1ED8A

Structure of e. coli alkaline phosphatase inhibited by the inorganic phosphate at 1.75a resolution
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 48-368 321 1-47 420-449 369-419 47 30 slipknot
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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3.1 46-372 327 1-45 411-449 373-410 45 39 slipknot
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3.1 46-410 365 1-45 416-449 411-415 45 34 slipknot
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2.1 38-415 378 1-37 421-449 416-420 37 29 slipknot
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2.1 29-366 338 1-9, 372-449 10-28, 367-371 9 78 slipknot
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2.1 39-415 377 1-37, 421-449 38-38, 416-420 37 29 slipknot
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2.1 37-368 332 1-28, 373-449 29-36, 369-372 28 77 slipknot
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3.1 45-415 371 1-38, 419-449 39-44, 416-418 38 31 slipknot
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2.1 44-418 375 1-38, 421-449 39-43, 419-420 38 29 slipknot
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2.1 40-366 327 1-29, 373-449 30-39, 367-372 29 77 slipknot
sequence length 449
structure length 449
publication title A revised mechanism for the alkaline phosphatase reaction involving three metal ions.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
source organism Escherichia coli
total genus Genus: 166
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-01-27
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ed8A00
1ANJA 1HQAA 1B8JA 3M7VA 1KH9A 1AJBA 3UO0A 1EQJA 1KHNA 1ELXA 1KH7A 1ED9A 3IGYB 1N2LA 3M8YA 4FDIA 2GA3A 1AUKA 1ELYA 2IFYA 3UN2A 1ANIA 3BDGA 1KHLA 1K7HA 3TX0A 1AJAA 3BDGB 1ALJA 3UNYA 1ALKA 2GLQA 1SHNA 1KHKA 1HDHA 1E1ZP 1EW9A 3DPCA 3UN3A 3SZYA 1HJKA 3SZZA 3T00A 1ZEDA 3TWZA 3ED4A 1ZEFA 3DYCA 2G9YA 3M8WA 1ELZA 1P49A 3UN5A 3T01A 1Y7AA 1SHQA 2ANHA 1ED8A 3CMRA 3IGZB 1FSUA 1EI6A 3MK1A 1AJCA 1URAA 3BDHA 1E33P 1ALIA 1KHJA 1ZEBA 1E3CP 3MK2A 1EW2A 4FDJA 1AJDA 1N2KA 3M8ZA 1O98A 1KH4A 1URBA 2QZUA 1O99A 1KH5A 1EW8A 3BDFA 3MK0A 1EJJA 3NVLA 1E2SP 3OT9A 3T02A 1Y6VA
chains in the KnotProt database with same CATH superfamily
1ANJA 1HQAA 1B8JA 3M7VA 1KH9A 1AJBA 3UO0A 1EQJA 1KHNA 1ELXA 1KH7A 1ED9A 3IGYB 1N2LA 3M8YA 4FDIA 2GA3A 1AUKA 1ELYA 2IFYA 3UN2A 1ANIA 3BDGA 1KHLA 1K7HA 3TX0A 1AJAA 3BDGB 1ALJA 3UNYA 1ALKA 2GLQA 1SHNA 1KHKA 1HDHA 1E1ZP 1EW9A 3DPCA 3UN3A 3SZYA 1HJKA 3SZZA 3T00A 1ZEDA 3TWZA 3ED4A 1ZEFA 3DYCA 2G9YA 3M8WA 1ELZA 1P49A 3UN5A 3T01A 1Y7AA 1SHQA 2ANHA 1ED8A 3CMRA 3IGZB 1FSUA 1EI6A 3MK1A 1AJCA 1URAA 3BDHA 1E33P 1ALIA 1KHJA 1ZEBA 1E3CP 3MK2A 1EW2A 4FDJA 1AJDA 1N2KA 3M8ZA 1O98A 1KH4A 1URBA 2QZUA 1O99A 1KH5A 1EW8A 3BDFA 3MK0A 1EJJA 3NVLA 1E2SP 3OT9A 3T02A 1Y6VA
chains in the KnotProt database with same CATH topology
