1FSUA

4-sulfatase (human)
Warning
  • Chain breaks within knot 31 (displayed as a gray area on the plot and as '-' on the sequence). The broken part of the chain has been replaced by a straight segment, which may affect what knot types are detected - be careful with interpreting results.
Genus: 164
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 8-259 252 1-7 288-492 260-287 7 205 slipknot
Chain Sequence
SRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQPL-TPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCS-----------------AFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
view details
2.1 8-268 261 1-7 283-474 269-282 7 192 slipknot
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3.1 7-282 276 1-6 288-474 283-287 6 187 slipknot
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3.1 9-278 270 1-6, 288-474 7-8, 279-287 6 187 slipknot
sequence length 492
structure length 474
publication title Structure of a human lysosomal sulfatase.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords N-ACETYLGALACTOSAMINE-4-SULFATASE
source organism Homo sapiens
missing residues 50, 365-381
total genus Genus: 164
ec nomenclature ec 3.1.6.12: N-acetylgalactosamine-4-sulfatase.
pdb deposition date 1996-07-29
KnotProt deposition date 2014-07-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00884 Sulfatase Sulfatase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1120.10 Alpha Beta 2-Layer Sandwich Arylsulfatase, C-terminal domain Arylsulfatase, C-terminal domain 1fsuA02
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1fsuA01
1ZEDA 1EW8A 3MK2A 1ANIA 1E2SP 3T02A 3MK1A 1ALIA 1ZEBA 1ED9A 1E1ZP 4FDJA 1N2LA 3IGZB 1KH5A 3M8ZA 3M8WA 3ED4A 3UNYA 3BDHA 1AJDA 1B8JA 3BDFA 3UN5A 1ZEFA 1HJKA 3T00A 3DPCA 1EI6A 1ELXA 2G9YA 1URAA 3SZYA 1AUKA 1KHNA 1EQJA 4FDIA 1HDHA 1KH4A 1KH7A 1SHQA 3CMRA 1ELYA 1AJBA 2QZUA 1AJCA 1E3CP 1ELZA 1O99A 1URBA 3DYCA 3M8YA 1Y7AA 1K7HA 1ANJA 1KHKA 1SHNA 2ANHA 3TX0A 1ED8A 1EW9A 3BDGB 3NVLA 1ALJA 1AJAA 1HQAA 1KHJA 1ALKA 1N2KA 3UO0A 2IFYA 1O98A 1FSUA 3BDGA 2GA3A 3TWZA 3SZZA 1EJJA 3UN2A 3UN3A 2GLQA 3MK0A 3OT9A 1KH9A 1Y6VA 3IGYB 1KHLA 3M7VA 1EW2A 3T01A 1P49A 1E33P
chains in the KnotProt database with same CATH superfamily
1ZEDA 1EW8A 3MK2A 1ANIA 1E2SP 3T02A 3MK1A 1ALIA 1ZEBA 1ED9A 1E1ZP 4FDJA 1N2LA 3IGZB 1KH5A 3M8ZA 3M8WA 3ED4A 3UNYA 3BDHA 1AJDA 1B8JA 3BDFA 3UN5A 1ZEFA 1HJKA 3T00A 3DPCA 1EI6A 1ELXA 2G9YA 1URAA 3SZYA 1AUKA 1KHNA 1EQJA 4FDIA 1HDHA 1KH4A 1KH7A 1SHQA 3CMRA 1ELYA 1AJBA 2QZUA 1AJCA 1E3CP 1ELZA 1O99A 1URBA 3DYCA 3M8YA 1Y7AA 1K7HA 1ANJA 1KHKA 1SHNA 2ANHA 3TX0A 1ED8A 1EW9A 3BDGB 3NVLA 1ALJA 1AJAA 1HQAA 1KHJA 1ALKA 1N2KA 3UO0A 2IFYA 1O98A 1FSUA 3BDGA 2GA3A 3TWZA 3SZZA 1EJJA 3UN2A 3UN3A 2GLQA 3MK0A 3OT9A 1KH9A 1Y6VA 3IGYB 1KHLA 3M7VA 1EW2A 3T01A 1P49A 1E33P
chains in the KnotProt database with same CATH topology
