1ZEBA

X-ray structure of alkaline phosphatase from human placenta in complex with 5'-amp
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 39-355 317 1-38 439-480 356-438 38 42 slipknot
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPA
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 20-354 335 1-19 360-480 355-359 19 121 slipknot
view details
3.1 39-359 321 1-38 438-480 360-437 38 43 slipknot
view details
2.1 36-437 402 1-35 441-480 438-440 35 40 slipknot
view details
2.1 29-354 326 1-19, 360-480 20-28, 355-359 19 121 slipknot
sequence length 480
structure length 480
publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus Genus: 173
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zebA00
1E1ZP 1HQAA 1AJAA 1ED8A 1ALIA 1ANIA 1EW8A 1ZEDA 1ELZA 2ANHA 1ELYA 1KHNA 1B8JA 3TX0A 3CMRA 1ELXA 3M8ZA 1SHNA 1ZEBA 3MK0A 3UN2A 2G9YA 2IFYA 1EW9A 1K7HA 3NVLA 1N2LA 4FDJA 1URAA 3ED4A 1SHQA 1AJDA 1EI6A 1URBA 3OT9A 1KH5A 1ALKA 3M8WA 1FSUA 1KHLA 2GA3A 1AUKA 1O98A 3T01A 3SZZA 3TWZA 1KH9A 1AJCA 3IGYB 1E3CP 1N2KA 1HDHA 1ZEFA 3BDHA 1P49A 1EW2A 1Y7AA 1EJJA 2GLQA 1KHKA 1E33P 3MK2A 3BDFA 1KH4A 3DPCA 3MK1A 3UNYA 3SZYA 3M7VA 3T02A 1EQJA 1KH7A 3M8YA 4FDIA 3UO0A 1ANJA 1KHJA 1Y6VA 3BDGB 2QZUA 3UN5A 1ED9A 1E2SP 3T00A 3IGZB 3UN3A 3DYCA 1HJKA 3BDGA 1ALJA 1AJBA 1O99A
chains in the KnotProt database with same CATH superfamily
1E1ZP 1HQAA 1AJAA 1ED8A 1ALIA 1ANIA 1EW8A 1ZEDA 1ELZA 2ANHA 1ELYA 1KHNA 1B8JA 3TX0A 3CMRA 1ELXA 3M8ZA 1SHNA 1ZEBA 3MK0A 3UN2A 2G9YA 2IFYA 1EW9A 1K7HA 3NVLA 1N2LA 4FDJA 1URAA 3ED4A 1SHQA 1AJDA 1EI6A 1URBA 3OT9A 1KH5A 1ALKA 3M8WA 1FSUA 1KHLA 2GA3A 1AUKA 1O98A 3T01A 3SZZA 3TWZA 1KH9A 1AJCA 3IGYB 1E3CP 1N2KA 1HDHA 1ZEFA 3BDHA 1P49A 1EW2A 1Y7AA 1EJJA 2GLQA 1KHKA 1E33P 3MK2A 3BDFA 1KH4A 3DPCA 3MK1A 3UNYA 3SZYA 3M7VA 3T02A 1EQJA 1KH7A 3M8YA 4FDIA 3UO0A 1ANJA 1KHJA 1Y6VA 3BDGB 2QZUA 3UN5A 1ED9A 1E2SP 3T00A 3IGZB 3UN3A 3DYCA 1HJKA 3BDGA 1ALJA 1AJBA 1O99A
chains in the KnotProt database with same CATH topology
1E1ZP 1HQAA 1AJAA 1ED8A 1ALIA 1ANIA 1EW8A 1ZEDA 1ELZA 2ANHA 1ELYA 1KHNA 1B8JA 3TX0A 3CMRA 1ELXA 3M8ZA 1SHNA 1ZEBA 3MK0A 3UN2A 2G9YA 2IFYA 1EW9A 1K7HA 3NVLA 1N2LA 4FDJA 1URAA 3ED4A 1SHQA 1AJDA 1EI6A 1URBA 3OT9A 1KH5A 1ALKA 3M8WA 1FSUA 1KHLA 2GA3A 1AUKA 1O98A 3T01A 3SZZA 3TWZA 1KH9A 1AJCA 3IGYB 1E3CP 1N2KA 1HDHA 1ZEFA 3BDHA 1P49A 1EW2A 1Y7AA 1EJJA 2GLQA 1KHKA 1E33P 3MK2A 3BDFA 1KH4A 3DPCA 3MK1A 3UNYA 3SZYA 3M7VA 3T02A 1EQJA 1KH7A 3M8YA 4FDIA 3UO0A 1ANJA 1KHJA 1Y6VA 3BDGB 2QZUA 3UN5A 1ED9A 1E2SP 3T00A 3IGZB 3UN3A 3DYCA 1HJKA 3BDGA 1ALJA 1AJBA 1O99A
