1EW2A

Crystal structure of a human phosphatase
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 40-356 317 1-39 438-479 357-437 39 42 slipknot
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPP
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 39-359 321 1-38 437-479 360-436 38 43 slipknot
view details
2.1 37-436 400 1-36 441-479 437-440 36 39 slipknot
view details
2.1 20-354 335 1-9, 360-479 10-19, 355-359 9 120 slipknot
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2.1 23-354 332 1-19, 360-479 20-22, 355-359 19 120 slipknot
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2.1 30-354 325 1-22, 360-479 23-29, 355-359 22 120 slipknot
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2.1 34-354 321 1-29, 360-479 30-33, 355-359 29 120 slipknot
sequence length 479
structure length 479
publication title Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords PHOSPHATASE
total genus Genus: 172
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-21
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew2A00
1ELXA 1EW9A 1HQAA 1KHKA 1KH9A 1N2KA 1URAA 1ALKA 1SHQA 1K7HA 3IGYB 1AUKA 1AJDA 1AJBA 1KH7A 3M8ZA 1SHNA 1URBA 2GLQA 3MK1A 3M8YA 3T01A 1EQJA 3T00A 1E33P 3OT9A 3SZZA 1ALJA 1E2SP 3UN2A 1ELZA 3BDGA 1AJAA 1ALIA 1ZEFA 3NVLA 3T02A 1HJKA 1ED8A 1EJJA 3DPCA 1ZEBA 3TWZA 1E3CP 3BDHA 1Y6VA 2QZUA 2GA3A 1KHNA 1EW2A 1AJCA 1O98A 1O99A 1ED9A 1ANIA 1FSUA 3UNYA 3SZYA 3TX0A 1EI6A 1ZEDA 3MK2A 3CMRA 3UN5A 1ANJA 3DYCA 4FDIA 3M7VA 1HDHA 3MK0A 1N2LA 1KHJA 2ANHA 2IFYA 1KH5A 1P49A 4FDJA 3ED4A 3IGZB 1B8JA 3M8WA 3BDGB 3UN3A 1ELYA 1E1ZP 3UO0A 1EW8A 1KH4A 1Y7AA 2G9YA 1KHLA 3BDFA
chains in the KnotProt database with same CATH superfamily
1ELXA 1EW9A 1HQAA 1KHKA 1KH9A 1N2KA 1URAA 1ALKA 1SHQA 1K7HA 3IGYB 1AUKA 1AJDA 1AJBA 1KH7A 3M8ZA 1SHNA 1URBA 2GLQA 3MK1A 3M8YA 3T01A 1EQJA 3T00A 1E33P 3OT9A 3SZZA 1ALJA 1E2SP 3UN2A 1ELZA 3BDGA 1AJAA 1ALIA 1ZEFA 3NVLA 3T02A 1HJKA 1ED8A 1EJJA 3DPCA 1ZEBA 3TWZA 1E3CP 3BDHA 1Y6VA 2QZUA 2GA3A 1KHNA 1EW2A 1AJCA 1O98A 1O99A 1ED9A 1ANIA 1FSUA 3UNYA 3SZYA 3TX0A 1EI6A 1ZEDA 3MK2A 3CMRA 3UN5A 1ANJA 3DYCA 4FDIA 3M7VA 1HDHA 3MK0A 1N2LA 1KHJA 2ANHA 2IFYA 1KH5A 1P49A 4FDJA 3ED4A 3IGZB 1B8JA 3M8WA 3BDGB 3UN3A 1ELYA 1E1ZP 3UO0A 1EW8A 1KH4A 1Y7AA 2G9YA 1KHLA 3BDFA
chains in the KnotProt database with same CATH topology
1ELXA 1EW9A 1HQAA 1KHKA 1KH9A 1N2KA 1URAA 1ALKA 1SHQA 1K7HA 3IGYB 1AUKA 1AJDA 1AJBA 1KH7A 3M8ZA 1SHNA 1URBA 2GLQA 3MK1A 3M8YA 3T01A 1EQJA 3T00A 1E33P 3OT9A 3SZZA 1ALJA 1E2SP 3UN2A 1ELZA 3BDGA 1AJAA 1ALIA 1ZEFA 3NVLA 3T02A 1HJKA 1ED8A 1EJJA 3DPCA 1ZEBA 3TWZA 1E3CP 3BDHA 1Y6VA 2QZUA 2GA3A 1KHNA 1EW2A 1AJCA 1O98A 1O99A 1ED9A 1ANIA 1FSUA 3UNYA 3SZYA 3TX0A 1EI6A 1ZEDA 3MK2A 3CMRA 3UN5A 1ANJA 3DYCA 4FDIA 3M7VA 1HDHA 3MK0A 1N2LA 1KHJA 2ANHA 2IFYA 1KH5A 1P49A 4FDJA 3ED4A 3IGZB 1B8JA 3M8WA 3BDGB 3UN3A 1ELYA 1E1ZP 3UO0A 1EW8A 