1ZEFA

Structure of alkaline phosphatase from human placenta in complex with its uncompetitive inhibitor l-phe
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 40-355 316 1-39 440-481 356-439 39 42 slipknot
Chain Sequence
IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVLKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPYTACDLAPPAG
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 35-355 321 1-34 362-481 356-361 34 120 slipknot
view details
3.1 39-358 320 1-38 437-481 359-436 38 45 slipknot
view details
2.1 36-436 401 1-35 441-481 437-440 35 41 slipknot
view details
2.1 40-404 365 1-38, 413-481 39-39, 405-412 38 69 slipknot
view details
2.1 41-403 363 1-39, 413-481 40-40, 404-412 39 69 slipknot
sequence length 481
structure length 481
publication title Structural Studies of Human Placental Alkaline Phosphatase in Complex with Functional Ligands.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Alkaline phosphatase
total genus Genus: 176
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2005-04-18
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1zefA00
3ED4A 4FDIA 2ANHA 3DYCA 3CMRA 1ALKA 1ZEDA 1ANJA 1KHJA 3IGYB 1E33P 1KH4A 1O98A 1EW2A 3M7VA 1E1ZP 3BDGA 1N2KA 1URBA 1K7HA 2GLQA 1FSUA 3M8WA 1O99A 3OT9A 3UN2A 1B8JA 1ALIA 1Y7AA 1KH9A 3DPCA 1HJKA 1HQAA 1P49A 3M8YA 1KH7A 1ZEBA 1URAA 1E3CP 3UN3A 1EJJA 1ED9A 1AJDA 3BDGB 3SZYA 3MK1A 3T02A 1ELXA 1AJAA 1Y6VA 3UO0A 3BDHA 3T00A 2G9YA 2QZUA 3TWZA 1ANIA 1AUKA 1N2LA 1AJBA 3BDFA 3M8ZA 1E2SP 1ELZA 1SHNA 1HDHA 4FDJA 1KHKA 3MK2A 3MK0A 1ED8A 3IGZB 1ELYA 3UN5A 1ZEFA 1EI6A 2IFYA 1EW9A 1KHLA 3T01A 2GA3A 1EQJA 3UNYA 3SZZA 1ALJA 1EW8A 1SHQA 3NVLA 1KH5A 1KHNA 1AJCA 3TX0A
chains in the KnotProt database with same CATH superfamily
3ED4A 4FDIA 2ANHA 3DYCA 3CMRA 1ALKA 1ZEDA 1ANJA 1KHJA 3IGYB 1E33P 1KH4A 1O98A 1EW2A 3M7VA 1E1ZP 3BDGA 1N2KA 1URBA 1K7HA 2GLQA 1FSUA 3M8WA 1O99A 3OT9A 3UN2A 1B8JA 1ALIA 1Y7AA 1KH9A 3DPCA 1HJKA 1HQAA 1P49A 3M8YA 1KH7A 1ZEBA 1URAA 1E3CP 3UN3A 1EJJA 1ED9A 1AJDA 3BDGB 3SZYA 3MK1A 3T02A 1ELXA 1AJAA 1Y6VA 3UO0A 3BDHA 3T00A 2G9YA 2QZUA 3TWZA 1ANIA 1AUKA 1N2LA 1AJBA 3BDFA 3M8ZA 1E2SP 1ELZA 1SHNA 1HDHA 4FDJA 1KHKA 3MK2A 3MK0A 1ED8A 3IGZB 1ELYA 3UN5A 1ZEFA 1EI6A 2IFYA 1EW9A 1KHLA 3T01A 2GA3A 1EQJA 3UNYA 3SZZA 1ALJA 1EW8A 1SHQA 3NVLA 1KH5A 1KHNA 1AJCA 3TX0A
chains in the KnotProt database with same CATH topology
3ED4A 4FDIA 2ANHA 3DYCA 3CMRA 1ALKA 1ZEDA 1ANJA 1KHJA 3IGYB 1E33P 1KH4A 1O98A 1EW2A 3M7VA 1E1ZP 3BDGA 1N2KA 1URBA 1K7HA 2GLQA 1FSUA 3M8WA 1O99A 3OT9A 3UN2A 1B8JA 1ALIA 1Y7AA 1KH9A 3DPCA 1HJKA 1HQAA 1P49A 3M8YA 1KH7A 1ZEBA 1URAA 1E3CP 3UN3A 1EJJA 1ED9A 1AJDA 3BDGB 3SZYA 3MK1A 3T02A 1ELXA 1AJAA 1Y6VA 3UO0A 3BDHA 3T00A 2G9YA 2QZUA 3TWZA 1ANIA 1AUKA 1N2LA 1AJBA 3BDFA 3M8ZA 1E2SP 1ELZA 1SHNA 1HDHA 4FDJA 1KHKA 3MK2A 3MK0A 1ED8A 3IGZB 1ELYA 3UN5A 1ZEFA 1EI6A 2IFYA 1EW9A 1KHLA 3T01A 2GA3A 1EQJA 3UNYA 3SZZA 1ALJA 1EW8A 1SHQA 3NVLA 1KH5A 1KHNA 1AJCA 3TX0A
