1AJDA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 46-369 324 1-45 420-449 370-419 45 30 slipknot
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 15-367 353 1-14 373-449 368-372 14 77 slipknot
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3.1 48-372 325 1-47 413-449 373-412 47 37 slipknot
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3.1 45-412 368 1-44 421-449 413-420 44 29 slipknot
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2.1 46-413 368 1-44, 418-449 45-45, 414-417 44 32 slipknot
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2.1 37-367 331 1-27, 373-449 28-36, 368-372 27 77 slipknot
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2.1 42-367 326 1-36, 373-449 37-41, 368-372 36 77 slipknot
sequence length 449
structure length 449
publication title Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Non specific mono-esterase
molecule keywords ALKALINE PHOSPHATASE INTERMEDIATE II OF HOLO ENZYME
source organism Escherichia coli
total genus Genus: 153
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-08-18
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajdA00
3ED4A 3TX0A 3MK2A 1ANJA 1ED9A 1HJKA 1KH9A 3UNYA 1O99A 1EJJA 1KH7A 1EQJA 1Y6VA 3M8YA 1EW9A 3TWZA 3OT9A 3T02A 1E2SP 1EW2A 2G9YA 1KH5A 1KHLA 1SHNA 1ALIA 3T00A 3CMRA 3M7VA 1N2LA 1URBA 1ELXA 3NVLA 1E1ZP 3DYCA 1N2KA 1K7HA 2GA3A 3BDGA 1AJBA 3M8ZA 1HDHA 4FDIA 1ALKA 3IGZB 1AJDA 1SHQA 3UO0A 1AJCA 1Y7AA 3UN5A 1E3CP 1ELZA 1ED8A 1URAA 1ZEFA 1E33P 1KHJA 3BDHA 1ALJA 1B8JA 4FDJA 1P49A 1KHNA 1AUKA 3MK0A 3SZYA 1HQAA 1KHKA 1AJAA 3UN3A 1ZEDA 1EI6A 1ZEBA 3SZZA 1O98A 3M8WA 1FSUA 3BDGB 1ANIA 1ELYA 1EW8A 2ANHA 1KH4A 2GLQA 3IGYB 2IFYA 2QZUA 3MK1A 3T01A 3UN2A 3BDFA 3DPCA
chains in the KnotProt database with same CATH superfamily
3ED4A 3TX0A 3MK2A 1ANJA 1ED9A 1HJKA 1KH9A 3UNYA 1O99A 1EJJA 1KH7A 1EQJA 1Y6VA 3M8YA 1EW9A 3TWZA 3OT9A 3T02A 1E2SP 1EW2A 2G9YA 1KH5A 1KHLA 1SHNA 1ALIA 3T00A 3CMRA 3M7VA 1N2LA 1URBA 1ELXA 3NVLA 1E1ZP 3DYCA 1N2KA 1K7HA 2GA3A 3BDGA 1AJBA 3M8ZA 1HDHA 4FDIA 1ALKA 3IGZB 1AJDA 1SHQA 3UO0A 1AJCA 1Y7AA 3UN5A 1E3CP 1ELZA 1ED8A 1URAA 1ZEFA 1E33P 1KHJA 3BDHA 1ALJA 1B8JA 4FDJA 1P49A 1KHNA 1AUKA 3MK0A 3SZYA 1HQAA 1KHKA 1AJAA 3UN3A 1ZEDA 1EI6A 1ZEBA 3SZZA 1O98A 3M8WA 1FSUA 3BDGB 1ANIA 1ELYA 1EW8A 2ANHA 1KH4A 2GLQA 3IGYB 2IFYA 2QZUA 3MK1A 3T01A 3UN2A 3BDFA 3DPCA
chains in the KnotProt database with same CATH topology
3ED4A 3TX0A 3MK2A 1ANJA 1ED9A 1HJKA 1KH9A 3UNYA 1O99A 1EJJA 1KH7A 1EQJA 1Y6VA 3M8YA 1EW9A 3TWZA 3OT9A 3T02A 1E2SP 1EW2A 2G9YA 1KH5A 1KHLA 1SHNA 1ALIA 3T00A 3CMRA 3M7VA 1N2LA 1URBA 1ELXA 3NVLA 1E1ZP 3DYCA 1N2KA 1K7HA 2GA3A 3BDGA 1AJBA 3M8ZA 1HDHA 4FDIA 1ALKA 3IGZB 1AJDA 1SHQA 3UO0A 1AJCA 1Y7AA 3UN5A 1E3CP 1ELZA 1ED8A 1URAA 1ZEFA 1E33P 1KHJA 3BDHA 1ALJA 1B8JA 4FDJA 1P49A 1KHNA 1AUKA 3MK0A 3SZYA 1HQAA 1KHKA 1AJAA 3UN3A 1ZEDA 1EI6A 1ZEBA 3SZZA 1O98A 3M8WA 1FSUA 3BDGB 1ANIA 