1KHNA

E. coli alkaline phosphatase mutant (d153hd330n) zinc form
Genus: 142
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 42-363 322 1-41 414-444 364-413 41 31 slipknot
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQHATPAALVAHVTSRKCYGPSATSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 13-361 349 1-12 367-444 362-366 12 78 slipknot
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2.1 34-364 331 1-33 372-444 365-371 33 73 slipknot
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3.1 43-365 323 1-42 412-444 366-411 42 33 slipknot
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2.1 41-411 371 1-40 416-444 412-415 40 29 slipknot
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2.1 31-361 331 1-16, 365-444 17-30, 362-364 16 80 slipknot
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2.1 38-361 324 1-30, 366-444 31-37, 362-365 30 79 slipknot
sequence length 444
structure length 444
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
source organism Escherichia coli
total genus Genus: 142
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-30
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1khnA00
1E3CP 3TX0A 3M8YA 1ELXA 3ED4A 1ZEFA 3TWZA 1HJKA 3M8ZA 3T01A 1K7HA 1P49A 3BDGB 3DPCA 2QZUA 3SZYA 3SZZA 1KH9A 1ALJA 1HDHA 1O98A 1E1ZP 3IGZB 2GLQA 3UO0A 2G9YA 1ANIA 3UN3A 3T00A 1EW9A 1Y7AA 1Y6VA 1KHNA 2ANHA 1KH5A 1ED9A 1ALIA 3BDFA 1AJBA 1AJCA 3IGYB 1KHLA 1KHKA 3DYCA 1B8JA 1O99A 1HQAA 1E2SP 1EJJA 2IFYA 1ELZA 3NVLA 1ED8A 3UNYA 3M7VA 3UN2A 1KH4A 3T02A 1KH7A 1N2LA 3BDHA 1E33P 1EW8A 1SHNA 1URAA 1SHQA 1ALKA 3MK1A 1EQJA 1EI6A 1N2KA 1ZEBA 3CMRA 1ELYA 1ANJA 3MK2A 4FDIA 1AJDA 1AUKA 3BDGA 1FSUA 3M8WA 1EW2A 1KHJA 1URBA 2GA3A 1AJAA 1ZEDA 3MK0A 3UN5A 4FDJA 3OT9A
chains in the KnotProt database with same CATH superfamily
1E3CP 3TX0A 3M8YA 1ELXA 3ED4A 1ZEFA 3TWZA 1HJKA 3M8ZA 3T01A 1K7HA 1P49A 3BDGB 3DPCA 2QZUA 3SZYA 3SZZA 1KH9A 1ALJA 1HDHA 1O98A 1E1ZP 3IGZB 2GLQA 3UO0A 2G9YA 1ANIA 3UN3A 3T00A 1EW9A 1Y7AA 1Y6VA 1KHNA 2ANHA 1KH5A 1ED9A 1ALIA 3BDFA 1AJBA 1AJCA 3IGYB 1KHLA 1KHKA 3DYCA 1B8JA 1O99A 1HQAA 1E2SP 1EJJA 2IFYA 1ELZA 3NVLA 1ED8A 3UNYA 3M7VA 3UN2A 1KH4A 3T02A 1KH7A 1N2LA 3BDHA 1E33P 1EW8A 1SHNA 1URAA 1SHQA 1ALKA 3MK1A 1EQJA 1EI6A 1N2KA 1ZEBA 3CMRA 1ELYA 1ANJA 3MK2A 4FDIA 1AJDA 1AUKA 3BDGA 1FSUA 3M8WA 1EW2A 1KHJA 1URBA 2GA3A 1AJAA 1ZEDA 3MK0A 3UN5A 4FDJA 3OT9A
chains in the KnotProt database with same CATH topology
1E3CP 3TX0A 3M8YA 1ELXA 3ED4A 1ZEFA 3TWZA 1HJKA 3M8ZA 3T01A 1K7HA 1P49A 3BDGB 3DPCA 2QZUA 3SZYA 3SZZA 1KH9A 1ALJA 1HDHA 1O98A 1E1ZP 3IGZB 2GLQA 3UO0A 2G9YA 1ANIA 3UN3A 3T00A 1EW9A 1Y7AA 1Y6VA 1KHNA 2ANHA 1KH5A 1ED9A 1ALIA 3BDFA 1AJBA 1AJCA 3IGYB 1KHLA 1KHKA 3DYCA 1B8JA 1O99A 1HQAA 1E2SP 1EJJA 2IFYA 1ELZA 3NVLA 1ED8A 3UNYA 3M7VA 3UN2A 1KH4A 3T02A 1KH7A 1N2LA 3BDHA 1E33P 1EW8A 1SHNA 1URAA 1SHQA 1ALKA 3MK1A 1EQJA 1EI6A 1N2KA 1ZEBA 3CMRA 1ELYA 1ANJA 3MK2A 4FDIA 1AJDA 1AUKA 3BDGA 1FSUA 3M8WA 1EW2A 1KHJA 1URBA 2GA3A 1AJAA 1ZEDA 3MK0A 3UN5A 4FDJA 3OT9A