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 3ED4 A;  4FDI A;  2ANH A;  3DYC A;  3CMR A;  1ALK A;  1ZED A;  1ANJ A;  1KHJ A;  3IGY B;  1E33 P;  1KH4 A;  1O98 A;  1EW2 A;  3M7V A;  1E1Z P;  3BDG A;  1N2K A;  1URB A;  1K7H A;  2GLQ A;  1FSU A;  3M8W A;  1O99 A;  3OT9 A;  3UN2 A;  1B8J A;  1ALI A;  1Y7A A;  1KH9 A;  3DPC A;  1HJK A;  1HQA A;  1P49 A;  3M8Y A;  1KH7 A;  1ZEB A;  1URA A;  1E3C P;  3UN3 A;  1EJJ A;  1ED9 A;  1AJD A;  3BDG B;  3SZY A;  3MK1 A;  3T02 A;  1ELX A;  1AJA A;  1Y6V A;  3UO0 A;  3BDH A;  3T00 A;  2G9Y A;  2QZU A;  3TWZ A;  1ANI A;  1AUK A;  1N2L A;  1AJB A;  3BDF A;  3M8Z A;  1E2S P;  1ELZ A;  1SHN A;  1HDH A;  4FDJ A;  1KHK A;  3MK2 A;  3MK0 A;  1ED8 A;  3IGZ B;  1ELY A;  3UN5 A;  1ZEF A;  1EI6 A;  2IFY A;  1EW9 A;  1KHL A;  3T01 A;  2GA3 A;  1EQJ A;  3UNY A;  3SZZ A;  1ALJ A;  1EW8 A;  1SHQ A;  3NVL A;  1KH5 A;  1KHN A;  1AJC A;  3TX0 A; 
#chains in the KnotProt database with same CATH topology
 3ED4 A;  4FDI A;  2ANH A;  3DYC A;  3CMR A;  1ALK A;  1ZED A;  1ANJ A;  1KHJ A;  3IGY B;  1E33 P;  1KH4 A;  1O98 A;  1EW2 A;  3M7V A;  1E1Z P;  3BDG A;  1N2K A;  1URB A;  1K7H A;  2GLQ A;  1FSU A;  3M8W A;  1O99 A;  3OT9 A;  3UN2 A;  1B8J A;  1ALI A;  1Y7A A;  1KH9 A;  3DPC A;  1HJK A;  1HQA A;  1P49 A;  3M8Y A;  1KH7 A;  1ZEB A;  1URA A;  1E3C P;  3UN3 A;  1EJJ A;  1ED9 A;  1AJD A;  3BDG B;  3SZY A;  3MK1 A;  3T02 A;  1ELX A;  1AJA A;  1Y6V A;  3UO0 A;  3BDH A;  3T00 A;  2G9Y A;  2QZU A;  3TWZ A;  1ANI A;  1AUK A;  1N2L A;  1AJB A;  3BDF A;  3M8Z A;  1E2S P;  1ELZ A;  1SHN A;  1HDH A;  4FDJ A;  1KHK A;  3MK2 A;  3MK0 A;  1ED8 A;  3IGZ B;  1ELY A;  3UN5 A;  1ZEF A;  1EI6 A;  2IFY A;  1EW9 A;  1KHL A;  3T01 A;  2GA3 A;  1EQJ A;  3UNY A;  3SZZ A;  1ALJ A;  1EW8 A;  1SHQ A;  3NVL A;  1KH5 A;  1KHN A;  1AJC A;  3TX0 A; 
#chains in the KnotProt database with same CATH homology
 3ED4 A;  4FDI A;  2ANH A;  3DYC A;  3CMR A;  1ALK A;  1ZED A;  1ANJ A;  1KHJ A;  3IGY B;  1E33 P;  1KH4 A;  1O98 A;  1EW2 A;  3M7V A;  1E1Z P;  3BDG A;  1N2K A;  1URB A;  1K7H A;  2GLQ A;  1FSU A;  3M8W A;  1O99 A;  3OT9 A;  3UN2 A;  1B8J A;  1ALI A;  1Y7A A;  1KH9 A;  3DPC A;  1HJK A;  1HQA A;  1P49 A;  3M8Y A;  1KH7 A;  1ZEB A;  1URA A;  1E3C P;  3UN3 A;  1EJJ A;  1ED9 A;  1AJD A;  3BDG B;  3SZY A;  3MK1 A;  3T02 A;  1ELX A;  1AJA A;  1Y6V A;  3UO0 A;  3BDH A;  3T00 A;  2G9Y A;  2QZU A;  3TWZ A;  1ANI A;  1AUK A;  1N2L A;  1AJB A;  3BDF A;  3M8Z A;  1E2S P;  1ELZ A;  1SHN A;  1HDH A;  4FDJ A;  1KHK A;  3MK2 A;  3MK0 A;  1ED8 A;  3IGZ B;  1ELY A;  3UN5 A;  1ZEF A;  1EI6 A;  2IFY A;  1EW9 A;  1KHL A;  3T01 A;  2GA3 A;  1EQJ A;  3UNY A;  3SZZ A;  1ALJ A;  1EW8 A;  1SHQ A;  3NVL A;  1KH5 A;  1KHN A;  1AJC A;  3TX0 A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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