1AJBA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Genus: 162
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 46-369 324 1-45 420-449 370-419 45 30 slipknot
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 48-371 324 1-47 417-449 372-416 47 33 slipknot
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3.1 44-416 373 1-43 420-449 417-419 43 30 slipknot
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2.1 43-419 377 1-1, 421-449 2-42, 420-420 1 29 slipknot
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2.1 13-368 356 1-6, 372-449 7-12, 369-371 6 78 slipknot
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3.1 14-368 355 1-12, 372-449 13-13, 369-371 12 78 slipknot
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2.1 43-366 324 1-25, 372-449 26-42, 367-371 25 78 slipknot
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2.1 45-416 372 1-43, 419-449 44-44, 417-418 43 31 slipknot
sequence length 449
structure length 449
publication title 3-D structure of the D153G mutant of Escherichia coli alkaline phosphatase: an enzyme with weaker magnesium binding and increased catalytic activity.
pubmed doi rcsb
molecule tags Non specific mono-esterase
molecule keywords ALKALINE PHOSPHATASE
source organism Escherichia coli
total genus Genus: 162
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-08-19
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajbA00
1E1ZP 1HQAA 1AJAA 1ED8A 1ALIA 1ANIA 1EW8A 1ZEDA 1ELZA 2ANHA 1ELYA 1KHNA 1B8JA 3TX0A 3CMRA 1ELXA 3M8ZA 1SHNA 1ZEBA 3MK0A 3UN2A 2G9YA 2IFYA 1EW9A 1K7HA 3NVLA 1N2LA 4FDJA 1URAA 3ED4A 1SHQA 1AJDA 1EI6A 1URBA 3OT9A 1KH5A 1ALKA 3M8WA 1FSUA 1KHLA 2GA3A 1AUKA 1O98A 3T01A 3SZZA 3TWZA 1KH9A 1AJCA 3IGYB 1E3CP 1N2KA 1HDHA 1ZEFA 3BDHA 1P49A 1EW2A 1Y7AA 1EJJA 2GLQA 1KHKA 1E33P 3MK2A 3BDFA 1KH4A 3DPCA 3MK1A 3UNYA 3SZYA 3M7VA 3T02A 1EQJA 1KH7A 3M8YA 4FDIA 3UO0A 1ANJA 1KHJA 1Y6VA 3BDGB 2QZUA 3UN5A 1ED9A 1E2SP 3T00A 3IGZB 3UN3A 3DYCA 1HJKA 3BDGA 1ALJA 1AJBA 1O99A
chains in the KnotProt database with same CATH superfamily
1E1ZP 1HQAA 1AJAA 1ED8A 1ALIA 1ANIA 1EW8A 1ZEDA 1ELZA 2ANHA 1ELYA 1KHNA 1B8JA 3TX0A 3CMRA 1ELXA 3M8ZA 1SHNA 1ZEBA 3MK0A 3UN2A 2G9YA 2IFYA 1EW9A 1K7HA 3NVLA 1N2LA 4FDJA 1URAA 3ED4A 1SHQA 1AJDA 1EI6A 1URBA 3OT9A 1KH5A 1ALKA 3M8WA 1FSUA 1KHLA 2GA3A 1AUKA 1O98A 3T01A 3SZZA 3TWZA 1KH9A 1AJCA 3IGYB 1E3CP 1N2KA 1HDHA 1ZEFA 3BDHA 1P49A 1EW2A 1Y7AA 1EJJA 2GLQA 1KHKA 1E33P 3MK2A 3BDFA 1KH4A 3DPCA 3MK1A 3UNYA 3SZYA 3M7VA 3T02A 1EQJA 1KH7A 3M8YA 4FDIA 3UO0A 1ANJA 1KHJA 1Y6VA 3BDGB 2QZUA 3UN5A 1ED9A 1E2SP 3T00A 3IGZB 3UN3A 3DYCA 1HJKA 3BDGA 1ALJA 1AJBA 1O99A
chains in the KnotProt database with same CATH topology
1E1ZP 1HQAA 1AJAA 1ED8A 1ALIA 1ANIA 1EW8A 1ZEDA 1ELZA 2ANHA 1ELYA 1KHNA 1B8JA 3TX0A 3CMRA 1ELXA 3M8ZA 1SHNA 1ZEBA 3MK0A 3UN2A 2G9YA 2IFYA 1EW9A 1K7HA 3NVLA 1N2LA 4FDJA 1URAA 3ED4A 1SHQA 1AJDA 1EI6A 1URBA 3OT9A 1KH5A 1ALKA 3M8WA 1FSUA 1KHLA 2GA3A 1AUKA 1O98A 3T01A 3SZZA 3TWZA 1KH9A 1AJCA 3IGYB 1E3CP 1N2KA 1HDHA 1ZEFA 3BDHA 1P49A 1EW2A 1Y7AA 1EJJA 2GLQA 1KHKA 1E33P 3MK2A 3BDFA 1KH4A 3DPCA 3MK1A 3UNYA 3SZYA 3M7VA 3T02A 1EQJA 1KH7A 3M8YA 4FDIA 3UO0A 1ANJA 1KHJA 1Y6VA 3BDGB 2QZUA 3UN5A 1ED9A 1E2SP 3T00A 3IGZB 3UN3A 3DYCA 1HJKA 3BDGA 1ALJA 1AJBA 1O99A
