1P49A

Structure of human placental estrone/dhea sulfatase
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 169
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 10-320 311 1-9 357-553 321-356 9 197 slipknot
Chain Sequence
AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPL-TPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVC----FATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDRE
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 6-317 312 1-5 322-548 318-321 5 227 slipknot
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3.1 10-320 311 1-9 342-548 321-341 9 207 slipknot
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3.1 7-353 347 1-6 357-548 354-356 6 192 slipknot
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2.1 9-345 337 1-5, 354-548 6-8, 346-353 5 195 slipknot
sequence length 553
structure length 548
publication title Structure of Human Estrone Sulfatase Suggests Functional Roles of Membrane Association
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords STERYL-SULFATASE
missing residues 53, 455-458
total genus Genus: 169
ec nomenclature ec 3.1.6.2: Steryl-sulfatase.
pdb deposition date 2003-04-21
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.287.550 Mainly Alpha Orthogonal Bundle Helix Hairpins Helix hairpin bin 1p49A02
3.30.1120.10 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 1p49A03
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1p49A01
1ANJA 1SHQA 2GLQA 1AUKA 3IGZB 3IGYB 1AJAA 3MK2A 4FDIA 2IFYA 3TWZA 1O99A 1KHJA 1ZEFA 1B8JA 1ZEDA 1FSUA 4FDJA 1HDHA 3UN2A 1ED9A 3BDFA 1ALIA 1ZEBA 3MK0A 3SZZA 1KH5A 3OT9A 1E33P 1P49A 3M8ZA 1O98A 3TX0A 1N2KA 3T00A 3UNYA 3DYCA 1E2SP 1EQJA 3NVLA 1KHNA 1ELZA 1URBA 1E3CP 1E1ZP 3MK1A 1ELXA 1HJKA 3M7VA 3UN5A 1EW9A 1AJDA 1ALKA 2ANHA 3BDGB 3T02A 3BDHA 3UN3A 1HQAA 1EJJA 1EI6A 1N2LA 1EW8A 3ED4A 1KH9A 1KHLA 3UO0A 3M8YA 1ANIA 1KHKA 3CMRA 1Y7AA 1EW2A 3SZYA 2G9YA 1AJBA 1SHNA 3T01A 1KH7A 2GA3A 1URAA 1ED8A 1ELYA 3BDGA 1Y6VA 1KH4A 1K7HA 2QZUA 3DPCA 3M8WA 1AJCA 1ALJA
chains in the KnotProt database with same CATH superfamily
1ANJA 1SHQA 2GLQA 1AUKA 3IGZB 3IGYB 1AJAA 3MK2A 4FDIA 2IFYA 3TWZA 1O99A 1KHJA 1ZEFA 1B8JA 1ZEDA 1FSUA 4FDJA 1HDHA 3UN2A 1ED9A 3BDFA 1ALIA 1ZEBA 3MK0A 3SZZA 1KH5A 3OT9A 1E33P 1P49A 3M8ZA 1O98A 3TX0A 1N2KA 3T00A 3UNYA 3DYCA 1E2SP 1EQJA 3NVLA 1KHNA 1ELZA 1URBA 1E3CP 1E1ZP 3MK1A 1ELXA 1HJKA 3M7VA 3UN5A 1EW9A 1AJDA 1ALKA 2ANHA 3BDGB 3T02A 3BDHA 3UN3A 1HQAA 1EJJA 1EI6A 1N2LA 1EW8A 3ED4A 1KH9A 1KHLA 3UO0A 3M8YA 2B5UA 1ANIA 1KHKA 3CMRA 1JCHA 1Y7AA 1EW2A 3SZYA 2G9YA 1AJBA 1SHNA 3T01A 1KH7A 2GA3A 1URAA 1ED8A 1ELYA 3BDGA 1Y6VA 1KH4A 1K7HA 2QZUA 3DPCA 3M8WA 1AJCA 1ALJA
chains in the KnotProt database with same CATH topology
