1AUKA

Human arylsulfatase a
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 7-263 257 1-6 294-485 264-293 6 192 slipknot
Chain Sequence
RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLXTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLG----ATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCP
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 7-265 259 1-6 275-481 266-274 6 207 slipknot
view details
2.1 6-275 270 1-5 292-481 276-291 5 190 slipknot
view details
2.1 8-281 274 1-5, 292-481 6-7, 282-291 5 190 slipknot
sequence length 485
structure length 481
publication title Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel mechanism for sulfate ester hydrolysis.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords ARYLSULFATASE A
source organism Homo sapiens
missing residues 426-429
total genus Genus: 154
ec nomenclature ec 3.1.6.8: Cerebroside-sulfatase.
pdb deposition date 1997-08-29
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.10 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 1aukA02
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1aukA01
1HDHA 2IFYA 1KH5A 1O99A 1KHNA 1URAA 2GA3A 1ELXA 1AJAA 3BDGB 1EW2A 1Y7AA 1HJKA 1URBA 1KHKA 1AUKA 2QZUA 3UNYA 1HQAA 3IGZB 2GLQA 1EQJA 3UN3A 1N2LA 1FSUA 1EI6A 1ALHA 3UO0A 1P49A 3SZZA 3MK2A 3T00A 1ZEDA 4FDIA 3M7VA 3TWZA 1ELZA 3BDHA 3BDGA 1KH4A 1AJDA 1B8JA 1KHJA 1ED8A 3ED4A 3NVLA 3SZYA 1E1ZP 3DYCA 3M8WA 3CMRA 3T01A 1K7HA 1ED9A 1O98A 1ZEBA 3M8ZA 1EW8A 1ANJA 1KH7A 1N2KA 4FDJA 1Y6VA 3BDFA 1AJCA 3OT9A 1ELYA 1KH9A 1KHLA 3UN5A 1ZEFA 2G9YA 1E2SP 1EJJA 3MK0A 1ANIA 1E3CP 1ALIA 3MK1A 3T02A 1EW9A 3UN2A 3M8YA 1ALKA 3DPCA 1SHQA 3IGYB 1ALJA 1SHNA 2ANHA 3TX0A 1AJBA 1E33P
chains in the KnotProt database with same CATH superfamily
1HDHA 2IFYA 1KH5A 1O99A 1KHNA 1URAA 2GA3A 1ELXA 1AJAA 3BDGB 1EW2A 1Y7AA 1HJKA 1URBA 1KHKA 1AUKA 2QZUA 3UNYA 1HQAA 3IGZB 2GLQA 1EQJA 3UN3A 1N2LA 1FSUA 1EI6A 1ALHA 3UO0A 1P49A 3SZZA 3MK2A 3T00A 1ZEDA 4FDIA 3M7VA 3TWZA 1ELZA 3BDHA 3BDGA 1KH4A 1AJDA 1B8JA 1KHJA 1ED8A 3ED4A 3NVLA 3SZYA 1E1ZP 3DYCA 3M8WA 3CMRA 3T01A 1K7HA 1ED9A 1O98A 1ZEBA 3M8ZA 1EW8A 1ANJA 1KH7A 1N2KA 4FDJA 1Y6VA 3BDFA 1AJCA 3OT9A 1ELYA 1KH9A 1KHLA 3UN5A 1ZEFA 2G9YA 1E2SP 1EJJA 3MK0A 1ANIA 1E3CP 1ALIA 3MK1A 3T02A 1EW9A 3UN2A 3M8YA 1ALKA 3DPCA 1SHQA 3IGYB 1ALJA 1SHNA 2ANHA 3TX0A 1AJBA 1E33P
chains in the KnotProt database with same CATH topology
1HDHA 2IFYA 1KH5A 1O99A 1KHNA 1URAA 2GA3A 1ELXA 1AJAA 3BDGB 1EW2A 1Y7AA 1HJKA 1URBA 1KHKA 1AUKA 2QZUA 3UNYA 1HQAA 3IGZB 2GLQA 1EQJA 3UN3A 1N2LA 1FSUA 1EI6A 1ALHA 3UO0A 1P49A 3SZZA 3MK2A 3T00A 1ZEDA 4FDIA 3M7VA 3TWZA 1ELZA 3BDHA 3BDGA 1KH4A 1AJDA 1B8JA 1KHJA 1ED8A 3ED4A 3NVLA 3SZYA 1E1ZP 3DYCA 3M8WA 3CMRA 3T01A 1K7HA 1ED9A 1O98A 1ZEBA 3M8ZA 1EW8A 1ANJA 1KH7A 1N2KA 4FDJA 1Y6VA 3BDFA 1AJCA 3OT9A 1ELYA 1KH9A 1KHLA 3UN5A 1ZEFA 2G9YA 1E2SP 1EJJA 3MK0A 1ANIA 1E3CP 1ALIA 3MK1A 3T02A 1EW9A 3UN2A 3M8YA 1ALKA 3DPCA 1SHQA 3IGYB 1ALJA 1SHNA 2ANHA 3TX0A 1AJBA 1E33P
