1EW2A

Crystal structure of a human phosphatase
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 40-356 317 1-39 438-479 357-437 39 42 slipknot
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPP
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 39-359 321 1-38 437-479 360-436 38 43 slipknot
view details
2.1 37-436 400 1-36 441-479 437-440 36 39 slipknot
view details
2.1 20-354 335 1-9, 360-479 10-19, 355-359 9 120 slipknot
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2.1 23-354 332 1-19, 360-479 20-22, 355-359 19 120 slipknot
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2.1 30-354 325 1-22, 360-479 23-29, 355-359 22 120 slipknot
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2.1 34-354 321 1-29, 360-479 30-33, 355-359 29 120 slipknot
sequence length 479
structure length 479
publication title Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords PHOSPHATASE
total genus Genus: 172
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-04-21
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ew2A00
1KHLA 3BDGA 3MK1A 1ED9A 1ELXA 1P49A 3TX0A 3T00A 1ANJA 3NVLA 1EI6A 1AJBA 3UNYA 1EJJA 3MK0A 1URAA 3UN3A 4FDJA 3UN2A 1AJDA 1ZEFA 1B8JA 1SHQA 3IGZB 3BDHA 2GA3A 3MK2A 1URBA 1KH5A 1ANIA 1HQAA 1SHNA 3CMRA 1N2LA 1KHKA 3BDGB 1E1ZP 1O99A 3T01A 3M8YA 3UN5A 2GLQA 1KH7A 1K7HA 1ELZA 4FDIA 1EQJA 1ELYA 3DYCA 1EW8A 3ED4A 1KHJA 3TWZA 1N2KA 3SZYA 1E3CP 1ZEBA 1EW9A 1HJKA 3M7VA 2IFYA 3M8WA 1ALJA 1AUKA 1Y6VA 1E2SP 3BDFA 3IGYB 1AJAA 1O98A 3T02A 1ED8A 2G9YA 1HDHA 1ALKA 3UO0A 2ANHA 1EW2A 1Y7AA 1FSUA 1ZEDA 1ALIA 3OT9A 2QZUA 1AJCA 1KH4A 3SZZA 1E33P 3DPCA 1KHNA 1KH9A 3M8ZA
chains in the KnotProt database with same CATH superfamily
1KHLA 3BDGA 3MK1A 1ED9A 1ELXA 1P49A 3TX0A 3T00A 1ANJA 3NVLA 1EI6A 1AJBA 3UNYA 1EJJA 3MK0A 1URAA 3UN3A 4FDJA 3UN2A 1AJDA 1ZEFA 1B8JA 1SHQA 3IGZB 3BDHA 2GA3A 3MK2A 1URBA 1KH5A 1ANIA 1HQAA 1SHNA 3CMRA 1N2LA 1KHKA 3BDGB 1E1ZP 1O99A 3T01A 3M8YA 3UN5A 2GLQA 1KH7A 1K7HA 1ELZA 4FDIA 1EQJA 1ELYA 3DYCA 1EW8A 3ED4A 1KHJA 3TWZA 1N2KA 3SZYA 1E3CP 1ZEBA 1EW9A 1HJKA 3M7VA 2IFYA 3M8WA 1ALJA 1AUKA 1Y6VA 1E2SP 3BDFA 3IGYB 1AJAA 1O98A 3T02A 1ED8A 2G9YA 1HDHA 1ALKA 3UO0A 2ANHA 1EW2A 1Y7AA 1FSUA 1ZEDA 1ALIA 3OT9A 2QZUA 1AJCA 1KH4A 3SZZA 1E33P 3DPCA 1KHNA 1KH9A 3M8ZA
chains in the KnotProt database with same CATH topology
1KHLA 3BDGA 3MK1A 1ED9A 1ELXA 1P49A 3TX0A 3T00A 1ANJA 3NVLA 1EI6A 1AJBA 3UNYA 1EJJA 3MK0A 1URAA 3UN3A 4FDJA 3UN2A 1AJDA 1ZEFA 1B8JA 1SHQA 3IGZB 3BDHA 2GA3A 3MK2A 1URBA 1KH5A 1ANIA 1HQAA 1SHNA 3CMRA 1N2LA 1KHKA 3BDGB 1E1ZP 1O99A 3T01A 3M8YA 3UN5A 2GLQA 1KH7A 1K7HA 1ELZA 4FDIA 1EQJA 1ELYA 3DYCA 1EW8A 3ED4A 1KHJA 3TWZA 1N2KA 3SZYA 1E3CP 1ZEBA 1EW9A 1HJKA 3M7VA 2IFYA 3M8WA 1ALJA 1AUKA 1Y6VA 1E2SP 3BDFA 3IGYB 1AJAA 1O98A 3T02A 1ED8A 2G9YA 1HDHA 1ALKA 3UO0A 2ANHA 1EW2A 1Y7AA 1FSUA 1ZEDA 1ALIA 3OT9A 2QZUA 1AJCA 1KH4A 