1E33P

Crystal structure of an arylsulfatase a mutant p426l
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 7-263 257 1-6 294-485 264-293 6 192 slipknot
Chain Sequence
RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLXTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQREDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPLLLYDLSKDPGENYNLLG----ATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCP
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 5-261 257 1-4 267-481 262-266 4 215 slipknot
view details
3.1 7-266 260 1-6 294-481 267-293 6 188 slipknot
view details
3.1 6-293 288 1-5 295-481 294-294 5 187 slipknot
view details
2.1 6-294 289 1-5 296-481 295-295 5 186 slipknot
sequence length 485
structure length 481
publication title Defective Oligomerization of Arylsulfatase a as a Cause of its Instability in Lysosomes and Metachromatic Leukodystrophy.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords ARYLSULFATASE A
missing residues 426-429
total genus Genus: 153
ec nomenclature ec 3.1.6.8: Cerebroside-sulfatase.
pdb deposition date 2000-06-06
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
P PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.10 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 1e33P02
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1e33P01
3M8WA 1E2SP 1ELXA 1AJCA 1O99A 1URBA 1E1ZP 1EW2A 1ED9A 1ANJA 1E3CP 3BDGA 3SZZA 1KH4A 1EW9A 1Y7AA 1EQJA 1KHLA 2G9YA 1AJAA 3MK0A 3MK2A 3OT9A 1EJJA 1AJBA 1KHNA 1N2KA 1ELZA 3UN2A 1N2LA 1K7HA 3DYCA 3T00A 1ALJA 3MK1A 1KHKA 1Y6VA 2GLQA 1ZEDA 1ANIA 1O98A 1KHJA 1ZEFA 3T02A 1ED8A 3UN3A 3CMRA 3T01A 3SZYA 1ZEBA 3TX0A 2QZUA 4FDIA 1B8JA 3DPCA 3BDHA 3UO0A 3IGZB 3TWZA 1AUKA 4FDJA 2IFYA 2GA3A 1SHQA 3UN5A 1KH7A 1ALIA 3BDGB 1HDHA 1ALKA 1HQAA 1FSUA 3M8ZA 1SHNA 3UNYA 1URAA 1HJKA 1EW8A 3ED4A 1AJDA 1ELYA 3M7VA 1E33P 3IGYB 3NVLA 1P49A 1EI6A 3BDFA 1KH9A 3M8YA 2ANHA 1KH5A
chains in the KnotProt database with same CATH superfamily
3M8WA 1E2SP 1ELXA 1AJCA 1O99A 1URBA 1E1ZP 1EW2A 1ED9A 1ANJA 1E3CP 3BDGA 3SZZA 1KH4A 1EW9A 1Y7AA 1EQJA 1KHLA 2G9YA 1AJAA 3MK0A 3MK2A 3OT9A 1EJJA 1AJBA 1KHNA 1N2KA 1ELZA 3UN2A 1N2LA 1K7HA 3DYCA 3T00A 1ALJA 3MK1A 1KHKA 1Y6VA 2GLQA 1ZEDA 1ANIA 1O98A 1KHJA 1ZEFA 3T02A 1ED8A 3UN3A 3CMRA 3T01A 3SZYA 1ZEBA 3TX0A 2QZUA 4FDIA 1B8JA 3DPCA 3BDHA 3UO0A 3IGZB 3TWZA 1AUKA 4FDJA 2IFYA 2GA3A 1SHQA 3UN5A 1KH7A 1ALIA 3BDGB 1HDHA 1ALKA 1HQAA 1FSUA 3M8ZA 1SHNA 3UNYA 1URAA 1HJKA 1EW8A 3ED4A 1AJDA 1ELYA 3M7VA 1E33P 3IGYB 3NVLA 1P49A 1EI6A 3BDFA 1KH9A 3M8YA 2ANHA 1KH5A
chains in the KnotProt database with same CATH topology
3M8WA 1E2SP 1ELXA 1AJCA 1O99A 1URBA 1E1ZP 1EW2A 1ED9A 1ANJA 1E3CP 3BDGA 3SZZA 1KH4A 1EW9A 1Y7AA 1EQJA 1KHLA 2G9YA 1AJAA 3MK0A 3MK2A 3OT9A 1EJJA 1AJBA 1KHNA 1N2KA 1ELZA 3UN2A 1N2LA 1K7HA 3DYCA 3T00A 1ALJA 3MK1A 1KHKA 1Y6VA 2GLQA 1ZEDA 1ANIA 1O98A 1KHJA 1ZEFA 3T02A 1ED8A 3UN3A 3CMRA 3T01A 3SZYA 1ZEBA 3TX0A 2QZUA 4FDIA 1B8JA 3DPCA 3BDHA 3UO0A 3IGZB 3TWZA 1AUKA 4FDJA 2IFYA 2GA3A 1SHQA 3UN5A 1KH7A 1ALIA 3BDGB 1HDHA 1ALKA 1HQAA 1FSUA 3M8ZA 1SHNA 3UNYA 1URAA 1HJKA 1EW8A 3ED4A 1AJDA 1ELYA 3M7VA 1E33P 3IGYB 3NVLA 1P49A 1EI6A 3BDFA 1KH9A 3M8YA 2ANHA 1KH5A
