1FSUA

4-sulfatase (human)
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 164
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 8-259 252 1-7 288-492 260-287 7 205 slipknot
Chain Sequence
SRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQPL-TPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCS-----------------AFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 8-268 261 1-7 283-474 269-282 7 192 slipknot
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3.1 7-282 276 1-6 288-474 283-287 6 187 slipknot
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3.1 9-278 270 1-6, 288-474 7-8, 279-287 6 187 slipknot
sequence length 492
structure length 474
publication title Structure of a human lysosomal sulfatase.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords N-ACETYLGALACTOSAMINE-4-SULFATASE
source organism Homo sapiens
missing residues 50, 365-381
total genus Genus: 164
ec nomenclature ec 3.1.6.12: N-acetylgalactosamine-4-sulfatase.
pdb deposition date 1996-07-29
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.10 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 1fsuA02
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1fsuA01
1KH7A 2GLQA 3DYCA 3IGYB 3T01A 1KHNA 3T00A 1SHQA 3M8WA 1AJDA 1AJBA 1KH4A 1Y7AA 1AUKA 1ALKA 3M7VA 1B8JA 1ZEBA 3BDGB 3T02A 1EW8A 1Y6VA 3UN2A 1ELYA 1E3CP 3UN5A 1URBA 3TWZA 1E1ZP 1O98A 1HJKA 1ALIA 1E2SP 1EQJA 2G9YA 1KHJA 1O99A 3IGZB 3MK2A 1KHLA 1N2KA 1P49A 1ANIA 3SZYA 3M8YA 2QZUA 1ELZA 1EJJA 3OT9A 3UO0A 1K7HA 2GA3A 1N2LA 3UNYA 1AJCA 1ZEFA 2IFYA 3MK0A 1KH9A 3BDGA 1HDHA 1EW2A 3DPCA 1ALJA 1ED8A 1EI6A 2ANHA 3UN3A 3BDFA 3ED4A 1E33P 1EW9A 1KHKA 3SZZA 3NVLA 1ZEDA 1AJAA 1KH5A 1FSUA 3CMRA 3MK1A 3TX0A 1URAA 1ELXA 3M8ZA 1ANJA 1HQAA 1ED9A 4FDJA 3BDHA 4FDIA 1SHNA
chains in the KnotProt database with same CATH superfamily
1KH7A 2GLQA 3DYCA 3IGYB 3T01A 1KHNA 3T00A 1SHQA 3M8WA 1AJDA 1AJBA 1KH4A 1Y7AA 1AUKA 1ALKA 3M7VA 1B8JA 1ZEBA 3BDGB 3T02A 1EW8A 1Y6VA 3UN2A 1ELYA 1E3CP 3UN5A 1URBA 3TWZA 1E1ZP 1O98A 1HJKA 1ALIA 1E2SP 1EQJA 2G9YA 1KHJA 1O99A 3IGZB 3MK2A 1KHLA 1N2KA 1P49A 1ANIA 3SZYA 3M8YA 2QZUA 1ELZA 1EJJA 3OT9A 3UO0A 1K7HA 2GA3A 1N2LA 3UNYA 1AJCA 1ZEFA 2IFYA 3MK0A 1KH9A 3BDGA 1HDHA 1EW2A 3DPCA 1ALJA 1ED8A 1EI6A 2ANHA 3UN3A 3BDFA 3ED4A 1E33P 1EW9A 1KHKA 3SZZA 3NVLA 1ZEDA 1AJAA 1KH5A 1FSUA 3CMRA 3MK1A 3TX0A 1URAA 1ELXA 3M8ZA 1ANJA 1HQAA 1ED9A 4FDJA 3BDHA 4FDIA 1SHNA
chains in the KnotProt database with same CATH topology
1KH7A 2GLQA 3DYCA 3IGYB 3T01A 1KHNA 3T00A 1SHQA 3M8WA 1AJDA 1AJBA 1KH4A 1Y7AA 1AUKA 1ALKA 3M7VA 1B8JA 1ZEBA 3BDGB 3T02A 1EW8A 1Y6VA 3UN2A 1ELYA 1E3CP 3UN5A 1URBA 3TWZA 1E1ZP 1O98A 1HJKA 1ALIA 1E2SP 1EQJA 2G9YA 1KHJA 1O99A 3IGZB 3MK2A 1KHLA 1N2KA 1P49A 1ANIA 3SZYA 3M8YA 2QZUA 1ELZA 1EJJA 3OT9A 3UO0A 1K7HA 2GA3A 1N2LA 3UNYA 1AJCA 1ZEFA 2IFYA 3MK0A 1KH9A 3BDGA 1HDHA 1EW2A 3DPCA 1ALJA 1ED8A 1EI6A 2ANHA 3UN3A 3BDFA 3ED4A 1E33P 1EW9A 1KHKA 3SZZA 3NVLA 1ZEDA 1AJAA 1KH5A 1FSUA 3CMRA 3MK1A 3TX0A 1URAA 1ELXA 3M8ZA 1ANJA 1HQAA 1ED9A 4FDJA 3BDHA 4FDIA 1SHNA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1KH7 A;  2GLQ A;  3DYC A;  3IGY B;  3T01 A;  1KHN A;  3T00 A;  1SHQ A;  3M8W A;  1AJD A;  1AJB A;  1KH4 A;  1Y7A A;  1AUK A;  1ALK A;  3M7V A;  1B8J A;  1ZEB A;  3BDG B;  3T02 A;  1EW8 A;  1Y6V A;  3UN2 A;  1ELY A;  1E3C P;  3UN5 A;  1URB A;  3TWZ A;  1E1Z P;  1O98 A;  1HJK A;  1ALI A;  1E2S P;  1EQJ A;  2G9Y A;  1KHJ A;  1O99 A;  3IGZ B;  3MK2 A;  1KHL A;  1N2K A;  1P49 A;  1ANI A;  3SZY A;  3M8Y A;  2QZU A;  1ELZ A;  1EJJ A;  3OT9 A;  3UO0 A;  1K7H A;  2GA3 A;  1N2L A;  3UNY A;  1AJC A;  1ZEF A;  2IFY A;  3MK0 A;  1KH9 A;  3BDG A;  1HDH A;  1EW2 A;  3DPC A;  1ALJ A;  1ED8 A;  1EI6 A;  2ANH A;  3UN3 A;  3BDF A;  3ED4 A;  1E33 P;  1EW9 A;  1KHK A;  3SZZ A;  3NVL A;  1ZED A;  1AJA A;  1KH5 A;  1FSU A;  3CMR A;  3MK1 A;  3TX0 A;  1URA A;  1ELX A;  3M8Z A;  1ANJ A;  1HQA A;  1ED9 A;  4FDJ A;  3BDH A;  4FDI A;  1SHN A; 
#chains in the KnotProt database with same CATH topology
 1KH7 A;  2GLQ A;  3DYC A;  3IGY B;  3T01 A;  1KHN A;  3T00 A;  1SHQ A;  3M8W A;  1AJD A;  1AJB A;  1KH4 A;  1Y7A A;  1AUK A;  1ALK A;  3M7V A;  1B8J A;  1ZEB A;  3BDG B;  3T02 A;  1EW8 A;  1Y6V A;  3UN2 A;  1ELY A;  1E3C P;  3UN5 A;  1URB A;  3TWZ A;  1E1Z P;  1O98 A;  1HJK A;  1ALI A;  1E2S P;  1EQJ A;  2G9Y A;  1KHJ A;  1O99 A;  3IGZ B;  3MK2 A;  1KHL A;  1N2K A;  1P49 A;  1ANI A;  3SZY A;  3M8Y A;  2QZU A;  1ELZ A;  1EJJ A;  3OT9 A;  3UO0 A;  1K7H A;  2GA3 A;  1N2L A;  3UNY A;  1AJC A;  1ZEF A;  2IFY A;  3MK0 A;  1KH9 A;  3BDG A;  1HDH A;  1EW2 A;  3DPC A;  1ALJ A;  1ED8 A;  1EI6 A;  2ANH A;  3UN3 A;  3BDF A;  3ED4 A;  1E33 P;  1EW9 A;  1KHK A;  3SZZ A;  3NVL A;  1ZED A;  1AJA A;  1KH5 A;  1FSU A;  3CMR A;  3MK1 A;  3TX0 A;  1URA A;  1ELX A;  3M8Z A;  1ANJ A;  1HQA A;  1ED9 A;  4FDJ A;  3BDH A;  4FDI A;  1SHN A; 
#chains in the KnotProt database with same CATH homology
 1KH7 A;  2GLQ A;  3DYC A;  3IGY B;  3T01 A;  1KHN A;  3T00 A;  1SHQ A;  3M8W A;  1AJD A;  1AJB A;  1KH4 A;  1Y7A A;  1AUK A;  1ALK A;  3M7V A;  1B8J A;  1ZEB A;  3BDG B;  3T02 A;  1EW8 A;  1Y6V A;  3UN2 A;  1ELY A;  1E3C P;  3UN5 A;  1URB A;  3TWZ A;  1E1Z P;  1O98 A;  1HJK A;  1ALI A;  1E2S P;  1EQJ A;  2G9Y A;  1KHJ A;  1O99 A;  3IGZ B;  3MK2 A;  1KHL A;  1N2K A;  1P49 A;  1ANI A;  3SZY A;  3M8Y A;  2QZU A;  1ELZ A;  1EJJ A;  3OT9 A;  3UO0 A;  1K7H A;  2GA3 A;  1N2L A;  3UNY A;  1AJC A;  1ZEF A;  2IFY A;  3MK0 A;  1KH9 A;  3BDG A;  1HDH A;  1EW2 A;  3DPC A;  1ALJ A;  1ED8 A;  1EI6 A;  2ANH A;  3UN3 A;  3BDF A;  3ED4 A;  1E33 P;  1EW9 A;  1KHK A;  3SZZ A;  3NVL A;  1ZED A;  1AJA A;  1KH5 A;  1FSU A;  3CMR A;  3MK1 A;  3TX0 A;  1URA A;  1ELX A;  3M8Z A;  1ANJ A;  1HQA A;  1ED9 A;  4FDJ A;  3BDH A;  4FDI A;  1SHN A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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