1EW8 | KnotProt

Genus: 155

Slipknot S +3₁

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setting document base to "https://knotprot.cent.uw.edu.pl/view/1EW8/A/"

Jmol Version: 14.29.13 2018-04-17 17:17

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APPLETREADYCallback = "Jmol._readyCallback"

callback set for APPLETREADYCallback Jmol._readyCallback APPLETREADY

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language=en_US

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Jmol applet jmolApplet1__3525636703963184__ ready

Help Knotting data interpretation Full screen

					Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details				+3₁	46-366	321	1-45	420-449	367-419	45	30	slipknot

Chain Sequence

TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK

Whole chain analysis

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Subchain analysis

Knotoid cutoff: 0.5

Knotoid matrix content: 1

loadScript /static/js/j2s/core/package.js

loadScript /static/js/j2s/core/corejmol.z.js

loadScript /static/js/j2s/core/corescript.z.js

JSmol exec jmolApplet0 start applet null

Jmol JavaScript applet jmolApplet0__3525636703963184__ initializing

Jmol getValue debug null

Jmol getValue logLevel null

Jmol getValue allowjavascript null

AppletRegistry.checkIn(jmolApplet0__3525636703963184__)

vwrOptions:

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setting document base to "https://knotprot.cent.uw.edu.pl/view/1EW8/A/"

Jmol Version: 14.29.13 2018-04-17 17:17

java.vendor: Java2Script (HTML5)

java.version: 2018-01-28 23:38:52 (JSmol/j2s)

os.name: Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)

Access: ALL

memory: 0.0/0.0

processors available: 1

useCommandThread: false

appletId:jmolApplet0 (signed)

Jmol getValue emulate null

defaults = "Jmol"

Jmol getValue boxbgcolor null

Jmol getValue bgcolor white

backgroundColor = "white"

Jmol getValue ANIMFRAMECallback null

Jmol getValue APPLETREADYCallback Jmol._readyCallback

APPLETREADYCallback = "Jmol._readyCallback"

callback set for APPLETREADYCallback Jmol._readyCallback APPLETREADY

Jmol getValue ATOMMOVEDCallback null

Jmol getValue AUDIOCallback null

Jmol getValue CLICKCallback null

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Jmol applet jmolApplet0__3525636703963184__ ready

script 1 started

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Viewer cachePut cache://localLOAD_/static/knot_data/1ew8/A/1ew8_A.pdb.gz

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FileManager.getAtomSetCollectionFromFile(/static/knot_data/1ew8/A/1ew8_A.pdb.gz)

The Resolver thinks Pdb

loadScript /static/js/j2s/core/corebio.z.js

Time for openFile(/static/knot_data/1ew8/A/1ew8_A.pdb.gz): 588 ms

reading 449 atoms

ModelSet: haveSymmetry:false haveUnitcells:false haveFractionalCoord:false

1 model in this collection. Use getProperty "modelInfo" or getProperty "auxiliaryInfo" to inspect them.

Default Van der Waals type for model set to Jmol

449 atoms created

ModelSet: autobonding; use autobond=false to not generate bonds automatically

Time for creating model: 62 ms

Adding embedded #jmolscript: select ({0:448});backbone only;select *;

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Script completed

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loadScript /static/js/j2s/J/shape/Mesh.js

FileManager.getAtomSetCollectionFromFile(/static/knot_data/1ew8/A/1ew8_A.pdb.gz)

The Resolver thinks Pdb

Time for openFile(/static/knot_data/1ew8/A/1ew8_A.pdb.gz): 25 ms

reading 449 atoms

ModelSet: haveSymmetry:false haveUnitcells:false haveFractionalCoord:false

1 model in this collection. Use getProperty "modelInfo" or getProperty "auxiliaryInfo" to inspect them.

Default Van der Waals type for model set to Jmol

449 atoms created

ModelSet: autobonding; use autobond=false to not generate bonds automatically

Time for creating model: 35 ms

Adding embedded #jmolscript: select ({0:448});backbone only;select *;

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cartoonsFancy = true

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Script completed

Jmol script terminated

Help Knotoid subchains data interpretation Full screen

		Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details	3.1	47-370	324	1-46	387-449	371-386	46	63	slipknot
view details	3.1	47-386	340	1-46	417-449	387-416	46	33	slipknot
view details	2.1	45-416	372	1-44	421-449	417-420	44	29	slipknot
view details	3.1	48-370	323		1-46, 387-449	47-47, 371-386	46	63	slipknot
view details	3.1	48-386	339		1-46, 417-449	47-47, 387-416	46	33	slipknot

sequence length	449
structure length	449
publication title	Alternate modes of binding in two crystal structures of alkaline phosphatase-inhibitor complexes. pubmed rcsb
molecule tags	Hydrolase
molecule keywords	ALKALINE PHOSPHATASE
source organism	Escherichia coli
total genus	Genus: 155
ec nomenclature	ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date	2000-04-24
KnotProt deposition date	2014-07-31

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
A	PF00245	Alk_phosphatase	Alkaline phosphatase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	1ew8A00

3BDGA 1EJJA 1EW2A 2G9YA 1O98A 1ED8A 1ANJA 1ELXA 3MK0A 1FSUA 3T00A 1E33P 1SHQA 3UN2A 1HDHA 1Y7AA 1KHKA 3DPCA 3UN5A 2IFYA 3ED4A 3UO0A 1E3CP 3IGZB 1HJKA 3TWZA 1AJDA 1AJBA 1E1ZP 3T02A 1EW8A 3MK1A 1KH4A 1EI6A 3NVLA 2ANHA 4FDIA 3SZYA 4FDJA 3CMRA 3DYCA 2QZUA 1KHNA 1ALJA 1ELZA 3M8ZA 1Y6VA 1AJCA 1ALIA 3IGYB 3SZZA 2GA3A 1KHLA 1P49A 1URAA 1AJAA 1KH7A 1E2SP 3BDHA 3TX0A 1K7HA 1URBA 1N2KA 1KH5A 1EQJA 1ZEDA 1ZEBA 1ANIA 3M8WA 1EW9A 1ELYA 3OT9A 1HQAA 1B8JA 3T01A 3M8YA 1KH9A 1SHNA 3BDFA 1ZEFA 3UN3A 1ED9A 1ALKA 3UNYA 1N2LA 1O99A 1AUKA 3M7VA 3BDGB 3MK2A 1KHJA 2GLQA
chains in the KnotProt database with same CATH superfamily