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 3M8W A;  1E2S P;  1ELX A;  1AJC A;  1O99 A;  1URB A;  1E1Z P;  1EW2 A;  1ED9 A;  1ANJ A;  1E3C P;  3BDG A;  3SZZ A;  1KH4 A;  1EW9 A;  1Y7A A;  1EQJ A;  1KHL A;  2G9Y A;  1AJA A;  3MK0 A;  3MK2 A;  3OT9 A;  1EJJ A;  1AJB A;  1KHN A;  1N2K A;  1ELZ A;  3UN2 A;  1N2L A;  1K7H A;  3DYC A;  3T00 A;  1ALJ A;  3MK1 A;  1KHK A;  1Y6V A;  2GLQ A;  1ZED A;  1ANI A;  1O98 A;  1KHJ A;  1ZEF A;  3T02 A;  1ED8 A;  3UN3 A;  3CMR A;  3T01 A;  3SZY A;  1ZEB A;  3TX0 A;  2QZU A;  4FDI A;  1B8J A;  3DPC A;  3BDH A;  3UO0 A;  3IGZ B;  3TWZ A;  1AUK A;  4FDJ A;  2IFY A;  2GA3 A;  1SHQ A;  3UN5 A;  1KH7 A;  1ALI A;  3BDG B;  1HDH A;  1ALK A;  1HQA A;  1FSU A;  3M8Z A;  1SHN A;  3UNY A;  1URA A;  1HJK A;  1EW8 A;  3ED4 A;  1AJD A;  1ELY A;  3M7V A;  1E33 P;  3IGY B;  3NVL A;  1P49 A;  1EI6 A;  3BDF A;  1KH9 A;  3M8Y A;  2ANH A;  1KH5 A; 
#chains in the KnotProt database with same CATH topology
 3M8W A;  1E2S P;  1ELX A;  1AJC A;  1O99 A;  1URB A;  1E1Z P;  1EW2 A;  1ED9 A;  1ANJ A;  1E3C P;  3BDG A;  3SZZ A;  1KH4 A;  1EW9 A;  1Y7A A;  1EQJ A;  1KHL A;  2G9Y A;  1AJA A;  3MK0 A;  3MK2 A;  3OT9 A;  1EJJ A;  1AJB A;  1KHN A;  1N2K A;  1ELZ A;  3UN2 A;  1N2L A;  1K7H A;  3DYC A;  3T00 A;  1ALJ A;  3MK1 A;  1KHK A;  1Y6V A;  2GLQ A;  1ZED A;  1ANI A;  1O98 A;  1KHJ A;  1ZEF A;  3T02 A;  1ED8 A;  3UN3 A;  3CMR A;  3T01 A;  3SZY A;  1ZEB A;  3TX0 A;  2QZU A;  4FDI A;  1B8J A;  3DPC A;  3BDH A;  3UO0 A;  3IGZ B;  3TWZ A;  1AUK A;  4FDJ A;  2IFY A;  2GA3 A;  1SHQ A;  3UN5 A;  1KH7 A;  1ALI A;  3BDG B;  1HDH A;  1ALK A;  1HQA A;  1FSU A;  3M8Z A;  1SHN A;  3UNY A;  1URA A;  1HJK A;  1EW8 A;  3ED4 A;  1AJD A;  1ELY A;  3M7V A;  1E33 P;  3IGY B;  3NVL A;  1P49 A;  1EI6 A;  3BDF A;  1KH9 A;  3M8Y A;  2ANH A;  1KH5 A; 
#chains in the KnotProt database with same CATH homology
 3M8W A;  1E2S P;  1ELX A;  1AJC A;  1O99 A;  1URB A;  1E1Z P;  1EW2 A;  1ED9 A;  1ANJ A;  1E3C P;  3BDG A;  3SZZ A;  1KH4 A;  1EW9 A;  1Y7A A;  1EQJ A;  1KHL A;  2G9Y A;  1AJA A;  3MK0 A;  3MK2 A;  3OT9 A;  1EJJ A;  1AJB A;  1KHN A;  1N2K A;  1ELZ A;  3UN2 A;  1N2L A;  1K7H A;  3DYC A;  3T00 A;  1ALJ A;  3MK1 A;  1KHK A;  1Y6V A;  2GLQ A;  1ZED A;  1ANI A;  1O98 A;  1KHJ A;  1ZEF A;  3T02 A;  1ED8 A;  3UN3 A;  3CMR A;  3T01 A;  3SZY A;  1ZEB A;  3TX0 A;  2QZU A;  4FDI A;  1B8J A;  3DPC A;  3BDH A;  3UO0 A;  3IGZ B;  3TWZ A;  1AUK A;  4FDJ A;  2IFY A;  2GA3 A;  1SHQ A;  3UN5 A;  1KH7 A;  1ALI A;  3BDG B;  1HDH A;  1ALK A;  1HQA A;  1FSU A;  3M8Z A;  1SHN A;  3UNY A;  1URA A;  1HJK A;  1EW8 A;  3ED4 A;  1AJD A;  1ELY A;  3M7V A;  1E33 P;  3IGY B;  3NVL A;  1P49 A;  1EI6 A;  3BDF A;  1KH9 A;  3M8Y A;  2ANH A;  1KH5 A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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