1FSUA

4-sulfatase (human)
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 164
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 8-259 252 1-7 288-492 260-287 7 205 slipknot
Chain Sequence
SRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQPL-TPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCS-----------------AFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 8-268 261 1-7 283-474 269-282 7 192 slipknot
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3.1 7-282 276 1-6 288-474 283-287 6 187 slipknot
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3.1 9-278 270 1-6, 288-474 7-8, 279-287 6 187 slipknot
sequence length 492
structure length 474
publication title Structure of a human lysosomal sulfatase.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords N-ACETYLGALACTOSAMINE-4-SULFATASE
source organism Homo sapiens
missing residues 50, 365-381
total genus Genus: 164
ec nomenclature ec 3.1.6.12: N-acetylgalactosamine-4-sulfatase.
pdb deposition date 1996-07-29
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.10 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 1fsuA02
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1fsuA01
1E1ZP 1HQAA 1AJAA 1ED8A 1ALIA 1ANIA 1EW8A 1ZEDA 1ELZA 2ANHA 1ELYA 1KHNA 1B8JA 3TX0A 3CMRA 1ELXA 3M8ZA 1SHNA 1ZEBA 3MK0A 3UN2A 2G9YA 2IFYA 1EW9A 1K7HA 3NVLA 1N2LA 4FDJA 1URAA 3ED4A 1SHQA 1AJDA 1EI6A 1URBA 3OT9A 1KH5A 1ALKA 3M8WA 1FSUA 1KHLA 2GA3A 1AUKA 1O98A 3T01A 3SZZA 3TWZA 1KH9A 1AJCA 3IGYB 1E3CP 1N2KA 1HDHA 1ZEFA 3BDHA 1P49A 1EW2A 1Y7AA 1EJJA 2GLQA 1KHKA 1E33P 3MK2A 3BDFA 1KH4A 3DPCA 3MK1A 3UNYA 3SZYA 3M7VA 3T02A 1EQJA 1KH7A 3M8YA 4FDIA 3UO0A 1ANJA 1KHJA 1Y6VA 3BDGB 2QZUA 3UN5A 1ED9A 1E2SP 3T00A 3IGZB 3UN3A 3DYCA 1HJKA 3BDGA 1ALJA 1AJBA 1O99A
chains in the KnotProt database with same CATH superfamily
1E1ZP 1HQAA 1AJAA 1ED8A 1ALIA 1ANIA 1EW8A 1ZEDA 1ELZA 2ANHA 1ELYA 1KHNA 1B8JA 3TX0A 3CMRA 1ELXA 3M8ZA 1SHNA 1ZEBA 3MK0A 3UN2A 2G9YA 2IFYA 1EW9A 1K7HA 3NVLA 1N2LA 4FDJA 1URAA 3ED4A 1SHQA 1AJDA 1EI6A 1URBA 3OT9A 1KH5A 1ALKA 3M8WA 1FSUA 1KHLA 2GA3A 1AUKA 1O98A 3T01A 3SZZA 3TWZA 1KH9A 1AJCA 3IGYB 1E3CP 1N2KA 1HDHA 1ZEFA 3BDHA 1P49A 1EW2A 1Y7AA 1EJJA 2GLQA 1KHKA 1E33P 3MK2A 3BDFA 1KH4A 3DPCA 3MK1A 3UNYA 3SZYA 3M7VA 3T02A 1EQJA 1KH7A 3M8YA 4FDIA 3UO0A 1ANJA 1KHJA 1Y6VA 3BDGB 2QZUA 3UN5A 1ED9A 1E2SP 3T00A 3IGZB 3UN3A 3DYCA 1HJKA 3BDGA 1ALJA 1AJBA 1O99A
chains in the KnotProt database with same CATH topology
1E1ZP 1HQAA 1AJAA 1ED8A 1ALIA 1ANIA 1EW8A 1ZEDA 1ELZA 2ANHA 1ELYA 1KHNA 1B8JA 3TX0A 3CMRA 1ELXA 3M8ZA 1SHNA 1ZEBA 3MK0A 3UN2A 2G9YA 2IFYA 1EW9A 1K7HA 3NVLA 1N2LA 4FDJA 1URAA 3ED4A 1SHQA 1AJDA 1EI6A 1URBA 3OT9A 1KH5A 1ALKA 3M8WA 1FSUA 1KHLA 2GA3A 1AUKA 1O98A 3T01A 3SZZA 3TWZA 1KH9A 1AJCA 3IGYB 1E3CP 1N2KA 1HDHA 1ZEFA 3BDHA 1P49A 1EW2A 1Y7AA 1EJJA 2GLQA 1KHKA 1E33P 3MK2A 3BDFA 1KH4A 3DPCA 3MK1A 3UNYA 3SZYA 3M7VA 3T02A 1EQJA 1KH7A 3M8YA 4FDIA 3UO0A 1ANJA 1KHJA 1Y6VA 3BDGB 2QZUA 3UN5A 1ED9A 1E2SP 3T00A 3IGZB 3UN3A 3DYCA 1HJKA 3BDGA 1ALJA 1AJBA 1O99A
