1P49A

Structure of human placental estrone/dhea sulfatase
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 169
Slipknot S +31

  Help Knotting data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 10-320 311 1-9 357-553 321-356 9 197 slipknot
Chain Sequence
AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPL-TPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVC----FATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDRE
Whole chain analysis

  Help Knotoid data interpretation Full screen
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


  Help Knotoid subchains data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 6-317 312 1-5 322-548 318-321 5 227 slipknot
view details
3.1 10-320 311 1-9 342-548 321-341 9 207 slipknot
view details
3.1 7-353 347 1-6 357-548 354-356 6 192 slipknot
view details
2.1 9-345 337 1-5, 354-548 6-8, 346-353 5 195 slipknot
sequence length 553
structure length 548
publication title Structure of Human Estrone Sulfatase Suggests Functional Roles of Membrane Association
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords STERYL-SULFATASE
missing residues 53, 455-458
total genus Genus: 169
ec nomenclature ec 3.1.6.2: Steryl-sulfatase.
pdb deposition date 2003-04-21
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.287.550 Mainly Alpha Orthogonal Bundle Helix Hairpins Helix hairpin bin 1p49A02
3.30.1120.10 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 1p49A03
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1p49A01
1O98A 3UNYA 1ELYA 1EW8A 1ELZA 3ED4A 1B8JA 4FDJA 1KH9A 3MK1A 1EI6A 1SHNA 3DPCA 3M7VA 1ANJA 1KH7A 3T02A 3TX0A 2G9YA 3BDHA 1Y6VA 1AJDA 1FSUA 1EQJA 1ELXA 1HDHA 1ED8A 1AUKA 3IGYB 1E33P 3NVLA 1E1ZP 1ZEFA 1K7HA 1EJJA 3M8YA 1EW2A 2QZUA 1AJCA 1O99A 1ZEBA 1ALIA 1E2SP 3DYCA 3M8ZA 3MK2A 1HQAA 3BDFA 4FDIA 1Y7AA 3SZZA 3UN3A 1KHJA 3SZYA 1P49A 3TWZA 3UO0A 3UN2A 2ANHA 3T01A 1URBA 1EW9A 1KHLA 1ANIA 1N2KA 3M8WA 1E3CP 1ED9A 3CMRA 2GA3A 1AJBA 1URAA 1KH5A 1SHQA 1KHNA 3BDGA 3BDGB 3UN5A 1N2LA 2GLQA 1ALJA 1AJAA 1HJKA 1ZEDA 3IGZB 1ALKA 3T00A 3OT9A 1KHKA 2IFYA 3MK0A 1KH4A
chains in the KnotProt database with same CATH superfamily
1O98A 3UNYA 1ELYA 1EW8A 1ELZA 3ED4A 1B8JA 4FDJA 1KH9A 3MK1A 1EI6A 1SHNA 3DPCA 3M7VA 1ANJA 1KH7A 3T02A 3TX0A 2G9YA 3BDHA 1Y6VA 1AJDA 1JCHA 1FSUA 1EQJA 1ELXA 1HDHA 1ED8A 1AUKA 3IGYB 1E33P 3NVLA 1E1ZP 1ZEFA 1K7HA 1EJJA 3M8YA 1EW2A 2QZUA 1AJCA 1O99A 1ZEBA 1ALIA 1E2SP 3DYCA 3M8ZA 3MK2A 1HQAA 3BDFA 4FDIA 1Y7AA 3SZZA 3UN3A 1KHJA 3SZYA 1P49A 3TWZA 3UO0A 3UN2A 2ANHA 3T01A 1URBA 1EW9A 1KHLA 1ANIA 1N2KA 3M8WA 1E3CP 1ED9A 3CMRA 2GA3A 1AJBA 1URAA 1KH5A 1SHQA 1KHNA 3BDGA 3BDGB 3UN5A 1N2LA 2GLQA 1ALJA 1AJAA 1HJKA 1ZEDA 3IGZB 1ALKA 3T00A 3OT9A 1KHKA 2IFYA 2B5UA 3MK0A 1KH4A
chains in the KnotProt database with same CATH topology
1O98A 3UNYA 1ELYA 1EW8A 1ELZA 3ED4A 1B8JA 4FDJA 1KH9A 3MK1A 1EI6A 1SHNA 3DPCA 3M7VA 1ANJA 1KH7A 3T02A 3TX0A 2G9YA 3BDHA 1Y6VA 1AJDA 1FSUA 1EQJA 1ELXA 1HDHA 1ED8A 1AUKA 3IGYB 1E33P 3NVLA 1E1ZP 1ZEFA 1K7HA 1EJJA 3M8YA 1EW2A 2QZUA 1AJCA 1O99A 1ZEBA 1ALIA 1E2SP 3DYCA 3M8ZA 3MK2A 1HQAA 3BDFA 4FDIA 1Y7AA 3SZZA 3UN3A 1KHJA 3SZYA 1P49A 3TWZA 3UO0A 3UN2A 2ANHA 3T01A 1URBA 1EW9A 1KHLA 1ANIA 1N2KA 3M8WA 1E3CP 1ED9A 3CMRA 2GA3A 1AJBA 1URAA 1KH5A 1SHQA 1KHNA 3BDGA 3BDGB 3UN5A 1N2LA 2GLQA 1ALJA 1AJAA 1HJKA 1ZEDA 3IGZB 1ALKA 3T00A 3OT9A 1KHKA 2IFYA 3MK0A 1KH4A
