1ED8A

Structure of e. coli alkaline phosphatase inhibited by the inorganic phosphate at 1.75a resolution
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 48-368 321 1-47 420-449 369-419 47 30 slipknot
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 46-372 327 1-45 411-449 373-410 45 39 slipknot
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3.1 46-410 365 1-45 416-449 411-415 45 34 slipknot
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2.1 38-415 378 1-37 421-449 416-420 37 29 slipknot
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2.1 29-366 338 1-9, 372-449 10-28, 367-371 9 78 slipknot
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2.1 39-415 377 1-37, 421-449 38-38, 416-420 37 29 slipknot
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2.1 37-368 332 1-28, 373-449 29-36, 369-372 28 77 slipknot
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3.1 45-415 371 1-38, 419-449 39-44, 416-418 38 31 slipknot
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2.1 44-418 375 1-38, 421-449 39-43, 419-420 38 29 slipknot
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2.1 40-366 327 1-29, 373-449 30-39, 367-372 29 77 slipknot
sequence length 449
structure length 449
publication title A revised mechanism for the alkaline phosphatase reaction involving three metal ions.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
source organism Escherichia coli
total genus Genus: 166
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-01-27
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ed8A00
3MK0A 1EJJA 4FDJA 1KH4A 2QZUA 1Y6VA 3OT9A 1URBA 3NVLA 3ED4A 1ED9A 1ELZA 1Y7AA 3UN5A 3UN2A 3CMRA 1KHJA 1EQJA 1KH9A 1ZEDA 3MK2A 3IGYB 1E1ZP 3DYCA 1ELYA 1EW2A 3SZZA 3M8YA 1O99A 1KH7A 1O98A 1HJKA 4FDIA 1ALHA 1KHKA 1B8JA 3UO0A 2GA3A 3BDFA 3M8WA 1EW8A 1N2LA 3DPCA 1AJBA 1ANJA 3T00A 1ALKA 1ALIA 1EW9A 1E2SP 2G9YA 3UN3A 3TWZA 1KHNA 2ANHA 1KH5A 3BDHA 1ALJA 1E33P 1AJDA 3TX0A 1HDHA 1KHLA 3M8ZA 3UNYA 1P49A 3T01A 3BDGA 2IFYA 3M7VA 1E3CP 2GLQA 1ELXA 3IGZB 1ED8A 1AJCA 1SHNA 1N2KA 3MK1A 1EI6A 1ZEFA 1AJAA 1SHQA 3BDGB 3SZYA 1AUKA 1FSUA 1K7HA 1ANIA 1HQAA 1URAA 1ZEBA 3T02A
chains in the KnotProt database with same CATH superfamily
3MK0A 1EJJA 4FDJA 1KH4A 2QZUA 1Y6VA 3OT9A 1URBA 3NVLA 3ED4A 1ED9A 1ELZA 1Y7AA 3UN5A 3UN2A 3CMRA 1KHJA 1EQJA 1KH9A 1ZEDA 3MK2A 3IGYB 1E1ZP 3DYCA 1ELYA 1EW2A 3SZZA 3M8YA 1O99A 1KH7A 1O98A 1HJKA 4FDIA 1ALHA 1KHKA 1B8JA 3UO0A 2GA3A 3BDFA 3M8WA 1EW8A 1N2LA 3DPCA 1AJBA 1ANJA 3T00A 1ALKA 1ALIA 1EW9A 1E2SP 2G9YA 3UN3A 3TWZA 1KHNA 2ANHA 1KH5A 3BDHA 1ALJA 1E33P 1AJDA 3TX0A 1HDHA 1KHLA 3M8ZA 3UNYA 1P49A 3T01A 3BDGA 2IFYA 3M7VA 1E3CP 2GLQA 1ELXA 3IGZB 1ED8A 1AJCA 1SHNA 1N2KA 3MK1A 1EI6A 1ZEFA 1AJAA 1SHQA 3BDGB 3SZYA 1AUKA 1FSUA 1K7HA 1ANIA 1HQAA 1URAA 1ZEBA 3T02A
chains in the KnotProt database with same CATH topology
