1KH9A

E. coli alkaline phosphatase mutant (d153gd330n) complex with phosphate
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 42-363 322 1-41 414-444 364-413 41 31 slipknot
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 11-362 352 1-10 368-444 363-367 10 77 slipknot
view details
3.1 40-364 325 1-39 383-444 365-382 39 62 slipknot
view details
3.1 42-365 324 1-41 406-444 366-405 41 39 slipknot
view details
3.1 39-406 368 1-38 414-444 407-413 38 31 slipknot
view details
2.1 36-362 327 1-10, 365-444 11-35, 363-364 10 80 slipknot
sequence length 444
structure length 444
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
source organism Escherichia coli
total genus Genus: 144
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh9A00
1Y6VA 3BDGA 1ANJA 3IGZB 1ZEFA 1AJAA 3MK0A 1FSUA 1EQJA 1ZEDA 1N2KA 1EI6A 3NVLA 3TWZA 1ALJA 3TX0A 1ELZA 3BDHA 1KH4A 3MK1A 1SHNA 1KHKA 1O98A 1ALIA 3DYCA 3ED4A 4FDJA 1E3CP 3T01A 1ED9A 1AJDA 1KH5A 3BDFA 1N2LA 1K7HA 2ANHA 3M7VA 3IGYB 3OT9A 3SZZA 3BDGB 2IFYA 1HJKA 3UO0A 1KHJA 2GLQA 3DPCA 1KHNA 1EW2A 3M8WA 1ED8A 2GA3A 1KHLA 1AJCA 1B8JA 1EW9A 3T02A 1EW8A 1KH7A 1E1ZP 1O99A 1ALKA 2QZUA 1URAA 1Y7AA 3UN2A 1KH9A 1P49A 1URBA 1ZEBA 3M8YA 3UN3A 2G9YA 1E2SP 1HDHA 3T00A 1ELYA 3MK2A 1ELXA 1AUKA 3M8ZA 1AJBA 3UNYA 1HQAA 3CMRA 1EJJA 1ANIA 1SHQA 3SZYA 1E33P 4FDIA 3UN5A
chains in the KnotProt database with same CATH superfamily
1Y6VA 3BDGA 1ANJA 3IGZB 1ZEFA 1AJAA 3MK0A 1FSUA 1EQJA 1ZEDA 1N2KA 1EI6A 3NVLA 3TWZA 1ALJA 3TX0A 1ELZA 3BDHA 1KH4A 3MK1A 1SHNA 1KHKA 1O98A 1ALIA 3DYCA 3ED4A 4FDJA 1E3CP 3T01A 1ED9A 1AJDA 1KH5A 3BDFA 1N2LA 1K7HA 2ANHA 3M7VA 3IGYB 3OT9A 3SZZA 3BDGB 2IFYA 1HJKA 3UO0A 1KHJA 2GLQA 3DPCA 1KHNA 1EW2A 3M8WA 1ED8A 2GA3A 1KHLA 1AJCA 1B8JA 1EW9A 3T02A 1EW8A 1KH7A 1E1ZP 1O99A 1ALKA 2QZUA 1URAA 1Y7AA 3UN2A 1KH9A 1P49A 1URBA 1ZEBA 3M8YA 3UN3A 2G9YA 1E2SP 1HDHA 3T00A 1ELYA 3MK2A 1ELXA 1AUKA 3M8ZA 1AJBA 3UNYA 1HQAA 3CMRA 1EJJA 1ANIA 1SHQA 3SZYA 1E33P 4FDIA 3UN5A
chains in the KnotProt database with same CATH topology
1Y6VA 3BDGA 1ANJA 3IGZB 1ZEFA 1AJAA 3MK0A 1FSUA 1EQJA 1ZEDA 1N2KA 1EI6A 3NVLA 3TWZA 1ALJA 3TX0A 1ELZA 3BDHA 1KH4A 3MK1A 1SHNA 1KHKA 1O98A 1ALIA 3DYCA 3ED4A 4FDJA 1E3CP 3T01A 1ED9A 1AJDA 1KH5A 3BDFA 1N2LA 1K7HA 2ANHA 3M7VA 3IGYB 3OT9A 3SZZA 3BDGB 2IFYA 1HJKA 3UO0A 1KHJA 2GLQA 3DPCA 1KHNA 1EW2A 3M8WA 1ED8A 2GA3A 1KHLA 1AJCA 1B8JA 1EW9A 3T02A 1EW8A 1KH7A 1E1ZP 1O99A 1ALKA 2QZUA 1URAA 1Y7AA 3UN2A 1KH9A 1P49A 1URBA 1ZEBA 3M8YA 3UN3A 2G9YA 1E2SP 1HDHA 3T00A 1ELYA 3MK2A 1ELXA 1AUKA 3M8ZA 1AJBA 3UNYA 1HQAA 3CMRA 1EJJA 1ANIA 1SHQA 3SZYA 1E33P 4FDIA 3UN5A