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1E1Z P;  1HQA A;  1AJA A;  1ED8 A;  1ALI A;  1ANI A;  1EW8 A;  1ZED A;  1ELZ A;  2ANH A;  1ELY A;  1KHN A;  1B8J A;  3TX0 A;  3CMR A;  1ELX A;  3M8Z A;  1SHN A;  1ZEB A;  3MK0 A;  3UN2 A;  2G9Y A;  2IFY A;  1EW9 A;  1K7H A;  3NVL A;  1N2L A;  4FDJ A;  1URA A;  3ED4 A;  1SHQ A;  1AJD A;  1EI6 A;  1URB A;  3OT9 A;  1KH5 A;  1ALK A;  3M8W A;  1FSU A;  1KHL A;  2GA3 A;  1AUK A;  1O98 A;  3T01 A;  3SZZ A;  3TWZ A;  1KH9 A;  1AJC A;  3IGY B;  1E3C P;  1N2K A;  1HDH A;  1ZEF A;  3BDH A;  1P49 A;  1EW2 A;  1Y7A A;  1EJJ A;  2GLQ A;  1KHK A;  1E33 P;  3MK2 A;  3BDF A;  1KH4 A;  3DPC A;  3MK1 A;  3UNY A;  3SZY A;  3M7V A;  3T02 A;  1EQJ A;  1KH7 A;  3M8Y A;  4FDI A;  3UO0 A;  1ANJ A;  1KHJ A;  1Y6V A;  3BDG B;  2QZU A;  3UN5 A;  1ED9 A;  1E2S P;  3T00 A;  3IGZ B;  3UN3 A;  3DYC A;  1HJK A;  3BDG A;  1ALJ A;  1AJB A;  1O99 A; 
#chains in the KnotProt database with same CATH topology
 1E1Z P;  1HQA A;  1AJA A;  1ED8 A;  1ALI A;  1ANI A;  1EW8 A;  1ZED A;  1ELZ A;  2ANH A;  1ELY A;  1KHN A;  1B8J A;  3TX0 A;  3CMR A;  1ELX A;  3M8Z A;  1SHN A;  1ZEB A;  3MK0 A;  3UN2 A;  2G9Y A;  2IFY A;  1EW9 A;  1K7H A;  3NVL A;  1N2L A;  4FDJ A;  1URA A;  3ED4 A;  1SHQ A;  1AJD A;  1EI6 A;  1URB A;  3OT9 A;  1KH5 A;  1ALK A;  3M8W A;  1FSU A;  1KHL A;  2GA3 A;  1AUK A;  1O98 A;  3T01 A;  3SZZ A;  3TWZ A;  1KH9 A;  1AJC A;  3IGY B;  1E3C P;  1N2K A;  1HDH A;  1ZEF A;  3BDH A;  1P49 A;  1EW2 A;  1Y7A A;  1EJJ A;  2GLQ A;  1KHK A;  1E33 P;  3MK2 A;  3BDF A;  1KH4 A;  3DPC A;  3MK1 A;  3UNY A;  3SZY A;  3M7V A;  3T02 A;  1EQJ A;  1KH7 A;  3M8Y A;  4FDI A;  3UO0 A;  1ANJ A;  1KHJ A;  1Y6V A;  3BDG B;  2QZU A;  3UN5 A;  1ED9 A;  1E2S P;  3T00 A;  3IGZ B;  3UN3 A;  3DYC A;  1HJK A;  3BDG A;  1ALJ A;  1AJB A;  1O99 A; 
#chains in the KnotProt database with same CATH homology
 1E1Z P;  1HQA A;  1AJA A;  1ED8 A;  1ALI A;  1ANI A;  1EW8 A;  1ZED A;  1ELZ A;  2ANH A;  1ELY A;  1KHN A;  1B8J A;  3TX0 A;  3CMR A;  1ELX A;  3M8Z A;  1SHN A;  1ZEB A;  3MK0 A;  3UN2 A;  2G9Y A;  2IFY A;  1EW9 A;  1K7H A;  3NVL A;  1N2L A;  4FDJ A;  1URA A;  3ED4 A;  1SHQ A;  1AJD A;  1EI6 A;  1URB A;  3OT9 A;  1KH5 A;  1ALK A;  3M8W A;  1FSU A;  1KHL A;  2GA3 A;  1AUK A;  1O98 A;  3T01 A;  3SZZ A;  3TWZ A;  1KH9 A;  1AJC A;  3IGY B;  1E3C P;  1N2K A;  1HDH A;  1ZEF A;  3BDH A;  1P49 A;  1EW2 A;  1Y7A A;  1EJJ A;  2GLQ A;  1KHK A;  1E33 P;  3MK2 A;  3BDF A;  1KH4 A;  3DPC A;  3MK1 A;  3UNY A;  3SZY A;  3M7V A;  3T02 A;  1EQJ A;  1KH7 A;  3M8Y A;  4FDI A;  3UO0 A;  1ANJ A;  1KHJ A;  1Y6V A;  3BDG B;  2QZU A;  3UN5 A;  1ED9 A;  1E2S P;  3T00 A;  3IGZ B;  3UN3 A;  3DYC A;  1HJK A;  3BDG A;  1ALJ A;  1AJB A;  1O99 A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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