1P49A

Structure of human placental estrone/dhea sulfatase
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 169
Slipknot S +31

  Help Knotting data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 10-320 311 1-9 357-553 321-356 9 197 slipknot
Chain Sequence
AASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPL-TPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVC----FATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDRE
Whole chain analysis

  Help Knotoid data interpretation Full screen
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


  Help Knotoid subchains data interpretation Full screen
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 6-317 312 1-5 322-548 318-321 5 227 slipknot
view details
3.1 10-320 311 1-9 342-548 321-341 9 207 slipknot
view details
3.1 7-353 347 1-6 357-548 354-356 6 192 slipknot
view details
2.1 9-345 337 1-5, 354-548 6-8, 346-353 5 195 slipknot
sequence length 553
structure length 548
publication title Structure of Human Estrone Sulfatase Suggests Functional Roles of Membrane Association
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords STERYL-SULFATASE
missing residues 53, 455-458
total genus Genus: 169
ec nomenclature ec 3.1.6.2: Steryl-sulfatase.
pdb deposition date 2003-04-21
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.287.550 Mainly Alpha Orthogonal Bundle Helix Hairpins Helix hairpin bin 1p49A02
3.30.1120.10 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 1p49A03
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1p49A01
1AJCA 1HQAA 1ED9A 1ZEFA 1URBA 1AJAA 1Y6VA 1EJJA 1N2KA 1P49A 3UN2A 3M8YA 3M8ZA 3UN5A 3M8WA 4FDJA 1B8JA 2GA3A 3DYCA 3MK2A 1ZEDA 1E3CP 3IGYB 3TX0A 1ELXA 2QZUA 1EQJA 3SZYA 3DPCA 1EW9A 2G9YA 1AUKA 3BDGA 1O98A 1E1ZP 3MK1A 3IGZB 1EW8A 1KHKA 1KH9A 1KHNA 3BDGB 1K7HA 3UNYA 1E33P 3TWZA 1KH7A 1KH5A 2ANHA 1AJDA 1N2LA 3ED4A 1E2SP 1ANIA 2IFYA 1HDHA 3T01A 1AJBA 3UO0A 1FSUA 1ZEBA 1KHLA 3BDFA 4FDIA 3M7VA 1ED8A 3T02A 1O99A 1ALJA 1EW2A 3CMRA 2GLQA 1ALKA 3NVLA 1ELYA 1EI6A 3T00A 1HJKA 3MK0A 1ALIA 1ELZA 1URAA 1SHQA 1Y7AA 3SZZA 3BDHA 1ANJA 1SHNA 1KHJA 1KH4A 3OT9A 3UN3A
chains in the KnotProt database with same CATH superfamily
2B5UA 1AJCA 1HQAA 1ED9A 1ZEFA 1URBA 1AJAA 1Y6VA 1EJJA 1N2KA 1P49A 3UN2A 3M8YA 3M8ZA 3UN5A 3M8WA 4FDJA 1B8JA 2GA3A 3DYCA 3MK2A 1ZEDA 1E3CP 3IGYB 3TX0A 1ELXA 1JCHA 2QZUA 1EQJA 3SZYA 3DPCA 1EW9A 2G9YA 1AUKA 3BDGA 1O98A 1E1ZP 3MK1A 3IGZB 1EW8A 1KHKA 1KH9A 1KHNA 3BDGB 1K7HA 3UNYA 1E33P 3TWZA 1KH7A 1KH5A 2ANHA 1AJDA 1N2LA 3ED4A 1E2SP 1ANIA 2IFYA 1HDHA 3T01A 1AJBA 3UO0A 1FSUA 1ZEBA 1KHLA 3BDFA 4FDIA 3M7VA 1ED8A 3T02A 1O99A 1ALJA 1EW2A 3CMRA 2GLQA 1ALKA 3NVLA 1ELYA 1EI6A 3T00A 1HJKA 3MK0A 1ALIA 1ELZA 1URAA 1SHQA 1Y7AA 3SZZA 3BDHA 1ANJA 1SHNA 1KHJA 1KH4A 3OT9A 3UN3A
chains in the KnotProt database with same CATH topology
1AJCA 1HQAA 1ED9A 1ZEFA 1URBA 1AJAA 1Y6VA 1EJJA 1N2KA 1P49A 3UN2A 3M8YA 3M8ZA 3UN5A 3M8WA 4FDJA 1B8JA 2GA3A 3DYCA 3MK2A 1ZEDA 1E3CP 3IGYB 3TX0A 1ELXA 2QZUA 1EQJA 3SZYA 3DPCA 1EW9A 2G9YA 1AUKA 3BDGA 1O98A 1E1ZP 3MK1A 3IGZB 1EW8A 1KHKA 1KH9A 1KHNA 3BDGB 1K7HA 3UNYA 1E33P 3TWZA 1KH7A 1KH5A 2ANHA 1AJDA 1N2LA 3ED4A 1E2SP 1ANIA 2IFYA 1HDHA 3T01A 1AJBA 3UO0A 1FSUA 1ZEBA 1KHLA 3BDFA 4FDIA 3M7VA 1ED8A 3T02A 1O99A 1ALJA 1EW2A 3CMRA 2GLQA 1ALKA 3NVLA 1ELYA 1EI6A 3T00A 1HJKA 3MK0A 1ALIA 1ELZA 1URAA 1SHQA 1Y7AA 3SZZA 3BDHA 1ANJA 1SHNA 1KHJA 1KH4A 3OT9A 3UN3A
