1AJBA

Three-dimensional structure of the d153g mutant of e. coli alkaline phosphatase: a mutant with weaker magnesium binding and increased catalytic activity
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 46-369 324 1-45 420-449 370-419 45 30 slipknot
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 48-371 324 1-47 417-449 372-416 47 33 slipknot
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3.1 44-416 373 1-43 420-449 417-419 43 30 slipknot
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2.1 43-419 377 1-1, 421-449 2-42, 420-420 1 29 slipknot
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2.1 13-368 356 1-6, 372-449 7-12, 369-371 6 78 slipknot
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3.1 14-368 355 1-12, 372-449 13-13, 369-371 12 78 slipknot
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2.1 43-366 324 1-25, 372-449 26-42, 367-371 25 78 slipknot
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2.1 45-416 372 1-43, 419-449 44-44, 417-418 43 31 slipknot
sequence length 449
structure length 449
publication title 3-D structure of the D153G mutant of Escherichia coli alkaline phosphatase: an enzyme with weaker magnesium binding and increased catalytic activity.
pubmed doi rcsb
molecule tags Non specific mono-esterase
molecule keywords ALKALINE PHOSPHATASE
source organism Escherichia coli
total genus Genus: 162
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 1995-08-19
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ajbA00
1O99A 1ALJA 1P49A 1URAA 1ED8A 1E3CP 1KHLA 3NVLA 1AJAA 1HJKA 1ANJA 1KHJA 1KH4A 1HQAA 2QZUA 1KH9A 1E2SP 1EW2A 1EQJA 1AUKA 1ELZA 3MK2A 1ALIA 1AJDA 3UN2A 3DYCA 3TX0A 3MK1A 3UN3A 1KH5A 1ZEFA 3T00A 1AJBA 1ED9A 1SHNA 3UN5A 1ZEBA 1FSUA 1E33P 3BDFA 3M8WA 1KHKA 1O98A 3TWZA 1ELYA 1ELXA 1ZEDA 1B8JA 2GLQA 1EI6A 1KH7A 4FDIA 3M8YA 1N2LA 3SZZA 1K7HA 1SHQA 3DPCA 3M8ZA 1EW9A 1Y6VA 3UO0A 2G9YA 1KHNA 3MK0A 4FDJA 2ANHA 3BDGA 3SZYA 3T02A 3IGZB 3BDHA 3IGYB 1E1ZP 3CMRA 1ALKA 1URBA 1HDHA 1AJCA 1ANIA 1EW8A 2IFYA 3M7VA 3ED4A 3UNYA 3OT9A 1N2KA 3BDGB 1EJJA 1Y7AA 3T01A 2GA3A
chains in the KnotProt database with same CATH superfamily
1O99A 1ALJA 1P49A 1URAA 1ED8A 1E3CP 1KHLA 3NVLA 1AJAA 1HJKA 1ANJA 1KHJA 1KH4A 1HQAA 2QZUA 1KH9A 1E2SP 1EW2A 1EQJA 1AUKA 1ELZA 3MK2A 1ALIA 1AJDA 3UN2A 3DYCA 3TX0A 3MK1A 3UN3A 1KH5A 1ZEFA 3T00A 1AJBA 1ED9A 1SHNA 3UN5A 1ZEBA 1FSUA 1E33P 3BDFA 3M8WA 1KHKA 1O98A 3TWZA 1ELYA 1ELXA 1ZEDA 1B8JA 2GLQA 1EI6A 1KH7A 4FDIA 3M8YA 1N2LA 3SZZA 1K7HA 1SHQA 3DPCA 3M8ZA 1EW9A 1Y6VA 3UO0A 2G9YA 1KHNA 3MK0A 4FDJA 2ANHA 3BDGA 3SZYA 3T02A 3IGZB 3BDHA 3IGYB 1E1ZP 3CMRA 1ALKA 1URBA 1HDHA 1AJCA 1ANIA 1EW8A 2IFYA 3M7VA 3ED4A 3UNYA 3OT9A 1N2KA 3BDGB 1EJJA 1Y7AA 3T01A 2GA3A
chains in the KnotProt database with same CATH topology
1O99A 1ALJA 1P49A 1URAA 1ED8A 1E3CP 1KHLA 3NVLA 1AJAA 1HJKA 1ANJA 1KHJA 1KH4A 1HQAA 2QZUA 1KH9A 1E2SP 1EW2A 1EQJA 1AUKA 1ELZA 3MK2A 1ALIA 1AJDA 3UN2A 3DYCA 3TX0A 3MK1A 3UN3A 1KH5A 1ZEFA 3T00A 1AJBA 1ED9A 1SHNA 3UN5A 1ZEBA 1FSUA 1E33P 3BDFA 3M8WA 1KHKA 1O98A 3TWZA 1ELYA 1ELXA 1ZEDA 1B8JA 2GLQA 1EI6A 1KH7A 4FDIA 3M8YA 1N2LA 3SZZA 1K7HA 1SHQA 3DPCA 3M8ZA 1EW9A 1Y6VA 3UO0A 2G9YA 1KHNA 3MK0A 4FDJA 2ANHA 3BDGA 3SZYA 3T02A 3IGZB 3BDHA 3IGYB 1E1ZP 3CMRA 1ALKA 1URBA 1HDHA 1AJCA 1ANIA 1EW8A 2IFYA 3M7VA 3ED4A 3UNYA 3OT9A 1N2KA 3BDGB 1EJJA 1Y7AA 3T01A 2GA3A
