1FSUA

4-sulfatase (human)
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 164
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 8-259 252 1-7 288-492 260-287 7 205 slipknot
Chain Sequence
SRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQPL-TPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCS-----------------AFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 8-268 261 1-7 283-474 269-282 7 192 slipknot
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3.1 7-282 276 1-6 288-474 283-287 6 187 slipknot
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3.1 9-278 270 1-6, 288-474 7-8, 279-287 6 187 slipknot
sequence length 492
structure length 474
publication title Structure of a human lysosomal sulfatase.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords N-ACETYLGALACTOSAMINE-4-SULFATASE
source organism Homo sapiens
missing residues 50, 365-381
total genus Genus: 164
ec nomenclature ec 3.1.6.12: N-acetylgalactosamine-4-sulfatase.
pdb deposition date 1996-07-29
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.10 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 1fsuA02
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1fsuA01
1AUKA 3DYCA 4FDJA 1EQJA 3M8ZA 2QZUA 3MK2A 2G9YA 3UN5A 3T00A 1KHJA 3T01A 1ELYA 1E3CP 1KH7A 3DPCA 3IGYB 3IGZB 3BDFA 1O99A 1ZEBA 1EJJA 1KH9A 1KH4A 1ZEFA 3UO0A 3SZZA 1URBA 1EW8A 1ALKA 3UN2A 1HJKA 3BDGA 1AJAA 1FSUA 4FDIA 1ALJA 3TWZA 2GA3A 1N2LA 1ED8A 1E2SP 1KHLA 3ED4A 1EI6A 3TX0A 3T02A 3NVLA 1KH5A 1AJCA 1P49A 1KHNA 1EW9A 1AJBA 1KHKA 3SZYA 3BDGB 3M7VA 1URAA 1HDHA 3MK1A 2ANHA 3OT9A 1ALIA 3UNYA 1Y7AA 1E33P 1ZEDA 1HQAA 1K7HA 3MK0A 3CMRA 1ANIA 1B8JA 1ED9A 1ELZA 1Y6VA 3BDHA 2IFYA 1ANJA 3UN3A 1E1ZP 1EW2A 1ELXA 3M8YA 1O98A 1AJDA 2GLQA 3M8WA 1SHNA 1N2KA 1SHQA
chains in the KnotProt database with same CATH superfamily
1AUKA 3DYCA 4FDJA 1EQJA 3M8ZA 2QZUA 3MK2A 2G9YA 3UN5A 3T00A 1KHJA 3T01A 1ELYA 1E3CP 1KH7A 3DPCA 3IGYB 3IGZB 3BDFA 1O99A 1ZEBA 1EJJA 1KH9A 1KH4A 1ZEFA 3UO0A 3SZZA 1URBA 1EW8A 1ALKA 3UN2A 1HJKA 3BDGA 1AJAA 1FSUA 4FDIA 1ALJA 3TWZA 2GA3A 1N2LA 1ED8A 1E2SP 1KHLA 3ED4A 1EI6A 3TX0A 3T02A 3NVLA 1KH5A 1AJCA 1P49A 1KHNA 1EW9A 1AJBA 1KHKA 3SZYA 3BDGB 3M7VA 1URAA 1HDHA 3MK1A 2ANHA 3OT9A 1ALIA 3UNYA 1Y7AA 1E33P 1ZEDA 1HQAA 1K7HA 3MK0A 3CMRA 1ANIA 1B8JA 1ED9A 1ELZA 1Y6VA 3BDHA 2IFYA 1ANJA 3UN3A 1E1ZP 1EW2A 1ELXA 3M8YA 1O98A 1AJDA 2GLQA 3M8WA 1SHNA 1N2KA 1SHQA
chains in the KnotProt database with same CATH topology
1AUKA 3DYCA 4FDJA 1EQJA 3M8ZA 2QZUA 3MK2A 2G9YA 3UN5A 3T00A 1KHJA 3T01A 1ELYA 1E3CP 1KH7A 3DPCA 3IGYB 3IGZB 3BDFA 1O99A 1ZEBA 1EJJA 1KH9A 1KH4A 1ZEFA 3UO0A 3SZZA 1URBA 1EW8A 1ALKA 3UN2A 1HJKA 3BDGA 1AJAA 1FSUA 4FDIA 1ALJA 3TWZA 2GA3A 1N2LA 1ED8A 1E2SP 1KHLA 3ED4A 1EI6A 3TX0A 3T02A 3NVLA 1KH5A 1AJCA 1P49A 1KHNA 1EW9A 1AJBA 1KHKA 3SZYA 3BDGB 3M7VA 1URAA 1HDHA 3MK1A 2ANHA 3OT9A 1ALIA 3UNYA 1Y7AA 1E33P 1ZEDA 1HQAA 1K7HA 3MK0A 3CMRA 1ANIA 1B8JA 1ED9A 