1ED9A

Structure of e. coli alkaline phosphatase without the inorganic phosphate at 1.75a resolution
Slipknot S +31
Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
+31 46-369 324 1-45 419-449 370-418 45 31 slipknot
Chain Sequence
TPEMPVLENRAAQGDITAPGGARRLTGDQTAALRDSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQDATPAALVAHVTSRKCYGPSATSEKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREQAQARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQDHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis
Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1

Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
3.1 47-371 325 1-46 417-449 372-416 46 33 slipknot
view details
2.1 45-416 372 1-44 421-449 417-420 44 29 slipknot
view details
2.1 24-367 344 1-11, 372-449 12-23, 368-371 11 78 slipknot
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3.1 37-368 332 1-24, 372-449 25-36, 369-371 24 78 slipknot
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2.1 43-366 324 1-26, 372-449 27-42, 367-371 26 78 slipknot
sequence length 449
structure length 449
publication title A revised mechanism for the alkaline phosphatase reaction involving three metal ions.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords ALKALINE PHOSPHATASE
source organism Escherichia coli
total genus Genus: 167
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2000-01-27
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00245 Alk_phosphatase Alkaline phosphatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1ed9A00
3T00A 1AJCA 1ZEDA 1AJAA 3OT9A 3BDGB 3IGZB 1EI6A 3M8ZA 3T01A 1EQJA 1KH4A 3MK0A 3M8WA 3DPCA 1KH9A 3M8YA 1ED8A 1Y6VA 1URAA 3UO0A 4FDIA 1P49A 1SHNA 2GA3A 1EJJA 1EW8A 1KHJA 1Y7AA 1E33P 3MK1A 1KHKA 2ANHA 1HDHA 3NVLA 1AJBA 3DYCA 1FSUA 1E3CP 1ED9A 3T02A 3UN5A 1HJKA 1SHQA 3CMRA 1AJDA 1ELZA 3UN2A 1EW9A 1O98A 4FDJA 3SZYA 1KHNA 3SZZA 3TWZA 3ED4A 1KHLA 1URBA 3BDGA 3M7VA 3TX0A 1N2KA 3IGYB 3UN3A 1K7HA 3MK2A 1AUKA 1ZEFA 1O99A 2G9YA 2IFYA 1N2LA 1EW2A 1B8JA 1KH7A 1E1ZP 1E2SP 3UNYA 1ANJA 1ANIA 1HQAA 3BDFA 1ZEBA 3BDHA 1KH5A 1ELXA 1ALKA 1ELYA 1ALHA 1ALIA 1ALJA 2GLQA 2QZUA
chains in the KnotProt database with same CATH superfamily
3T00A 1AJCA 1ZEDA 1AJAA 3OT9A 3BDGB 3IGZB 1EI6A 3M8ZA 3T01A 1EQJA 1KH4A 3MK0A 3M8WA 3DPCA 1KH9A 3M8YA 1ED8A 1Y6VA 1URAA 3UO0A 4FDIA 1P49A 1SHNA 2GA3A 1EJJA 1EW8A 1KHJA 1Y7AA 1E33P 3MK1A 1KHKA 2ANHA 1HDHA 3NVLA 1AJBA 3DYCA 1FSUA 1E3CP 1ED9A 3T02A 3UN5A 1HJKA 1SHQA 3CMRA 1AJDA 1ELZA 3UN2A 1EW9A 1O98A 4FDJA 3SZYA 1KHNA 3SZZA 3TWZA 3ED4A 1KHLA 1URBA 3BDGA 3M7VA 3TX0A 1N2KA 3IGYB 3UN3A 1K7HA 3MK2A 1AUKA 1ZEFA 1O99A 2G9YA 2IFYA 1N2LA 1EW2A 1B8JA 1KH7A 1E1ZP 1E2SP 3UNYA 1ANJA 1ANIA 1HQAA 3BDFA 1ZEBA 3BDHA 1KH5A 1ELXA 1ALKA 1ELYA 1ALHA 1ALIA 1ALJA 2GLQA 2QZUA
chains in the KnotProt database with same CATH topology
3T00A 1AJCA 1ZEDA 1AJAA 3OT9A 3BDGB 3IGZB 1EI6A 3M8ZA 3T01A 1EQJA 1KH4A 3MK0A 3M8WA 3DPCA 1KH9A 3M8YA 1ED8A 1Y6VA 1URAA 3UO0A 4FDIA 1P49A 1SHNA 2GA3A 1EJJA 1EW8A 1KHJA 1Y7AA 1E33P 3MK1A 1KHKA 2ANHA 1HDHA 3NVLA 1AJBA 3DYCA 1FSUA 1E3CP 1ED9A 3T02A 3UN5A 1HJKA 1SHQA 3CMRA 1AJDA 1ELZA 3UN2A 1EW9A 1O98A 4FDJA 3SZYA 1KHNA 3SZZA 3TWZA 3ED4A 1KHLA 1URBA 3BDGA 3M7VA 3TX0A 1N2KA 3IGYB 3UN3A 1K7HA 3MK2A 1AUKA 1ZEFA 1O99A 2G9YA 2IFYA 1N2LA 1EW2A 1B8JA 1KH7A 1E1ZP 1E2SP 3UNYA 1ANJA 1ANIA 1HQAA 3BDFA 1ZEBA 3BDHA 1KH5A 1ELXA 1ALKA 1ELYA 1ALHA 1ALIA 1ALJA 2GLQA 2QZUA
chains in the KnotProt database with same CATH homology