1ELYA 1EW8A 2ANHA 1KH4A 2GLQA 3IGYB 2IFYA 2QZUA 3MK1A 3T01A 3UN2A 3BDFA 3DPCA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 3ED4 A;  3TX0 A;  3MK2 A;  1ANJ A;  1ED9 A;  1HJK A;  1KH9 A;  3UNY A;  1O99 A;  1EJJ A;  1KH7 A;  1EQJ A;  1Y6V A;  3M8Y A;  1EW9 A;  3TWZ A;  3OT9 A;  3T02 A;  1E2S P;  1EW2 A;  2G9Y A;  1KH5 A;  1KHL A;  1SHN A;  1ALI A;  3T00 A;  3CMR A;  3M7V A;  1N2L A;  1URB A;  1ELX A;  3NVL A;  1E1Z P;  3DYC A;  1N2K A;  1K7H A;  2GA3 A;  3BDG A;  1AJB A;  3M8Z A;  1HDH A;  4FDI A;  1ALK A;  3IGZ B;  1AJD A;  1SHQ A;  3UO0 A;  1AJC A;  1Y7A A;  3UN5 A;  1E3C P;  1ELZ A;  1ED8 A;  1URA A;  1ZEF A;  1E33 P;  1KHJ A;  3BDH A;  1ALJ A;  1B8J A;  4FDJ A;  1P49 A;  1KHN A;  1AUK A;  3MK0 A;  3SZY A;  1HQA A;  1KHK A;  1AJA A;  3UN3 A;  1ZED A;  1EI6 A;  1ZEB A;  3SZZ A;  1O98 A;  3M8W A;  1FSU A;  3BDG B;  1ANI A;  1ELY A;  1EW8 A;  2ANH A;  1KH4 A;  2GLQ A;  3IGY B;  2IFY A;  2QZU A;  3MK1 A;  3T01 A;  3UN2 A;  3BDF A;  3DPC A; 
#chains in the KnotProt database with same CATH topology
 3ED4 A;  3TX0 A;  3MK2 A;  1ANJ A;  1ED9 A;  1HJK A;  1KH9 A;  3UNY A;  1O99 A;  1EJJ A;  1KH7 A;  1EQJ A;  1Y6V A;  3M8Y A;  1EW9 A;  3TWZ A;  3OT9 A;  3T02 A;  1E2S P;  1EW2 A;  2G9Y A;  1KH5 A;  1KHL A;  1SHN A;  1ALI A;  3T00 A;  3CMR A;  3M7V A;  1N2L A;  1URB A;  1ELX A;  3NVL A;  1E1Z P;  3DYC A;  1N2K A;  1K7H A;  2GA3 A;  3BDG A;  1AJB A;  3M8Z A;  1HDH A;  4FDI A;  1ALK A;  3IGZ B;  1AJD A;  1SHQ A;  3UO0 A;  1AJC A;  1Y7A A;  3UN5 A;  1E3C P;  1ELZ A;  1ED8 A;  1URA A;  1ZEF A;  1E33 P;  1KHJ A;  3BDH A;  1ALJ A;  1B8J A;  4FDJ A;  1P49 A;  1KHN A;  1AUK A;  3MK0 A;  3SZY A;  1HQA A;  1KHK A;  1AJA A;  3UN3 A;  1ZED A;  1EI6 A;  1ZEB A;  3SZZ A;  1O98 A;  3M8W A;  1FSU A;  3BDG B;  1ANI A;  1ELY A;  1EW8 A;  2ANH A;  1KH4 A;  2GLQ A;  3IGY B;  2IFY A;  2QZU A;  3MK1 A;  3T01 A;  3UN2 A;  3BDF A;  3DPC A; 
#chains in the KnotProt database with same CATH homology
 3ED4 A;  3TX0 A;  3MK2 A;  1ANJ A;  1ED9 A;  1HJK A;  1KH9 A;  3UNY A;  1O99 A;  1EJJ A;  1KH7 A;  1EQJ A;  1Y6V A;  3M8Y A;  1EW9 A;  3TWZ A;  3OT9 A;  3T02 A;  1E2S P;  1EW2 A;  2G9Y A;  1KH5 A;  1KHL A;  1SHN A;  1ALI A;  3T00 A;  3CMR A;  3M7V A;  1N2L A;  1URB A;  1ELX A;  3NVL A;  1E1Z P;  3DYC A;  1N2K A;  1K7H A;  2GA3 A;  3BDG A;  1AJB A;  3M8Z A;  1HDH A;  4FDI A;  1ALK A;  3IGZ B;  1AJD A;  1SHQ A;  3UO0 A;  1AJC A;  1Y7A A;  3UN5 A;  1E3C P;  1ELZ A;  1ED8 A;  1URA A;  1ZEF A;  1E33 P;  1KHJ A;  3BDH A;  1ALJ A;  1B8J A;  4FDJ A;  1P49 A;  1KHN A;  1AUK A;  3MK0 A;  3SZY A;  1HQA A;  1KHK A;  1AJA A;  3UN3 A;  1ZED A;  1EI6 A;  1ZEB A;  3SZZ A;  1O98 A;  3M8W A;  1FSU A;  3BDG B;  1ANI A;  1ELY A;  1EW8 A;  2ANH A;  1KH4 A;  2GLQ A;  3IGY B;  2IFY A;  2QZU A;  3MK1 A;  3T01 A;  3UN2 A;  3BDF A;  3DPC A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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