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1E1Z P;  1HQA A;  1AJA A;  1ED8 A;  1ALI A;  1ANI A;  1EW8 A;  1ZED A;  1ELZ A;  2ANH A;  1ELY A;  1KHN A;  1B8J A;  3TX0 A;  3CMR A;  1ELX A;  3M8Z A;  1SHN A;  1ZEB A;  3MK0 A;  3UN2 A;  2G9Y A;  2IFY A;  1EW9 A;  1K7H A;  3NVL A;  1N2L A;  4FDJ A;  1URA A;  3ED4 A;  1SHQ A;  1AJD A;  1EI6 A;  1URB A;  3OT9 A;  1KH5 A;  1ALK A;  3M8W A;  1FSU A;  1KHL A;  2GA3 A;  1AUK A;  1O98 A;  3T01 A;  3SZZ A;  3TWZ A;  1KH9 A;  1AJC A;  3IGY B;  1E3C P;  1N2K A;  1HDH A;  1ZEF A;  3BDH A;  1P49 A;  1EW2 A;  1Y7A A;  1EJJ A;  2GLQ A;  1KHK A;  1E33 P;  3MK2 A;  3BDF A;  1KH4 A;  3DPC A;  3MK1 A;  3UNY A;  3SZY A;  3M7V A;  3T02 A;  1EQJ A;  1KH7 A;  3M8Y A;  4FDI A;  3UO0 A;  1ANJ A;  1KHJ A;  1Y6V A;  3BDG B;  2QZU A;  3UN5 A;  1ED9 A;  1E2S P;  3T00 A;  3IGZ B;  3UN3 A;  3DYC A;  1HJK A;  3BDG A;  1ALJ A;  1AJB A;  1O99 A; 
#chains in the KnotProt database with same CATH topology
 1E1Z P;  1HQA A;  1AJA A;  1ED8 A;  1ALI A;  1ANI A;  1EW8 A;  1ZED A;  1ELZ A;  2ANH A;  1ELY A;  1KHN A;  1B8J A;  3TX0 A;  3CMR A;  1ELX A;  3M8Z A;  1SHN A;  1ZEB A;  3MK0 A;  3UN2 A;  2G9Y A;  2IFY A;  1EW9 A;  1K7H A;  3NVL A;  1N2L A;  4FDJ A;  1URA A;  3ED4 A;  1SHQ A;  1AJD A;  1EI6 A;  1URB A;  3OT9 A;  1KH5 A;  1ALK A;  3M8W A;  1FSU A;  1KHL A;  2GA3 A;  1AUK A;  1O98 A;  3T01 A;  3SZZ A;  3TWZ A;  1KH9 A;  1AJC A;  3IGY B;  1E3C P;  1N2K A;  1HDH A;  1ZEF A;  3BDH A;  1P49 A;  1EW2 A;  1Y7A A;  1EJJ A;  2GLQ A;  1KHK A;  1E33 P;  3MK2 A;  3BDF A;  1KH4 A;  3DPC A;  3MK1 A;  3UNY A;  3SZY A;  3M7V A;  3T02 A;  1EQJ A;  1KH7 A;  3M8Y A;  4FDI A;  3UO0 A;  1ANJ A;  1KHJ A;  1Y6V A;  3BDG B;  2QZU A;  3UN5 A;  1ED9 A;  1E2S P;  3T00 A;  3IGZ B;  3UN3 A;  3DYC A;  1HJK A;  3BDG A;  1ALJ A;  1AJB A;  1O99 A; 
#chains in the KnotProt database with same CATH homology
 1E1Z P;  1HQA A;  1AJA A;  1ED8 A;  1ALI A;  1ANI A;  1EW8 A;  1ZED A;  1ELZ A;  2ANH A;  1ELY A;  1KHN A;  1B8J A;  3TX0 A;  3CMR A;  1ELX A;  3M8Z A;  1SHN A;  1ZEB A;  3MK0 A;  3UN2 A;  2G9Y A;  2IFY A;  1EW9 A;  1K7H A;  3NVL A;  1N2L A;  4FDJ A;  1URA A;  3ED4 A;  1SHQ A;  1AJD A;  1EI6 A;  1URB A;  3OT9 A;  1KH5 A;  1ALK A;  3M8W A;  1FSU A;  1KHL A;  2GA3 A;  1AUK A;  1O98 A;  3T01 A;  3SZZ A;  3TWZ A;  1KH9 A;  1AJC A;  3IGY B;  1E3C P;  1N2K A;  1HDH A;  1ZEF A;  3BDH A;  1P49 A;  1EW2 A;  1Y7A A;  1EJJ A;  2GLQ A;  1KHK A;  1E33 P;  3MK2 A;  3BDF A;  1KH4 A;  3DPC A;  3MK1 A;  3UNY A;  3SZY A;  3M7V A;  3T02 A;  1EQJ A;  1KH7 A;  3M8Y A;  4FDI A;  3UO0 A;  1ANJ A;  1KHJ A;  1Y6V A;  3BDG B;  2QZU A;  3UN5 A;  1ED9 A;  1E2S P;  3T00 A;  3IGZ B;  3UN3 A;  3DYC A;  1HJK A;  3BDG A;  1ALJ A;  1AJB A;  1O99 A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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