1KH7A

E. coli alkaline phosphatase mutant (d153gd330n)
Genus: 151
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 41-363 323 1-40 414-444 364-413 40 31 slipknot
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSKTSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 39-362 324 1-38 370-444 363-369 38 75 slipknot
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3.1 44-365 322 1-43 383-444 366-382 43 62 slipknot
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3.1 44-382 339 1-43 407-444 383-406 43 38 slipknot
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3.1 44-406 363 1-43 412-444 407-411 43 33 slipknot
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2.1 39-411 373 1-38 416-444 412-415 38 29 slipknot
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2.1 40-411 372 1-38, 414-444 39-39, 412-413 38 31 slipknot
sequence length 444
structure length 444
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords alkaline phosphatase
source organism Escherichia coli
total genus Genus: 151
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29
KnotProt deposition date 2014-07-31
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh7A00
1P49A 1KH4A 1SHQA 3OT9A 3T01A 3DPCA 2IFYA 3T02A 1EW8A 1AJAA 1ALJA 1FSUA 1O99A 1ZEDA 3IGZB 2QZUA 2G9YA 1KHKA 1ELXA 4FDIA 1AJCA 1ED9A 1KH5A 3ED4A 1AUKA 1AJDA 1HJKA 3BDGB 1EW2A 1EQJA 1AJBA 1O98A 1URAA 1KH9A 3TX0A 1ALKA 1KHJA 2GA3A 3NVLA 3T00A 3M7VA 1KHLA 3TWZA 1ZEBA 1EI6A 4FDJA 3SZYA 1EJJA 3DYCA 3UN3A 1KH7A 3MK1A 3M8YA 1Y7AA 1ANJA 3MK2A 1ELZA 2GLQA 1N2LA 1KHNA 1SHNA 1N2KA 1E2SP 3BDGA 1K7HA 2ANHA 1HQAA 3M8WA 3UO0A 1ELYA 3BDFA 1ZEFA 1EW9A 3MK0A 1Y6VA 3UN2A 1E3CP 3M8ZA 3SZZA 3UN5A 1B8JA 3IGYB 1ED8A 1E1ZP 1ALIA 1E33P 1URBA 1HDHA 1ANIA 3BDHA 3CMRA 3UNYA
chains in the KnotProt database with same CATH superfamily
1P49A 1KH4A 1SHQA 3OT9A 3T01A 3DPCA 2IFYA 3T02A 1EW8A 1AJAA 1ALJA 1FSUA 1O99A 1ZEDA 3IGZB 2QZUA 2G9YA 1KHKA 1ELXA 4FDIA 1AJCA 1ED9A 1KH5A 3ED4A 1AUKA 1AJDA 1HJKA 3BDGB 1EW2A 1EQJA 1AJBA 1O98A 1URAA 1KH9A 3TX0A 1ALKA 1KHJA 2GA3A 3NVLA 3T00A 3M7VA 1KHLA 3TWZA 1ZEBA 1EI6A 4FDJA 3SZYA 1EJJA 3DYCA 3UN3A 1KH7A 3MK1A 3M8YA 1Y7AA 1ANJA 3MK2A 1ELZA 2GLQA 1N2LA 1KHNA 1SHNA 1N2KA 1E2SP 3BDGA 1K7HA 2ANHA 1HQAA 3M8WA 3UO0A 1ELYA 3BDFA 1ZEFA 1EW9A 3MK0A 1Y6VA 3UN2A 1E3CP 3M8ZA 3SZZA 3UN5A 1B8JA 3IGYB 1ED8A 1E1ZP 1ALIA 1E33P 1URBA 1HDHA 1ANIA 3BDHA 3CMRA 3UNYA
chains in the KnotProt database with same CATH topology
1P49A 1KH4A 1SHQA 3OT9A 3T01A 3DPCA 2IFYA 3T02A 1EW8A 1AJAA 1ALJA 1FSUA 1O99A 1ZEDA 3IGZB 2QZUA 2G9YA 1KHKA 1ELXA 4FDIA 1AJCA 1ED9A 1KH5A 3ED4A 1AUKA 1AJDA 1HJKA 3BDGB 1EW2A 1EQJA 1AJBA 1O98A 1URAA 1KH9A 3TX0A 1ALKA 1KHJA 2GA3A 3NVLA 3T00A 3M7VA 1KHLA 3TWZA 1ZEBA 1EI6A 4FDJA 3SZYA 1EJJA 3DYCA 3UN3A 1KH7A 3MK1A 3M8YA 1Y7AA 1ANJA 3MK2A 1ELZA 2GLQA 1N2LA 1KHNA 1SHNA 1N2KA 1E2SP 3BDGA 1K7HA 2ANHA 1HQAA 3M8WA 3UO0A 1ELYA 3BDFA 1ZEFA 1EW9A 3MK0A 1Y6VA 3UN2A 