVC----FATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDRE
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 6-317 312 1-5 322-548 318-321 5 227 slipknot
view details
3.1 10-320 311 1-9 342-548 321-341 9 207 slipknot
view details
3.1 7-353 347 1-6 357-548 354-356 6 192 slipknot
view details
2.1 9-345 337 1-5, 354-548 6-8, 346-353 5 195 slipknot
sequence length 553
structure length 548
publication title Structure of Human Estrone Sulfatase Suggests Functional Roles of Membrane Association
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords STERYL-SULFATASE
missing residues 53, 455-458
total genus Genus: 169
ec nomenclature ec 3.1.6.2: Steryl-sulfatase.
pdb deposition date 2003-04-21
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.287.550 Mainly Alpha Orthogonal Bundle Helix Hairpins Helix hairpin bin 1p49A02
3.30.1120.10 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 1p49A03
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1p49A01
1AJDA 1EW9A 1URBA 3SZYA 3BDFA 2GLQA 3M8WA 1Y6VA 1HJKA 1E1ZP 1KHLA 2ANHA 3UN5A 1AJBA 1KHKA 3MK2A 1AUKA 1EW8A 3M7VA 4FDIA 3BDGA 2GA3A 3DYCA 3NVLA 1SHQA 3UN2A 4FDJA 3T00A 1E2SP 2IFYA 1EQJA 1Y7AA 3UO0A 1E3CP 3OT9A 3TWZA 3CMRA 1ELXA 1KH5A 1KHNA 3TX0A 1ED9A 3M8YA 1HQAA 1ZEBA 3SZZA 3UNYA 1ANJA 3MK0A 1HDHA 1ELZA 2G9YA 1EI6A 1N2KA 3IGYB 3DPCA 1N2LA 1B8JA 1E33P 2QZUA 1FSUA 1KH4A 1O98A 3T01A 1ED8A 1EW2A 1SHNA 1ELYA 1AJCA 3UN3A 1ALJA 1K7HA 3IGZB 3ED4A 1P49A 1URAA 1ANIA 1KHJA 3BDGB 3M8ZA 3MK1A 1AJAA 1ZEFA 3BDHA 1EJJA 3T02A 1ALIA 1ALKA 1ZEDA 1KH9A 1KH7A 1O99A
chains in the KnotProt database with same CATH superfamily
1AJDA 1EW9A 1URBA 3SZYA 3BDFA 2GLQA 3M8WA 1Y6VA 1HJKA 1E1ZP 1KHLA 2ANHA 3UN5A 1AJBA 1KHKA 3MK2A 1AUKA 1EW8A 3M7VA 4FDIA 3BDGA 2GA3A 3DYCA 3NVLA 1SHQA 3UN2A 4FDJA 3T00A 1E2SP 2IFYA 1EQJA 1Y7AA 3UO0A 1E3CP 3OT9A 3TWZA 3CMRA 2B5UA 1ELXA 1KH5A 1KHNA 3TX0A 1ED9A 3M8YA 1HQAA 1ZEBA 3SZZA 3UNYA 1JCHA 1ANJA 3MK0A 1HDHA 1ELZA 2G9YA 1EI6A 1N2KA 3IGYB 3DPCA 1N2LA 1B8JA 1E33P 2QZUA 1FSUA 1KH4A 1O98A 3T01A 1ED8A 1EW2A 1SHNA 1ELYA 1AJCA 3UN3A 1ALJA 1K7HA 3IGZB 3ED4A 1P49A 1URAA 1ANIA 1KHJA 3BDGB 3M8ZA 3MK1A 1AJAA 1ZEFA 3BDHA 1EJJA 3T02A 1ALIA 1ALKA 1ZEDA 1KH9A 1KH7A 1O99A
chains in the KnotProt database with same CATH topology
1AJDA 1EW9A 1URBA 3SZYA 3BDFA 2GLQA 3M8WA 1Y6VA 1HJKA 1E1ZP 1KHLA 2ANHA 3UN5A 1AJBA 1KHKA 3MK2A 1AUKA 1EW8A 3M7VA 4FDIA 3BDGA 2GA3A 3DYCA 3NVLA 1SHQA 3UN2A 4FDJA 3T00A 1E2SP 2IFYA 1EQJA 1Y7AA 3UO0A 1E3CP 3OT9A 3TWZA 3CMRA 1ELXA 1KH5A 1KHNA 3TX0A 1ED9A 3M8YA 1HQAA 1ZEBA 3SZZA 3UNYA 1ANJA 3MK0A 1HDHA 1ELZA 2G9YA 1EI6A 1N2KA 3IGYB 3DPCA 1N2LA 1B8JA 1E33P 2QZUA 1FSUA 1KH4A 1O98A 3T01A 1ED8A 1EW2A 1SHNA 1ELYA 1AJCA 3UN3A 1ALJA 1K7HA 3IGZB 3ED4A 1P49A 1URAA 1ANIA 1KHJA 3BDGB 3M8ZA 3MK1A 1AJAA 1ZEFA 3BDHA 1EJJA 3T02A 1ALIA 1ALKA 1ZEDA 1KH9A 1KH7A 1O99A