1ELZA 1Y6VA 3BDHA 2IFYA 1ANJA 3UN3A 1E1ZP 1EW2A 1ELXA 3M8YA 1O98A 1AJDA 2GLQA 3M8WA 1SHNA 1N2KA 1SHQA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1AUK A;  3DYC A;  4FDJ A;  1EQJ A;  3M8Z A;  2QZU A;  3MK2 A;  2G9Y A;  3UN5 A;  3T00 A;  1KHJ A;  3T01 A;  1ELY A;  1E3C P;  1KH7 A;  3DPC A;  3IGY B;  3IGZ B;  3BDF A;  1O99 A;  1ZEB A;  1EJJ A;  1KH9 A;  1KH4 A;  1ZEF A;  3UO0 A;  3SZZ A;  1URB A;  1EW8 A;  1ALK A;  3UN2 A;  1HJK A;  3BDG A;  1AJA A;  1FSU A;  4FDI A;  1ALJ A;  3TWZ A;  2GA3 A;  1N2L A;  1ED8 A;  1E2S P;  1KHL A;  3ED4 A;  1EI6 A;  3TX0 A;  3T02 A;  3NVL A;  1KH5 A;  1AJC A;  1P49 A;  1KHN A;  1EW9 A;  1AJB A;  1KHK A;  3SZY A;  3BDG B;  3M7V A;  1URA A;  1HDH A;  3MK1 A;  2ANH A;  3OT9 A;  1ALI A;  3UNY A;  1Y7A A;  1E33 P;  1ZED A;  1HQA A;  1K7H A;  3MK0 A;  3CMR A;  1ANI A;  1B8J A;  1ED9 A;  1ELZ A;  1Y6V A;  3BDH A;  2IFY A;  1ANJ A;  3UN3 A;  1E1Z P;  1EW2 A;  1ELX A;  3M8Y A;  1O98 A;  1AJD A;  2GLQ A;  3M8W A;  1SHN A;  1N2K A;  1SHQ A; 
#chains in the KnotProt database with same CATH topology
 1AUK A;  3DYC A;  4FDJ A;  1EQJ A;  3M8Z A;  2QZU A;  3MK2 A;  2G9Y A;  3UN5 A;  3T00 A;  1KHJ A;  3T01 A;  1ELY A;  1E3C P;  1KH7 A;  3DPC A;  3IGY B;  3IGZ B;  3BDF A;  1O99 A;  1ZEB A;  1EJJ A;  1KH9 A;  1KH4 A;  1ZEF A;  3UO0 A;  3SZZ A;  1URB A;  1EW8 A;  1ALK A;  3UN2 A;  1HJK A;  3BDG A;  1AJA A;  1FSU A;  4FDI A;  1ALJ A;  3TWZ A;  2GA3 A;  1N2L A;  1ED8 A;  1E2S P;  1KHL A;  3ED4 A;  1EI6 A;  3TX0 A;  3T02 A;  3NVL A;  1KH5 A;  1AJC A;  1P49 A;  1KHN A;  1EW9 A;  1AJB A;  1KHK A;  3SZY A;  3BDG B;  3M7V A;  1URA A;  1HDH A;  3MK1 A;  2ANH A;  3OT9 A;  1ALI A;  3UNY A;  1Y7A A;  1E33 P;  1ZED A;  1HQA A;  1K7H A;  3MK0 A;  3CMR A;  1ANI A;  1B8J A;  1ED9 A;  1ELZ A;  1Y6V A;  3BDH A;  2IFY A;  1ANJ A;  3UN3 A;  1E1Z P;  1EW2 A;  1ELX A;  3M8Y A;  1O98 A;  1AJD A;  2GLQ A;  3M8W A;  1SHN A;  1N2K A;  1SHQ A; 
#chains in the KnotProt database with same CATH homology
 1AUK A;  3DYC A;  4FDJ A;  1EQJ A;  3M8Z A;  2QZU A;  3MK2 A;  2G9Y A;  3UN5 A;  3T00 A;  1KHJ A;  3T01 A;  1ELY A;  1E3C P;  1KH7 A;  3DPC A;  3IGY B;  3IGZ B;  3BDF A;  1O99 A;  1ZEB A;  1EJJ A;  1KH9 A;  1KH4 A;  1ZEF A;  3UO0 A;  3SZZ A;  1URB A;  1EW8 A;  1ALK A;  3UN2 A;  1HJK A;  3BDG A;  1AJA A;  1FSU A;  4FDI A;  1ALJ A;  3TWZ A;  2GA3 A;  1N2L A;  1ED8 A;  1E2S P;  1KHL A;  3ED4 A;  1EI6 A;  3TX0 A;  3T02 A;  3NVL A;  1KH5 A;  1AJC A;  1P49 A;  1KHN A;  1EW9 A;  1AJB A;  1KHK A;  3SZY A;  3BDG B;  3M7V A;  1URA A;  1HDH A;  3MK1 A;  2ANH A;  3OT9 A;  1ALI A;  3UNY A;  1Y7A A;  1E33 P;  1ZED A;  1HQA A;  1K7H A;  3MK0 A;  3CMR A;  1ANI A;  1B8J A;  1ED9 A;  1ELZ A;  1Y6V A;  3BDH A;  2IFY A;  1ANJ A;  3UN3 A;  1E1Z P;  1EW2 A;  1ELX A;  3M8Y A;  1O98 A;  1AJD A;  2GLQ A;  3M8W A;  1SHN A;  1N2K A;  1SHQ A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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