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1Y6V A;  3BDG A;  1ANJ A;  3IGZ B;  1ZEF A;  1AJA A;  3MK0 A;  1FSU A;  1EQJ A;  1ZED A;  1N2K A;  1EI6 A;  3NVL A;  3TWZ A;  1ALJ A;  3TX0 A;  1ELZ A;  3BDH A;  1KH4 A;  3MK1 A;  1SHN A;  1KHK A;  1O98 A;  1ALI A;  3DYC A;  3ED4 A;  4FDJ A;  1E3C P;  3T01 A;  1ED9 A;  1AJD A;  1KH5 A;  3BDF A;  1N2L A;  1K7H A;  2ANH A;  3M7V A;  3IGY B;  3OT9 A;  3SZZ A;  3BDG B;  2IFY A;  1HJK A;  3UO0 A;  1KHJ A;  2GLQ A;  3DPC A;  1KHN A;  1EW2 A;  3M8W A;  1ED8 A;  2GA3 A;  1KHL A;  1AJC A;  1B8J A;  1EW9 A;  3T02 A;  1EW8 A;  1KH7 A;  1E1Z P;  1O99 A;  1ALK A;  2QZU A;  1URA A;  1Y7A A;  3UN2 A;  1KH9 A;  1P49 A;  1URB A;  1ZEB A;  3M8Y A;  3UN3 A;  2G9Y A;  1E2S P;  1HDH A;  3T00 A;  1ELY A;  3MK2 A;  1ELX A;  1AUK A;  3M8Z A;  1AJB A;  3UNY A;  1HQA A;  3CMR A;  1EJJ A;  1ANI A;  1SHQ A;  3SZY A;  1E33 P;  4FDI A;  3UN5 A; 
#chains in the KnotProt database with same CATH topology
 1Y6V A;  3BDG A;  1ANJ A;  3IGZ B;  1ZEF A;  1AJA A;  3MK0 A;  1FSU A;  1EQJ A;  1ZED A;  1N2K A;  1EI6 A;  3NVL A;  3TWZ A;  1ALJ A;  3TX0 A;  1ELZ A;  3BDH A;  1KH4 A;  3MK1 A;  1SHN A;  1KHK A;  1O98 A;  1ALI A;  3DYC A;  3ED4 A;  4FDJ A;  1E3C P;  3T01 A;  1ED9 A;  1AJD A;  1KH5 A;  3BDF A;  1N2L A;  1K7H A;  2ANH A;  3M7V A;  3IGY B;  3OT9 A;  3SZZ A;  3BDG B;  2IFY A;  1HJK A;  3UO0 A;  1KHJ A;  2GLQ A;  3DPC A;  1KHN A;  1EW2 A;  3M8W A;  1ED8 A;  2GA3 A;  1KHL A;  1AJC A;  1B8J A;  1EW9 A;  3T02 A;  1EW8 A;  1KH7 A;  1E1Z P;  1O99 A;  1ALK A;  2QZU A;  1URA A;  1Y7A A;  3UN2 A;  1KH9 A;  1P49 A;  1URB A;  1ZEB A;  3M8Y A;  3UN3 A;  2G9Y A;  1E2S P;  1HDH A;  3T00 A;  1ELY A;  3MK2 A;  1ELX A;  1AUK A;  3M8Z A;  1AJB A;  3UNY A;  1HQA A;  3CMR A;  1EJJ A;  1ANI A;  1SHQ A;  3SZY A;  1E33 P;  4FDI A;  3UN5 A; 
#chains in the KnotProt database with same CATH homology
 1Y6V A;  3BDG A;  1ANJ A;  3IGZ B;  1ZEF A;  1AJA A;  3MK0 A;  1FSU A;  1EQJ A;  1ZED A;  1N2K A;  1EI6 A;  3NVL A;  3TWZ A;  1ALJ A;  3TX0 A;  1ELZ A;  3BDH A;  1KH4 A;  3MK1 A;  1SHN A;  1KHK A;  1O98 A;  1ALI A;  3DYC A;  3ED4 A;  4FDJ A;  1E3C P;  3T01 A;  1ED9 A;  1AJD A;  1KH5 A;  3BDF A;  1N2L A;  1K7H A;  2ANH A;  3M7V A;  3IGY B;  3OT9 A;  3SZZ A;  3BDG B;  2IFY A;  1HJK A;  3UO0 A;  1KHJ A;  2GLQ A;  3DPC A;  1KHN A;  1EW2 A;  3M8W A;  1ED8 A;  2GA3 A;  1KHL A;  1AJC A;  1B8J A;  1EW9 A;  3T02 A;  1EW8 A;  1KH7 A;  1E1Z P;  1O99 A;  1ALK A;  2QZU A;  1URA A;  1Y7A A;  3UN2 A;  1KH9 A;  1P49 A;  1URB A;  1ZEB A;  3M8Y A;  3UN3 A;  2G9Y A;  1E2S P;  1HDH A;  3T00 A;  1ELY A;  3MK2 A;  1ELX A;  1AUK A;  3M8Z A;  1AJB A;  3UNY A;  1HQA A;  3CMR A;  1EJJ A;  1ANI A;  1SHQ A;  3SZY A;  1E33 P;  4FDI A;  3UN5 A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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