 
#chains in the KnotProt database with same CATH superfamily
 3T00 A;  1AJC A;  1ZED A;  1AJA A;  3OT9 A;  3BDG B;  3IGZ B;  1EI6 A;  3M8Z A;  3T01 A;  1EQJ A;  1KH4 A;  3MK0 A;  3M8W A;  3DPC A;  1KH9 A;  3M8Y A;  1ED8 A;  1Y6V A;  1URA A;  3UO0 A;  4FDI A;  1P49 A;  1SHN A;  2GA3 A;  1EJJ A;  1EW8 A;  1KHJ A;  1Y7A A;  1E33 P;  3MK1 A;  1KHK A;  2ANH A;  1HDH A;  3NVL A;  1AJB A;  3DYC A;  1FSU A;  1E3C P;  1ED9 A;  3T02 A;  3UN5 A;  1HJK A;  1SHQ A;  3CMR A;  1AJD A;  1ELZ A;  3UN2 A;  1EW9 A;  1O98 A;  4FDJ A;  3SZY A;  1KHN A;  3SZZ A;  3TWZ A;  3ED4 A;  1KHL A;  1URB A;  3BDG A;  3M7V A;  3TX0 A;  1N2K A;  3IGY B;  3UN3 A;  1K7H A;  3MK2 A;  1AUK A;  1ZEF A;  1O99 A;  2G9Y A;  2IFY A;  1N2L A;  1EW2 A;  1B8J A;  1KH7 A;  1E1Z P;  1E2S P;  3UNY A;  1ANJ A;  1ANI A;  1HQA A;  3BDF A;  1ZEB A;  3BDH A;  1KH5 A;  1ELX A;  1ALK A;  1ELY A;  1ALH A;  1ALI A;  1ALJ A;  2GLQ A;  2QZU A; 
#chains in the KnotProt database with same CATH topology
 3T00 A;  1AJC A;  1ZED A;  1AJA A;  3OT9 A;  3BDG B;  3IGZ B;  1EI6 A;  3M8Z A;  3T01 A;  1EQJ A;  1KH4 A;  3MK0 A;  3M8W A;  3DPC A;  1KH9 A;  3M8Y A;  1ED8 A;  1Y6V A;  1URA A;  3UO0 A;  4FDI A;  1P49 A;  1SHN A;  2GA3 A;  1EJJ A;  1EW8 A;  1KHJ A;  1Y7A A;  1E33 P;  3MK1 A;  1KHK A;  2ANH A;  1HDH A;  3NVL A;  1AJB A;  3DYC A;  1FSU A;  1E3C P;  1ED9 A;  3T02 A;  3UN5 A;  1HJK A;  1SHQ A;  3CMR A;  1AJD A;  1ELZ A;  3UN2 A;  1EW9 A;  1O98 A;  4FDJ A;  3SZY A;  1KHN A;  3SZZ A;  3TWZ A;  3ED4 A;  1KHL A;  1URB A;  3BDG A;  3M7V A;  3TX0 A;  1N2K A;  3IGY B;  3UN3 A;  1K7H A;  3MK2 A;  1AUK A;  1ZEF A;  1O99 A;  2G9Y A;  2IFY A;  1N2L A;  1EW2 A;  1B8J A;  1KH7 A;  1E1Z P;  1E2S P;  3UNY A;  1ANJ A;  1ANI A;  1HQA A;  3BDF A;  1ZEB A;  3BDH A;  1KH5 A;  1ELX A;  1ALK A;  1ELY A;  1ALH A;  1ALI A;  1ALJ A;  2GLQ A;  2QZU A; 
#chains in the KnotProt database with same CATH homology
 3T00 A;  1AJC A;  1ZED A;  1AJA A;  3OT9 A;  3BDG B;  3IGZ B;  1EI6 A;  3M8Z A;  3T01 A;  1EQJ A;  1KH4 A;  3MK0 A;  3M8W A;  3DPC A;  1KH9 A;  3M8Y A;  1ED8 A;  1Y6V A;  1URA A;  3UO0 A;  4FDI A;  1P49 A;  1SHN A;  2GA3 A;  1EJJ A;  1EW8 A;  1KHJ A;  1Y7A A;  1E33 P;  3MK1 A;  1KHK A;  2ANH A;  1HDH A;  3NVL A;  1AJB A;  3DYC A;  1FSU A;  1E3C P;  1ED9 A;  3T02 A;  3UN5 A;  1HJK A;  1SHQ A;  3CMR A;  1AJD A;  1ELZ A;  3UN2 A;  1EW9 A;  1O98 A;  4FDJ A;  3SZY A;  1KHN A;  3SZZ A;  3TWZ A;  3ED4 A;  1KHL A;  1URB A;  3BDG A;  3M7V A;  3TX0 A;  1N2K A;  3IGY B;  3UN3 A;  1K7H A;  3MK2 A;  1AUK A;  1ZEF A;  1O99 A;  2G9Y A;  2IFY A;  1N2L A;  1EW2 A;  1B8J A;  1KH7 A;  1E1Z P;  1E2S P;  3UNY A;  1ANJ A;  1ANI A;  1HQA A;  3BDF A;  1ZEB A;  3BDH A;  1KH5 A;  1ELX A;  1ALK A;  1ELY A;  1ALH A;  1ALI A;  1ALJ A;  2GLQ A;  2QZU A; 
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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