3MK0A 1EJJA 4FDJA 1KH4A 2QZUA 1Y6VA 3OT9A 1URBA 3NVLA 3ED4A 1ED9A 1ELZA 1Y7AA 3UN5A 3UN2A 3CMRA 1KHJA 1EQJA 1KH9A 1ZEDA 3MK2A 3IGYB 1E1ZP 3DYCA 1ELYA 1EW2A 3SZZA 3M8YA 1O99A 1KH7A 1O98A 1HJKA 4FDIA 1ALHA 1KHKA 1B8JA 3UO0A 2GA3A 3BDFA 3M8WA 1EW8A 1N2LA 3DPCA 1AJBA 1ANJA 3T00A 1ALKA 1ALIA 1EW9A 1E2SP 2G9YA 3UN3A 3TWZA 1KHNA 2ANHA 1KH5A 3BDHA 1ALJA 1E33P 1AJDA 3TX0A 1HDHA 1KHLA 3M8ZA 3UNYA 1P49A 3T01A 3BDGA 2IFYA 3M7VA 1E3CP 2GLQA 1ELXA 3IGZB 1ED8A 1AJCA 1SHNA 1N2KA 3MK1A 1EI6A 1ZEFA 1AJAA 1SHQA 3BDGB 3SZYA 1AUKA 1FSUA 1K7HA 1ANIA 1HQAA 1URAA 1ZEBA 3T02A
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 3MK0 A;  1EJJ A;  4FDJ A;  1KH4 A;  2QZU A;  1Y6V A;  3OT9 A;  1URB A;  3NVL A;  3ED4 A;  1ED9 A;  1ELZ A;  1Y7A A;  3UN5 A;  3UN2 A;  3CMR A;  1KHJ A;  1EQJ A;  1KH9 A;  1ZED A;  3MK2 A;  3IGY B;  1E1Z P;  3DYC A;  1ELY A;  1EW2 A;  3SZZ A;  3M8Y A;  1O99 A;  1KH7 A;  1O98 A;  1HJK A;  4FDI A;  1ALH A;  1KHK A;  1B8J A;  3UO0 A;  2GA3 A;  3BDF A;  3M8W A;  1EW8 A;  1N2L A;  3DPC A;  1AJB A;  1ANJ A;  3T00 A;  1ALK A;  1ALI A;  1EW9 A;  1E2S P;  2G9Y A;  3UN3 A;  3TWZ A;  1KHN A;  2ANH A;  1KH5 A;  3BDH A;  1ALJ A;  1E33 P;  1AJD A;  3TX0 A;  1HDH A;  1KHL A;  3M8Z A;  3UNY A;  1P49 A;  3T01 A;  3BDG A;  2IFY A;  3M7V A;  1E3C P;  2GLQ A;  1ELX A;  3IGZ B;  1ED8 A;  1AJC A;  1SHN A;  1N2K A;  3MK1 A;  1EI6 A;  1ZEF A;  1AJA A;  1SHQ A;  3BDG B;  3SZY A;  1AUK A;  1FSU A;  1K7H A;  1ANI A;  1HQA A;  1URA A;  1ZEB A;  3T02 A; 
#chains in the KnotProt database with same CATH topology
 3MK0 A;  1EJJ A;  4FDJ A;  1KH4 A;  2QZU A;  1Y6V A;  3OT9 A;  1URB A;  3NVL A;  3ED4 A;  1ED9 A;  1ELZ A;  1Y7A A;  3UN5 A;  3UN2 A;  3CMR A;  1KHJ A;  1EQJ A;  1KH9 A;  1ZED A;  3MK2 A;  3IGY B;  1E1Z P;  3DYC A;  1ELY A;  1EW2 A;  3SZZ A;  3M8Y A;  1O99 A;  1KH7 A;  1O98 A;  1HJK A;  4FDI A;  1ALH A;  1KHK A;  1B8J A;  3UO0 A;  2GA3 A;  3BDF A;  3M8W A;  1EW8 A;  1N2L A;  3DPC A;  1AJB A;  1ANJ A;  3T00 A;  1ALK A;  1ALI A;  1EW9 A;  1E2S P;  2G9Y A;  3UN3 A;  3TWZ A;  1KHN A;  2ANH A;  1KH5 A;  3BDH A;  1ALJ A;  1E33 P;  1AJD A;  3TX0 A;  1HDH A;  1KHL A;  3M8Z A;  3UNY A;  1P49 A;  3T01 A;  3BDG A;  2IFY A;  3M7V A;  1E3C P;  2GLQ A;  1ELX A;  3IGZ B;  1ED8 A;  1AJC A;  1SHN A;  1N2K A;  3MK1 A;  1EI6 A;  1ZEF A;  1AJA A;  1SHQ A;  3BDG B;  3SZY A;  1AUK A;  1FSU A;  1K7H A;  1ANI A;  1HQA A;  1URA A;  1ZEB A;  3T02 A; 
#chains in the KnotProt database with same CATH homology
 3MK0 A;  1EJJ A;  4FDJ A;  1KH4 A;  2QZU A;  1Y6V A;  3OT9 A;  1URB A;  3NVL A;  3ED4 A;  1ED9 A;  1ELZ A;  1Y7A A;  3UN5 A;  3UN2 A;  3CMR A;  1KHJ A;  1EQJ A;  1KH9 A;  1ZED A;  3MK2 A;  3IGY B;  1E1Z P;  3DYC A;  1ELY A;  1EW2 A;  3SZZ A;  3M8Y A;  1O99 A;  1KH7 A;  1O98 A;  1HJK A;  4FDI A;  1ALH A;  1KHK A;  1B8J A;  3UO0 A;  2GA3 A;  3BDF A;  3M8W A;  1EW8 A;  1N2L A;  3DPC A;  1AJB A;  1ANJ A;  3T00 A;  1ALK A;  1ALI A;  1EW9 A;  1E2S P;  2G9Y A;  3UN3 A;  3TWZ A;  1KHN A;  2ANH A;  1KH5 A;  3BDH A;  1ALJ A;  1E33 P;  1AJD A;  3TX0 A;  1HDH A;  1KHL A;  3M8Z A;  3UNY A;  1P49 A;  3T01 A;  3BDG A;  2IFY A;  3M7V A;  1E3C P;  2GLQ A;  1ELX A;  3IGZ B;  1ED8 A;  1AJC A;  1SHN A;  1N2K A;  3MK1 A;  1EI6 A;  1ZEF A;  1AJA A;  1SHQ A;  3BDG B;  3SZY A;  1AUK A;  1FSU A;  1K7H A;  1ANI A;  1HQA A;  1URA A;  1ZEB A;  3T02 A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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