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1O99 A;  1ALJ A;  1P49 A;  1URA A;  1ED8 A;  1E3C P;  1KHL A;  3NVL A;  1AJA A;  1HJK A;  1ANJ A;  1KHJ A;  1KH4 A;  1HQA A;  2QZU A;  1KH9 A;  1E2S P;  1EW2 A;  1EQJ A;  1AUK A;  1ELZ A;  3MK2 A;  1ALI A;  1AJD A;  3UN2 A;  3DYC A;  3TX0 A;  3MK1 A;  3UN3 A;  1KH5 A;  1ZEF A;  3T00 A;  1AJB A;  1ED9 A;  1SHN A;  3UN5 A;  1ZEB A;  1FSU A;  1E33 P;  3BDF A;  3M8W A;  1KHK A;  1O98 A;  3TWZ A;  1ELY A;  1ELX A;  1ZED A;  1B8J A;  2GLQ A;  1EI6 A;  1KH7 A;  4FDI A;  3M8Y A;  1N2L A;  3SZZ A;  1K7H A;  1SHQ A;  3DPC A;  3M8Z A;  1EW9 A;  1Y6V A;  3UO0 A;  2G9Y A;  1KHN A;  3MK0 A;  4FDJ A;  2ANH A;  3BDG A;  3SZY A;  3T02 A;  3IGZ B;  3BDH A;  3IGY B;  1E1Z P;  3CMR A;  1ALK A;  1URB A;  1HDH A;  1AJC A;  1ANI A;  1EW8 A;  2IFY A;  3M7V A;  3ED4 A;  3UNY A;  3OT9 A;  1N2K A;  3BDG B;  1EJJ A;  1Y7A A;  3T01 A;  2GA3 A; 
#chains in the KnotProt database with same CATH topology
 1O99 A;  1ALJ A;  1P49 A;  1URA A;  1ED8 A;  1E3C P;  1KHL A;  3NVL A;  1AJA A;  1HJK A;  1ANJ A;  1KHJ A;  1KH4 A;  1HQA A;  2QZU A;  1KH9 A;  1E2S P;  1EW2 A;  1EQJ A;  1AUK A;  1ELZ A;  3MK2 A;  1ALI A;  1AJD A;  3UN2 A;  3DYC A;  3TX0 A;  3MK1 A;  3UN3 A;  1KH5 A;  1ZEF A;  3T00 A;  1AJB A;  1ED9 A;  1SHN A;  3UN5 A;  1ZEB A;  1FSU A;  1E33 P;  3BDF A;  3M8W A;  1KHK A;  1O98 A;  3TWZ A;  1ELY A;  1ELX A;  1ZED A;  1B8J A;  2GLQ A;  1EI6 A;  1KH7 A;  4FDI A;  3M8Y A;  1N2L A;  3SZZ A;  1K7H A;  1SHQ A;  3DPC A;  3M8Z A;  1EW9 A;  1Y6V A;  3UO0 A;  2G9Y A;  1KHN A;  3MK0 A;  4FDJ A;  2ANH A;  3BDG A;  3SZY A;  3T02 A;  3IGZ B;  3BDH A;  3IGY B;  1E1Z P;  3CMR A;  1ALK A;  1URB A;  1HDH A;  1AJC A;  1ANI A;  1EW8 A;  2IFY A;  3M7V A;  3ED4 A;  3UNY A;  3OT9 A;  1N2K A;  3BDG B;  1EJJ A;  1Y7A A;  3T01 A;  2GA3 A; 
#chains in the KnotProt database with same CATH homology
 1O99 A;  1ALJ A;  1P49 A;  1URA A;  1ED8 A;  1E3C P;  1KHL A;  3NVL A;  1AJA A;  1HJK A;  1ANJ A;  1KHJ A;  1KH4 A;  1HQA A;  2QZU A;  1KH9 A;  1E2S P;  1EW2 A;  1EQJ A;  1AUK A;  1ELZ A;  3MK2 A;  1ALI A;  1AJD A;  3UN2 A;  3DYC A;  3TX0 A;  3MK1 A;  3UN3 A;  1KH5 A;  1ZEF A;  3T00 A;  1AJB A;  1ED9 A;  1SHN A;  3UN5 A;  1ZEB A;  1FSU A;  1E33 P;  3BDF A;  3M8W A;  1KHK A;  1O98 A;  3TWZ A;  1ELY A;  1ELX A;  1ZED A;  1B8J A;  2GLQ A;  1EI6 A;  1KH7 A;  4FDI A;  3M8Y A;  1N2L A;  3SZZ A;  1K7H A;  1SHQ A;  3DPC A;  3M8Z A;  1EW9 A;  1Y6V A;  3UO0 A;  2G9Y A;  1KHN A;  3MK0 A;  4FDJ A;  2ANH A;  3BDG A;  3SZY A;  3T02 A;  3IGZ B;  3BDH A;  3IGY B;  1E1Z P;  3CMR A;  1ALK A;  1URB A;  1HDH A;  1AJC A;  1ANI A;  1EW8 A;  2IFY A;  3M7V A;  3ED4 A;  3UNY A;  3OT9 A;  1N2K A;  3BDG B;  1EJJ A;  1Y7A A;  3T01 A;  2GA3 A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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