1E33 | KnotProt

Genus: 153

Slipknot S +3₁

script 1 started

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AppletRegistry.checkIn(jmolApplet1__957558316711359__)

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setting document base to "https://knotprot.cent.uw.edu.pl/view/1E33/P/"

Jmol Version: 14.29.13 2018-04-17 17:17

java.vendor: Java2Script (HTML5)

java.version: 2018-01-28 23:38:52 (JSmol/j2s)

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Jmol getValue emulate null

defaults = "Jmol"

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Jmol getValue bgcolor white

backgroundColor = "white"

Jmol getValue ANIMFRAMECallback null

Jmol getValue APPLETREADYCallback Jmol._readyCallback

APPLETREADYCallback = "Jmol._readyCallback"

callback set for APPLETREADYCallback Jmol._readyCallback APPLETREADY

Jmol getValue ATOMMOVEDCallback null

Jmol getValue AUDIOCallback null

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Jmol applet jmolApplet1__957558316711359__ ready

Help Knotting data interpretation Full screen

					Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details				+3₁	7-263	257	1-6	294-485	264-293	6	192	slipknot

Chain Sequence

RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLXTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQREDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPLLLYDLSKDPGENYNLLG----ATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCP

Whole chain analysis

Help Knotoid data interpretation Full screen

Subchain analysis

Knotoid cutoff: 0.5

Knotoid matrix content: 1

loadScript /static/js/j2s/core/package.js

loadScript /static/js/j2s/core/corejmol.z.js

loadScript /static/js/j2s/core/corescript.z.js

JSmol exec jmolApplet0 start applet null

Jmol JavaScript applet jmolApplet0__957558316711359__ initializing

Jmol getValue debug null

Jmol getValue logLevel null

Jmol getValue allowjavascript null

AppletRegistry.checkIn(jmolApplet0__957558316711359__)

vwrOptions:

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setting document base to "https://knotprot.cent.uw.edu.pl/view/1E33/P/"

Jmol Version: 14.29.13 2018-04-17 17:17

java.vendor: Java2Script (HTML5)

java.version: 2018-01-28 23:38:52 (JSmol/j2s)

os.name: Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)

Access: ALL

memory: 0.0/0.0

processors available: 1

useCommandThread: false

appletId:jmolApplet0 (signed)

Jmol getValue emulate null

defaults = "Jmol"

Jmol getValue boxbgcolor null

Jmol getValue bgcolor white

backgroundColor = "white"

Jmol getValue ANIMFRAMECallback null

Jmol getValue APPLETREADYCallback Jmol._readyCallback

APPLETREADYCallback = "Jmol._readyCallback"

callback set for APPLETREADYCallback Jmol._readyCallback APPLETREADY

Jmol getValue ATOMMOVEDCallback null

Jmol getValue AUDIOCallback null

Jmol getValue CLICKCallback null

Jmol getValue DRAGDROPCallback null

Jmol getValue ECHOCallback null

Jmol getValue ERRORCallback null

Jmol getValue EVALCallback null

Jmol getValue HOVERCallback null

Jmol getValue IMAGECallback null

Jmol getValue LOADSTRUCTCallback null

Jmol getValue MEASURECallback null

Jmol getValue MESSAGECallback null

Jmol getValue MINIMIZATIONCallback null

Jmol getValue SERVICECallback null

Jmol getValue PICKCallback null

Jmol getValue RESIZECallback null

Jmol getValue SCRIPTCallback null

Jmol getValue SYNCCallback null

Jmol getValue STRUCTUREMODIFIEDCallback null

Jmol getValue doTranslate null

language=en_US

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Jmol applet jmolApplet0__957558316711359__ ready

script 1 started

platformSpeed = 8

Viewer cachePut cache://localLOAD_/static/knot_data/1e33/P/1e33_P.pdb.gz

Viewer cachePut https://knotprot.cent.uw.edu.pl/static/knot_data/1e33/P/1e33_P.pdb.gz

Viewer cachePut cache://localLOAD_/static/knot_data/1e33/P/1e33_P.pdb.gz

Viewer cachePut https://knotprot.cent.uw.edu.pl/static/knot_data/1e33/P/1e33_P.pdb.gz

FileManager.getAtomSetCollectionFromFile(/static/knot_data/1e33/P/1e33_P.pdb.gz)

The Resolver thinks Pdb

loadScript /static/js/j2s/core/corebio.z.js

Time for openFile(/static/knot_data/1e33/P/1e33_P.pdb.gz): 1622 ms

reading 481 atoms

ModelSet: haveSymmetry:false haveUnitcells:false haveFractionalCoord:false

1 model in this collection. Use getProperty "modelInfo" or getProperty "auxiliaryInfo" to inspect them.