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1HDH A;  2IFY A;  1KH5 A;  1O99 A;  1KHN A;  1URA A;  2GA3 A;  1ELX A;  1AJA A;  3BDG B;  1EW2 A;  1Y7A A;  1HJK A;  1URB A;  1KHK A;  1AUK A;  2QZU A;  3UNY A;  1HQA A;  3IGZ B;  2GLQ A;  1EQJ A;  3UN3 A;  1N2L A;  1FSU A;  1EI6 A;  1ALH A;  3UO0 A;  1P49 A;  3SZZ A;  3MK2 A;  3T00 A;  1ZED A;  4FDI A;  3M7V A;  3TWZ A;  1ELZ A;  3BDH A;  3BDG A;  1KH4 A;  1AJD A;  1B8J A;  1KHJ A;  1ED8 A;  3ED4 A;  3NVL A;  3SZY A;  1E1Z P;  3DYC A;  3M8W A;  3CMR A;  3T01 A;  1K7H A;  1ED9 A;  1O98 A;  1ZEB A;  3M8Z A;  1EW8 A;  1ANJ A;  1KH7 A;  1N2K A;  4FDJ A;  1Y6V A;  3BDF A;  1AJC A;  3OT9 A;  1ELY A;  1KH9 A;  1KHL A;  3UN5 A;  1ZEF A;  2G9Y A;  1E2S P;  1EJJ A;  3MK0 A;  1ANI A;  1E3C P;  1ALI A;  3MK1 A;  3T02 A;  1EW9 A;  3UN2 A;  3M8Y A;  1ALK A;  3DPC A;  1SHQ A;  3IGY B;  1ALJ A;  1SHN A;  2ANH A;  3TX0 A;  1AJB A;  1E33 P; 
#chains in the KnotProt database with same CATH topology
 1HDH A;  2IFY A;  1KH5 A;  1O99 A;  1KHN A;  1URA A;  2GA3 A;  1ELX A;  1AJA A;  3BDG B;  1EW2 A;  1Y7A A;  1HJK A;  1URB A;  1KHK A;  1AUK A;  2QZU A;  3UNY A;  1HQA A;  3IGZ B;  2GLQ A;  1EQJ A;  3UN3 A;  1N2L A;  1FSU A;  1EI6 A;  1ALH A;  3UO0 A;  1P49 A;  3SZZ A;  3MK2 A;  3T00 A;  1ZED A;  4FDI A;  3M7V A;  3TWZ A;  1ELZ A;  3BDH A;  3BDG A;  1KH4 A;  1AJD A;  1B8J A;  1KHJ A;  1ED8 A;  3ED4 A;  3NVL A;  3SZY A;  1E1Z P;  3DYC A;  3M8W A;  3CMR A;  3T01 A;  1K7H A;  1ED9 A;  1O98 A;  1ZEB A;  3M8Z A;  1EW8 A;  1ANJ A;  1KH7 A;  1N2K A;  4FDJ A;  1Y6V A;  3BDF A;  1AJC A;  3OT9 A;  1ELY A;  1KH9 A;  1KHL A;  3UN5 A;  1ZEF A;  2G9Y A;  1E2S P;  1EJJ A;  3MK0 A;  1ANI A;  1E3C P;  1ALI A;  3MK1 A;  3T02 A;  1EW9 A;  3UN2 A;  3M8Y A;  1ALK A;  3DPC A;  1SHQ A;  3IGY B;  1ALJ A;  1SHN A;  2ANH A;  3TX0 A;  1AJB A;  1E33 P; 
#chains in the KnotProt database with same CATH homology
 1HDH A;  2IFY A;  1KH5 A;  1O99 A;  1KHN A;  1URA A;  2GA3 A;  1ELX A;  1AJA A;  3BDG B;  1EW2 A;  1Y7A A;  1HJK A;  1URB A;  1KHK A;  1AUK A;  2QZU A;  3UNY A;  1HQA A;  3IGZ B;  2GLQ A;  1EQJ A;  3UN3 A;  1N2L A;  1FSU A;  1EI6 A;  1ALH A;  3UO0 A;  1P49 A;  3SZZ A;  3MK2 A;  3T00 A;  1ZED A;  4FDI A;  3M7V A;  3TWZ A;  1ELZ A;  3BDH A;  3BDG A;  1KH4 A;  1AJD A;  1B8J A;  1KHJ A;  1ED8 A;  3ED4 A;  3NVL A;  3SZY A;  1E1Z P;  3DYC A;  3M8W A;  3CMR A;  3T01 A;  1K7H A;  1ED9 A;  1O98 A;  1ZEB A;  3M8Z A;  1EW8 A;  1ANJ A;  1KH7 A;  1N2K A;  4FDJ A;  1Y6V A;  3BDF A;  1AJC A;  3OT9 A;  1ELY A;  1KH9 A;  1KHL A;  3UN5 A;  1ZEF A;  2G9Y A;  1E2S P;  1EJJ A;  3MK0 A;  1ANI A;  1E3C P;  1ALI A;  3MK1 A;  3T02 A;  1EW9 A;  3UN2 A;  3M8Y A;  1ALK A;  3DPC A;  1SHQ A;  3IGY B;  1ALJ A;  1SHN A;  2ANH A;  3TX0 A;  1AJB A;  1E33 P; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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