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1AJD A;  1EW9 A;  1URB A;  3SZY A;  3BDF A;  2GLQ A;  3M8W A;  1Y6V A;  1HJK A;  1E1Z P;  1KHL A;  2ANH A;  3UN5 A;  1AJB A;  1KHK A;  3MK2 A;  1AUK A;  1EW8 A;  3M7V A;  4FDI A;  3BDG A;  2GA3 A;  3DYC A;  3NVL A;  1SHQ A;  3UN2 A;  4FDJ A;  3T00 A;  1E2S P;  2IFY A;  1EQJ A;  1Y7A A;  3UO0 A;  1E3C P;  3OT9 A;  3TWZ A;  3CMR A;  1ELX A;  1KH5 A;  1KHN A;  3TX0 A;  1ED9 A;  3M8Y A;  1HQA A;  1ZEB A;  3SZZ A;  3UNY A;  1ANJ A;  3MK0 A;  1HDH A;  1ELZ A;  2G9Y A;  1EI6 A;  1N2K A;  3IGY B;  3DPC A;  1N2L A;  1B8J A;  1E33 P;  2QZU A;  1FSU A;  1KH4 A;  1O98 A;  3T01 A;  1ED8 A;  1EW2 A;  1SHN A;  1ELY A;  1AJC A;  3UN3 A;  1ALJ A;  1K7H A;  3IGZ B;  3ED4 A;  1P49 A;  1URA A;  1ANI A;  1KHJ A;  3BDG B;  3M8Z A;  3MK1 A;  1AJA A;  1ZEF A;  3BDH A;  1EJJ A;  3T02 A;  1ALI A;  1ALK A;  1ZED A;  1KH9 A;  1KH7 A;  1O99 A; 
#chains in the KnotProt database with same CATH topology
 1AJD A;  1EW9 A;  1URB A;  3SZY A;  3BDF A;  2GLQ A;  3M8W A;  1Y6V A;  1HJK A;  1E1Z P;  1KHL A;  2ANH A;  3UN5 A;  1AJB A;  1KHK A;  3MK2 A;  1AUK A;  1EW8 A;  3M7V A;  4FDI A;  3BDG A;  2GA3 A;  3DYC A;  3NVL A;  1SHQ A;  3UN2 A;  4FDJ A;  3T00 A;  1E2S P;  2IFY A;  1EQJ A;  1Y7A A;  3UO0 A;  1E3C P;  3OT9 A;  3TWZ A;  3CMR A;  2B5U A;  1ELX A;  1KH5 A;  1KHN A;  3TX0 A;  1ED9 A;  3M8Y A;  1HQA A;  1ZEB A;  3SZZ A;  3UNY A;  1JCH A;  1ANJ A;  3MK0 A;  1HDH A;  1ELZ A;  2G9Y A;  1EI6 A;  1N2K A;  3IGY B;  3DPC A;  1N2L A;  1B8J A;  1E33 P;  2QZU A;  1FSU A;  1KH4 A;  1O98 A;  3T01 A;  1ED8 A;  1EW2 A;  1SHN A;  1ELY A;  1AJC A;  3UN3 A;  1ALJ A;  1K7H A;  3IGZ B;  3ED4 A;  1P49 A;  1URA A;  1ANI A;  1KHJ A;  3BDG B;  3M8Z A;  3MK1 A;  1AJA A;  1ZEF A;  3BDH A;  1EJJ A;  3T02 A;  1ALI A;  1ALK A;  1ZED A;  1KH9 A;  1KH7 A;  1O99 A; 
#chains in the KnotProt database with same CATH homology
 1AJD A;  1EW9 A;  1URB A;  3SZY A;  3BDF A;  2GLQ A;  3M8W A;  1Y6V A;  1HJK A;  1E1Z P;  1KHL A;  2ANH A;  3UN5 A;  1AJB A;  1KHK A;  3MK2 A;  1AUK A;  1EW8 A;  3M7V A;  4FDI A;  3BDG A;  2GA3 A;  3DYC A;  3NVL A;  1SHQ A;  3UN2 A;  4FDJ A;  3T00 A;  1E2S P;  2IFY A;  1EQJ A;  1Y7A A;  3UO0 A;  1E3C P;  3OT9 A;  3TWZ A;  3CMR A;  1ELX A;  1KH5 A;  1KHN A;  3TX0 A;  1ED9 A;  3M8Y A;  1HQA A;  1ZEB A;  3SZZ A;  3UNY A;  1ANJ A;  3MK0 A;  1HDH A;  1ELZ A;  2G9Y A;  1EI6 A;  1N2K A;  3IGY B;  3DPC A;  1N2L A;  1B8J A;  1E33 P;  2QZU A;  1FSU A;  1KH4 A;  1O98 A;  3T01 A;  1ED8 A;  1EW2 A;  1SHN A;  1ELY A;  1AJC A;  3UN3 A;  1ALJ A;  1K7H A;  3IGZ B;  3ED4 A;  1P49 A;  1URA A;  1ANI A;  1KHJ A;  3BDG B;  3M8Z A;  3MK1 A;  1AJA A;  1ZEF A;  3BDH A;  1EJJ A;  3T02 A;  1ALI A;  1ALK A;  1ZED A;  1KH9 A;  1KH7 A;  1O99 A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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