Default Van der Waals type for model set to Jmol

481 atoms created

ModelSet: autobonding; use autobond=false to not generate bonds automatically

Time for creating model: 60 ms

Adding embedded #jmolscript: select ({0:480});backbone only;select *;

FileManager.getAtomSetCollectionFromFile(/static/knot_data/1e33/P/1e33_P.pdb.gz)

The Resolver thinks Pdb

Time for openFile(/static/knot_data/1e33/P/1e33_P.pdb.gz): 56 ms

reading 481 atoms

ModelSet: haveSymmetry:false haveUnitcells:false haveFractionalCoord:false

1 model in this collection. Use getProperty "modelInfo" or getProperty "auxiliaryInfo" to inspect them.

Default Van der Waals type for model set to Jmol

481 atoms created

ModelSet: autobonding; use autobond=false to not generate bonds automatically

Time for creating model: 51 ms

Adding embedded #jmolscript: select ({0:480});backbone only;select *;

platformSpeed = 7

cartoonsFancy = true

sheetSmoothing = 1.0

traceAlpha = true

loadScript /static/js/j2s/core/corescriptcmd.z.js

platformSpeed = 7

cartoonsFancy = true

sheetSmoothing = 1.0

traceAlpha = true

specularPower = 9

ambientPercent = 20

antialiasDisplay = true

Script completed

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loadScript /static/js/j2s/J/g3d/HermiteRenderer.js

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loadScript /static/js/j2s/J/render/MeshRenderer.js

loadScript /static/js/j2s/J/shape/Mesh.js

specularPower = 9

ambientPercent = 20

antialiasDisplay = true

Script completed

Jmol script terminated

Help Knotoid subchains data interpretation Full screen

		Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details	2.1	5-261	257	1-4	267-481	262-266	4	215	slipknot
view details	3.1	7-266	260	1-6	294-481	267-293	6	188	slipknot
view details	3.1	6-293	288	1-5	295-481	294-294	5	187	slipknot
view details	2.1	6-294	289	1-5	296-481	295-295	5	186	slipknot

sequence length	485
structure length	481
publication title	Defective Oligomerization of Arylsulfatase a as a Cause of its Instability in Lysosomes and Metachromatic Leukodystrophy. pubmed doi rcsb
molecule tags	Hydrolase
molecule keywords	ARYLSULFATASE A
missing residues	426-429
total genus	Genus: 153
ec nomenclature	ec 3.1.6.8: Cerebroside-sulfatase.
pdb deposition date	2000-06-06
KnotProt deposition date	2014-07-31

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
P	PF00884	Sulfatase	Sulfatase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.30.1120.10	Alpha Beta	2-Layer Sandwich	Arylsulfatase, C-terminal domain	Arylsulfatase, C-terminal domain	1e33P02
3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	1e33P01

3BDGA 1EJJA 1EW2A 2G9YA 1O98A 1ED8A 1ANJA 1ELXA 3MK0A 1FSUA 3T00A 1E33P 1SHQA 3UN2A 1HDHA 1Y7AA 1KHKA 3DPCA 3UN5A 3ED4A 2IFYA 3UO0A 1E3CP 3IGZB 1HJKA 3TWZA 1AJDA 1AJBA 1E1ZP 3T02A 1EW8A 3MK1A 1KH4A 1EI6A 3NVLA 4FDIA 2ANHA 3SZYA 4FDJA 3CMRA 3DYCA 2QZUA 1KHNA 1ALJA 1ELZA 3M8ZA 1Y6VA 1AJCA 1ALIA 3IGYB 3SZZA 2GA3A 1P49A 1KHLA 1URAA 1AJAA 1KH7A 1E2SP 3BDHA 3TX0A 1K7HA 1URBA 1N2KA 1KH5A 1EQJA 1ZEDA 1ZEBA 1ANIA 3M8WA 1EW9A 1ELYA 3OT9A 1HQAA 1B8JA 3T01A 3M8YA 1KH9A 1SHNA 3BDFA 1ZEFA 3UN3A 1ED9A 1ALKA 3UNYA 1N2LA 1O99A 1AUKA 3M7VA 3BDGB 3MK2A 1KHJA 2GLQA
chains in the KnotProt database with same CATH superfamily