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1AJC A;  1HQA A;  1ED9 A;  1ZEF A;  1URB A;  1AJA A;  1Y6V A;  1EJJ A;  1N2K A;  1P49 A;  3UN2 A;  3M8Y A;  3M8Z A;  3UN5 A;  3M8W A;  4FDJ A;  1B8J A;  2GA3 A;  3DYC A;  3MK2 A;  1ZED A;  1E3C P;  3IGY B;  3TX0 A;  1ELX A;  2QZU A;  1EQJ A;  3SZY A;  3DPC A;  1EW9 A;  2G9Y A;  1AUK A;  3BDG A;  1O98 A;  1E1Z P;  3MK1 A;  3IGZ B;  1EW8 A;  1KHK A;  1KH9 A;  1KHN A;  3BDG B;  1K7H A;  3UNY A;  1E33 P;  3TWZ A;  1KH7 A;  1KH5 A;  2ANH A;  1AJD A;  1N2L A;  3ED4 A;  1E2S P;  1ANI A;  2IFY A;  1HDH A;  3T01 A;  1AJB A;  3UO0 A;  1FSU A;  1ZEB A;  1KHL A;  3BDF A;  4FDI A;  3M7V A;  1ED8 A;  3T02 A;  1O99 A;  1ALJ A;  1EW2 A;  3CMR A;  2GLQ A;  1ALK A;  3NVL A;  1ELY A;  1EI6 A;  3T00 A;  1HJK A;  3MK0 A;  1ALI A;  1ELZ A;  1URA A;  1SHQ A;  1Y7A A;  3SZZ A;  3BDH A;  1ANJ A;  1SHN A;  1KHJ A;  1KH4 A;  3OT9 A;  3UN3 A; 
#chains in the KnotProt database with same CATH topology
 2B5U A;  1AJC A;  1HQA A;  1ED9 A;  1ZEF A;  1URB A;  1AJA A;  1Y6V A;  1EJJ A;  1N2K A;  1P49 A;  3UN2 A;  3M8Y A;  3M8Z A;  3UN5 A;  3M8W A;  4FDJ A;  1B8J A;  2GA3 A;  3DYC A;  3MK2 A;  1ZED A;  1E3C P;  3IGY B;  3TX0 A;  1ELX A;  1JCH A;  2QZU A;  1EQJ A;  3SZY A;  3DPC A;  1EW9 A;  2G9Y A;  1AUK A;  3BDG A;  1O98 A;  1E1Z P;  3MK1 A;  3IGZ B;  1EW8 A;  1KHK A;  1KH9 A;  1KHN A;  3BDG B;  1K7H A;  3UNY A;  1E33 P;  3TWZ A;  1KH7 A;  1KH5 A;  2ANH A;  1AJD A;  1N2L A;  3ED4 A;  1E2S P;  1ANI A;  2IFY A;  1HDH A;  3T01 A;  1AJB A;  3UO0 A;  1FSU A;  1ZEB A;  1KHL A;  3BDF A;  4FDI A;  3M7V A;  1ED8 A;  3T02 A;  1O99 A;  1ALJ A;  1EW2 A;  3CMR A;  2GLQ A;  1ALK A;  3NVL A;  1ELY A;  1EI6 A;  3T00 A;  1HJK A;  3MK0 A;  1ALI A;  1ELZ A;  1URA A;  1SHQ A;  1Y7A A;  3SZZ A;  3BDH A;  1ANJ A;  1SHN A;  1KHJ A;  1KH4 A;  3OT9 A;  3UN3 A; 
#chains in the KnotProt database with same CATH homology
 1AJC A;  1HQA A;  1ED9 A;  1ZEF A;  1URB A;  1AJA A;  1Y6V A;  1EJJ A;  1N2K A;  1P49 A;  3UN2 A;  3M8Y A;  3M8Z A;  3UN5 A;  3M8W A;  4FDJ A;  1B8J A;  2GA3 A;  3DYC A;  3MK2 A;  1ZED A;  1E3C P;  3IGY B;  3TX0 A;  1ELX A;  2QZU A;  1EQJ A;  3SZY A;  3DPC A;  1EW9 A;  2G9Y A;  1AUK A;  3BDG A;  1O98 A;  1E1Z P;  3MK1 A;  3IGZ B;  1EW8 A;  1KHK A;  1KH9 A;  1KHN A;  3BDG B;  1K7H A;  3UNY A;  1E33 P;  3TWZ A;  1KH7 A;  1KH5 A;  2ANH A;  1AJD A;  1N2L A;  3ED4 A;  1E2S P;  1ANI A;  2IFY A;  1HDH A;  3T01 A;  1AJB A;  3UO0 A;  1FSU A;  1ZEB A;  1KHL A;  3BDF A;  4FDI A;  3M7V A;  1ED8 A;  3T02 A;  1O99 A;  1ALJ A;  1EW2 A;  3CMR A;  2GLQ A;  1ALK A;  3NVL A;  1ELY A;  1EI6 A;  3T00 A;  1HJK A;  3MK0 A;  1ALI A;  1ELZ A;  1URA A;  1SHQ A;  1Y7A A;  3SZZ A;  3BDH A;  1ANJ A;  1SHN A;  1KHJ A;  1KH4 A;  3OT9 A;  3UN3 A;
...loading similar chains, please wait...
similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...
How to cite
KnotProt | Interdisciplinary Laboratory of Biological Systems Modelling