3SZZA 1E33P 3DPCA 1KHNA 1KH9A 3M8ZA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1KHL A;  3BDG A;  3MK1 A;  1ED9 A;  1ELX A;  1P49 A;  3TX0 A;  3T00 A;  1ANJ A;  3NVL A;  1EI6 A;  1AJB A;  3UNY A;  1EJJ A;  3MK0 A;  1URA A;  3UN3 A;  4FDJ A;  3UN2 A;  1AJD A;  1ZEF A;  1B8J A;  1SHQ A;  3IGZ B;  3BDH A;  2GA3 A;  3MK2 A;  1URB A;  1KH5 A;  1ANI A;  1HQA A;  1SHN A;  3CMR A;  1N2L A;  1KHK A;  3BDG B;  1E1Z P;  1O99 A;  3T01 A;  3M8Y A;  3UN5 A;  2GLQ A;  1KH7 A;  1K7H A;  1ELZ A;  4FDI A;  1EQJ A;  1ELY A;  3DYC A;  1EW8 A;  3ED4 A;  1KHJ A;  3TWZ A;  1N2K A;  3SZY A;  1E3C P;  1ZEB A;  1EW9 A;  1HJK A;  3M7V A;  2IFY A;  3M8W A;  1ALJ A;  1AUK A;  1Y6V A;  1E2S P;  3BDF A;  3IGY B;  1AJA A;  1O98 A;  3T02 A;  1ED8 A;  2G9Y A;  1HDH A;  1ALK A;  3UO0 A;  2ANH A;  1EW2 A;  1Y7A A;  1FSU A;  1ZED A;  1ALI A;  3OT9 A;  2QZU A;  1AJC A;  1KH4 A;  3SZZ A;  1E33 P;  3DPC A;  1KHN A;  1KH9 A;  3M8Z A; 
#chains in the KnotProt database with same CATH topology
 1KHL A;  3BDG A;  3MK1 A;  1ED9 A;  1ELX A;  1P49 A;  3TX0 A;  3T00 A;  1ANJ A;  3NVL A;  1EI6 A;  1AJB A;  3UNY A;  1EJJ A;  3MK0 A;  1URA A;  3UN3 A;  4FDJ A;  3UN2 A;  1AJD A;  1ZEF A;  1B8J A;  1SHQ A;  3IGZ B;  3BDH A;  2GA3 A;  3MK2 A;  1URB A;  1KH5 A;  1ANI A;  1HQA A;  1SHN A;  3CMR A;  1N2L A;  1KHK A;  3BDG B;  1E1Z P;  1O99 A;  3T01 A;  3M8Y A;  3UN5 A;  2GLQ A;  1KH7 A;  1K7H A;  1ELZ A;  4FDI A;  1EQJ A;  1ELY A;  3DYC A;  1EW8 A;  3ED4 A;  1KHJ A;  3TWZ A;  1N2K A;  3SZY A;  1E3C P;  1ZEB A;  1EW9 A;  1HJK A;  3M7V A;  2IFY A;  3M8W A;  1ALJ A;  1AUK A;  1Y6V A;  1E2S P;  3BDF A;  3IGY B;  1AJA A;  1O98 A;  3T02 A;  1ED8 A;  2G9Y A;  1HDH A;  1ALK A;  3UO0 A;  2ANH A;  1EW2 A;  1Y7A A;  1FSU A;  1ZED A;  1ALI A;  3OT9 A;  2QZU A;  1AJC A;  1KH4 A;  3SZZ A;  1E33 P;  3DPC A;  1KHN A;  1KH9 A;  3M8Z A; 
#chains in the KnotProt database with same CATH homology
 1KHL A;  3BDG A;  3MK1 A;  1ED9 A;  1ELX A;  1P49 A;  3TX0 A;  3T00 A;  1ANJ A;  3NVL A;  1EI6 A;  1AJB A;  3UNY A;  1EJJ A;  3MK0 A;  1URA A;  3UN3 A;  4FDJ A;  3UN2 A;  1AJD A;  1ZEF A;  1B8J A;  1SHQ A;  3IGZ B;  3BDH A;  2GA3 A;  3MK2 A;  1URB A;  1KH5 A;  1ANI A;  1HQA A;  1SHN A;  3CMR A;  1N2L A;  1KHK A;  3BDG B;  1E1Z P;  1O99 A;  3T01 A;  3M8Y A;  3UN5 A;  2GLQ A;  1KH7 A;  1K7H A;  1ELZ A;  4FDI A;  1EQJ A;  1ELY A;  3DYC A;  1EW8 A;  3ED4 A;  1KHJ A;  3TWZ A;  1N2K A;  3SZY A;  1E3C P;  1ZEB A;  1EW9 A;  1HJK A;  3M7V A;  2IFY A;  3M8W A;  1ALJ A;  1AUK A;  1Y6V A;  1E2S P;  3BDF A;  3IGY B;  1AJA A;  1O98 A;  3T02 A;  1ED8 A;  2G9Y A;  1HDH A;  1ALK A;  3UO0 A;  2ANH A;  1EW2 A;  1Y7A A;  1FSU A;  1ZED A;  1ALI A;  3OT9 A;  2QZU A;  1AJC A;  1KH4 A;  3SZZ A;  1E33 P;  3DPC A;  1KHN A;  1KH9 A;  3M8Z A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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