1ANJA 1HQAA 1B8JA 3M7VA 1KH9A 1AJBA 3UO0A 1EQJA 1KHNA 1ELXA 1KH7A 1ED9A 3IGYB 1N2LA 3M8YA 4FDIA 2GA3A 1AUKA 1ELYA 2IFYA 3UN2A 1ANIA 3BDGA 1KHLA 1K7HA 3TX0A 1AJAA 3BDGB 1ALJA 3UNYA 1ALKA 2GLQA 1SHNA 1KHKA 1HDHA 1E1ZP 1EW9A 3DPCA 3UN3A 3SZYA 1HJKA 3SZZA 3T00A 1ZEDA 3TWZA 3ED4A 1ZEFA 3DYCA 2G9YA 3M8WA 1ELZA 1P49A 3UN5A 3T01A 1Y7AA 1SHQA 2ANHA 1ED8A 3CMRA 3IGZB 1FSUA 1EI6A 3MK1A 1AJCA 1URAA 3BDHA 1E33P 1ALIA 1KHJA 1ZEBA 1E3CP 3MK2A 1EW2A 4FDJA 1AJDA 1N2KA 3M8ZA 1O98A 1KH4A 1URBA 2QZUA 1O99A 1KH5A 1EW8A 3BDFA 3MK0A 1EJJA 3NVLA 1E2SP 3OT9A 3T02A 1Y6VA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 1ANJ A;  1HQA A;  1B8J A;  3M7V A;  1KH9 A;  1AJB A;  3UO0 A;  1EQJ A;  1KHN A;  1ELX A;  1KH7 A;  1ED9 A;  3IGY B;  1N2L A;  3M8Y A;  4FDI A;  2GA3 A;  1AUK A;  1ELY A;  2IFY A;  3UN2 A;  1ANI A;  3BDG A;  1KHL A;  1K7H A;  3TX0 A;  1AJA A;  3BDG B;  1ALJ A;  3UNY A;  1ALK A;  2GLQ A;  1SHN A;  1KHK A;  1HDH A;  1E1Z P;  1EW9 A;  3DPC A;  3UN3 A;  3SZY A;  1HJK A;  3SZZ A;  3T00 A;  1ZED A;  3TWZ A;  3ED4 A;  1ZEF A;  3DYC A;  2G9Y A;  3M8W A;  1ELZ A;  1P49 A;  3UN5 A;  3T01 A;  1Y7A A;  1SHQ A;  2ANH A;  1ED8 A;  3CMR A;  3IGZ B;  1FSU A;  1EI6 A;  3MK1 A;  1AJC A;  1URA A;  3BDH A;  1E33 P;  1ALI A;  1KHJ A;  1ZEB A;  1E3C P;  3MK2 A;  1EW2 A;  4FDJ A;  1AJD A;  1N2K A;  3M8Z A;  1O98 A;  1KH4 A;  1URB A;  2QZU A;  1O99 A;  1KH5 A;  1EW8 A;  3BDF A;  3MK0 A;  1EJJ A;  3NVL A;  1E2S P;  3OT9 A;  3T02 A;  1Y6V A; 
#chains in the KnotProt database with same CATH topology
 1ANJ A;  1HQA A;  1B8J A;  3M7V A;  1KH9 A;  1AJB A;  3UO0 A;  1EQJ A;  1KHN A;  1ELX A;  1KH7 A;  1ED9 A;  3IGY B;  1N2L A;  3M8Y A;  4FDI A;  2GA3 A;  1AUK A;  1ELY A;  2IFY A;  3UN2 A;  1ANI A;  3BDG A;  1KHL A;  1K7H A;  3TX0 A;  1AJA A;  3BDG B;  1ALJ A;  3UNY A;  1ALK A;  2GLQ A;  1SHN A;  1KHK A;  1HDH A;  1E1Z P;  1EW9 A;  3DPC A;  3UN3 A;  3SZY A;  1HJK A;  3SZZ A;  3T00 A;  1ZED A;  3TWZ A;  3ED4 A;  1ZEF A;  3DYC A;  2G9Y A;  3M8W A;  1ELZ A;  1P49 A;  3UN5 A;  3T01 A;  1Y7A A;  1SHQ A;  2ANH A;  1ED8 A;  3CMR A;  3IGZ B;  1FSU A;  1EI6 A;  3MK1 A;  1AJC A;  1URA A;  3BDH A;  1E33 P;  1ALI A;  1KHJ A;  1ZEB A;  1E3C P;  3MK2 A;  1EW2 A;  4FDJ A;  1AJD A;  1N2K A;  3M8Z A;  1O98 A;  1KH4 A;  1URB A;  2QZU A;  1O99 A;  1KH5 A;  1EW8 A;  3BDF A;  3MK0 A;  1EJJ A;  3NVL A;  1E2S P;  3OT9 A;  3T02 A;  1Y6V A; 
#chains in the KnotProt database with same CATH homology
 1ANJ A;  1HQA A;  1B8J A;  3M7V A;  1KH9 A;  1AJB A;  3UO0 A;  1EQJ A;  1KHN A;  1ELX A;  1KH7 A;  1ED9 A;  3IGY B;  1N2L A;  3M8Y A;  4FDI A;  2GA3 A;  1AUK A;  1ELY A;  2IFY A;  3UN2 A;  1ANI A;  3BDG A;  1KHL A;  1K7H A;  3TX0 A;  1AJA A;  3BDG B;  1ALJ A;  3UNY A;  1ALK A;  2GLQ A;  1SHN A;  1KHK A;  1HDH A;  1E1Z P;  1EW9 A;  3DPC A;  3UN3 A;  3SZY A;  1HJK A;  3SZZ A;  3T00 A;  1ZED A;  3TWZ A;  3ED4 A;  1ZEF A;  3DYC A;  2G9Y A;  3M8W A;  1ELZ A;  1P49 A;  3UN5 A;  3T01 A;  1Y7A A;  1SHQ A;  2ANH A;  1ED8 A;  3CMR A;  3IGZ B;  1FSU A;  1EI6 A;  3MK1 A;  1AJC A;  1URA A;  3BDH A;  1E33 P;  1ALI A;  1KHJ A;  1ZEB A;  1E3C P;  3MK2 A;  1EW2 A;  4FDJ A;  1AJD A;  1N2K A;  3M8Z A;  1O98 A;  1KH4 A;  1URB A;  2QZU A;  1O99 A;  1KH5 A;  1EW8 A;  3BDF A;  3MK0 A;  1EJJ A;  3NVL A;  1E2S P;  3OT9 A;  3T02 A;  1Y6V A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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