1ANJA 1SHQA 2GLQA 1AUKA 3IGZB 3IGYB 1AJAA 3MK2A 4FDIA 2IFYA 3TWZA 1O99A 1KHJA 1ZEFA 1B8JA 1ZEDA 1FSUA 4FDJA 1HDHA 3UN2A 1ED9A 3BDFA 1ALIA 1ZEBA 3MK0A 3SZZA 1KH5A 3OT9A 1E33P 1P49A 3M8ZA 1O98A 3TX0A 1N2KA 3T00A 3UNYA 3DYCA 1E2SP 1EQJA 3NVLA 1KHNA 1ELZA 1URBA 1E3CP 1E1ZP 3MK1A 1ELXA 1HJKA 3M7VA 3UN5A 1EW9A 1AJDA 1ALKA 2ANHA 3BDGB 3T02A 3BDHA 3UN3A 1HQAA 1EJJA 1EI6A 1N2LA 1EW8A 3ED4A 1KH9A 1KHLA 3UO0A 3M8YA 1ANIA 1KHKA 3CMRA 1Y7AA 1EW2A 3SZYA 2G9YA 1AJBA 1SHNA 3T01A 1KH7A 2GA3A 1URAA 1ED8A 1ELYA 3BDGA 1Y6VA 1KH4A 1K7HA 2QZUA 3DPCA 3M8WA 1AJCA 1ALJA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1ANJ A;  1SHQ A;  2GLQ A;  1AUK A;  3IGZ B;  3IGY B;  1AJA A;  3MK2 A;  4FDI A;  2IFY A;  3TWZ A;  1O99 A;  1KHJ A;  1ZEF A;  1B8J A;  1ZED A;  1FSU A;  4FDJ A;  1HDH A;  3UN2 A;  1ED9 A;  3BDF A;  1ALI A;  1ZEB A;  3MK0 A;  3SZZ A;  1KH5 A;  3OT9 A;  1E33 P;  1P49 A;  3M8Z A;  1O98 A;  3TX0 A;  1N2K A;  3T00 A;  3UNY A;  3DYC A;  1E2S P;  1EQJ A;  3NVL A;  1KHN A;  1ELZ A;  1URB A;  1E3C P;  1E1Z P;  3MK1 A;  1ELX A;  1HJK A;  3M7V A;  3UN5 A;  1EW9 A;  1AJD A;  1ALK A;  2ANH A;  3BDG B;  3T02 A;  3BDH A;  3UN3 A;  1HQA A;  1EJJ A;  1EI6 A;  1N2L A;  1EW8 A;  3ED4 A;  1KH9 A;  1KHL A;  3UO0 A;  3M8Y A;  1ANI A;  1KHK A;  3CMR A;  1Y7A A;  1EW2 A;  3SZY A;  2G9Y A;  1AJB A;  1SHN A;  3T01 A;  1KH7 A;  2GA3 A;  1URA A;  1ED8 A;  1ELY A;  3BDG A;  1Y6V A;  1KH4 A;  1K7H A;  2QZU A;  3DPC A;  3M8W A;  1AJC A;  1ALJ A; 
#chains in the KnotProt database with same CATH topology
 1ANJ A;  1SHQ A;  2GLQ A;  1AUK A;  3IGZ B;  3IGY B;  1AJA A;  3MK2 A;  4FDI A;  2IFY A;  3TWZ A;  1O99 A;  1KHJ A;  1ZEF A;  1B8J A;  1ZED A;  1FSU A;  4FDJ A;  1HDH A;  3UN2 A;  1ED9 A;  3BDF A;  1ALI A;  1ZEB A;  3MK0 A;  3SZZ A;  1KH5 A;  3OT9 A;  1E33 P;  1P49 A;  3M8Z A;  1O98 A;  3TX0 A;  1N2K A;  3T00 A;  3UNY A;  3DYC A;  1E2S P;  1EQJ A;  3NVL A;  1KHN A;  1ELZ A;  1URB A;  1E3C P;  1E1Z P;  3MK1 A;  1ELX A;  1HJK A;  3M7V A;  3UN5 A;  1EW9 A;  1AJD A;  1ALK A;  2ANH A;  3BDG B;  3T02 A;  3BDH A;  3UN3 A;  1HQA A;  1EJJ A;  1EI6 A;  1N2L A;  1EW8 A;  3ED4 A;  1KH9 A;  1KHL A;  3UO0 A;  3M8Y A;  2B5U A;  1ANI A;  1KHK A;  3CMR A;  1JCH A;  1Y7A A;  1EW2 A;  3SZY A;  2G9Y A;  1AJB A;  1SHN A;  3T01 A;  1KH7 A;  2GA3 A;  1URA A;  1ED8 A;  1ELY A;  3BDG A;  1Y6V A;  1KH4 A;  1K7H A;  2QZU A;  3DPC A;  3M8W A;  1AJC A;  1ALJ A; 
#chains in the KnotProt database with same CATH homology
 1ANJ A;  1SHQ A;  2GLQ A;  1AUK A;  3IGZ B;  3IGY B;  1AJA A;  3MK2 A;  4FDI A;  2IFY A;  3TWZ A;  1O99 A;  1KHJ A;  1ZEF A;  1B8J A;  1ZED A;  1FSU A;  4FDJ A;  1HDH A;  3UN2 A;  1ED9 A;  3BDF A;  1ALI A;  1ZEB A;  3MK0 A;  3SZZ A;  1KH5 A;  3OT9 A;  1E33 P;  1P49 A;  3M8Z A;  1O98 A;  3TX0 A;  1N2K A;  3T00 A;  3UNY A;  3DYC A;  1E2S P;  1EQJ A;  3NVL A;  1KHN A;  1ELZ A;  1URB A;  1E3C P;  1E1Z P;  3MK1 A;  1ELX A;  1HJK A;  3M7V A;  3UN5 A;  1EW9 A;  1AJD A;  1ALK A;  2ANH A;  3BDG B;  3T02 A;  3BDH A;  3UN3 A;  1HQA A;  1EJJ A;  1EI6 A;  1N2L A;  1EW8 A;  3ED4 A;  1KH9 A;  1KHL A;  3UO0 A;  3M8Y A;  1ANI A;  1KHK A;  3CMR A;  1Y7A A;  1EW2 A;  3SZY A;  2G9Y A;  1AJB A;  1SHN A;  3T01 A;  1KH7 A;  2GA3 A;  1URA A;  1ED8 A;  1ELY A;  3BDG A;  1Y6V A;  1KH4 A;  1K7H A;  2QZU A;  3DPC A;  3M8W A;  1AJC A;  1ALJ A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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