1E3C | KnotProt

Genus: 158

Slipknot S +3₁

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setting document base to "https://knotprot.cent.uw.edu.pl/view/1e3c/P/"

Jmol Version: 14.29.13 2018-04-17 17:17

java.vendor: Java2Script (HTML5)

java.version: 2018-01-28 23:38:52 (JSmol/j2s)

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APPLETREADYCallback = "Jmol._readyCallback"

callback set for APPLETREADYCallback Jmol._readyCallback APPLETREADY

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Help Knotting data interpretation Full screen

					Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details				+3₁	7-263	257	1-6	294-485	264-293	6	192	slipknot

Chain Sequence

RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLSTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQREDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHELASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPLLYDLSKDPGENYNLLG----ATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPRPACCHCP

Whole chain analysis

Help Knotoid data interpretation Full screen

Subchain analysis

Knotoid cutoff: 0.5

Knotoid matrix content: 1

loadScript /static/js/j2s/core/package.js

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loadScript /static/js/j2s/core/corescript.z.js

JSmol exec jmolApplet0 start applet null

Jmol JavaScript applet jmolApplet0__019419027762358__ initializing

Jmol getValue debug null

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AppletRegistry.checkIn(jmolApplet0__019419027762358__)

vwrOptions:

{ "name":"jmolApplet0","applet":true,"documentBase":"https://knotprot.cent.uw.edu.pl/view/1e3c/P/","platform":"J.awtjs2d.Platform","fullName":"jmolApplet0__019419027762358__","codePath":"https:/static/js/j2s/","display":"jmolApplet0_canvas2d","signedApplet":"true","appletReadyCallback":"Jmol._readyCallback","statusListener":"[J.appletjs.Jmol object]","syncId":"019419027762358","bgcolor":"white" }

setting document base to "https://knotprot.cent.uw.edu.pl/view/1e3c/P/"

Jmol Version: 14.29.13 2018-04-17 17:17

java.vendor: Java2Script (HTML5)

java.version: 2018-01-28 23:38:52 (JSmol/j2s)

os.name: Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)

Access: ALL

memory: 0.0/0.0

processors available: 1

useCommandThread: false

appletId:jmolApplet0 (signed)

Jmol getValue emulate null

defaults = "Jmol"

Jmol getValue boxbgcolor null

Jmol getValue bgcolor white

backgroundColor = "white"

Jmol getValue ANIMFRAMECallback null

Jmol getValue APPLETREADYCallback Jmol._readyCallback

APPLETREADYCallback = "Jmol._readyCallback"

callback set for APPLETREADYCallback Jmol._readyCallback APPLETREADY

Jmol getValue ATOMMOVEDCallback null

Jmol getValue AUDIOCallback null

Jmol getValue CLICKCallback null

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Jmol getValue IMAGECallback null

Jmol getValue LOADSTRUCTCallback null

Jmol getValue MEASURECallback null

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Jmol applet jmolApplet0__019419027762358__ ready

script 1 started

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Viewer cachePut cache://localLOAD_/static/knot_data/1e3c/P/1e3c_P.pdb.gz

Viewer cachePut https://knotprot.cent.uw.edu.pl/static/knot_data/1e3c/P/1e3c_P.pdb.gz

FileManager.getAtomSetCollectionFromFile(/static/knot_data/1e3c/P/1e3c_P.pdb.gz)

The Resolver thinks Pdb

loadScript /static/js/j2s/core/corebio.z.js

Time for openFile(/static/knot_data/1e3c/P/1e3c_P.pdb.gz): 525 ms

reading 481 atoms

ModelSet: haveSymmetry:false haveUnitcells:false haveFractionalCoord:false

1 model in this collection. Use getProperty "modelInfo" or getProperty "auxiliaryInfo" to inspect them.

Default Van der Waals type for model set to Jmol

481 atoms created

ModelSet: autobonding; use autobond=false to not generate bonds automatically

Time for creating model: 31 ms

Adding embedded #jmolscript: select ({0:480});backbone only;select *;

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Script completed

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loadScript /static/js/j2s/J/shape/Mesh.js

Viewer cachePut cache://localLOAD_/static/knot_data/1e3c/P/1e3c_P.pdb.gz

Viewer cachePut https://knotprot.cent.uw.edu.pl/static/knot_data/1e3c/P/1e3c_P.pdb.gz

FileManager.getAtomSetCollectionFromFile(/static/knot_data/1e3c/P/1e3c_P.pdb.gz)

The Resolver thinks Pdb

Time for openFile(/static/knot_data/1e3c/P/1e3c_P.pdb.gz): 28 ms

reading 481 atoms

ModelSet: haveSymmetry:false haveUnitcells:false haveFractionalCoord:false

1 model in this collection. Use getProperty "modelInfo" or getProperty "auxiliaryInfo" to inspect them.