#chains in the KnotProt database with same CATH superfamily
 3BDG A;  1EJJ A;  1EW2 A;  2G9Y A;  1O98 A;  1ED8 A;  1ANJ A;  1ELX A;  3MK0 A;  1FSU A;  3T00 A;  1E33 P;  1SHQ A;  3UN2 A;  1HDH A;  1Y7A A;  1KHK A;  3DPC A;  3UN5 A;  3ED4 A;  2IFY A;  3UO0 A;  1E3C P;  3IGZ B;  1HJK A;  3TWZ A;  1AJD A;  1AJB A;  1E1Z P;  3T02 A;  1EW8 A;  3MK1 A;  1KH4 A;  1EI6 A;  3NVL A;  4FDI A;  2ANH A;  3SZY A;  4FDJ A;  3CMR A;  3DYC A;  2QZU A;  1KHN A;  1ALJ A;  1ELZ A;  3M8Z A;  1Y6V A;  1AJC A;  1ALI A;  3IGY B;  3SZZ A;  2GA3 A;  1P49 A;  1KHL A;  1URA A;  1AJA A;  1KH7 A;  1E2S P;  3BDH A;  3TX0 A;  1K7H A;  1URB A;  1N2K A;  1KH5 A;  1EQJ A;  1ZED A;  1ZEB A;  1ANI A;  3M8W A;  1EW9 A;  1ELY A;  3OT9 A;  1HQA A;  1B8J A;  3T01 A;  3M8Y A;  1KH9 A;  1SHN A;  3BDF A;  1ZEF A;  3UN3 A;  1ED9 A;  1ALK A;  3UNY A;  1N2L A;  1O99 A;  1AUK A;  3M7V A;  3BDG B;  3MK2 A;  1KHJ A;  2GLQ A; 
#chains in the KnotProt database with same CATH topology
 3BDG A;  1EJJ A;  1EW2 A;  2G9Y A;  1O98 A;  1ED8 A;  1ANJ A;  1ELX A;  3MK0 A;  1FSU A;  3T00 A;  1E33 P;  1SHQ A;  3UN2 A;  1HDH A;  1Y7A A;  1KHK A;  3DPC A;  3UN5 A;  3ED4 A;  2IFY A;  3UO0 A;  1E3C P;  3IGZ B;  1HJK A;  3TWZ A;  1AJD A;  1AJB A;  1E1Z P;  3T02 A;  1EW8 A;  3MK1 A;  1KH4 A;  1EI6 A;  3NVL A;  4FDI A;  2ANH A;  3SZY A;  4FDJ A;  3CMR A;  3DYC A;  2QZU A;  1KHN A;  1ALJ A;  1ELZ A;  3M8Z A;  1Y6V A;  1AJC A;  1ALI A;  3IGY B;  3SZZ A;  2GA3 A;  1P49 A;  1KHL A;  1URA A;  1AJA A;  1KH7 A;  1E2S P;  3BDH A;  3TX0 A;  1K7H A;  1URB A;  1N2K A;  1KH5 A;  1EQJ A;  1ZED A;  1ZEB A;  1ANI A;  3M8W A;  1EW9 A;  1ELY A;  3OT9 A;  1HQA A;  1B8J A;  3T01 A;  3M8Y A;  1KH9 A;  1SHN A;  3BDF A;  1ZEF A;  3UN3 A;  1ED9 A;  1ALK A;  3UNY A;  1N2L A;  1O99 A;  1AUK A;  3M7V A;  3BDG B;  3MK2 A;  1KHJ A;  2GLQ A; 
#chains in the KnotProt database with same CATH homology
 3BDG A;  1EJJ A;  1EW2 A;  2G9Y A;  1O98 A;  1ED8 A;  1ANJ A;  1ELX A;  3MK0 A;  1FSU A;  3T00 A;  1E33 P;  1SHQ A;  3UN2 A;  1HDH A;  1Y7A A;  1KHK A;  3DPC A;  3UN5 A;  3ED4 A;  2IFY A;  3UO0 A;  1E3C P;  3IGZ B;  1HJK A;  3TWZ A;  1AJD A;  1AJB A;  1E1Z P;  3T02 A;  1EW8 A;  3MK1 A;  1KH4 A;  1EI6 A;  3NVL A;  4FDI A;  2ANH A;  3SZY A;  4FDJ A;  3CMR A;  3DYC A;  2QZU A;  1KHN A;  1ALJ A;  1ELZ A;  3M8Z A;  1Y6V A;  1AJC A;  1ALI A;  3IGY B;  3SZZ A;  2GA3 A;  1P49 A;  1KHL A;  1URA A;  1AJA A;  1KH7 A;  1E2S P;  3BDH A;  3TX0 A;  1K7H A;  1URB A;  1N2K A;  1KH5 A;  1EQJ A;  1ZED A;  1ZEB A;  1ANI A;  3M8W A;  1EW9 A;  1ELY A;  3OT9 A;  1HQA A;  1B8J A;  3T01 A;  3M8Y A;  1KH9 A;  1SHN A;  3BDF A;  1ZEF A;  3UN3 A;  1ED9 A;  1ALK A;  3UNY A;  1N2L A;  1O99 A;  1AUK A;  3M7V A;  3BDG B;  3MK2 A;  1KHJ A;  2GLQ A;

1AUKA 1E1ZP 1E2SP 1E3CP 1N2KA 1N2LA
similar chains in the KnotProt database (40% sequence similarity)

None
similar chains in the pdb database (40% sequence similarity)

#similar chains in the KnotProt database (40% sequence similarity)
1AUK A; 1E1Z P; 1E2S P; 1E3C P; 1N2K A; 1N2L A; 
#similar chains, but unknotted

#similar chains in the pdb database (40% sequence similarity)

1E33P

Slipknot S +31

Chain Sequence

pfam database annotations

Slipknot S +3₁