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1E3C P;  3TX0 A;  3M8Y A;  1ELX A;  3ED4 A;  1ZEF A;  3TWZ A;  1HJK A;  3M8Z A;  3T01 A;  1K7H A;  1P49 A;  3BDG B;  3DPC A;  2QZU A;  3SZY A;  3SZZ A;  1KH9 A;  1ALJ A;  1HDH A;  1O98 A;  1E1Z P;  3IGZ B;  2GLQ A;  3UO0 A;  2G9Y A;  1ANI A;  3UN3 A;  3T00 A;  1EW9 A;  1Y7A A;  1Y6V A;  1KHN A;  2ANH A;  1KH5 A;  1ED9 A;  1ALI A;  3BDF A;  1AJB A;  1AJC A;  3IGY B;  1KHL A;  1KHK A;  3DYC A;  1B8J A;  1O99 A;  1HQA A;  1E2S P;  1EJJ A;  2IFY A;  1ELZ A;  3NVL A;  1ED8 A;  3UNY A;  3M7V A;  3UN2 A;  1KH4 A;  3T02 A;  1KH7 A;  1N2L A;  3BDH A;  1E33 P;  1EW8 A;  1SHN A;  1URA A;  1SHQ A;  1ALK A;  3MK1 A;  1EQJ A;  1EI6 A;  1N2K A;  1ZEB A;  3CMR A;  1ELY A;  1ANJ A;  3MK2 A;  4FDI A;  1AJD A;  1AUK A;  3BDG A;  1FSU A;  3M8W A;  1EW2 A;  1KHJ A;  1URB A;  2GA3 A;  1AJA A;  1ZED A;  3MK0 A;  3UN5 A;  4FDJ A;  3OT9 A; 
#chains in the KnotProt database with same CATH topology
 1E3C P;  3TX0 A;  3M8Y A;  1ELX A;  3ED4 A;  1ZEF A;  3TWZ A;  1HJK A;  3M8Z A;  3T01 A;  1K7H A;  1P49 A;  3BDG B;  3DPC A;  2QZU A;  3SZY A;  3SZZ A;  1KH9 A;  1ALJ A;  1HDH A;  1O98 A;  1E1Z P;  3IGZ B;  2GLQ A;  3UO0 A;  2G9Y A;  1ANI A;  3UN3 A;  3T00 A;  1EW9 A;  1Y7A A;  1Y6V A;  1KHN A;  2ANH A;  1KH5 A;  1ED9 A;  1ALI A;  3BDF A;  1AJB A;  1AJC A;  3IGY B;  1KHL A;  1KHK A;  3DYC A;  1B8J A;  1O99 A;  1HQA A;  1E2S P;  1EJJ A;  2IFY A;  1ELZ A;  3NVL A;  1ED8 A;  3UNY A;  3M7V A;  3UN2 A;  1KH4 A;  3T02 A;  1KH7 A;  1N2L A;  3BDH A;  1E33 P;  1EW8 A;  1SHN A;  1URA A;  1SHQ A;  1ALK A;  3MK1 A;  1EQJ A;  1EI6 A;  1N2K A;  1ZEB A;  3CMR A;  1ELY A;  1ANJ A;  3MK2 A;  4FDI A;  1AJD A;  1AUK A;  3BDG A;  1FSU A;  3M8W A;  1EW2 A;  1KHJ A;  1URB A;  2GA3 A;  1AJA A;  1ZED A;  3MK0 A;  3UN5 A;  4FDJ A;  3OT9 A; 
#chains in the KnotProt database with same CATH homology
 1E3C P;  3TX0 A;  3M8Y A;  1ELX A;  3ED4 A;  1ZEF A;  3TWZ A;  1HJK A;  3M8Z A;  3T01 A;  1K7H A;  1P49 A;  3BDG B;  3DPC A;  2QZU A;  3SZY A;  3SZZ A;  1KH9 A;  1ALJ A;  1HDH A;  1O98 A;  1E1Z P;  3IGZ B;  2GLQ A;  3UO0 A;  2G9Y A;  1ANI A;  3UN3 A;  3T00 A;  1EW9 A;  1Y7A A;  1Y6V A;  1KHN A;  2ANH A;  1KH5 A;  1ED9 A;  1ALI A;  3BDF A;  1AJB A;  1AJC A;  3IGY B;  1KHL A;  1KHK A;  3DYC A;  1B8J A;  1O99 A;  1HQA A;  1E2S P;  1EJJ A;  2IFY A;  1ELZ A;  3NVL A;  1ED8 A;  3UNY A;  3M7V A;  3UN2 A;  1KH4 A;  3T02 A;  1KH7 A;  1N2L A;  3BDH A;  1E33 P;  1EW8 A;  1SHN A;  1URA A;  1SHQ A;  1ALK A;  3MK1 A;  1EQJ A;  1EI6 A;  1N2K A;  1ZEB A;  3CMR A;  1ELY A;  1ANJ A;  3MK2 A;  4FDI A;  1AJD A;  1AUK A;  3BDG A;  1FSU A;  3M8W A;  1EW2 A;  1KHJ A;  1URB A;  2GA3 A;  1AJA A;  1ZED A;  3MK0 A;  3UN5 A;  4FDJ A;  3OT9 A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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