Default Van der Waals type for model set to Jmol

481 atoms created

ModelSet: autobonding; use autobond=false to not generate bonds automatically

Time for creating model: 20 ms

Adding embedded #jmolscript: select ({0:480});backbone only;select *;

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cartoonsFancy = true

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Script completed

Jmol script terminated

Help Knotoid subchains data interpretation Full screen

		Knot core range	Knot core length	Knot tails range	Slipknot tails range	Slipknot loops range	N-end length	C-end length	Type
view details	3.1	7-266	260	1-6	287-481	267-286	6	195	slipknot
view details	3.1	7-290	284	1-6	296-481	291-295	6	186	slipknot
view details	2.1	8-282	275		1-3, 289-481	4-7, 283-288	3	193	slipknot

sequence length	485
structure length	481
publication title	Crystal Structure of an Enzyme-Substrate Complex Provides Insight Into the Interaction between Human Arylsulfatase a and its Substrates During Catalysis pubmed doi rcsb
molecule tags	Hydrolase
molecule keywords	ARYLSULFATASE A
missing residues	426-429
total genus	Genus: 158
ec nomenclature	ec 3.1.6.8: Cerebroside-sulfatase.
pdb deposition date	2000-06-13
KnotProt deposition date	2014-07-31

pfam database annotations

chain	Pfam Accession Code	Pfam Family Identifier	Pfam Description
P	PF00884	Sulfatase	Sulfatase

Image from the rcsb pdb (www.rcsb.org)

cath code	Class	Architecture	Topology	Homology	Domain
3.30.1120.10	Alpha Beta	2-Layer Sandwich	Arylsulfatase, C-terminal domain	Arylsulfatase, C-terminal domain	1e3cP02
3.40.720.10	Alpha Beta	3-Layer(aba) Sandwich	Alkaline Phosphatase, subunit A	Alkaline Phosphatase, subunit A	1e3cP01

1E1ZP 3DYCA 1AJCA 1Y6VA 4FDIA 1KH9A 3BDFA 3MK1A 3NVLA 1ANJA 1KH5A 2ANHA 3T02A 1O99A 1E3CP 1Y7AA 1ZEBA 1EW2A 2GA3A 1KHJA 3IGYB 1N2KA 3M8ZA 3SZYA 3BDGA 3TWZA 3BDGB 3TX0A 3UN3A 1EI6A 2IFYA 1ELZA 1ANIA 3CMRA 3UO0A 3IGZB 3BDHA 4FDJA 1K7HA 1KHNA 1ZEFA 1SHNA 3UNYA 1KH4A 3MK2A 1ED9A 1ALIA 1AJBA 3T00A 1EW9A 2G9YA 3UN5A 1ELXA 1P49A 3DPCA 1AJAA 3M8YA 1N2LA 1B8JA 1EQJA 1ALKA 1FSUA 2QZUA 3ED4A 1URAA 1ZEDA 1SHQA 1AJDA 3M7VA 1ED8A 1KHKA 1ALJA 1ELYA 1E33P 3T01A 1EJJA 1KHLA 2GLQA 3OT9A 3M8WA 3MK0A 1HDHA 3UN2A 1E2SP 3SZZA 1KH7A 1URBA 1HJKA 1AUKA 1O98A 1HQAA 1EW8A
chains in the KnotProt database with same CATH superfamily

