1EW2A

Crystal structure of a human phosphatase
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 40-356 317 1-39 438-479 357-437 39 42 slipknot
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPP
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 39-359 321 1-38 437-479 360-436 38 43 slipknot
view details
2.1 37-436 400 1-36 441-479 437-440 36 39 slipknot
view details
2.1 20-354 335 1-9, 360-479 10-19, 355-359 9 120 slipknot
view details
2.1 23-354 332 1-19, 360-479 20-22, 355-359 19 120 slipknot
view details
2.1 30-354 325 1-22, 360-479 23-29, 355-359 22 120 slipknot
view details
2.1 34-354 321 1-29, 360-479 30-33, 355-359 29 120 slipknot
sequence length 479
structure length 479
publication title Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords PHOSPHATASE
total genus Genus: 172
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-21
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew2A00
3UN3A 3IGZB 1AUKA 1P49A 1EW2A 3TWZA 1FSUA 3T02A 3UN5A 1ED8A 1EI6A 1E3CP 1ALJA 1B8JA 1ELZA 1ALIA 1KHNA 3IGYB 1AJDA 1AJAA 1O99A 1E2SP 3UO0A 1N2LA 1Y7AA 1EQJA 1EW9A 3MK2A 1AJBA 4FDIA 3SZYA 1ZEDA 3M8YA 1SHNA 1E1ZP 3T01A 1HDHA 3DYCA 1ALHA 2ANHA 1KHJA 3ED4A 3OT9A 2QZUA 2IFYA 2GLQA 1ED9A 1ELXA 1KHKA 3NVLA 3UNYA 1KHLA 3UN2A 1ANJA 1KH4A 1Y6VA 1ZEBA 1URAA 3M8WA 1HJKA 1ELYA 1KH9A 3CMRA 1HQAA 1KH5A 1SHQA 3T00A 1EJJA 3SZZA 3M8ZA 1URBA 3M7VA 3MK1A 3TX0A 1ZEFA 3BDHA 3MK0A 1ALKA 3BDGB 4FDJA 1E33P 1K7HA 2G9YA 1ANIA 3BDGA 1N2KA 1EW8A 3BDFA 1KH7A 2GA3A 3DPCA 1O98A 1AJCA
chains in the KnotProt database with same CATH superfamily
3UN3A 3IGZB 1AUKA 1P49A 1EW2A 3TWZA 1FSUA 3T02A 3UN5A 1ED8A 1EI6A 1E3CP 1ALJA 1B8JA 1ELZA 1ALIA 1KHNA 3IGYB 1AJDA 1AJAA 1O99A 1E2SP 3UO0A 1N2LA 1Y7AA 1EQJA 1EW9A 3MK2A 1AJBA 4FDIA 3SZYA 1ZEDA 3M8YA 1SHNA 1E1ZP 3T01A 1HDHA 3DYCA 1ALHA 2ANHA 1KHJA 3ED4A 3OT9A 2QZUA 2IFYA 2GLQA 1ED9A 1ELXA 1KHKA 3NVLA 3UNYA 1KHLA 3UN2A 1ANJA 1KH4A 1Y6VA 1ZEBA 1URAA 3M8WA 1HJKA 1ELYA 1KH9A 3CMRA 1HQAA 1KH5A 1SHQA 3T00A 1EJJA 3SZZA 3M8ZA 1URBA 3M7VA 3MK1A 3TX0A 1ZEFA 3BDHA 3MK0A 1ALKA 3BDGB 4FDJA 1E33P 1K7HA 2G9YA 1ANIA 3BDGA 1N2KA 1EW8A 3BDFA 1KH7A 2GA3A 3DPCA 1O98A 1AJCA
chains in the KnotProt database with same CATH topology
3UN3A 3IGZB 1AUKA 1P49A 1EW2A 3TWZA 1FSUA 3T02A 3UN5A 1ED8A 1EI6A 1E3CP 1ALJA 1B8JA 1ELZA 1ALIA 1KHNA 3IGYB 1AJDA 1AJAA 1O99A 1E2SP 3UO0A 1N2LA 1Y7AA 1EQJA 1EW9A 3MK2A 1AJBA 4FDIA 3SZYA 1ZEDA 3M8YA 1SHNA 1E1ZP 3T01A 1HDHA 3DYCA 1ALHA 2ANHA 1KHJA 3ED4A 3OT9A 2QZUA 2IFYA 2GLQA 1ED9A 1ELXA 1KHKA 3NVLA 3UNYA 1KHLA 3UN2A 1ANJA 1KH4A 1Y6VA 1ZEBA 1URAA 3M8WA 1HJKA 1ELYA 1KH9A 3CMRA 1HQAA 1KH5A 1SHQA 3T00A 1EJJA 3SZZA 3M8ZA 1URBA 3M7VA 3MK1A 3TX0A 1ZEFA 3BDHA 3MK0A 1ALKA 3BDGB 4FDJA 1E33P 1K7HA 2G9YA 1ANIA 3BDGA 1N2KA 1EW8A 3BDFA 1KH7A 2GA3A 3DPCA 1O98A 1AJCA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 