1E3CP 3M8ZA 3SZZA 3UN5A 1B8JA 3IGYB 1ED8A 1E1ZP 1ALIA 1E33P 1URBA 1HDHA 1ANIA 3BDHA 3CMRA 3UNYA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1P49 A;  1KH4 A;  1SHQ A;  3OT9 A;  3T01 A;  3DPC A;  2IFY A;  3T02 A;  1EW8 A;  1AJA A;  1ALJ A;  1FSU A;  1O99 A;  1ZED A;  3IGZ B;  2QZU A;  2G9Y A;  1KHK A;  1ELX A;  4FDI A;  1AJC A;  1ED9 A;  1KH5 A;  3ED4 A;  1AUK A;  1AJD A;  1HJK A;  3BDG B;  1EW2 A;  1EQJ A;  1AJB A;  1O98 A;  1URA A;  1KH9 A;  3TX0 A;  1ALK A;  1KHJ A;  2GA3 A;  3NVL A;  3T00 A;  3M7V A;  1KHL A;  3TWZ A;  1ZEB A;  1EI6 A;  4FDJ A;  3SZY A;  1EJJ A;  3DYC A;  3UN3 A;  1KH7 A;  3MK1 A;  3M8Y A;  1Y7A A;  1ANJ A;  3MK2 A;  1ELZ A;  2GLQ A;  1N2L A;  1KHN A;  1SHN A;  1N2K A;  1E2S P;  3BDG A;  1K7H A;  2ANH A;  1HQA A;  3M8W A;  3UO0 A;  1ELY A;  3BDF A;  1ZEF A;  1EW9 A;  3MK0 A;  1Y6V A;  3UN2 A;  1E3C P;  3M8Z A;  3SZZ A;  3UN5 A;  1B8J A;  3IGY B;  1ED8 A;  1E1Z P;  1ALI A;  1E33 P;  1URB A;  1HDH A;  1ANI A;  3BDH A;  3CMR A;  3UNY A; 
#chains in the KnotProt database with same CATH topology
 1P49 A;  1KH4 A;  1SHQ A;  3OT9 A;  3T01 A;  3DPC A;  2IFY A;  3T02 A;  1EW8 A;  1AJA A;  1ALJ A;  1FSU A;  1O99 A;  1ZED A;  3IGZ B;  2QZU A;  2G9Y A;  1KHK A;  1ELX A;  4FDI A;  1AJC A;  1ED9 A;  1KH5 A;  3ED4 A;  1AUK A;  1AJD A;  1HJK A;  3BDG B;  1EW2 A;  1EQJ A;  1AJB A;  1O98 A;  1URA A;  1KH9 A;  3TX0 A;  1ALK A;  1KHJ A;  2GA3 A;  3NVL A;  3T00 A;  3M7V A;  1KHL A;  3TWZ A;  1ZEB A;  1EI6 A;  4FDJ A;  3SZY A;  1EJJ A;  3DYC A;  3UN3 A;  1KH7 A;  3MK1 A;  3M8Y A;  1Y7A A;  1ANJ A;  3MK2 A;  1ELZ A;  2GLQ A;  1N2L A;  1KHN A;  1SHN A;  1N2K A;  1E2S P;  3BDG A;  1K7H A;  2ANH A;  1HQA A;  3M8W A;  3UO0 A;  1ELY A;  3BDF A;  1ZEF A;  1EW9 A;  3MK0 A;  1Y6V A;  3UN2 A;  1E3C P;  3M8Z A;  3SZZ A;  3UN5 A;  1B8J A;  3IGY B;  1ED8 A;  1E1Z P;  1ALI A;  1E33 P;  1URB A;  1HDH A;  1ANI A;  3BDH A;  3CMR A;  3UNY A; 
#chains in the KnotProt database with same CATH homology
 1P49 A;  1KH4 A;  1SHQ A;  3OT9 A;  3T01 A;  3DPC A;  2IFY A;  3T02 A;  1EW8 A;  1AJA A;  1ALJ A;  1FSU A;  1O99 A;  1ZED A;  3IGZ B;  2QZU A;  2G9Y A;  1KHK A;  1ELX A;  4FDI A;  1AJC A;  1ED9 A;  1KH5 A;  3ED4 A;  1AUK A;  1AJD A;  1HJK A;  3BDG B;  1EW2 A;  1EQJ A;  1AJB A;  1O98 A;  1URA A;  1KH9 A;  3TX0 A;  1ALK A;  1KHJ A;  2GA3 A;  3NVL A;  3T00 A;  3M7V A;  1KHL A;  3TWZ A;  1ZEB A;  1EI6 A;  4FDJ A;  3SZY A;  1EJJ A;  3DYC A;  3UN3 A;  1KH7 A;  3MK1 A;  3M8Y A;  1Y7A A;  1ANJ A;  3MK2 A;  1ELZ A;  2GLQ A;  1N2L A;  1KHN A;  1SHN A;  1N2K A;  1E2S P;  3BDG A;  1K7H A;  2ANH A;  1HQA A;  3M8W A;  3UO0 A;  1ELY A;  3BDF A;  1ZEF A;  1EW9 A;  3MK0 A;  1Y6V A;  3UN2 A;  1E3C P;  3M8Z A;  3SZZ A;  3UN5 A;  1B8J A;  3IGY B;  1ED8 A;  1E1Z P;  1ALI A;  1E33 P;  1URB A;  1HDH A;  1ANI A;  3BDH A;  3CMR A;  3UNY A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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