#chains in the KnotProt database with same CATH superfamily
 3BDG A;  1EJJ A;  1EW2 A;  2G9Y A;  1O98 A;  1ED8 A;  1ANJ A;  1ELX A;  3MK0 A;  1FSU A;  3T00 A;  1E33 P;  1SHQ A;  3UN2 A;  1HDH A;  1Y7A A;  1KHK A;  3DPC A;  3UN5 A;  2IFY A;  3ED4 A;  3UO0 A;  1E3C P;  3IGZ B;  1HJK A;  3TWZ A;  1AJD A;  1AJB A;  1E1Z P;  3T02 A;  1EW8 A;  3MK1 A;  1KH4 A;  1EI6 A;  3NVL A;  2ANH A;  4FDI A;  3SZY A;  4FDJ A;  3CMR A;  3DYC A;  2QZU A;  1KHN A;  1ALJ A;  1ELZ A;  3M8Z A;  1Y6V A;  1AJC A;  1ALI A;  3IGY B;  3SZZ A;  2GA3 A;  1KHL A;  1P49 A;  1URA A;  1AJA A;  1KH7 A;  1E2S P;  3BDH A;  3TX0 A;  1K7H A;  1URB A;  1N2K A;  1KH5 A;  1EQJ A;  1ZED A;  1ZEB A;  1ANI A;  3M8W A;  1EW9 A;  1ELY A;  3OT9 A;  1HQA A;  1B8J A;  3T01 A;  3M8Y A;  1KH9 A;  1SHN A;  3BDF A;  1ZEF A;  3UN3 A;  1ED9 A;  1ALK A;  3UNY A;  1N2L A;  1O99 A;  1AUK A;  3M7V A;  3BDG B;  3MK2 A;  1KHJ A;  2GLQ A; 
#chains in the KnotProt database with same CATH topology
 3BDG A;  1EJJ A;  1EW2 A;  2G9Y A;  1O98 A;  1ED8 A;  1ANJ A;  1ELX A;  3MK0 A;  1FSU A;  3T00 A;  1E33 P;  1SHQ A;  3UN2 A;  1HDH A;  1Y7A A;  1KHK A;  3DPC A;  3UN5 A;  2IFY A;  3ED4 A;  3UO0 A;  1E3C P;  3IGZ B;  1HJK A;  3TWZ A;  1AJD A;  1AJB A;  1E1Z P;  3T02 A;  1EW8 A;  3MK1 A;  1KH4 A;  1EI6 A;  3NVL A;  2ANH A;  4FDI A;  3SZY A;  4FDJ A;  3CMR A;  3DYC A;  2QZU A;  1KHN A;  1ALJ A;  1ELZ A;  3M8Z A;  1Y6V A;  1AJC A;  1ALI A;  3IGY B;  3SZZ A;  2GA3 A;  1KHL A;  1P49 A;  1URA A;  1AJA A;  1KH7 A;  1E2S P;  3BDH A;  3TX0 A;  1K7H A;  1URB A;  1N2K A;  1KH5 A;  1EQJ A;  1ZED A;  1ZEB A;  1ANI A;  3M8W A;  1EW9 A;  1ELY A;  3OT9 A;  1HQA A;  1B8J A;  3T01 A;  3M8Y A;  1KH9 A;  1SHN A;  3BDF A;  1ZEF A;  3UN3 A;  1ED9 A;  1ALK A;  3UNY A;  1N2L A;  1O99 A;  1AUK A;  3M7V A;  3BDG B;  3MK2 A;  1KHJ A;  2GLQ A; 
#chains in the KnotProt database with same CATH homology
 3BDG A;  1EJJ A;  1EW2 A;  2G9Y A;  1O98 A;  1ED8 A;  1ANJ A;  1ELX A;  3MK0 A;  1FSU A;  3T00 A;  1E33 P;  1SHQ A;  3UN2 A;  1HDH A;  1Y7A A;  1KHK A;  3DPC A;  3UN5 A;  2IFY A;  3ED4 A;  3UO0 A;  1E3C P;  3IGZ B;  1HJK A;  3TWZ A;  1AJD A;  1AJB A;  1E1Z P;  3T02 A;  1EW8 A;  3MK1 A;  1KH4 A;  1EI6 A;  3NVL A;  2ANH A;  4FDI A;  3SZY A;  4FDJ A;  3CMR A;  3DYC A;  2QZU A;  1KHN A;  1ALJ A;  1ELZ A;  3M8Z A;  1Y6V A;  1AJC A;  1ALI A;  3IGY B;  3SZZ A;  2GA3 A;  1KHL A;  1P49 A;  1URA A;  1AJA A;  1KH7 A;  1E2S P;  3BDH A;  3TX0 A;  1K7H A;  1URB A;  1N2K A;  1KH5 A;  1EQJ A;  1ZED A;  1ZEB A;  1ANI A;  3M8W A;  1EW9 A;  1ELY A;  3OT9 A;  1HQA A;  1B8J A;  3T01 A;  3M8Y A;  1KH9 A;  1SHN A;  3BDF A;  1ZEF A;  3UN3 A;  1ED9 A;  1ALK A;  3UNY A;  1N2L A;  1O99 A;  1AUK A;  3M7V A;  3BDG B;  3MK2 A;  1KHJ A;  2GLQ A;

1ED8A 1ED9A 1EW8A 1EW9A 1Y6VA 3BDGB 3BDHA 3TG0A 5C66A
similar chains in the KnotProt database (40% sequence similarity)

None
similar chains in the pdb database (40% sequence similarity)

#similar chains in the KnotProt database (40% sequence similarity)
1ED8 A; 1ED9 A; 1EW8 A; 1EW9 A; 1Y6V A; 3BDG B; 3BDH A; 3TG0 A; 5C66 A; 
#similar chains, but unknotted

#similar chains in the pdb database (40% sequence similarity)

1EW8A

Slipknot S +31

Chain Sequence

pfam database annotations

Slipknot S +3₁