1KH7A

E. coli alkaline phosphatase mutant (d153gd330n)
Genus: 151
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 41-363 323 1-40 414-444 364-413 40 31 slipknot
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSKTSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 39-362 324 1-38 370-444 363-369 38 75 slipknot
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3.1 44-365 322 1-43 383-444 366-382 43 62 slipknot
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3.1 44-382 339 1-43 407-444 383-406 43 38 slipknot
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3.1 44-406 363 1-43 412-444 407-411 43 33 slipknot
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2.1 39-411 373 1-38 416-444 412-415 38 29 slipknot
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2.1 40-411 372 1-38, 414-444 39-39, 412-413 38 31 slipknot
sequence length 444
structure length 444
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords alkaline phosphatase
source organism Escherichia coli
total genus Genus: 151
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29
KnotProt deposition date 2014-07-31
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh7A00
1ANJA 1SHQA 2GLQA 1AUKA 3IGZB 3IGYB 1AJAA 3MK2A 4FDIA 2IFYA 3TWZA 1O99A 1KHJA 1ZEFA 1B8JA 1ZEDA 1FSUA 4FDJA 1HDHA 3UN2A 1ED9A 3BDFA 1ALIA 1ZEBA 3MK0A 3SZZA 1KH5A 3OT9A 1E33P 1P49A 3M8ZA 1O98A 3TX0A 1N2KA 3T00A 3UNYA 3DYCA 1E2SP 1EQJA 3NVLA 1KHNA 1ELZA 1URBA 1E3CP 1E1ZP 3MK1A 1ELXA 1HJKA 3M7VA 3UN5A 1EW9A 1AJDA 1ALKA 2ANHA 3BDGB 3T02A 3BDHA 3UN3A 1HQAA 1EJJA 1EI6A 1N2LA 1EW8A 1KH9A 1KHLA 3ED4A 3UO0A 3M8YA 1ANIA 1KHKA 3CMRA 1Y7AA 1EW2A 3SZYA 2G9YA 1AJBA 1SHNA 3T01A 1KH7A 2GA3A 1URAA 1ED8A 1ELYA 3BDGA 1Y6VA 1KH4A 1K7HA 2QZUA 3DPCA 3M8WA 1AJCA 1ALJA
chains in the KnotProt database with same CATH superfamily
1ANJA 1SHQA 2GLQA 1AUKA 3IGZB 3IGYB 1AJAA 3MK2A 4FDIA 2IFYA 3TWZA 1O99A 1KHJA 1ZEFA 1B8JA 1ZEDA 1FSUA 4FDJA 1HDHA 3UN2A 1ED9A 3BDFA 1ALIA 1ZEBA 3MK0A 3SZZA 1KH5A 3OT9A 1E33P 1P49A 3M8ZA 1O98A 3TX0A 1N2KA 3T00A 3UNYA 3DYCA 1E2SP 1EQJA 3NVLA 1KHNA 1ELZA 1URBA 1E3CP 1E1ZP 3MK1A 1ELXA 1HJKA 3M7VA 3UN5A 1EW9A 1AJDA 1ALKA 2ANHA 3BDGB 3T02A 3BDHA 3UN3A 1HQAA 1EJJA 1EI6A 1N2LA 1EW8A 1KH9A 1KHLA 3ED4A 3UO0A 3M8YA 1ANIA 1KHKA 3CMRA 1Y7AA 1EW2A 3SZYA 2G9YA 1AJBA 1SHNA 3T01A 1KH7A 2GA3A 1URAA 1ED8A 1ELYA 3BDGA 1Y6VA 1KH4A 1K7HA 2QZUA 3DPCA 3M8WA 1AJCA 1ALJA
chains in the KnotProt database with same CATH topology
1ANJA 1SHQA 2GLQA 1AUKA 3IGZB 3IGYB 1AJAA 3MK2A 4FDIA 2IFYA 3TWZA 1O99A 1KHJA 1ZEFA 1B8JA 1ZEDA 1FSUA 4FDJA 1HDHA 3UN2A 1ED9A 3BDFA 1ALIA 1ZEBA 3MK0A 3SZZA 1KH5A 3OT9A 1E33P 1P49A 3M8ZA 1O98A 3TX0A 1N2KA 3T00A 3UNYA 3DYCA 1E2SP 1EQJA 3NVLA 1KHNA 1ELZA 1URBA 1E3CP 1E1ZP 3MK1A 1ELXA 1HJKA 3M7VA 3UN5A 1EW9A 1AJDA 1ALKA 2ANHA 3BDGB 3T02A 3BDHA 3UN3A 1HQAA 1EJJA 1EI6A 1N2LA 1EW8A 1KH9A 1KHLA 3ED4A 3UO0A 3M8YA 1ANIA 1KHKA 3CMRA 1Y7AA 1EW2A 3SZYA 2G9YA 1AJBA 