1KH4A 1Y7AA 2G9YA 1KHLA 3BDFA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1ELX A;  1EW9 A;  1HQA A;  1KHK A;  1KH9 A;  1N2K A;  1URA A;  1ALK A;  1SHQ A;  1K7H A;  3IGY B;  1AUK A;  1AJD A;  1AJB A;  1KH7 A;  3M8Z A;  1SHN A;  1URB A;  2GLQ A;  3MK1 A;  3M8Y A;  3T01 A;  1EQJ A;  3T00 A;  1E33 P;  3OT9 A;  3SZZ A;  1ALJ A;  1E2S P;  3UN2 A;  1ELZ A;  3BDG A;  1AJA A;  1ALI A;  1ZEF A;  3NVL A;  3T02 A;  1HJK A;  1ED8 A;  1EJJ A;  3DPC A;  1ZEB A;  3TWZ A;  1E3C P;  3BDH A;  1Y6V A;  2QZU A;  2GA3 A;  1KHN A;  1EW2 A;  1AJC A;  1O98 A;  1O99 A;  1ED9 A;  1ANI A;  1FSU A;  3UNY A;  3SZY A;  3TX0 A;  1EI6 A;  1ZED A;  3MK2 A;  3CMR A;  3UN5 A;  1ANJ A;  3DYC A;  4FDI A;  3M7V A;  1HDH A;  3MK0 A;  1N2L A;  1KHJ A;  2ANH A;  2IFY A;  1KH5 A;  1P49 A;  4FDJ A;  3ED4 A;  3IGZ B;  1B8J A;  3M8W A;  3BDG B;  3UN3 A;  1ELY A;  1E1Z P;  3UO0 A;  1EW8 A;  1KH4 A;  1Y7A A;  2G9Y A;  1KHL A;  3BDF A; 
#chains in the KnotProt database with same CATH topology
 1ELX A;  1EW9 A;  1HQA A;  1KHK A;  1KH9 A;  1N2K A;  1URA A;  1ALK A;  1SHQ A;  1K7H A;  3IGY B;  1AUK A;  1AJD A;  1AJB A;  1KH7 A;  3M8Z A;  1SHN A;  1URB A;  2GLQ A;  3MK1 A;  3M8Y A;  3T01 A;  1EQJ A;  3T00 A;  1E33 P;  3OT9 A;  3SZZ A;  1ALJ A;  1E2S P;  3UN2 A;  1ELZ A;  3BDG A;  1AJA A;  1ALI A;  1ZEF A;  3NVL A;  3T02 A;  1HJK A;  1ED8 A;  1EJJ A;  3DPC A;  1ZEB A;  3TWZ A;  1E3C P;  3BDH A;  1Y6V A;  2QZU A;  2GA3 A;  1KHN A;  1EW2 A;  1AJC A;  1O98 A;  1O99 A;  1ED9 A;  1ANI A;  1FSU A;  3UNY A;  3SZY A;  3TX0 A;  1EI6 A;  1ZED A;  3MK2 A;  3CMR A;  3UN5 A;  1ANJ A;  3DYC A;  4FDI A;  3M7V A;  1HDH A;  3MK0 A;  1N2L A;  1KHJ A;  2ANH A;  2IFY A;  1KH5 A;  1P49 A;  4FDJ A;  3ED4 A;  3IGZ B;  1B8J A;  3M8W A;  3BDG B;  3UN3 A;  1ELY A;  1E1Z P;  3UO0 A;  1EW8 A;  1KH4 A;  1Y7A A;  2G9Y A;  1KHL A;  3BDF A; 
#chains in the KnotProt database with same CATH homology
 1ELX A;  1EW9 A;  1HQA A;  1KHK A;  1KH9 A;  1N2K A;  1URA A;  1ALK A;  1SHQ A;  1K7H A;  3IGY B;  1AUK A;  1AJD A;  1AJB A;  1KH7 A;  3M8Z A;  1SHN A;  1URB A;  2GLQ A;  3MK1 A;  3M8Y A;  3T01 A;  1EQJ A;  3T00 A;  1E33 P;  3OT9 A;  3SZZ A;  1ALJ A;  1E2S P;  3UN2 A;  1ELZ A;  3BDG A;  1AJA A;  1ALI A;  1ZEF A;  3NVL A;  3T02 A;  1HJK A;  1ED8 A;  1EJJ A;  3DPC A;  1ZEB A;  3TWZ A;  1E3C P;  3BDH A;  1Y6V A;  2QZU A;  2GA3 A;  1KHN A;  1EW2 A;  1AJC A;  1O98 A;  1O99 A;  1ED9 A;  1ANI A;  1FSU A;  3UNY A;  3SZY A;  3TX0 A;  1EI6 A;  1ZED A;  3MK2 A;  3CMR A;  3UN5 A;  1ANJ A;  3DYC A;  4FDI A;  3M7V A;  1HDH A;  3MK0 A;  1N2L A;  1KHJ A;  2ANH A;  2IFY A;  1KH5 A;  1P49 A;  4FDJ A;  3ED4 A;  3IGZ B;  1B8J A;  3M8W A;  3BDG B;  3UN3 A;  1ELY A;  1E1Z P;  3UO0 A;  1EW8 A;  1KH4 A;  1Y7A A;  2G9Y A;  1KHL A;  3BDF A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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