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1E1Z P;  1HQA A;  1AJA A;  1ED8 A;  1ALI A;  1ANI A;  1EW8 A;  1ZED A;  1ELZ A;  2ANH A;  1ELY A;  1KHN A;  1B8J A;  3TX0 A;  3CMR A;  1ELX A;  3M8Z A;  1SHN A;  1ZEB A;  3MK0 A;  3UN2 A;  2G9Y A;  2IFY A;  1EW9 A;  1K7H A;  3NVL A;  1N2L A;  4FDJ A;  1URA A;  3ED4 A;  1SHQ A;  1AJD A;  1EI6 A;  1URB A;  3OT9 A;  1KH5 A;  1ALK A;  3M8W A;  1FSU A;  1KHL A;  2GA3 A;  1AUK A;  1O98 A;  3T01 A;  3SZZ A;  3TWZ A;  1KH9 A;  1AJC A;  3IGY B;  1E3C P;  1N2K A;  1HDH A;  1ZEF A;  3BDH A;  1P49 A;  1EW2 A;  1Y7A A;  1EJJ A;  2GLQ A;  1KHK A;  1E33 P;  3MK2 A;  3BDF A;  1KH4 A;  3DPC A;  3MK1 A;  3UNY A;  3SZY A;  3M7V A;  3T02 A;  1EQJ A;  1KH7 A;  3M8Y A;  4FDI A;  3UO0 A;  1ANJ A;  1KHJ A;  1Y6V A;  3BDG B;  2QZU A;  3UN5 A;  1ED9 A;  1E2S P;  3T00 A;  3IGZ B;  3UN3 A;  3DYC A;  1HJK A;  3BDG A;  1ALJ A;  1AJB A;  1O99 A; 
#chains in the KnotProt database with same CATH topology
 1E1Z P;  1HQA A;  1AJA A;  1ED8 A;  1ALI A;  1ANI A;  1EW8 A;  1ZED A;  1ELZ A;  2ANH A;  1ELY A;  1KHN A;  1B8J A;  3TX0 A;  3CMR A;  1ELX A;  3M8Z A;  1SHN A;  1ZEB A;  3MK0 A;  3UN2 A;  2G9Y A;  2IFY A;  1EW9 A;  1K7H A;  3NVL A;  1N2L A;  4FDJ A;  1URA A;  3ED4 A;  1SHQ A;  1AJD A;  1EI6 A;  1URB A;  3OT9 A;  1KH5 A;  1ALK A;  3M8W A;  1FSU A;  1KHL A;  2GA3 A;  1AUK A;  1O98 A;  3T01 A;  3SZZ A;  3TWZ A;  1KH9 A;  1AJC A;  3IGY B;  1E3C P;  1N2K A;  1HDH A;  1ZEF A;  3BDH A;  1P49 A;  1EW2 A;  1Y7A A;  1EJJ A;  2GLQ A;  1KHK A;  1E33 P;  3MK2 A;  3BDF A;  1KH4 A;  3DPC A;  3MK1 A;  3UNY A;  3SZY A;  3M7V A;  3T02 A;  1EQJ A;  1KH7 A;  3M8Y A;  4FDI A;  3UO0 A;  1ANJ A;  1KHJ A;  1Y6V A;  3BDG B;  2QZU A;  3UN5 A;  1ED9 A;  1E2S P;  3T00 A;  3IGZ B;  3UN3 A;  3DYC A;  1HJK A;  3BDG A;  1ALJ A;  1AJB A;  1O99 A; 
#chains in the KnotProt database with same CATH homology
 1E1Z P;  1HQA A;  1AJA A;  1ED8 A;  1ALI A;  1ANI A;  1EW8 A;  1ZED A;  1ELZ A;  2ANH A;  1ELY A;  1KHN A;  1B8J A;  3TX0 A;  3CMR A;  1ELX A;  3M8Z A;  1SHN A;  1ZEB A;  3MK0 A;  3UN2 A;  2G9Y A;  2IFY A;  1EW9 A;  1K7H A;  3NVL A;  1N2L A;  4FDJ A;  1URA A;  3ED4 A;  1SHQ A;  1AJD A;  1EI6 A;  1URB A;  3OT9 A;  1KH5 A;  1ALK A;  3M8W A;  1FSU A;  1KHL A;  2GA3 A;  1AUK A;  1O98 A;  3T01 A;  3SZZ A;  3TWZ A;  1KH9 A;  1AJC A;  3IGY B;  1E3C P;  1N2K A;  1HDH A;  1ZEF A;  3BDH A;  1P49 A;  1EW2 A;  1Y7A A;  1EJJ A;  2GLQ A;  1KHK A;  1E33 P;  3MK2 A;  3BDF A;  1KH4 A;  3DPC A;  3MK1 A;  3UNY A;  3SZY A;  3M7V A;  3T02 A;  1EQJ A;  1KH7 A;  3M8Y A;  4FDI A;  3UO0 A;  1ANJ A;  1KHJ A;  1Y6V A;  3BDG B;  2QZU A;  3UN5 A;  1ED9 A;  1E2S P;  3T00 A;  3IGZ B;  3UN3 A;  3DYC A;  1HJK A;  3BDG A;  1ALJ A;  1AJB A;  1O99 A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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