#chains in the KnotProt database with same CATH superfamily
 1E1Z P;  3DYC A;  1AJC A;  1Y6V A;  4FDI A;  1KH9 A;  3BDF A;  3MK1 A;  3NVL A;  1ANJ A;  1KH5 A;  2ANH A;  3T02 A;  1O99 A;  1E3C P;  1Y7A A;  1ZEB A;  1EW2 A;  2GA3 A;  1KHJ A;  3IGY B;  1N2K A;  3M8Z A;  3SZY A;  3BDG A;  3TWZ A;  3BDG B;  3TX0 A;  3UN3 A;  1EI6 A;  2IFY A;  1ELZ A;  1ANI A;  3CMR A;  3UO0 A;  3IGZ B;  3BDH A;  4FDJ A;  1K7H A;  1KHN A;  1ZEF A;  1SHN A;  3UNY A;  1KH4 A;  3MK2 A;  1ED9 A;  1ALI A;  1AJB A;  3T00 A;  1EW9 A;  2G9Y A;  3UN5 A;  1ELX A;  1P49 A;  3DPC A;  1AJA A;  3M8Y A;  1N2L A;  1B8J A;  1EQJ A;  1ALK A;  1FSU A;  2QZU A;  3ED4 A;  1URA A;  1ZED A;  1SHQ A;  1AJD A;  3M7V A;  1ED8 A;  1KHK A;  1ALJ A;  1ELY A;  1E33 P;  3T01 A;  1EJJ A;  1KHL A;  2GLQ A;  3OT9 A;  3M8W A;  3MK0 A;  1HDH A;  3UN2 A;  1E2S P;  3SZZ A;  1KH7 A;  1URB A;  1HJK A;  1AUK A;  1O98 A;  1HQA A;  1EW8 A; 
#chains in the KnotProt database with same CATH topology
 1E1Z P;  3DYC A;  1AJC A;  1Y6V A;  4FDI A;  1KH9 A;  3BDF A;  3MK1 A;  3NVL A;  1ANJ A;  1KH5 A;  2ANH A;  3T02 A;  1O99 A;  1E3C P;  1Y7A A;  1ZEB A;  1EW2 A;  2GA3 A;  1KHJ A;  3IGY B;  1N2K A;  3M8Z A;  3SZY A;  3BDG A;  3TWZ A;  3BDG B;  3TX0 A;  3UN3 A;  1EI6 A;  2IFY A;  1ELZ A;  1ANI A;  3CMR A;  3UO0 A;  3IGZ B;  3BDH A;  4FDJ A;  1K7H A;  1KHN A;  1ZEF A;  1SHN A;  3UNY A;  1KH4 A;  3MK2 A;  1ED9 A;  1ALI A;  1AJB A;  3T00 A;  1EW9 A;  2G9Y A;  3UN5 A;  1ELX A;  1P49 A;  3DPC A;  1AJA A;  3M8Y A;  1N2L A;  1B8J A;  1EQJ A;  1ALK A;  1FSU A;  2QZU A;  3ED4 A;  1URA A;  1ZED A;  1SHQ A;  1AJD A;  3M7V A;  1ED8 A;  1KHK A;  1ALJ A;  1ELY A;  1E33 P;  3T01 A;  1EJJ A;  1KHL A;  2GLQ A;  3OT9 A;  3M8W A;  3MK0 A;  1HDH A;  3UN2 A;  1E2S P;  3SZZ A;  1KH7 A;  1URB A;  1HJK A;  1AUK A;  1O98 A;  1HQA A;  1EW8 A; 
#chains in the KnotProt database with same CATH homology
 1E1Z P;  3DYC A;  1AJC A;  1Y6V A;  4FDI A;  1KH9 A;  3BDF A;  3MK1 A;  3NVL A;  1ANJ A;  1KH5 A;  2ANH A;  3T02 A;  1O99 A;  1E3C P;  1Y7A A;  1ZEB A;  1EW2 A;  2GA3 A;  1KHJ A;  3IGY B;  1N2K A;  3M8Z A;  3SZY A;  3BDG A;  3TWZ A;  3BDG B;  3TX0 A;  3UN3 A;  1EI6 A;  2IFY A;  1ELZ A;  1ANI A;  3CMR A;  3UO0 A;  3IGZ B;  3BDH A;  4FDJ A;  1K7H A;  1KHN A;  1ZEF A;  1SHN A;  3UNY A;  1KH4 A;  3MK2 A;  1ED9 A;  1ALI A;  1AJB A;  3T00 A;  1EW9 A;  2G9Y A;  3UN5 A;  1ELX A;  1P49 A;  3DPC A;  1AJA A;  3M8Y A;  1N2L A;  1B8J A;  1EQJ A;  1ALK A;  1FSU A;  2QZU A;  3ED4 A;  1URA A;  1ZED A;  1SHQ A;  1AJD A;  3M7V A;  1ED8 A;  1KHK A;  1ALJ A;  1ELY A;  1E33 P;  3T01 A;  1EJJ A;  1KHL A;  2GLQ A;  3OT9 A;  3M8W A;  3MK0 A;  1HDH A;  3UN2 A;  1E2S P;  3SZZ A;  1KH7 A;  1URB A;  1HJK A;  1AUK A;  1O98 A;  1HQA A;  1EW8 A;

1AUKA 1E1ZP 1E2SP 1E33P 1N2KA 1N2LA
similar chains in the KnotProt database (40% sequence similarity)

None
similar chains in the pdb database (40% sequence similarity)

#similar chains in the KnotProt database (40% sequence similarity)
1AUK A; 1E1Z P; 1E2S P; 1E33 P; 1N2K A; 1N2L A; 
#similar chains, but unknotted

#similar chains in the pdb database (40% sequence similarity)

1E3CP

Slipknot S +31

Chain Sequence

pfam database annotations

Slipknot S +3₁