1SHNA 3T01A 1KH7A 2GA3A 1URAA 1ED8A 1ELYA 3BDGA 1Y6VA 1KH4A 1K7HA 2QZUA 3DPCA 3M8WA 1AJCA 1ALJA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1ANJ A;  1SHQ A;  2GLQ A;  1AUK A;  3IGZ B;  3IGY B;  1AJA A;  3MK2 A;  4FDI A;  2IFY A;  3TWZ A;  1O99 A;  1KHJ A;  1ZEF A;  1B8J A;  1ZED A;  1FSU A;  4FDJ A;  1HDH A;  3UN2 A;  1ED9 A;  3BDF A;  1ALI A;  1ZEB A;  3MK0 A;  3SZZ A;  1KH5 A;  3OT9 A;  1E33 P;  1P49 A;  3M8Z A;  1O98 A;  3TX0 A;  1N2K A;  3T00 A;  3UNY A;  3DYC A;  1E2S P;  1EQJ A;  3NVL A;  1KHN A;  1ELZ A;  1URB A;  1E3C P;  1E1Z P;  3MK1 A;  1ELX A;  1HJK A;  3M7V A;  3UN5 A;  1EW9 A;  1AJD A;  1ALK A;  2ANH A;  3BDG B;  3T02 A;  3BDH A;  3UN3 A;  1HQA A;  1EJJ A;  1EI6 A;  1N2L A;  1EW8 A;  1KH9 A;  1KHL A;  3ED4 A;  3UO0 A;  3M8Y A;  1ANI A;  1KHK A;  3CMR A;  1Y7A A;  1EW2 A;  3SZY A;  2G9Y A;  1AJB A;  1SHN A;  3T01 A;  1KH7 A;  2GA3 A;  1URA A;  1ED8 A;  1ELY A;  3BDG A;  1Y6V A;  1KH4 A;  1K7H A;  2QZU A;  3DPC A;  3M8W A;  1AJC A;  1ALJ A; 
#chains in the KnotProt database with same CATH topology
 1ANJ A;  1SHQ A;  2GLQ A;  1AUK A;  3IGZ B;  3IGY B;  1AJA A;  3MK2 A;  4FDI A;  2IFY A;  3TWZ A;  1O99 A;  1KHJ A;  1ZEF A;  1B8J A;  1ZED A;  1FSU A;  4FDJ A;  1HDH A;  3UN2 A;  1ED9 A;  3BDF A;  1ALI A;  1ZEB A;  3MK0 A;  3SZZ A;  1KH5 A;  3OT9 A;  1E33 P;  1P49 A;  3M8Z A;  1O98 A;  3TX0 A;  1N2K A;  3T00 A;  3UNY A;  3DYC A;  1E2S P;  1EQJ A;  3NVL A;  1KHN A;  1ELZ A;  1URB A;  1E3C P;  1E1Z P;  3MK1 A;  1ELX A;  1HJK A;  3M7V A;  3UN5 A;  1EW9 A;  1AJD A;  1ALK A;  2ANH A;  3BDG B;  3T02 A;  3BDH A;  3UN3 A;  1HQA A;  1EJJ A;  1EI6 A;  1N2L A;  1EW8 A;  1KH9 A;  1KHL A;  3ED4 A;  3UO0 A;  3M8Y A;  1ANI A;  1KHK A;  3CMR A;  1Y7A A;  1EW2 A;  3SZY A;  2G9Y A;  1AJB A;  1SHN A;  3T01 A;  1KH7 A;  2GA3 A;  1URA A;  1ED8 A;  1ELY A;  3BDG A;  1Y6V A;  1KH4 A;  1K7H A;  2QZU A;  3DPC A;  3M8W A;  1AJC A;  1ALJ A; 
#chains in the KnotProt database with same CATH homology
 1ANJ A;  1SHQ A;  2GLQ A;  1AUK A;  3IGZ B;  3IGY B;  1AJA A;  3MK2 A;  4FDI A;  2IFY A;  3TWZ A;  1O99 A;  1KHJ A;  1ZEF A;  1B8J A;  1ZED A;  1FSU A;  4FDJ A;  1HDH A;  3UN2 A;  1ED9 A;  3BDF A;  1ALI A;  1ZEB A;  3MK0 A;  3SZZ A;  1KH5 A;  3OT9 A;  1E33 P;  1P49 A;  3M8Z A;  1O98 A;  3TX0 A;  1N2K A;  3T00 A;  3UNY A;  3DYC A;  1E2S P;  1EQJ A;  3NVL A;  1KHN A;  1ELZ A;  1URB A;  1E3C P;  1E1Z P;  3MK1 A;  1ELX A;  1HJK A;  3M7V A;  3UN5 A;  1EW9 A;  1AJD A;  1ALK A;  2ANH A;  3BDG B;  3T02 A;  3BDH A;  3UN3 A;  1HQA A;  1EJJ A;  1EI6 A;  1N2L A;  1EW8 A;  1KH9 A;  1KHL A;  3ED4 A;  3UO0 A;  3M8Y A;  1ANI A;  1KHK A;  3CMR A;  1Y7A A;  1EW2 A;  3SZY A;  2G9Y A;  1AJB A;  1SHN A;  3T01 A;  1KH7 A;  2GA3 A;  1URA A;  1ED8 A;  1ELY A;  3BDG A;  1Y6V A;  1KH4 A;  1K7H A;  2QZU A;  3DPC A;  3M8W A;  1AJC A;  1ALJ A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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