3UN3 A;  3IGZ B;  1AUK A;  1P49 A;  1EW2 A;  3TWZ A;  1FSU A;  3T02 A;  3UN5 A;  1ED8 A;  1EI6 A;  1E3C P;  1ALJ A;  1B8J A;  1ELZ A;  1ALI A;  1KHN A;  3IGY B;  1AJD A;  1AJA A;  1O99 A;  1E2S P;  3UO0 A;  1N2L A;  1Y7A A;  1EQJ A;  1EW9 A;  3MK2 A;  1AJB A;  4FDI A;  3SZY A;  1ZED A;  3M8Y A;  1SHN A;  1E1Z P;  3T01 A;  1HDH A;  3DYC A;  1ALH A;  2ANH A;  1KHJ A;  3ED4 A;  3OT9 A;  2QZU A;  2IFY A;  2GLQ A;  1ED9 A;  1ELX A;  1KHK A;  3NVL A;  3UNY A;  1KHL A;  3UN2 A;  1ANJ A;  1KH4 A;  1Y6V A;  1ZEB A;  1URA A;  3M8W A;  1HJK A;  1ELY A;  1KH9 A;  3CMR A;  1HQA A;  1KH5 A;  1SHQ A;  3T00 A;  1EJJ A;  3SZZ A;  3M8Z A;  1URB A;  3M7V A;  3MK1 A;  3TX0 A;  1ZEF A;  3BDH A;  3MK0 A;  1ALK A;  3BDG B;  4FDJ A;  1E33 P;  1K7H A;  2G9Y A;  1ANI A;  3BDG A;  1N2K A;  1EW8 A;  3BDF A;  1KH7 A;  2GA3 A;  3DPC A;  1O98 A;  1AJC A; 
#chains in the KnotProt database with same CATH topology
 3UN3 A;  3IGZ B;  1AUK A;  1P49 A;  1EW2 A;  3TWZ A;  1FSU A;  3T02 A;  3UN5 A;  1ED8 A;  1EI6 A;  1E3C P;  1ALJ A;  1B8J A;  1ELZ A;  1ALI A;  1KHN A;  3IGY B;  1AJD A;  1AJA A;  1O99 A;  1E2S P;  3UO0 A;  1N2L A;  1Y7A A;  1EQJ A;  1EW9 A;  3MK2 A;  1AJB A;  4FDI A;  3SZY A;  1ZED A;  3M8Y A;  1SHN A;  1E1Z P;  3T01 A;  1HDH A;  3DYC A;  1ALH A;  2ANH A;  1KHJ A;  3ED4 A;  3OT9 A;  2QZU A;  2IFY A;  2GLQ A;  1ED9 A;  1ELX A;  1KHK A;  3NVL A;  3UNY A;  1KHL A;  3UN2 A;  1ANJ A;  1KH4 A;  1Y6V A;  1ZEB A;  1URA A;  3M8W A;  1HJK A;  1ELY A;  1KH9 A;  3CMR A;  1HQA A;  1KH5 A;  1SHQ A;  3T00 A;  1EJJ A;  3SZZ A;  3M8Z A;  1URB A;  3M7V A;  3MK1 A;  3TX0 A;  1ZEF A;  3BDH A;  3MK0 A;  1ALK A;  3BDG B;  4FDJ A;  1E33 P;  1K7H A;  2G9Y A;  1ANI A;  3BDG A;  1N2K A;  1EW8 A;  3BDF A;  1KH7 A;  2GA3 A;  3DPC A;  1O98 A;  1AJC A; 
#chains in the KnotProt database with same CATH homology
 3UN3 A;  3IGZ B;  1AUK A;  1P49 A;  1EW2 A;  3TWZ A;  1FSU A;  3T02 A;  3UN5 A;  1ED8 A;  1EI6 A;  1E3C P;  1ALJ A;  1B8J A;  1ELZ A;  1ALI A;  1KHN A;  3IGY B;  1AJD A;  1AJA A;  1O99 A;  1E2S P;  3UO0 A;  1N2L A;  1Y7A A;  1EQJ A;  1EW9 A;  3MK2 A;  1AJB A;  4FDI A;  3SZY A;  1ZED A;  3M8Y A;  1SHN A;  1E1Z P;  3T01 A;  1HDH A;  3DYC A;  1ALH A;  2ANH A;  1KHJ A;  3ED4 A;  3OT9 A;  2QZU A;  2IFY A;  2GLQ A;  1ED9 A;  1ELX A;  1KHK A;  3NVL A;  3UNY A;  1KHL A;  3UN2 A;  1ANJ A;  1KH4 A;  1Y6V A;  1ZEB A;  1URA A;  3M8W A;  1HJK A;  1ELY A;  1KH9 A;  3CMR A;  1HQA A;  1KH5 A;  1SHQ A;  3T00 A;  1EJJ A;  3SZZ A;  3M8Z A;  1URB A;  3M7V A;  3MK1 A;  3TX0 A;  1ZEF A;  3BDH A;  3MK0 A;  1ALK A;  3BDG B;  4FDJ A;  1E33 P;  1K7H A;  2G9Y A;  1ANI A;  3BDG A;  1N2K A;  1EW8 A;  3BDF A;  1KH7 A;  2GA3 A;  3DPC A;  1O98 A;  1AJC A; 
...loading similar chains, please wait...
similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling