1FSUA

4-sulfatase (human)
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 164
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 8-259 252 1-7 288-492 260-287 7 205 slipknot
Chain Sequence
SRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQPL-TPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCS-----------------AFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 8-268 261 1-7 283-474 269-282 7 192 slipknot
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3.1 7-282 276 1-6 288-474 283-287 6 187 slipknot
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3.1 9-278 270 1-6, 288-474 7-8, 279-287 6 187 slipknot
sequence length 492
structure length 474
publication title Structure of a human lysosomal sulfatase.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords N-ACETYLGALACTOSAMINE-4-SULFATASE
source organism Homo sapiens
missing residues 50, 365-381
total genus Genus: 164
ec nomenclature ec 3.1.6.12: N-acetylgalactosamine-4-sulfatase.
pdb deposition date 1996-07-29
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.10 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 1fsuA02
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1fsuA01
3BDHA 3M8ZA 1ALIA 3M8WA 1ANIA 1AJBA 4FDJA 3DPCA 1ALKA 1EW2A 1ZEDA 1HQAA 1EW9A 1E33P 3UNYA 1HDHA 3T02A 1Y7AA 3T00A 1ZEFA 1ED9A 1SHNA 1EW8A 3TX0A 3UN3A 1ELZA 2GLQA 1KH5A 1KHLA 3UO0A 1Y6VA 3UN5A 3OT9A 3UN2A 1ZEBA 1N2KA 2G9YA 3MK1A 3TWZA 3BDFA 1E1ZP 3T01A 3ED4A 1B8JA 1KH9A 2QZUA 1KHJA 1ALJA 3M8YA 1KH4A 3CMRA 1E3CP 1O99A 3IGYB 1AUKA 3IGZB 1N2LA 2GA3A 2IFYA 3SZZA 1KHKA 3M7VA 1ELYA 3MK2A 1P49A 1KHNA 3BDGA 4FDIA 1KH7A 3NVLA 1E2SP 1URAA 1EJJA 1K7HA 3DYCA 1ELXA 1AJCA 1AJAA 2ANHA 3MK0A 1EQJA 1SHQA 1ED8A 1ANJA 1AJDA 1O98A 3BDGB 3SZYA 1HJKA 1EI6A 1FSUA 1URBA
chains in the KnotProt database with same CATH superfamily
3BDHA 3M8ZA 1ALIA 3M8WA 1ANIA 1AJBA 4FDJA 3DPCA 1ALKA 1EW2A 1ZEDA 1HQAA 1EW9A 1E33P 3UNYA 1HDHA 3T02A 1Y7AA 3T00A 1ZEFA 1ED9A 1SHNA 1EW8A 3TX0A 3UN3A 1ELZA 2GLQA 1KH5A 1KHLA 3UO0A 1Y6VA 3UN5A 3OT9A 3UN2A 1ZEBA 1N2KA 2G9YA 3MK1A 3TWZA 3BDFA 1E1ZP 3T01A 3ED4A 1B8JA 1KH9A 2QZUA 1KHJA 1ALJA 3M8YA 1KH4A 3CMRA 1E3CP 1O99A 3IGYB 1AUKA 3IGZB 1N2LA 2GA3A 2IFYA 3SZZA 1KHKA 3M7VA 1ELYA 3MK2A 1P49A 1KHNA 3BDGA 4FDIA 1KH7A 3NVLA 1E2SP 1URAA 1EJJA 1K7HA 3DYCA 1ELXA 1AJCA 1AJAA 2ANHA 3MK0A 1EQJA 1SHQA 1ED8A 1ANJA 1AJDA 1O98A 3BDGB 3SZYA 1HJKA 1EI6A 1FSUA 1URBA
chains in the KnotProt database with same CATH topology
3BDHA 3M8ZA 1ALIA 3M8WA 1ANIA 1AJBA 4FDJA 3DPCA 1ALKA 1EW2A 1ZEDA 1HQAA 1EW9A 1E33P 3UNYA 1HDHA 3T02A 1Y7AA 3T00A 1ZEFA 1ED9A 1SHNA 1EW8A 3TX0A 3UN3A 1ELZA 2GLQA 1KH5A 1KHLA 3UO0A 1Y6VA 3UN5A 3OT9A 3UN2A 1ZEBA 1N2KA 2G9YA 3MK1A 3TWZA 3BDFA 1E1ZP 3T01A 3ED4A 1B8JA 1KH9A 2QZUA 1KHJA 1ALJA 3M8YA 1KH4A 3CMRA 1E3CP 1O99A 3IGYB 1AUKA 3IGZB 1N2LA 2GA3A 2IFYA 3SZZA 1KHKA 3M7VA 1ELYA 3MK2A 1P49A 1KHNA 3BDGA 4FDIA 1KH7A 3NVLA 1E2SP 1URAA 1EJJA 1K7HA 3DYCA 1ELXA 1AJCA 1AJAA 2ANHA 3MK0A 1EQJA 1SHQA 1ED8A 1ANJA 1AJDA 1O98A 3BDGB 3SZYA 1HJKA 1EI6A 1FSUA 1URBA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 3BDH A;  3M8Z A;  1ALI A;  3M8W A;  1ANI A;  1AJB A;  4FDJ A;  3DPC A;  1ALK A;  1EW2 A;  1ZED A;  1HQA A;  1EW9 A;  1E33 P;  3UNY A;  1HDH A;  3T02 A;  1Y7A A;  3T00 A;  1ZEF A;  1ED9 A;  1SHN A;  1EW8 A;  3TX0 A;  3UN3 A;  1ELZ A;  2GLQ A;  1KH5 A;  1KHL A;  3UO0 A;  1Y6V A;  3UN5 A;  3OT9 A;  3UN2 A;  1ZEB A;  1N2K A;  2G9Y A;  3MK1 A;  3TWZ A;  3BDF A;  1E1Z P;  3T01 A;  3ED4 A;  1B8J A;  1KH9 A;  2QZU A;  1KHJ A;  1ALJ A;  3M8Y A;  1KH4 A;  3CMR A;  1E3C P;  1O99 A;  3IGY B;  1AUK A;  3IGZ B;  1N2L A;  2GA3 A;  2IFY A;  3SZZ A;  1KHK A;  3M7V A;  1ELY A;  3MK2 A;  1P49 A;  1KHN A;  3BDG A;  4FDI A;  1KH7 A;  3NVL A;  1E2S P;  1URA A;  1EJJ A;  1K7H A;  3DYC A;  1ELX A;  1AJC A;  1AJA A;  2ANH A;  3MK0 A;  1EQJ A;  1SHQ A;  1ED8 A;  1ANJ A;  1AJD A;  1O98 A;  3BDG B;  3SZY A;  1HJK A;  1EI6 A;  1FSU A;  1URB A; 
#chains in the KnotProt database with same CATH topology
 3BDH A;  3M8Z A;  1ALI A;  3M8W A;  1ANI A;  1AJB A;  4FDJ A;  3DPC A;  1ALK A;  1EW2 A;  1ZED A;  1HQA A;  1EW9 A;  1E33 P;  3UNY A;  1HDH A;  3T02 A;  1Y7A A;  3T00 A;  1ZEF A;  1ED9 A;  1SHN A;  1EW8 A;  3TX0 A;  3UN3 A;  1ELZ A;  2GLQ A;  1KH5 A;  1KHL A;  3UO0 A;  1Y6V A;  3UN5 A;  3OT9 A;  3UN2 A;  1ZEB A;  1N2K A;  2G9Y A;  3MK1 A;  3TWZ A;  3BDF A;  1E1Z P;  3T01 A;  3ED4 A;  1B8J A;  1KH9 A;  2QZU A;  1KHJ A;  1ALJ A;  3M8Y A;  1KH4 A;  3CMR A;  1E3C P;  1O99 A;  3IGY B;  1AUK A;  3IGZ B;  1N2L A;  2GA3 A;  2IFY A;  3SZZ A;  1KHK A;  3M7V A;  1ELY A;  3MK2 A;  1P49 A;  1KHN A;  3BDG A;  4FDI A;  1KH7 A;  3NVL A;  1E2S P;  1URA A;  1EJJ A;  1K7H A;  3DYC A;  1ELX A;  1AJC A;  1AJA A;  2ANH A;  3MK0 A;  1EQJ A;  1SHQ A;  1ED8 A;  1ANJ A;  1AJD A;  1O98 A;  3BDG B;  3SZY A;  1HJK A;  1EI6 A;  1FSU A;  1URB A; 
#chains in the KnotProt database with same CATH homology
 3BDH A;  3M8Z A;  1ALI A;  3M8W A;  1ANI A;  1AJB A;  4FDJ A;  3DPC A;  1ALK A;  1EW2 A;  1ZED A;  1HQA A;  1EW9 A;  1E33 P;  3UNY A;  1HDH A;  3T02 A;  1Y7A A;  3T00 A;  1ZEF A;  1ED9 A;  1SHN A;  1EW8 A;  3TX0 A;  3UN3 A;  1ELZ A;  2GLQ A;  1KH5 A;  1KHL A;  3UO0 A;  1Y6V A;  3UN5 A;  3OT9 A;  3UN2 A;  1ZEB A;  1N2K A;  2G9Y A;  3MK1 A;  3TWZ A;  3BDF A;  1E1Z P;  3T01 A;  3ED4 A;  1B8J A;  1KH9 A;  2QZU A;  1KHJ A;  1ALJ A;  3M8Y A;  1KH4 A;  3CMR A;  1E3C P;  1O99 A;  3IGY B;  1AUK A;  3IGZ B;  1N2L A;  2GA3 A;  2IFY A;  3SZZ A;  1KHK A;  3M7V A;  1ELY A;  3MK2 A;  1P49 A;  1KHN A;  3BDG A;  4FDI A;  1KH7 A;  3NVL A;  1E2S P;  1URA A;  1EJJ A;  1K7H A;  3DYC A;  1ELX A;  1AJC A;  1AJA A;  2ANH A;  3MK0 A;  1EQJ A;  1SHQ A;  1ED8 A;  1ANJ A;  1AJD A;  1O98 A;  3BDG B;  3SZY A;  1HJK A;  1EI6 A;  1FSU A;  1URB A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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