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1O98 A;  3UNY A;  1ELY A;  1EW8 A;  1ELZ A;  3ED4 A;  1B8J A;  4FDJ A;  1KH9 A;  3MK1 A;  1EI6 A;  1SHN A;  3DPC A;  3M7V A;  1ANJ A;  1KH7 A;  3T02 A;  3TX0 A;  2G9Y A;  3BDH A;  1Y6V A;  1AJD A;  1FSU A;  1EQJ A;  1ELX A;  1HDH A;  1ED8 A;  1AUK A;  3IGY B;  1E33 P;  3NVL A;  1E1Z P;  1ZEF A;  1K7H A;  1EJJ A;  3M8Y A;  1EW2 A;  2QZU A;  1AJC A;  1O99 A;  1ZEB A;  1ALI A;  1E2S P;  3DYC A;  3M8Z A;  3MK2 A;  1HQA A;  3BDF A;  4FDI A;  1Y7A A;  3SZZ A;  3UN3 A;  1KHJ A;  3SZY A;  1P49 A;  3TWZ A;  3UO0 A;  3UN2 A;  2ANH A;  3T01 A;  1URB A;  1EW9 A;  1KHL A;  1ANI A;  1N2K A;  3M8W A;  1E3C P;  1ED9 A;  3CMR A;  2GA3 A;  1AJB A;  1URA A;  1KH5 A;  1SHQ A;  1KHN A;  3BDG A;  3BDG B;  3UN5 A;  1N2L A;  2GLQ A;  1ALJ A;  1AJA A;  1HJK A;  1ZED A;  3IGZ B;  1ALK A;  3T00 A;  3OT9 A;  1KHK A;  2IFY A;  3MK0 A;  1KH4 A; 
#chains in the KnotProt database with same CATH topology
 1O98 A;  3UNY A;  1ELY A;  1EW8 A;  1ELZ A;  3ED4 A;  1B8J A;  4FDJ A;  1KH9 A;  3MK1 A;  1EI6 A;  1SHN A;  3DPC A;  3M7V A;  1ANJ A;  1KH7 A;  3T02 A;  3TX0 A;  2G9Y A;  3BDH A;  1Y6V A;  1AJD A;  1JCH A;  1FSU A;  1EQJ A;  1ELX A;  1HDH A;  1ED8 A;  1AUK A;  3IGY B;  1E33 P;  3NVL A;  1E1Z P;  1ZEF A;  1K7H A;  1EJJ A;  3M8Y A;  1EW2 A;  2QZU A;  1AJC A;  1O99 A;  1ZEB A;  1ALI A;  1E2S P;  3DYC A;  3M8Z A;  3MK2 A;  1HQA A;  3BDF A;  4FDI A;  1Y7A A;  3SZZ A;  3UN3 A;  1KHJ A;  3SZY A;  1P49 A;  3TWZ A;  3UO0 A;  3UN2 A;  2ANH A;  3T01 A;  1URB A;  1EW9 A;  1KHL A;  1ANI A;  1N2K A;  3M8W A;  1E3C P;  1ED9 A;  3CMR A;  2GA3 A;  1AJB A;  1URA A;  1KH5 A;  1SHQ A;  1KHN A;  3BDG A;  3BDG B;  3UN5 A;  1N2L A;  2GLQ A;  1ALJ A;  1AJA A;  1HJK A;  1ZED A;  3IGZ B;  1ALK A;  3T00 A;  3OT9 A;  1KHK A;  2IFY A;  2B5U A;  3MK0 A;  1KH4 A; 
#chains in the KnotProt database with same CATH homology
 1O98 A;  3UNY A;  1ELY A;  1EW8 A;  1ELZ A;  3ED4 A;  1B8J A;  4FDJ A;  1KH9 A;  3MK1 A;  1EI6 A;  1SHN A;  3DPC A;  3M7V A;  1ANJ A;  1KH7 A;  3T02 A;  3TX0 A;  2G9Y A;  3BDH A;  1Y6V A;  1AJD A;  1FSU A;  1EQJ A;  1ELX A;  1HDH A;  1ED8 A;  1AUK A;  3IGY B;  1E33 P;  3NVL A;  1E1Z P;  1ZEF A;  1K7H A;  1EJJ A;  3M8Y A;  1EW2 A;  2QZU A;  1AJC A;  1O99 A;  1ZEB A;  1ALI A;  1E2S P;  3DYC A;  3M8Z A;  3MK2 A;  1HQA A;  3BDF A;  4FDI A;  1Y7A A;  3SZZ A;  3UN3 A;  1KHJ A;  3SZY A;  1P49 A;  3TWZ A;  3UO0 A;  3UN2 A;  2ANH A;  3T01 A;  1URB A;  1EW9 A;  1KHL A;  1ANI A;  1N2K A;  3M8W A;  1E3C P;  1ED9 A;  3CMR A;  2GA3 A;  1AJB A;  1URA A;  1KH5 A;  1SHQ A;  1KHN A;  3BDG A;  3BDG B;  3UN5 A;  1N2L A;  2GLQ A;  1ALJ A;  1AJA A;  1HJK A;  1ZED A;  3IGZ B;  1ALK A;  3T00 A;  3OT9 A;  1KHK A;  2IFY A;  3MK0 A;  1KH4 A;
...loading similar chains, please wait...
similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...
How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling