1KH7A

E. coli alkaline phosphatase mutant (d153gd330n)
Genus: 151
Slipknot S +31

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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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+31 41-363 323 1-40 414-444 364-413 40 31 slipknot
Chain Sequence
VLENRAAQGNITAPGGARRLTGDQTAALRNSLSDKPAKNIILLIGDGMGDSEITAARNYAEGAGGFFKGIDALPLTGQYTHYALNKKTGKPDYVTDSAASATAWSTGVKTYNGALGVDIHEKDHPTILEMAKAAGLATGNVSTAELQGATPAALVAHVTSRKCYGPSKTSQKCPGNALEKGGKGSITEQLLNARADVTLGGGAKTFAETATAGEWQGKTLREEAEARGYQLVSDAASLNSVTEANQQKPLLGLFADGNMPVRWLGPKATYHGNIDKPAVTCTPNPQRNDSVPTLAQMTDKAIELLSKNEKGFFLQVEGASIDKQNHAANPCGQIGETVDLDEAVQRALEFAKKEGNTLVIVTADHAHASQIVAPDTKAPGLTQALNTKDGAVMVMSYGNSEEDSQEHTGSQLRIAAYGPHAANVVGLTDQTDLFYTMKAALGLK
Whole chain analysis

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Subchain analysis 

Knotoid cutoff: 0.5


Knotoid matrix content: 1


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Knot core range Knot core length Knot tails range Slipknot tails range Slipknot loops range N-end length C-end length Type
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2.1 39-362 324 1-38 370-444 363-369 38 75 slipknot
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3.1 44-365 322 1-43 383-444 366-382 43 62 slipknot
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3.1 44-382 339 1-43 407-444 383-406 43 38 slipknot
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3.1 44-406 363 1-43 412-444 407-411 43 33 slipknot
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2.1 39-411 373 1-38 416-444 412-415 38 29 slipknot
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2.1 40-411 372 1-38, 414-444 39-39, 412-413 38 31 slipknot
sequence length 444
structure length 444
publication title Artificial evolution of an enzyme active site: structural studies of three highly active mutants of Escherichia coli alkaline phosphatase.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords alkaline phosphatase
source organism Escherichia coli
total genus Genus: 151
ec nomenclature ec 3.1.3.1: Alkaline phosphatase.
pdb deposition date 2001-11-29
KnotProt deposition date 2014-07-31
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.720.10 Alpha Beta 3-Layer(aba) Sandwich Alkaline Phosphatase, subunit A Alkaline Phosphatase, subunit A 1kh7A00
1KHLA 3BDGA 3MK1A 1ED9A 1ELXA 1P49A 3TX0A 3T00A 1ANJA 3NVLA 1EI6A 1AJBA 3UNYA 1EJJA 3MK0A 1URAA 3UN3A 4FDJA 3UN2A 1AJDA 1ZEFA 1B8JA 1SHQA 3IGZB 3BDHA 2GA3A 3MK2A 1URBA 1KH5A 1ANIA 1HQAA 1SHNA 3CMRA 1N2LA 1KHKA 3BDGB 1E1ZP 1O99A 3T01A 3M8YA 3UN5A 2GLQA 1KH7A 1K7HA 1ELZA 4FDIA 1EQJA 1ELYA 3DYCA 1EW8A 3ED4A 1KHJA 3TWZA 1N2KA 3SZYA 1E3CP 1ZEBA 1EW9A 1HJKA 3M7VA 2IFYA 3M8WA 1ALJA 1AUKA 1Y6VA 1E2SP 3BDFA 3IGYB 1AJAA 1O98A 3T02A 1ED8A 2G9YA 1HDHA 1ALKA 3UO0A 2ANHA 1EW2A 1Y7AA 1FSUA 1ZEDA 1ALIA 3OT9A 2QZUA 1AJCA 1KH4A 3SZZA 1E33P 3DPCA 1KHNA 1KH9A 3M8ZA
chains in the KnotProt database with same CATH superfamily
1KHLA 3BDGA 3MK1A 1ED9A 1ELXA 1P49A 3TX0A 3T00A 1ANJA 3NVLA 1EI6A 1AJBA 3UNYA 1EJJA 3MK0A 1URAA 3UN3A 4FDJA 3UN2A 1AJDA 1ZEFA 1B8JA 1SHQA 3IGZB 3BDHA 2GA3A 3MK2A 1URBA 1KH5A 1ANIA 1HQAA 1SHNA 3CMRA 1N2LA 1KHKA 3BDGB 1E1ZP 1O99A 3T01A 3M8YA 3UN5A 2GLQA 1KH7A 1K7HA 1ELZA 4FDIA 1EQJA 1ELYA 3DYCA 1EW8A 3ED4A 1KHJA 3TWZA 1N2KA 3SZYA 1E3CP 1ZEBA 1EW9A 1HJKA 3M7VA 2IFYA 3M8WA 1ALJA 1AUKA 1Y6VA 1E2SP 3BDFA 3IGYB 1AJAA 1O98A 3T02A 1ED8A 2G9YA 1HDHA 1ALKA 3UO0A 2ANHA 1EW2A 1Y7AA 1FSUA 1ZEDA 1ALIA 3OT9A 2QZUA 1AJCA 1KH4A 3SZZA 1E33P 3DPCA 1KHNA 1KH9A 3M8ZA
chains in the KnotProt database with same CATH topology
1KHLA 3BDGA 3MK1A 1ED9A 1ELXA 1P49A 3TX0A 3T00A 1ANJA 3NVLA 1EI6A 1AJBA 3UNYA 1EJJA 3MK0A 1URAA 3UN3A 4FDJA 3UN2A 1AJDA 1ZEFA 1B8JA 1SHQA 3IGZB 3BDHA 2GA3A 3MK2A 1URBA 1KH5A 1ANIA 1HQAA 1SHNA 3CMRA 1N2LA 1KHKA 3BDGB 1E1ZP 1O99A 3T01A 3M8YA 3UN5A 2GLQA 1KH7A 1K7HA 1ELZA 4FDIA 1EQJA 1ELYA 3DYCA 1EW8A 3ED4A 1KHJA 3TWZA 1N2KA 3SZYA 1E3CP 1ZEBA 1EW9A 1HJKA 3M7VA 2IFYA 3M8WA 1ALJA 1AUKA 1Y6VA 1E2SP 3BDFA 3IGYB 1AJAA 1O98A 3T02A 1ED8A 2G9YA 1HDHA 1ALKA 3UO0A 2ANHA 1EW2A 1Y7AA 1FSUA 1ZEDA 1ALIA 3OT9A 2QZUA 1AJCA 1KH4A 3SZZA 1E33P 3DPCA 1KHNA 1KH9A 3M8ZA
chains in the KnotProt database with same CATH homology

  
#chains in the KnotProt database with same CATH superfamily
 1KHL A;  3BDG A;  3MK1 A;  1ED9 A;  1ELX A;  1P49 A;  3TX0 A;  3T00 A;  1ANJ A;  3NVL A;  1EI6 A;  1AJB A;  3UNY A;  1EJJ A;  3MK0 A;  1URA A;  3UN3 A;  4FDJ A;  3UN2 A;  1AJD A;  1ZEF A;  1B8J A;  1SHQ A;  3IGZ B;  3BDH A;  2GA3 A;  3MK2 A;  1URB A;  1KH5 A;  1ANI A;  1HQA A;  1SHN A;  3CMR A;  1N2L A;  1KHK A;  3BDG B;  1E1Z P;  1O99 A;  3T01 A;  3M8Y A;  3UN5 A;  2GLQ A;  1KH7 A;  1K7H A;  1ELZ A;  4FDI A;  1EQJ A;  1ELY A;  3DYC A;  1EW8 A;  3ED4 A;  1KHJ A;  3TWZ A;  1N2K A;  3SZY A;  1E3C P;  1ZEB A;  1EW9 A;  1HJK A;  3M7V A;  2IFY A;  3M8W A;  1ALJ A;  1AUK A;  1Y6V A;  1E2S P;  3BDF A;  3IGY B;  1AJA A;  1O98 A;  3T02 A;  1ED8 A;  2G9Y A;  1HDH A;  1ALK A;  3UO0 A;  2ANH A;  1EW2 A;  1Y7A A;  1FSU A;  1ZED A;  1ALI A;  3OT9 A;  2QZU A;  1AJC A;  1KH4 A;  3SZZ A;  1E33 P;  3DPC A;  1KHN A;  1KH9 A;  3M8Z A; 
#chains in the KnotProt database with same CATH topology
 1KHL A;  3BDG A;  3MK1 A;  1ED9 A;  1ELX A;  1P49 A;  3TX0 A;  3T00 A;  1ANJ A;  3NVL A;  1EI6 A;  1AJB A;  3UNY A;  1EJJ A;  3MK0 A;  1URA A;  3UN3 A;  4FDJ A;  3UN2 A;  1AJD A;  1ZEF A;  1B8J A;  1SHQ A;  3IGZ B;  3BDH A;  2GA3 A;  3MK2 A;  1URB A;  1KH5 A;  1ANI A;  1HQA A;  1SHN A;  3CMR A;  1N2L A;  1KHK A;  3BDG B;  1E1Z P;  1O99 A;  3T01 A;  3M8Y A;  3UN5 A;  2GLQ A;  1KH7 A;  1K7H A;  1ELZ A;  4FDI A;  1EQJ A;  1ELY A;  3DYC A;  1EW8 A;  3ED4 A;  1KHJ A;  3TWZ A;  1N2K A;  3SZY A;  1E3C P;  1ZEB A;  1EW9 A;  1HJK A;  3M7V A;  2IFY A;  3M8W A;  1ALJ A;  1AUK A;  1Y6V A;  1E2S P;  3BDF A;  3IGY B;  1AJA A;  1O98 A;  3T02 A;  1ED8 A;  2G9Y A;  1HDH A;  1ALK A;  3UO0 A;  2ANH A;  1EW2 A;  1Y7A A;  1FSU A;  1ZED A;  1ALI A;  3OT9 A;  2QZU A;  1AJC A;  1KH4 A;  3SZZ A;  1E33 P;  3DPC A;  1KHN A;  1KH9 A;  3M8Z A; 
#chains in the KnotProt database with same CATH homology
 1KHL A;  3BDG A;  3MK1 A;  1ED9 A;  1ELX A;  1P49 A;  3TX0 A;  3T00 A;  1ANJ A;  3NVL A;  1EI6 A;  1AJB A;  3UNY A;  1EJJ A;  3MK0 A;  1URA A;  3UN3 A;  4FDJ A;  3UN2 A;  1AJD A;  1ZEF A;  1B8J A;  1SHQ A;  3IGZ B;  3BDH A;  2GA3 A;  3MK2 A;  1URB A;  1KH5 A;  1ANI A;  1HQA A;  1SHN A;  3CMR A;  1N2L A;  1KHK A;  3BDG B;  1E1Z P;  1O99 A;  3T01 A;  3M8Y A;  3UN5 A;  2GLQ A;  1KH7 A;  1K7H A;  1ELZ A;  4FDI A;  1EQJ A;  1ELY A;  3DYC A;  1EW8 A;  3ED4 A;  1KHJ A;  3TWZ A;  1N2K A;  3SZY A;  1E3C P;  1ZEB A;  1EW9 A;  1HJK A;  3M7V A;  2IFY A;  3M8W A;  1ALJ A;  1AUK A;  1Y6V A;  1E2S P;  3BDF A;  3IGY B;  1AJA A;  1O98 A;  3T02 A;  1ED8 A;  2G9Y A;  1HDH A;  1ALK A;  3UO0 A;  2ANH A;  1EW2 A;  1Y7A A;  1FSU A;  1ZED A;  1ALI A;  3OT9 A;  2QZU A;  1AJC A;  1KH4 A;  3SZZ A;  1E33 P;  3DPC A;  1KHN A;  1KH9 A;  3M8Z A;
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similar chains in the KnotProt database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the KnotProt database (?% sequence similarity)
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#similar chains, but unknotted
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