1ZEDA 1EW8A 3MK2A 1ANIA 1E2SP 3T02A 3MK1A 1ALIA 1ZEBA 1ED9A 1E1ZP 4FDJA 1N2LA 3IGZB 1KH5A 3M8ZA 3M8WA 3ED4A 3UNYA 3BDHA 1AJDA 1B8JA 3BDFA 3UN5A 1ZEFA 1HJKA 3T00A 3DPCA 1EI6A 1ELXA 2G9YA 1URAA 3SZYA 1AUKA 1KHNA 1EQJA 4FDIA 1HDHA 1KH4A 1KH7A 1SHQA 3CMRA 1ELYA 1AJBA 2QZUA 1AJCA 1E3CP 1ELZA 1O99A 1URBA 3DYCA 3M8YA 1Y7AA 1K7HA 1ANJA 1KHKA 1SHNA 2ANHA 3TX0A 1ED8A 1EW9A 3BDGB 3NVLA 1ALJA 1AJAA 1HQAA 1KHJA 1ALKA 1N2KA 3UO0A 2IFYA 1O98A 1FSUA 3BDGA 2GA3A 3TWZA 3SZZA 1EJJA 3UN2A 3UN3A 2GLQA 3MK0A 3OT9A 1KH9A 1Y6VA 3IGYB 1KHLA 3M7VA 1EW2A 3T01A 1P49A 1E33P
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1ZED A;  1EW8 A;  3MK2 A;  1ANI A;  1E2S P;  3T02 A;  3MK1 A;  1ALI A;  1ZEB A;  1ED9 A;  1E1Z P;  4FDJ A;  1N2L A;  3IGZ B;  1KH5 A;  3M8Z A;  3M8W A;  3ED4 A;  3UNY A;  3BDH A;  1AJD A;  1B8J A;  3BDF A;  3UN5 A;  1ZEF A;  1HJK A;  3T00 A;  3DPC A;  1EI6 A;  1ELX A;  2G9Y A;  1URA A;  3SZY A;  1AUK A;  1KHN A;  1EQJ A;  4FDI A;  1HDH A;  1KH4 A;  1KH7 A;  1SHQ A;  3CMR A;  1ELY A;  1AJB A;  2QZU A;  1AJC A;  1E3C P;  1ELZ A;  1O99 A;  1URB A;  3DYC A;  3M8Y A;  1Y7A A;  1K7H A;  1ANJ A;  1KHK A;  1SHN A;  2ANH A;  3TX0 A;  1ED8 A;  1EW9 A;  3BDG B;  3NVL A;  1ALJ A;  1AJA A;  1HQA A;  1KHJ A;  1ALK A;  1N2K A;  3UO0 A;  2IFY A;  1O98 A;  1FSU A;  3BDG A;  2GA3 A;  3TWZ A;  3SZZ A;  1EJJ A;  3UN2 A;  3UN3 A;  2GLQ A;  3MK0 A;  3OT9 A;  1KH9 A;  1Y6V A;  3IGY B;  1KHL A;  3M7V A;  1EW2 A;  3T01 A;  1P49 A;  1E33 P; 
#chains in the KnotProt database with same CATH topology
 1ZED A;  1EW8 A;  3MK2 A;  1ANI A;  1E2S P;  3T02 A;  3MK1 A;  1ALI A;  1ZEB A;  1ED9 A;  1E1Z P;  4FDJ A;  1N2L A;  3IGZ B;  1KH5 A;  3M8Z A;  3M8W A;  3ED4 A;  3UNY A;  3BDH A;  1AJD A;  1B8J A;  3BDF A;  3UN5 A;  1ZEF A;  1HJK A;  3T00 A;  3DPC A;  1EI6 A;  1ELX A;  2G9Y A;  1URA A;  3SZY A;  1AUK A;  1KHN A;  1EQJ A;  4FDI A;  1HDH A;  1KH4 A;  1KH7 A;  1SHQ A;  3CMR A;  1ELY A;  1AJB A;  2QZU A;  1AJC A;  1E3C P;  1ELZ A;  1O99 A;  1URB A;  3DYC A;  3M8Y A;  1Y7A A;  1K7H A;  1ANJ A;  1KHK A;  1SHN A;  2ANH A;  3TX0 A;  1ED8 A;  1EW9 A;  3BDG B;  3NVL A;  1ALJ A;  1AJA A;  1HQA A;  1KHJ A;  1ALK A;  1N2K A;  3UO0 A;  2IFY A;  1O98 A;  1FSU A;  3BDG A;  2GA3 A;  3TWZ A;  3SZZ A;  1EJJ A;  3UN2 A;  3UN3 A;  2GLQ A;  3MK0 A;  3OT9 A;  1KH9 A;  1Y6V A;  3IGY B;  1KHL A;  3M7V A;  1EW2 A;  3T01 A;  1P49 A;  1E33 P; 
#chains in the KnotProt database with same CATH homology
 1ZED A;  1EW8 A;  3MK2 A;  1ANI A;  1E2S P;  3T02 A;  3MK1 A;  1ALI A;  1ZEB A;  1ED9 A;  1E1Z P;  4FDJ A;  1N2L A;  3IGZ B;  1KH5 A;  3M8Z A;  3M8W A;  3ED4 A;  3UNY A;  3BDH A;  1AJD A;  1B8J A;  3BDF A;  3UN5 A;  1ZEF A;  1HJK A;  3T00 A;  3DPC A;  1EI6 A;  1ELX A;  2G9Y A;  1URA A;  3SZY A;  1AUK A;  1KHN A;  1EQJ A;  4FDI A;  1HDH A;  1KH4 A;  1KH7 A;  1SHQ A;  3CMR A;  1ELY A;  1AJB A;  2QZU A;  1AJC A;  1E3C P;  1ELZ A;  1O99 A;  1URB A;  3DYC A;  3M8Y A;  1Y7A A;  1K7H A;  1ANJ A;  1KHK A;  1SHN A;  2ANH A;  3TX0 A;  1ED8 A;  1EW9 A;  3BDG B;  3NVL A;  1ALJ A;  1AJA A;  1HQA A;  1KHJ A;  1ALK A;  1N2K A;  3UO0 A;  2IFY A;  1O98 A;  1FSU A;  3BDG A;  2GA3 A;  3TWZ A;  3SZZ A;  1EJJ A;  3UN2 A;  3UN3 A;  2GLQ A;  3MK0 A;  3OT9 A;  1KH9 A;  1Y6V A;  3IGY B;  1KHL A;  3M7V A;  1EW2 A;  3T01 A;  1P49 A;  1E33 P;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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